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Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.

Foulkes DM, Byrne DP, Yeung W, Shrestha S, Bailey FP, Ferries S, Eyers CE, Keeshan K, Wells C, Drewry DH, Zuercher WJ, Kannan N, Eyers PA.

Sci Signal. 2018 Sep 25;11(549). pii: eaat7951. doi: 10.1126/scisignal.aat7951.


Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1.

Jamieson SA, Ruan Z, Burgess AE, Curry JR, McMillan HD, Brewster JL, Dunbier AK, Axtman AD, Kannan N, Mace PD.

Sci Signal. 2018 Sep 25;11(549). pii: eaau0597. doi: 10.1126/scisignal.aau0597.


Choroidal structural analysis and vascularity index in retinal dystrophies.

Wei X, Mishra C, Kannan NB, Holder GE, Khandelwal N, Kim R, Agrawal R.

Acta Ophthalmol. 2018 Sep 4. doi: 10.1111/aos.13836. [Epub ahead of print]


Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC-β4 loop insertion mutations.

Ruan Z, Kannan N.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8162-E8171. doi: 10.1073/pnas.1803152115. Epub 2018 Aug 13.


Patients Who Benefit from Intracranial Pressure Monitoring without Cerebrospinal Fluid Drainage After Severe Traumatic Brain Injury.

CHIRAG (Collaborative Head Injury and Guidelines) Study .

Neurosurgery. 2018 Jul 25. doi: 10.1093/neuros/nyy247. [Epub ahead of print]


Comparative study of inverted internal limiting membrane (ILM) flap and ILM peeling technique in large macular holes: a randomized-control trial.

Kannan NB, Kohli P, Parida H, Adenuga OO, Ramasamy K.

BMC Ophthalmol. 2018 Jul 20;18(1):177. doi: 10.1186/s12886-018-0826-y.


Macrophages stimulate mammary stem cells.

Kannan N, Eaves CJ.

Science. 2018 Jun 29;360(6396):1401-1402. doi: 10.1126/science.aau1394. No abstract available.


Correction: Physiochemical characterization and cytotoxicity evaluation of mercury-based formulation for the development of anticancer therapeuticals.

Kannan N, Shanmuga Sundar S, Balaji S, Amuthan A, Anil Kumar NV, Balasubramanian N.

PLoS One. 2018 Jun 26;13(6):e0200035. doi: 10.1371/journal.pone.0200035. eCollection 2018.


Myosin-1c promotes E-cadherin tension and force-dependent recruitment of α-actinin to the epithelial cell junction.

Kannan N, Tang VW.

J Cell Sci. 2018 Jun 27;131(12). pii: jcs211334. doi: 10.1242/jcs.211334.


Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources.

Huang LC, Ross KE, Baffi TR, Drabkin H, Kochut KJ, Ruan Z, D'Eustachio P, McSkimming D, Arighi C, Chen C, Natale DA, Smith C, Gaudet P, Newton AC, Wu C, Kannan N.

Sci Rep. 2018 Apr 25;8(1):6518. doi: 10.1038/s41598-018-24457-1.


Physiochemical characterization and cytotoxicity evaluation of mercury-based formulation for the development of anticancer therapeuticals.

N K, S SS, S B, Amuthan A, Nv AK, N B.

PLoS One. 2018 Apr 18;13(4):e0195800. doi: 10.1371/journal.pone.0195800. eCollection 2018. Erratum in: PLoS One. 2018 Jun 26;13(6):e0200035.


Monitoring OH-PCBs in PCB transport worker's urine as a non-invasive exposure assessment tool.

Haga Y, Suzuki M, Matsumura C, Okuno T, Tsurukawa M, Fujimori K, Kannan N, Weber R, Nakano T.

Environ Sci Pollut Res Int. 2018 Jun;25(17):16446-16454. doi: 10.1007/s11356-018-1927-0. Epub 2018 Apr 14.


Recent updates on phthalate exposure and human health: a special focus on liver toxicity and stem cell regeneration.

Praveena SM, Teh SW, Rajendran RK, Kannan N, Lin CC, Abdullah R, Kumar S.

Environ Sci Pollut Res Int. 2018 Apr;25(12):11333-11342. doi: 10.1007/s11356-018-1652-8. Epub 2018 Mar 15.


Incidence of Endophthalmitis after Intravitreal Injections: Risk Factors, Microbiology Profile, and Clinical Outcomes.

Mishra C, Lalitha P, Rameshkumar G, Agrawal R, Balne PK, Iswarya M, Kannan NB, Ramasamy K.

Ocul Immunol Inflamm. 2018;26(4):559-568. doi: 10.1080/09273948.2018.1430238. Epub 2018 Feb 13.


Coupled regulation by the juxtamembrane and sterile α motif (SAM) linker is a hallmark of ephrin tyrosine kinase evolution.

Kwon A, John M, Ruan Z, Kannan N.

J Biol Chem. 2018 Apr 6;293(14):5102-5116. doi: 10.1074/jbc.RA117.001296. Epub 2018 Feb 12.


Paper pulp modification and deinking efficiency of cellulase-xylanase complex from Escherichia coli SD5.

Vinod Kumar N, Rani ME, Gunaseeli R, Kannan ND.

Int J Biol Macromol. 2018 May;111:289-295. doi: 10.1016/j.ijbiomac.2017.12.126. Epub 2018 Jan 5.


Simulation of the Emergency Department Care Process for Pediatric Traumatic Brain Injury.

Ajdari A, Boyle LN, Kannan N, Wang J, Rivara FP, Vavilala MS.

J Healthc Qual. 2018 Mar/Apr;40(2):110-118. doi: 10.1097/JHQ.0000000000000119.


Mass Cytometric Analysis Reveals Viable Activated Caspase-3+ Luminal Progenitors in the Normal Adult Human Mammary Gland.

Knapp DJHF, Kannan N, Pellacani D, Eaves CJ.

Cell Rep. 2017 Oct 24;21(4):1116-1126. doi: 10.1016/j.celrep.2017.09.096.


Characterization of a cytoplasmic glucosyltransferase that extends the core trisaccharide of the Toxoplasma Skp1 E3 ubiquitin ligase subunit.

Rahman K, Mandalasi M, Zhao P, Sheikh MO, Taujale R, Kim HW, van der Wel H, Matta K, Kannan N, Glushka JN, Wells L, West CM.

J Biol Chem. 2017 Nov 10;292(45):18644-18659. doi: 10.1074/jbc.M117.809301. Epub 2017 Sep 19.


Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation.

Fulton MD, Hanold LE, Ruan Z, Patel S, Beedle AM, Kannan N, Kennedy EJ.

Bioorg Med Chem. 2018 Mar 15;26(6):1167-1173. doi: 10.1016/j.bmc.2017.08.051. Epub 2017 Sep 5.


Frequency of and factors associated with emergency department intracranial pressure monitor placement in severe paediatric traumatic brain injury.

Kannan N, Quistberg A, Wang J, Groner JI, Mink RB, Wainwright MS, Bell MJ, Giza CC, Zatzick DF, Ellenbogen RG, Boyle LN, Mitchell PH, Vavilala MS.

Brain Inj. 2017;31(13-14):1745-1752. doi: 10.1080/02699052.2017.1346296. Epub 2017 Aug 22.


Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia.

Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, Tayyari F, McSkimming D, Kannan N, Tojo A, Edison AS, Ito T.

Nature. 2017 May 25;545(7655):500-504. doi: 10.1038/nature22314. Epub 2017 May 17.


Eyelid Malignancies- Always Quite Challenging.

Balasubramanian A, Kannan NS.

J Clin Diagn Res. 2017 Mar;11(3):XR01-XR04. doi: 10.7860/JCDR/2017/23695.9582. Epub 2017 Mar 1.


Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.

Morris EJ, Kawamura E, Gillespie JA, Balgi A, Kannan N, Muller WJ, Roberge M, Dedhar S.

Nat Commun. 2017 May 5;8:15289. doi: 10.1038/ncomms15289.


BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells.

He Z, Kannan N, Nemirovsky O, Chen H, Connell M, Taylor B, Jiang J, Pilarski LM, Fleisch MC, Niederacher D, Pujana MA, Eaves CJ, Maxwell CA.

Oncotarget. 2017 May 16;8(20):32461-32475. doi: 10.18632/oncotarget.15688.


The Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate Tetrahymena.

Jiang YY, Maier W, Baumeister R, Minevich G, Joachimiak E, Ruan Z, Kannan N, Clarke D, Frankel J, Gaertig J.

Genetics. 2017 Jun;206(2):873-888. doi: 10.1534/genetics.117.200766. Epub 2017 Apr 16.


Mediastinal Pseudocyst: Varied Presentations and Management-Experience from a Tertiary Referral Care Centre in India.

Segamalai D, Abdul Jameel AR, Kannan N, Anbalagan A, Duraisamy B, Raju P, Devy Gounder K.

HPB Surg. 2017;2017:5247626. doi: 10.1155/2017/5247626. Epub 2017 Mar 14.


Patterns of Presentation, Treatment, and Survival Rates of Gallbladder Cancer: a Prospective Study at a Tertiary Care Centre.

Singh SK, Talwar R, Kannan N, Tyagi AK, Jaiswal P, Kumar A.

J Gastrointest Cancer. 2018 Sep;49(3):268-274. doi: 10.1007/s12029-017-9940-y.


Structural and elemental characterization of traditional Indian Siddha formulation: Thalagak karuppu.

Kannan N, Balaji S, Anil Kumar NV.

J Ayurveda Integr Med. 2017 Jul - Sep;8(3):184-189. doi: 10.1016/j.jaim.2016.11.005. Epub 2017 Mar 27.


Examining Emergency Department Treatment Processes in Severe Pediatric Traumatic Brain Injury.

Ajdari A, Boyle LN, Kannan N, Rowhani-Rahbar A, Wang J, Mink R, Ries B, Wainwright M, Groner JI, Bell MJ, Giza C, Zatzick DF, Ellenbogen RG, Mitchell PH, Rivara FP, Vavilala MS.

J Healthc Qual. 2017 Nov/Dec;39(6):334-344. doi: 10.1097/JHQ.0000000000000052.


Classifying kinase conformations using a machine learning approach.

McSkimming DI, Rasheed K, Kannan N.

BMC Bioinformatics. 2017 Feb 2;18(1):86. doi: 10.1186/s12859-017-1506-2.


RNA binding protein MSI2 positively regulates FLT3 expression in myeloid leukemia.

Hattori A, McSkimming D, Kannan N, Ito T.

Leuk Res. 2017 Mar;54:47-54. doi: 10.1016/j.leukres.2017.01.015. Epub 2017 Jan 11.


Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.

Ruan Z, Katiyar S, Kannan N.

Biochemistry. 2017 Jan 10;56(1):22-32. doi: 10.1021/acs.biochem.6b00572. Epub 2016 Dec 22.


Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease.

Eyers PA, Keeshan K, Kannan N.

Trends Cell Biol. 2017 Apr;27(4):284-298. doi: 10.1016/j.tcb.2016.11.002. Epub 2016 Nov 28. Review.


Effectiveness of Centchroman on Regression of Fibroadenosis and Mastalgia.

Rajswaroob U, Kannan R, Kannan NS, Tirouaroul T.

J Clin Diagn Res. 2016 Oct;10(10):PC10-PC14. Epub 2016 Oct 1.


Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks.

Pellacani D, Bilenky M, Kannan N, Heravi-Moussavi A, Knapp DJHF, Gakkhar S, Moksa M, Carles A, Moore R, Mungall AJ, Marra MA, Jones SJM, Aparicio S, Hirst M, Eaves CJ.

Cell Rep. 2016 Nov 15;17(8):2060-2074. doi: 10.1016/j.celrep.2016.10.058.


A Review on Polychlorinated Biphenyls (PCBs) and Polybrominated Diphenyl Ethers (PBDEs) in South Asia with a Focus on Malaysia.

Kaw HY, Kannan N.

Rev Environ Contam Toxicol. 2017;242:153-181. doi: 10.1007/398_2016_14. Review.


KinView: a visual comparative sequence analysis tool for integrated kinome research.

McSkimming DI, Dastgheib S, Baffi TR, Byrne DP, Ferries S, Scott ST, Newton AC, Eyers CE, Kochut KJ, Eyers PA, Kannan N.

Mol Biosyst. 2016 Nov 15;12(12):3651-3665.


Correction: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N.

PLoS Genet. 2016 Aug 11;12(8):e1006265. doi: 10.1371/journal.pgen.1006265. eCollection 2016 Aug.


Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.

Stefely JA, Licitra F, Laredj L, Reidenbach AG, Kemmerer ZA, Grangeray A, Jaeg-Ehret T, Minogue CE, Ulbrich A, Hutchins PD, Wilkerson EM, Ruan Z, Aydin D, Hebert AS, Guo X, Freiberger EC, Reutenauer L, Jochem A, Chergova M, Johnson IE, Lohman DC, Rush MJP, Kwiecien NW, Singh PK, Schlagowski AI, Floyd BJ, Forsman U, Sindelar PJ, Westphall MS, Pierrel F, Zoll J, Dal Peraro M, Kannan N, Bingman CA, Coon JJ, Isope P, Puccio H, Pagliarini DJ.

Mol Cell. 2016 Aug 18;63(4):608-620. doi: 10.1016/j.molcel.2016.06.030. Epub 2016 Aug 4.


Nephroprotective Effect of Bauhinia tomentosa Linn against Cisplatin-Induced Renal Damage.

Kannan N, Sakthivel KM, Guruvayoorappan C.

J Environ Pathol Toxicol Oncol. 2016;35(2):99-107. doi: 10.1615/JEnvironPatholToxicolOncol.2016013981.


Influence of ZrO2, SiO2, Al2O3 and TiO2 nanoparticles on maize seed germination under different growth conditions.

Karunakaran G, Suriyaprabha R, Rajendran V, Kannan N.

IET Nanobiotechnol. 2016 Aug;10(4):171-7. doi: 10.1049/iet-nbt.2015.0007.


Penile Epidermal Cyst: A Case Report.

Kumaraguru V, Prabhu R, Kannan NS.

J Clin Diagn Res. 2016 May;10(5):PD05-6. doi: 10.7860/JCDR/2016/18246.7794. Epub 2016 May 1.


Timely Hemodynamic Resuscitation and Outcomes in Severe Pediatric Traumatic Brain Injury: Preliminary Findings.

Kannan N, Wang J, Mink RB, Wainwright MS, Groner JI, Bell MJ, Giza CC, Zatzick DF, Ellenbogen RG, Boyle LN, Mitchell PH, Rivara FP, Rowhani-Rahbar A, Vavilala MS; PEGASUS (Pediatric Guideline Adherence Outcomes) Study.

Pediatr Emerg Care. 2018 May;34(5):325-329. doi: 10.1097/PEC.0000000000000803.


Variation in seizure prophylaxis in severe pediatric traumatic brain injury.

Ostahowski PJ, Kannan N, Wainwright MS, Qiu Q, Mink RB, Groner JI, Bell MJ, Giza CC, Zatzick DF, Ellenbogen RG, Boyle LN, Mitchell PH, Vavilala MS; PEGASUS (Pediatric Guideline Adherence and Outcomes) Study.

J Neurosurg Pediatr. 2016 Oct;18(4):499-506. Epub 2016 Jun 3.


Outcome of 2 cc pure sulfur hexafluoride gas tamponade for macular hole surgery.

Kannan NB, Adenuga OO, Kumar K, Ramasamy K.

BMC Ophthalmol. 2016 Jun 3;16:73. doi: 10.1186/s12886-016-0254-9.


Ainhum - A Rare Case Report.

Prabhu R, Kannan NS, Vinoth S, Praveen CB.

J Clin Diagn Res. 2016 Apr;10(4):PD17-8. doi: 10.7860/JCDR/2016/17556.7648. Epub 2016 Apr 1.


Origins of suspended particulate matter based on sterol distribution in low salinity water mass observed in the offshore East China Sea.

Kim M, Jung JH, Jin Y, Han GM, Lee T, Hong SH, Yim UH, Shim WJ, Choi DL, Kannan N.

Mar Pollut Bull. 2016 Jul 15;108(1-2):281-8. doi: 10.1016/j.marpolbul.2016.04.049. Epub 2016 May 8.


Isolation, identification and diesel-oil biodegradation capacities of indigenous hydrocarbon-degrading strains of Cellulosimicrobium cellulans and Acinetobacter baumannii from tarball at Terengganu beach, Malaysia.

Nkem BM, Halimoon N, Yusoff FM, Johari WLW, Zakaria MP, Medipally SR, Kannan N.

Mar Pollut Bull. 2016 Jun 15;107(1):261-268. doi: 10.1016/j.marpolbul.2016.03.060. Epub 2016 Apr 13.


Management of Ocular Siderosis: Visual Outcome and Electroretinographic Changes.

Kannan NB, Adenuga OO, Rajan RP, Ramasamy K.

J Ophthalmol. 2016;2016:7272465. doi: 10.1155/2016/7272465. Epub 2016 Mar 17.

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