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Items: 1 to 50 of 226

1.

Targeting Apoptosis Inhibition to Activate Antitumor Immunity.

Kesavardhana S, Kanneganti TD.

Trends Immunol. 2019 Dec;40(12):1073-1075. doi: 10.1016/j.it.2019.11.002. Epub 2019 Nov 14.

PMID:
31735511
2.

Hidden Aspects of Valency in Immune System Regulation.

Samir P, Kanneganti TD.

Trends Immunol. 2019 Dec;40(12):1082-1094. doi: 10.1016/j.it.2019.10.005. Epub 2019 Nov 13. Review.

PMID:
31734148
3.

The nonreceptor tyrosine kinase SYK induces autoinflammatory osteomyelitis in a mouse model of chronic recurrent multifocal osteomyelitis.

Dasari TK, Geiger R, Karki R, Banoth B, Sharma BR, Gurung P, Burton A, Kanneganti TD.

J Biol Chem. 2019 Nov 12. pii: jbc.RA119.010623. doi: 10.1074/jbc.RA119.010623. [Epub ahead of print]

4.

HA stability regulates H1N1 influenza virus replication and pathogenicity in mice by modulating type I interferon responses in dendritic cells.

Russier M, Yang G, Briard B, Meliopoulos V, Cherry S, Kanneganti TD, Schultz-Cherry S, Vogel P, Russell CJ.

J Virol. 2019 Nov 6. pii: JVI.01423-19. doi: 10.1128/JVI.01423-19. [Epub ahead of print]

PMID:
31694942
5.

Inflammasomes in the pathophysiology of autoinflammatory syndromes.

Tartey S, Kanneganti TD.

J Leukoc Biol. 2019 Oct 14. doi: 10.1002/JLB.3MIR0919-191R. [Epub ahead of print] Review.

PMID:
31608507
6.

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.

Samir P, Kesavardhana S, Patmore DM, Gingras S, Malireddi RKS, Karki R, Guy CS, Briard B, Place DE, Bhattacharya A, Sharma BR, Nourse A, King SV, Pitre A, Burton AR, Pelletier S, Gilbertson RJ, Kanneganti TD.

Nature. 2019 Sep;573(7775):590-594. doi: 10.1038/s41586-019-1551-2. Epub 2019 Sep 11.

PMID:
31511697
7.

Role of AIM2 inflammasome in inflammatory diseases, cancer and infection.

Sharma BR, Karki R, Kanneganti TD.

Eur J Immunol. 2019 Nov;49(11):1998-2011. doi: 10.1002/eji.201848070. Epub 2019 Aug 14. Review.

PMID:
31372985
8.

The NLRC4 inflammasome requires IRF8-dependent production of NAIPs.

Lee E, Karki R, Kanneganti TD.

Cell Stress. 2018 May 22;2(6):144-146. doi: 10.15698/cst2018.06.141.

9.

Cell death-mediated cytokine release and its therapeutic implications.

Place DE, Kanneganti TD.

J Exp Med. 2019 Jul 1;216(7):1474-1486. doi: 10.1084/jem.20181892. Epub 2019 Jun 11. Review.

PMID:
31186281
10.

On the Road to Discovering the Elusive Executioner of Pyroptosis.

Place DE, Kanneganti TD.

J Immunol. 2019 Apr 1;202(7):1911-1912. doi: 10.4049/jimmunol.1900115. No abstract available.

PMID:
30885986
11.

Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice.

Thiem K, Hoeke G, van den Berg S, Hijmans A, Jacobs CWM, Zhou E, Mol IM, Mouktaroudi M, Bussink J, Kanneganti TD, Lutgens E, Stienstra R, Tack CJ, Netea MG, Rensen PCN, Berbée JFP, van Diepen JA.

Sci Rep. 2019 Mar 13;9(1):4337. doi: 10.1038/s41598-019-40663-x.

12.

Diverging inflammasome signals in tumorigenesis and potential targeting.

Karki R, Kanneganti TD.

Nat Rev Cancer. 2019 Apr;19(4):197-214. doi: 10.1038/s41568-019-0123-y. Review.

PMID:
30842595
13.

Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae.

Rodriguez AE, Bogart C, Gilbert CM, McCullers JA, Smith AM, Kanneganti TD, Lupfer CR.

PLoS One. 2019 Feb 22;14(2):e0212236. doi: 10.1371/journal.pone.0212236. eCollection 2019.

14.

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.

Luo H, Mu WC, Karki R, Chiang HH, Mohrin M, Shin JJ, Ohkubo R, Ito K, Kanneganti TD, Chen D.

Cell Rep. 2019 Jan 22;26(4):945-954.e4. doi: 10.1016/j.celrep.2018.12.101.

15.

Fueling Ketone Metabolism Quenches Salt-Induced Hypertension.

Place DE, Kanneganti TD.

Trends Endocrinol Metab. 2019 Mar;30(3):145-147. doi: 10.1016/j.tem.2019.01.004. Epub 2019 Jan 19.

PMID:
30670332
16.

Differential role of the NLRP3 inflammasome in infection and tumorigenesis.

Tartey S, Kanneganti TD.

Immunology. 2019 Apr;156(4):329-338. doi: 10.1111/imm.13046. Epub 2019 Feb 14. Review.

PMID:
30666624
17.

Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway.

Mishra PK, Palma M, Buechel B, Moore J, Davra V, Chu N, Millman A, Hallab NJ, Kanneganti TD, Birge RB, Behrens EM, Rivera A, Beebe KS, Benevenia J, Gause WC.

Nat Mater. 2019 Mar;18(3):289-297. doi: 10.1038/s41563-018-0271-6. Epub 2019 Jan 21.

18.

The signposts and winding roads to immunity and inflammation.

Kanneganti TD.

Nat Rev Immunol. 2019 Feb;19(2):81-82. doi: 10.1038/s41577-018-0108-1. No abstract available.

PMID:
30602731
19.

Is Inflammasome a Potential Target of Prophylaxis in Rheumatic Heart Disease?

Kuriakose T, Kanneganti TD.

Circulation. 2018 Dec 4;138(23):2662-2665. doi: 10.1161/CIRCULATIONAHA.118.036771. No abstract available.

20.

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.

Briard B, Karki R, Malireddi RKS, Bhattacharya A, Place DE, Mavuluri J, Peters JL, Vogel P, Yamamoto M, Kanneganti TD.

Nat Microbiol. 2019 Feb;4(2):316-327. doi: 10.1038/s41564-018-0298-0. Epub 2018 Dec 3.

21.

TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy.

Sharma D, Malik A, Guy C, Vogel P, Kanneganti TD.

J Clin Invest. 2019 Jan 2;129(1):150-162. doi: 10.1172/JCI121372. Epub 2018 Nov 19.

22.

Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida.

Zhu Q, Zheng M, Balakrishnan A, Karki R, Kanneganti TD.

J Immunol. 2018 Dec 15;201(12):3662-3668. doi: 10.4049/jimmunol.1800788. Epub 2018 Nov 7.

PMID:
30404813
23.

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice.

Xiao J, Wang C, Yao JC, Alippe Y, Xu C, Kress D, Civitelli R, Abu-Amer Y, Kanneganti TD, Link DC, Mbalaviele G.

PLoS Biol. 2018 Nov 2;16(11):e3000047. doi: 10.1371/journal.pbio.3000047. eCollection 2018 Nov.

24.

SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.

Malik A, Sharma D, Malireddi RKS, Guy CS, Chang TC, Olsen SR, Neale G, Vogel P, Kanneganti TD.

Immunity. 2018 Sep 18;49(3):515-530.e5. doi: 10.1016/j.immuni.2018.08.024.

25.

Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity.

Guo XJ, Dash P, Crawford JC, Allen EK, Zamora AE, Boyd DF, Duan S, Bajracharya R, Awad WA, Apiwattanakul N, Vogel P, Kanneganti TD, Thomas PG.

Immunity. 2018 Sep 18;49(3):531-544.e6. doi: 10.1016/j.immuni.2018.07.011. Epub 2018 Aug 28.

26.

Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses.

Tartey S, Gurung P, Samir P, Burton A, Kanneganti TD.

J Immunol. 2018 Sep 15;201(6):1639-1644. doi: 10.4049/jimmunol.1800760. Epub 2018 Aug 6.

27.

Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.

Balakrishnan A, Karki R, Berwin B, Yamamoto M, Kanneganti TD.

Cell Death Discov. 2018 Jun 27;4:3. doi: 10.1038/s41420-018-0068-z. eCollection 2018. Erratum in: Cell Death Discov. 2019 Jul 10;5:116.

28.

Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice.

Sharma BR, Karki R, Lee E, Zhu Q, Gurung P, Kanneganti TD.

Cell Death Differ. 2019 Mar;26(4):741-750. doi: 10.1038/s41418-018-0159-7. Epub 2018 Jul 23.

PMID:
30038386
29.

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis.

Gresnigt MS, Cunha C, Jaeger M, Gonçalves SM, Malireddi RKS, Ammerdorffer A, Lubbers R, Oosting M, Rasid O, Jouvion G, Fitting C, Jong DJ, Lacerda JF, Campos A Jr, Melchers WJG, Lagrou K, Maertens J, Kanneganti TD, Carvalho A, Ibrahim-Granet O, van de Veerdonk FL.

Nat Commun. 2018 Jul 6;9(1):2636. doi: 10.1038/s41467-018-04912-3.

30.

The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation.

Di A, Xiong S, Ye Z, Malireddi RKS, Kometani S, Zhong M, Mittal M, Hong Z, Kanneganti TD, Rehman J, Malik AB.

Immunity. 2018 Jul 17;49(1):56-65.e4. doi: 10.1016/j.immuni.2018.04.032. Epub 2018 Jun 26.

31.

The inflammasome starts rolling.

Kanneganti TD.

Nat Rev Immunol. 2018 Aug;18(8):483. doi: 10.1038/s41577-018-0027-1. No abstract available.

PMID:
29858587
32.

ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis.

Tartey S, Gurung P, Dasari TK, Burton A, Kanneganti TD.

J Clin Invest. 2018 May 1;128(5):2042-2047. doi: 10.1172/JCI98446. Epub 2018 Apr 9.

33.

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

Karki R, Lee E, Place D, Samir P, Mavuluri J, Sharma BR, Balakrishnan A, Malireddi RKS, Geiger R, Zhu Q, Neale G, Kanneganti TD.

Cell. 2018 May 3;173(4):920-933.e13. doi: 10.1016/j.cell.2018.02.055. Epub 2018 Mar 22.

34.

Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection.

Zhu Q, Man SM, Karki R, Malireddi RKS, Kanneganti TD.

Cell Rep. 2018 Mar 20;22(12):3168-3174. doi: 10.1016/j.celrep.2018.02.096.

35.

Food for Training-Western Diet and Inflammatory Memory.

Samir P, Malireddi RKS, Kanneganti TD.

Cell Metab. 2018 Mar 6;27(3):481-482. doi: 10.1016/j.cmet.2018.02.012.

36.

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation.

Malireddi RKS, Gurung P, Mavuluri J, Dasari TK, Klco JM, Chi H, Kanneganti TD.

J Exp Med. 2018 Apr 2;215(4):1023-1034. doi: 10.1084/jem.20171922. Epub 2018 Mar 2.

37.

ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.

Place DE, Samir P, Karki R, Briard B, Vogel P, Kanneganti TD.

Am J Pathol. 2018 Apr;188(4):1021-1030. doi: 10.1016/j.ajpath.2017.12.006. Epub 2018 Jan 31.

38.

Stressed-out ROS take a silent death route.

Kesavardhana S, Kanneganti TD.

Nat Immunol. 2018 Feb;19(2):103-105. doi: 10.1038/s41590-017-0034-6. No abstract available.

PMID:
29348507
39.

Gasdermin D Flashes an Exit Signal for IL-1.

Kuriakose T, Kanneganti TD.

Immunity. 2018 Jan 16;48(1):1-3. doi: 10.1016/j.immuni.2018.01.003.

40.

The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression.

Gresnigt MS, Jaeger M, Subbarao Malireddi RK, Rasid O, Jouvion G, Fitting C, Melchers WJG, Kanneganti TD, Carvalho A, Ibrahim-Granet O, van de Veerdonk FL.

Front Immunol. 2017 Dec 13;8:1777. doi: 10.3389/fimmu.2017.01777. eCollection 2017.

41.

IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection.

Kuriakose T, Zheng M, Neale G, Kanneganti TD.

J Immunol. 2018 Feb 15;200(4):1489-1495. doi: 10.4049/jimmunol.1701538. Epub 2018 Jan 10.

42.

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.

Van Opdenbosch N, Van Gorp H, Verdonckt M, Saavedra PHV, de Vasconcelos NM, Gonçalves A, Vande Walle L, Demon D, Matusiak M, Van Hauwermeiren F, D'Hont J, Hochepied T, Krautwald S, Kanneganti TD, Lamkanfi M.

Cell Rep. 2017 Dec 19;21(12):3427-3444. doi: 10.1016/j.celrep.2017.11.088.

43.

Function and regulation of IL-1α in inflammatory diseases and cancer.

Malik A, Kanneganti TD.

Immunol Rev. 2018 Jan;281(1):124-137. doi: 10.1111/imr.12615. Review.

44.

Mechanisms and Consequences of Inflammasome Activation.

Schroder K, Kanneganti TD, Shao F, Broz P.

J Mol Biol. 2018 Jan 19;430(2):131-132. doi: 10.1016/j.jmb.2017.12.005. Epub 2017 Dec 14. No abstract available.

PMID:
29247654
45.

ZBP1: Innate Sensor Regulating Cell Death and Inflammation.

Kuriakose T, Kanneganti TD.

Trends Immunol. 2018 Feb;39(2):123-134. doi: 10.1016/j.it.2017.11.002. Epub 2017 Nov 25. Review.

46.

Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.

Costa Franco MM, Marim F, Guimarães ES, Assis NRG, Cerqueira DM, Alves-Silva J, Harms J, Splitter G, Smith J, Kanneganti TD, de Queiroz NMGP, Gutman D, Barber GN, Oliveira SC.

J Immunol. 2018 Jan 15;200(2):607-622. doi: 10.4049/jimmunol.1700725. Epub 2017 Dec 4.

47.

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.

Sharma D, Malik A, Guy CS, Karki R, Vogel P, Kanneganti TD.

Gastroenterology. 2018 Mar;154(4):948-964.e8. doi: 10.1053/j.gastro.2017.11.276. Epub 2017 Dec 2.

48.

Inflammasome activation and assembly at a glance.

Malik A, Kanneganti TD.

J Cell Sci. 2017 Dec 1;130(23):3955-3963. doi: 10.1242/jcs.207365. Review.

49.

cGAMP: A tale of two signals.

Kuriakose T, Kanneganti TD.

J Exp Med. 2017 Dec 4;214(12):3471-3473. doi: 10.1084/jem.20171925. Epub 2017 Nov 17.

50.

Recent advances in inflammasome biology.

Place DE, Kanneganti TD.

Curr Opin Immunol. 2018 Feb;50:32-38. doi: 10.1016/j.coi.2017.10.011. Epub 2017 Nov 10. Review.

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