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Leveraging the interplay of nanotechnology and neuroscience: Designing new avenues for treating central nervous system disorders.

Smith ES, Porterfield JE, Kannan RM.

Adv Drug Deliv Rev. 2019 Mar 4. pii: S0169-409X(19)30025-0. doi: 10.1016/j.addr.2019.02.009. [Epub ahead of print]


Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics.

Sharma A, Liaw K, Sharma R, Zhang Z, Kannan S, Kannan RM.

Theranostics. 2018 Nov 5;8(20):5529-5547. doi: 10.7150/thno.29039. eCollection 2018.


Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain.

Niño DF, Zhou Q, Yamaguchi Y, Martin LY, Wang S, Fulton WB, Jia H, Lu P, Prindle T Jr, Zhang F, Crawford J, Hou Z, Mori S, Chen LL, Guajardo A, Fatemi A, Pletnikov M, Kannan RM, Kannan S, Sodhi CP, Hackam DJ.

Sci Transl Med. 2018 Dec 12;10(471). pii: eaan0237. doi: 10.1126/scitranslmed.aan0237.


Engineering clinical translation-Introduction to Special Issue Dedicated to 2017 Bioengineering and Translational Medicine Conference.

Kannan RM, Mitragotri S.

Bioeng Transl Med. 2018 Oct 8;3(3):185. doi: 10.1002/btm2.10115. eCollection 2018 Sep. No abstract available.


Scalable synthesis and validation of PAMAM dendrimer-N-acetyl cysteine conjugate for potential translation.

Sharma R, Sharma A, Kambhampati SP, Reddy RR, Zhang Z, Cleland JL, Kannan S, Kannan RM.

Bioeng Transl Med. 2018 May 25;3(2):87-101. doi: 10.1002/btm2.10094. eCollection 2018 May.


Engineering clinical translation-Introduction to Special Issue Dedicated to 2017 Bioengineering and Translational Medicine Conference.

Kannan RM, Mitragotri S.

Bioeng Transl Med. 2018 Jul 27;3(2):73. doi: 10.1002/btm2.10099. eCollection 2018 May. No abstract available.


Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model.

Sharma A, Porterfield JE, Smith E, Sharma R, Kannan S, Kannan RM.

J Control Release. 2018 Aug 10;283:175-189. doi: 10.1016/j.jconrel.2018.06.003. Epub 2018 Jun 5.


Subconjunctival dendrimer-drug therapy for the treatment of dry eye in a rabbit model of induced autoimmune dacryoadenitis.

Lin H, Liu Y, Kambhampati SP, Hsu CC, Kannan RM, Yiu SC.

Ocul Surf. 2018 Oct;16(4):415-423. doi: 10.1016/j.jtos.2018.05.004. Epub 2018 May 16.


Preferential and Increased Uptake of Hydroxyl-Terminated PAMAM Dendrimers by Activated Microglia in Rabbit Brain Mixed Glial Culture.

Alnasser Y, Kambhampati SP, Nance E, Rajbhandari L, Shrestha S, Venkatesan A, Kannan RM, Kannan S.

Molecules. 2018 Apr 27;23(5). pii: E1025. doi: 10.3390/molecules23051025.


Pediatric oral formulation of dendrimer-N-acetyl-l-cysteine conjugates for the treatment of neuroinflammation.

Yellepeddi VK, Mohammadpour R, Kambhampati SP, Sayre C, Mishra MK, Kannan RM, Ghandehari H.

Int J Pharm. 2018 Jul 10;545(1-2):113-116. doi: 10.1016/j.ijpharm.2018.04.040. Epub 2018 Apr 20.


Toward new design principles for superior gene silencing.

Kannan RM.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3200-3201. doi: 10.1073/pnas.1801554115. Epub 2018 Mar 16. No abstract available.


Correction to: Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome.

Nance E, Kambhampati SP, Smith ES, Zhang Z, Zhang F, Singh S, Johnston MV, Kannan RM, Blue ME, Kannan S.

J Neuroinflammation. 2018 Jan 12;15(1):14. doi: 10.1186/s12974-018-1056-1.


Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome.

Nance E, Kambhampati SP, Smith ES, Zhang Z, Zhang F, Singh S, Johnston MV, Kannan RM, Blue ME, Kannan S.

J Neuroinflammation. 2017 Dec 19;14(1):252. doi: 10.1186/s12974-017-1004-5. Erratum in: J Neuroinflammation. 2018 Jan 12;15(1):14.


Activated Microglia Targeting Dendrimer-Minocycline Conjugate as Therapeutics for Neuroinflammation.

Sharma R, Kim SY, Sharma A, Zhang Z, Kambhampati SP, Kannan S, Kannan RM.

Bioconjug Chem. 2017 Nov 15;28(11):2874-2886. doi: 10.1021/acs.bioconjchem.7b00569. Epub 2017 Oct 27.


Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury.

Lei J, Rosenzweig JM, Mishra MK, Alshehri W, Brancusi F, McLane M, Almalki A, Bahabry R, Arif H, Rozzah R, Alyousif G, Shabi Y, Alhehaily N, Zhong W, Facciabene A, Kannan S, Kannan RM, Burd I.

Sci Rep. 2017 Jul 21;7(1):6106. doi: 10.1038/s41598-017-06113-2.


Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic-ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia.

Nemeth CL, Drummond GT, Mishra MK, Zhang F, Carr P, Garcia MS, Doman S, Fatemi A, Johnston MV, Kannan RM, Kannan S, Wilson MA.

Nanomedicine. 2017 Oct;13(7):2359-2369. doi: 10.1016/j.nano.2017.06.014. Epub 2017 Jun 30.


Selective Localization of a Novel Dendrimer Nanoparticle in Myocardial Ischemia-Reperfusion Injury.

Magruder JT, Crawford TC, Lin YA, Zhang F, Grimm JC, Kannan RM, Kannan S, Sciortino CM.

Ann Thorac Surg. 2017 Sep;104(3):891-898. doi: 10.1016/j.athoracsur.2016.12.051. Epub 2017 Mar 31.


Emerging nanomedicine approaches in obstetrics.

Kannan RM, Kannan S.

Am J Obstet Gynecol. 2017 Mar;216(3):201-203. doi: 10.1016/j.ajog.2017.01.038. No abstract available.


Subconjunctival injectable dendrimer-dexamethasone gel for the treatment of corneal inflammation.

Soiberman U, Kambhampati SP, Wu T, Mishra MK, Oh Y, Sharma R, Wang J, Al Towerki AE, Yiu S, Stark WJ, Kannan RM.

Biomaterials. 2017 May;125:38-53. doi: 10.1016/j.biomaterials.2017.02.016. Epub 2017 Feb 16.


Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model.

Zhang F, Trent Magruder J, Lin YA, Crawford TC, Grimm JC, Sciortino CM, Wilson MA, Blue ME, Kannan S, Johnston MV, Baumgartner WA, Kannan RM.

J Control Release. 2017 Mar 10;249:173-182. doi: 10.1016/j.jconrel.2017.01.032. Epub 2017 Jan 27.


Surface functionality affects the biodistribution and microglia-targeting of intra-amniotically delivered dendrimers.

Zhang F, Nance E, Zhang Z, Jasty V, Kambhampati SP, Mishra MK, Burd I, Romero R, Kannan S, Kannan RM.

J Control Release. 2016 Sep 10;237:61-70. doi: 10.1016/j.jconrel.2016.06.046. Epub 2016 Jul 1.


Nanoscale effects in dendrimer-mediated targeting of neuroinflammation.

Nance E, Zhang F, Mishra MK, Zhang Z, Kambhampati SP, Kannan RM, Kannan S.

Biomaterials. 2016 Sep;101:96-107. doi: 10.1016/j.biomaterials.2016.05.044. Epub 2016 May 26.


Nanotechnology Approaches to Targeting Inflammation and Excitotoxicity in a Canine Model of Hypothermic Circulatory Arrest-Induced Brain Injury.

Grimm JC, Magruder JT, Wilson MA, Blue ME, Crawford TC, Troncoso JC, Zhang F, Kannan S, Sciortino CM, Johnston MV, Kannan RM, Baumgartner WA.

Ann Thorac Surg. 2016 Sep;102(3):743-750. doi: 10.1016/j.athoracsur.2016.02.077. Epub 2016 May 4.


Targeting specific cells in the brain with nanomedicines for CNS therapies.

Zhang F, Lin YA, Kannan S, Kannan RM.

J Control Release. 2016 Oct 28;240:212-226. doi: 10.1016/j.jconrel.2015.12.013. Epub 2015 Dec 11. Review.


Dendrimer-enabled transformation of Anaplasma phagocytophilum.

Oki AT, Seidman D, Lancina MG 3rd, Mishra MK, Kannan RM, Yang H, Carlyon JA.

Microbes Infect. 2015 Nov-Dec;17(11-12):817-22. doi: 10.1016/j.micinf.2015.09.001. Epub 2015 Sep 11.


In vivo bone formation by and inflammatory response to resorbable polymer-nanoclay constructs.

Baker KC, Maerz T, Saad H, Shaheen P, Kannan RM.

Nanomedicine. 2015 Nov;11(8):1871-81. doi: 10.1016/j.nano.2015.06.012. Epub 2015 Jul 26.


Systemic and Intravitreal Delivery of Dendrimers to Activated Microglia/Macrophage in Ischemia/Reperfusion Mouse Retina.

Kambhampati SP, Clunies-Ross AJ, Bhutto I, Mishra MK, Edwards M, McLeod DS, Kannan RM, Lutty G.

Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4413-24. doi: 10.1167/iovs.14-16250.


Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury.

Nance E, Porambo M, Zhang F, Mishra MK, Buelow M, Getzenberg R, Johnston M, Kannan RM, Fatemi A, Kannan S.

J Control Release. 2015 Sep 28;214:112-20. doi: 10.1016/j.jconrel.2015.07.009. Epub 2015 Jul 13.


Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers.

Zhang F, Mastorakos P, Mishra MK, Mangraviti A, Hwang L, Zhou J, Hanes J, Brem H, Olivi A, Tyler B, Kannan RM.

Biomaterials. 2015 Jun;52:507-16. doi: 10.1016/j.biomaterials.2015.02.053. Epub 2015 Mar 18.


Intracellular delivery of dendrimer triamcinolone acetonide conjugates into microglial and human retinal pigment epithelial cells.

Kambhampati SP, Mishra MK, Mastorakos P, Oh Y, Lutty GA, Kannan RM.

Eur J Pharm Biopharm. 2015 Sep;95(Pt B):239-49. doi: 10.1016/j.ejpb.2015.02.013. Epub 2015 Feb 19.


Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells.

Mastorakos P, Kambhampati SP, Mishra MK, Wu T, Song E, Hanes J, Kannan RM.

Nanoscale. 2015 Mar 7;7(9):3845-56. doi: 10.1039/c4nr04284k.


Emerging concepts in dendrimer-based nanomedicine: from design principles to clinical applications.

Kannan RM, Nance E, Kannan S, Tomalia DA.

J Intern Med. 2014 Dec;276(6):579-617. doi: 10.1111/joim.12280. Epub 2014 Jul 31. Review.


Fetal uptake of intra-amniotically delivered dendrimers in a mouse model of intrauterine inflammation and preterm birth.

Burd I, Zhang F, Dada T, Mishra MK, Borbiev T, Lesniak WG, Baghlaf H, Kannan S, Kannan RM.

Nanomedicine. 2014 Aug;10(6):1343-51. doi: 10.1016/j.nano.2014.03.008. Epub 2014 Mar 19.


Folate-functionalized dendrimers for targeting Chlamydia-infected tissues in a mouse model of reactive arthritis.

Benchaala I, Mishra MK, Wykes SM, Hali M, Kannan RM, Whittum-Hudson JA.

Int J Pharm. 2014 May 15;466(1-2):258-65. doi: 10.1016/j.ijpharm.2014.03.018. Epub 2014 Mar 5.


Dendrimer brain uptake and targeted therapy for brain injury in a large animal model of hypothermic circulatory arrest.

Mishra MK, Beaty CA, Lesniak WG, Kambhampati SP, Zhang F, Wilson MA, Blue ME, Troncoso JC, Kannan S, Johnston MV, Baumgartner WA, Kannan RM.

ACS Nano. 2014 Mar 25;8(3):2134-47. doi: 10.1021/nn404872e. Epub 2014 Feb 19.


Biodistribution of fluorescently labeled PAMAM dendrimers in neonatal rabbits: effect of neuroinflammation.

Lesniak WG, Mishra MK, Jyoti A, Balakrishnan B, Zhang F, Nance E, Romero R, Kannan S, Kannan RM.

Mol Pharm. 2013 Dec 2;10(12):4560-71. doi: 10.1021/mp400371r. Epub 2013 Oct 30.


Dendrimer-enabled transformation of Chlamydia trachomatis.

Kannan RM, Gérard HC, Mishra MK, Mao G, Wang S, Hali M, Whittum-Hudson JA, Hudson AP.

Microb Pathog. 2013 Dec;65:29-35. doi: 10.1016/j.micpath.2013.08.003. Epub 2013 Sep 25.


Concurrent quantification of tryptophan and its major metabolites.

Lesniak WG, Jyoti A, Mishra MK, Louissaint N, Romero R, Chugani DC, Kannan S, Kannan RM.

Anal Biochem. 2013 Dec 15;443(2):222-31. doi: 10.1016/j.ab.2013.09.001. Epub 2013 Sep 11.


Dendrimer-enabled DNA delivery and transformation of Chlamydia pneumoniae.

Gérard HC, Mishra MK, Mao G, Wang S, Hali M, Whittum-Hudson JA, Kannan RM, Hudson AP.

Nanomedicine. 2013 Oct;9(7):996-1008. doi: 10.1016/j.nano.2013.04.004. Epub 2013 Apr 29.


Nanotechnology approaches for ocular drug delivery.

Xu Q, Kambhampati SP, Kannan RM.

Middle East Afr J Ophthalmol. 2013 Jan-Mar;20(1):26-37. doi: 10.4103/0974-9233.106384. Review.


Use of single-site-functionalized PEG dendrons to prepare gene vectors that penetrate human mucus barriers.

Kim AJ, Boylan NJ, Suk JS, Hwangbo M, Yu T, Schuster BS, Cebotaru L, Lesniak WG, Oh JS, Adstamongkonkul P, Choi AY, Kannan RM, Hanes J.

Angew Chem Int Ed Engl. 2013 Apr 2;52(14):3985-8. doi: 10.1002/anie.201208556. Epub 2013 Mar 4. No abstract available.


Dendrimer nanoparticles for ocular drug delivery.

Kambhampati SP, Kannan RM.

J Ocul Pharmacol Ther. 2013 Mar;29(2):151-65. doi: 10.1089/jop.2012.0232. Epub 2013 Feb 14. Review.


Enhancing the efficacy of Ara-C through conjugation with PAMAM dendrimer and linear PEG: a comparative study.

Sk UH, Kambhampati SP, Mishra MK, Lesniak WG, Zhang F, Kannan RM.

Biomacromolecules. 2013 Mar 11;14(3):801-10. doi: 10.1021/bm3018615. Epub 2013 Feb 19.


Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model.

Kannan S, Dai H, Navath RS, Balakrishnan B, Jyoti A, Janisse J, Romero R, Kannan RM.

Sci Transl Med. 2012 Apr 18;4(130):130ra46. doi: 10.1126/scitranslmed.3003162.


A dendrimer-based immunosensor for improved capture and detection of tumor necrosis factor-α cytokine.

Bosnjakovic A, Mishra MK, Han HJ, Romero R, Kannan RM.

Anal Chim Acta. 2012 Mar 30;720:118-25. doi: 10.1016/j.aca.2012.01.017. Epub 2012 Jan 18.


Dendrimer-enabled modulation of gene expression in Chlamydia trachomatis.

Mishra MK, Gérard HC, Whittum-Hudson JA, Hudson AP, Kannan RM.

Mol Pharm. 2012 Mar 5;9(3):413-21. doi: 10.1021/mp200512f. Epub 2012 Jan 30.


Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration.

Iezzi R, Guru BR, Glybina IV, Mishra MK, Kennedy A, Kannan RM.

Biomaterials. 2012 Jan;33(3):979-88. doi: 10.1016/j.biomaterials.2011.10.010. Epub 2011 Nov 1.


PAMAM dendrimer-azithromycin conjugate nanodevices for the treatment of Chlamydia trachomatis infections.

Mishra MK, Kotta K, Hali M, Wykes S, Gerard HC, Hudson AP, Whittum-Hudson JA, Kannan RM.

Nanomedicine. 2011 Dec;7(6):935-44. doi: 10.1016/j.nano.2011.04.008. Epub 2011 May 19.


Supercritical carbon dioxide processed resorbable polymer nanocomposite bone graft substitutes.

Baker KC, Manitiu M, Bellair R, Gratopp CA, Herkowitz HN, Kannan RM.

Acta Biomater. 2011 Sep;7(9):3382-9. doi: 10.1016/j.actbio.2011.05.014. Epub 2011 May 14.


Injectable PAMAM dendrimer-PEG hydrogels for the treatment of genital infections: formulation and in vitro and in vivo evaluation.

Navath RS, Menjoge AR, Dai H, Romero R, Kannan S, Kannan RM.

Mol Pharm. 2011 Aug 1;8(4):1209-23. doi: 10.1021/mp200027z. Epub 2011 Jun 20.

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