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Items: 1 to 50 of 60

1.

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis.

Korhonen P, Pollari E, Kanninen KM, Savchenko E, Lehtonen Š, Wojciechowski S, Pomeshchik Y, Van Den Bosch L, Goldsteins G, Koistinaho J, Malm T.

IBRO Rep. 2019 Jan 11;6:74-86. doi: 10.1016/j.ibror.2019.01.005. eCollection 2019 Jun.

2.

Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes.

Gynther M, Puris E, Peltokangas S, Auriola S, Kanninen KM, Koistinaho J, Huttunen KM, Ruponen M, Vellonen KS.

Pharm Res. 2018 Nov 28;36(1):17. doi: 10.1007/s11095-018-2546-7.

3.

PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes.

Konttinen H, Gureviciene I, Oksanen M, Grubman A, Loppi S, Huuskonen MT, Korhonen P, Lampinen R, Keuters M, Belaya I, Tanila H, Kanninen KM, Goldsteins G, Landreth G, Koistinaho J, Malm T.

Glia. 2019 Jan;67(1):146-159. doi: 10.1002/glia.23534. Epub 2018 Nov 19.

PMID:
30453390
4.

CuII(atsm) Attenuates Neuroinflammation.

Choo XY, Liddell JR, Huuskonen MT, Grubman A, Moujalled D, Roberts J, Kysenius K, Patten L, Quek H, Oikari LE, Duncan C, James SA, McInnes LE, Hayne DJ, Donnelly PS, Pollari E, Vähätalo S, Lejavová K, Kettunen MI, Malm T, Koistinaho J, White AR, Kanninen KM.

Front Neurosci. 2018 Sep 24;12:668. doi: 10.3389/fnins.2018.00668. eCollection 2018.

5.

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage.

Loppi S, Kolosowska N, Kärkkäinen O, Korhonen P, Huuskonen M, Grubman A, Dhungana H, Wojciechowski S, Pomeshchik Y, Giordano M, Kagechika H, White A, Auriola S, Koistinaho J, Landreth G, Hanhineva K, Kanninen K, Malm T.

Brain Behav Immun. 2018 Oct;73:670-681. doi: 10.1016/j.bbi.2018.07.021. Epub 2018 Jul 29.

PMID:
30063972
6.

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration.

Abdalkader M, Lampinen R, Kanninen KM, Malm TM, Liddell JR.

Front Neurosci. 2018 Jul 10;12:466. doi: 10.3389/fnins.2018.00466. eCollection 2018. Review.

7.

Long-Term Exercise Protects against Cellular Stresses in Aged Mice.

Belaya I, Suwa M, Chen T, Giniatullin R, Kanninen KM, Atalay M, Kumagai S.

Oxid Med Cell Longev. 2018 Mar 25;2018:2894247. doi: 10.1155/2018/2894247. eCollection 2018.

8.

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation.

Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T.

J Neuroinflammation. 2017 Dec 4;14(1):237. doi: 10.1186/s12974-017-1010-7.

9.

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.

Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen Š, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J.

Stem Cell Reports. 2017 Dec 12;9(6):1885-1897. doi: 10.1016/j.stemcr.2017.10.016. Epub 2017 Nov 16.

10.

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.

Vellonen KS, Ihalainen J, Boucau MC, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M.

Pharm Res. 2017 Dec;34(12):2652-2662. doi: 10.1007/s11095-017-2263-7. Epub 2017 Sep 26.

PMID:
28952054
11.

Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy.

Nissinen J, Andrade P, Natunen T, Hiltunen M, Malm T, Kanninen K, Soares JI, Shatillo O, Sallinen J, Ndode-Ekane XE, Pitkänen A.

Epilepsy Res. 2017 Oct;136:18-34. doi: 10.1016/j.eplepsyres.2017.07.005. Epub 2017 Jul 12.

PMID:
28753497
12.

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder.

Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm T, Koistinaho J, Kanninen KM.

Dis Model Mech. 2017 Sep 1;10(9):1089-1100. doi: 10.1242/dmm.029165. Epub 2017 Jul 21.

13.

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy.

Leinonen H, Keksa-Goldsteine V, Ragauskas S, Kohlmann P, Singh Y, Savchenko E, Puranen J, Malm T, Kalesnykas G, Koistinaho J, Tanila H, Kanninen KM.

Sci Rep. 2017 May 9;7(1):1597. doi: 10.1038/s41598-017-01716-1.

15.

Lack of collagen XV is protective after ischemic stroke in mice.

Dhungana H, Huuskonen MT, Pihlajaniemi T, Heljasvaara R, Vivien D, Kanninen KM, Malm T, Koistinaho J, Lemarchant S.

Cell Death Dis. 2017 Jan 12;8(1):e2541. doi: 10.1038/cddis.2016.456.

16.

The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu.

Huuskonen MT, Tuo QZ, Loppi S, Dhungana H, Korhonen P, McInnes LE, Donnelly PS, Grubman A, Wojciechowski S, Lejavova K, Pomeshchik Y, Periviita L, Kosonen L, Giordano M, Walker FR, Liu R, Bush AI, Koistinaho J, Malm T, White AR, Lei P, Kanninen KM.

Neurotherapeutics. 2017 Apr;14(2):519-532. doi: 10.1007/s13311-016-0504-9.

17.

Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets.

Grubman A, Kanninen KM, Malm T.

J Mol Neurosci. 2016 Nov;60(3):390-404. Epub 2016 Sep 22. Review.

PMID:
27660215
18.

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy.

Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM.

Sci Rep. 2016 Sep 14;6:33176. doi: 10.1038/srep33176.

19.

Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage.

Rolova T, Dhungana H, Korhonen P, Valonen P, Kolosowska N, Konttinen H, Kanninen K, Tanila H, Malm T, Koistinaho J.

Aging Dis. 2015 Nov 23;7(4):450-65. doi: 10.14336/AD.2015.1123. eCollection 2016 Aug.

20.

Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.

Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J.

Glia. 2016 Sep;64(9):1492-507. doi: 10.1002/glia.23017. Epub 2016 Jun 15.

PMID:
27301579
21.

Exosomes in Alzheimer's disease.

Malm T, Loppi S, Kanninen KM.

Neurochem Int. 2016 Jul;97:193-9. doi: 10.1016/j.neuint.2016.04.011. Epub 2016 Apr 27. Review.

PMID:
27131734
22.

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.

Liddell JR, Lehtonen S, Duncan C, Keksa-Goldsteine V, Levonen AL, Goldsteins G, Malm T, White AR, Koistinaho J, Kanninen KM.

J Neuroinflammation. 2016 Feb 26;13:49. doi: 10.1186/s12974-016-0515-9.

23.

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J.

Mol Neurodegener. 2016 Feb 8;11:15. doi: 10.1186/s13024-016-0080-9. No abstract available.

24.

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J.

Mol Neurodegener. 2016 Jan 25;11:10. doi: 10.1186/s13024-016-0078-3. Erratum in: Mol Neurodegener. 2016;11:15.

25.

Exosomes in cerebral diseases - novel form of intercellular communication.

Kanninen K, Malm T.

Duodecim. 2016;132(21):1957-63. Review.

PMID:
29190047
26.

Exosomes as new diagnostic tools in CNS diseases.

Kanninen KM, Bister N, Koistinaho J, Malm T.

Biochim Biophys Acta. 2016 Mar;1862(3):403-10. doi: 10.1016/j.bbadis.2015.09.020. Epub 2015 Oct 20. Review. No abstract available.

27.

Editorial: Metals and neurodegeneration: restoring the balance.

White AR, Kanninen KM, Crouch PJ.

Front Aging Neurosci. 2015 Jul 2;7:127. doi: 10.3389/fnagi.2015.00127. eCollection 2015. No abstract available.

28.

Applications of the Keap1-Nrf2 system for gene and cell therapy.

Kanninen KM, Pomeshchik Y, Leinonen H, Malm T, Koistinaho J, Levonen AL.

Free Radic Biol Med. 2015 Nov;88(Pt B):350-361. doi: 10.1016/j.freeradbiomed.2015.06.037. Epub 2015 Jul 8. Review.

PMID:
26164630
29.

Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation.

Korhonen P, Kanninen KM, Lehtonen Š, Lemarchant S, Puttonen KA, Oksanen M, Dhungana H, Loppi S, Pollari E, Wojciechowski S, Kidin I, García-Berrocoso T, Giralt D, Montaner J, Koistinaho J, Malm T.

Brain Behav Immun. 2015 Oct;49:322-36. doi: 10.1016/j.bbi.2015.06.013. Epub 2015 Jun 22.

PMID:
26111431
30.

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

Moujalled D, James JL, Yang S, Zhang K, Duncan C, Moujalled DM, Parker SJ, Caragounis A, Lidgerwood G, Turner BJ, Atkin JD, Grubman A, Liddell JR, Proepper C, Boeckers TM, Kanninen KM, Blair I, Crouch PJ, White AR.

Hum Mol Genet. 2015 Mar 15;24(6):1655-69. doi: 10.1093/hmg/ddu578. Epub 2014 Nov 19.

PMID:
25410660
31.

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury.

Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T.

Brain Behav Immun. 2015 Feb;44:68-81. doi: 10.1016/j.bbi.2014.08.002. Epub 2014 Aug 18.

PMID:
25153903
32.

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder.

Grubman A, James SA, James J, Duncan C, Volitakis I, Hickey JL, Crouch PJ, Donnelly PS, Kanninen KM, Liddell JR, Cotman SL, de Jonge, White AR.

Chem Sci. 2014 Jun;5(6):2503-2516.

33.

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

Roberts BR, Lim NK, McAllum EJ, Donnelly PS, Hare DJ, Doble PA, Turner BJ, Price KA, Lim SC, Paterson BM, Hickey JL, Rhoads TW, Williams JR, Kanninen KM, Hung LW, Liddell JR, Grubman A, Monty JF, Llanos RM, Kramer DR, Mercer JF, Bush AI, Masters CL, Duce JA, Li QX, Beckman JS, Barnham KJ, White AR, Crouch PJ.

J Neurosci. 2014 Jun 4;34(23):8021-31. doi: 10.1523/JNEUROSCI.4196-13.2014.

34.

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

Grubman A, Pollari E, Duncan C, Caragounis A, Blom T, Volitakis I, Wong A, Cooper J, Crouch PJ, Koistinaho J, Jalanko A, White AR, Kanninen KM.

Metallomics. 2014 Apr;6(4):932-43.

PMID:
24804307
35.

Nrf2 regulates neurogenesis and protects neural progenitor cells against Aβ toxicity.

Kärkkäinen V, Pomeshchik Y, Savchenko E, Dhungana H, Kurronen A, Lehtonen S, Naumenko N, Tavi P, Levonen AL, Yamamoto M, Malm T, Magga J, Kanninen KM, Koistinaho J.

Stem Cells. 2014 Jul;32(7):1904-16. doi: 10.1002/stem.1666.

36.

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder.

Grubman A, Lidgerwood GE, Duncan C, Bica L, Tan JL, Parker SJ, Caragounis A, Meyerowitz J, Volitakis I, Moujalled D, Liddell JR, Hickey JL, Horne M, Longmuir S, Koistinaho J, Donnelly PS, Crouch PJ, Tammen I, White AR, Kanninen KM.

Acta Neuropathol Commun. 2014 Feb 28;2:25. doi: 10.1186/2051-5960-2-25.

37.

Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit.

Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T.

Neurobiol Dis. 2014 Apr;64:16-29. doi: 10.1016/j.nbd.2013.12.003. Epub 2013 Dec 15.

PMID:
24345324
38.

ADAMTS proteoglycanases in the physiological and pathological central nervous system.

Lemarchant S, Pruvost M, Montaner J, Emery E, Vivien D, Kanninen K, Koistinaho J.

J Neuroinflammation. 2013 Oct 31;10:133. doi: 10.1186/1742-2094-10-133. Review.

39.

Does Nrf2 gene transfer facilitate recovery after contusion spinal cord injury?

Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J.

Antioxid Redox Signal. 2014 Mar 10;20(8):1313-23. doi: 10.1089/ars.2013.5453. Epub 2013 Aug 20.

PMID:
23841575
40.

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.

Moujalled D, James JL, Parker SJ, Lidgerwood GE, Duncan C, Meyerowitz J, Nonaka T, Hasegawa M, Kanninen KM, Grubman A, Liddell JR, Crouch PJ, White AR.

PLoS One. 2013 Jun 26;8(6):e67433. doi: 10.1371/journal.pone.0067433. Print 2013.

41.

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis.

Kanninen KM, Grubman A, Caragounis A, Duncan C, Parker SJ, Lidgerwood GE, Volitakis I, Ganio G, Crouch PJ, White AR.

Biol Open. 2013 May 20;2(6):635-46. doi: 10.1242/bio.20134804. Print 2013 Jun 15.

42.

Biometals in rare neurodegenerative disorders of childhood.

Parker SJ, Koistinaho J, White AR, Kanninen KM.

Front Aging Neurosci. 2013 Mar 25;5:14. doi: 10.3389/fnagi.2013.00014. eCollection 2013.

43.

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.

Kanninen KM, Grubman A, Meyerowitz J, Duncan C, Tan JL, Parker SJ, Crouch PJ, Paterson BM, Hickey JL, Donnelly PS, Volitakis I, Tammen I, Palmer DN, White AR.

PLoS One. 2013;8(3):e58644. doi: 10.1371/journal.pone.0058644. Epub 2013 Mar 14.

44.

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.

Parker SJ, Meyerowitz J, James JL, Liddell JR, Nonaka T, Hasegawa M, Kanninen KM, Lim S, Paterson BM, Donnelly PS, Crouch PJ, White AR.

PLoS One. 2012;7(8):e42277. doi: 10.1371/journal.pone.0042277. Epub 2012 Aug 3.

45.

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates.

Parker SJ, Meyerowitz J, James JL, Liddell JR, Crouch PJ, Kanninen KM, White AR.

Neurochem Int. 2012 Mar;60(4):415-24. doi: 10.1016/j.neuint.2012.01.019. Epub 2012 Jan 27.

PMID:
22306778
46.

Glycogen synthase kinase-3.

Crouch P, Cole A, Cousin M, Martinez A, Kanninen K.

Int J Alzheimers Dis. 2011;2011:279234. doi: 10.4061/2011/279234. Epub 2011 Dec 11. No abstract available.

47.

Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications.

Malm T, Koistinaho J, Kanninen K.

Int J Alzheimers Dis. 2011;2011:517160. doi: 10.4061/2011/517160. Epub 2011 Oct 30.

48.

A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5.

Du T, Caragounis A, Parker SJ, Meyerowitz J, La Fontaine S, Kanninen KM, Perreau VM, Crouch PJ, White AR.

Free Radic Biol Med. 2011 Dec 1;51(11):2060-72. doi: 10.1016/j.freeradbiomed.2011.09.006. Epub 2011 Sep 16.

PMID:
21971347
49.

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress.

Meyerowitz J, Parker SJ, Vella LJ, Ng DCh, Price KA, Liddell JR, Caragounis A, Li QX, Masters CL, Nonaka T, Hasegawa M, Bogoyevitch MA, Kanninen KM, Crouch PJ, White AR.

Mol Neurodegener. 2011 Aug 8;6:57. doi: 10.1186/1750-1326-6-57.

50.

Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis.

Pollari E, Savchenko E, Jaronen M, Kanninen K, Malm T, Wojciechowski S, Ahtoniemi T, Goldsteins G, Giniatullina R, Giniatullin R, Koistinaho J, Magga J.

J Neuroinflammation. 2011 Jun 28;8:74. doi: 10.1186/1742-2094-8-74.

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