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Pharmacokinetics, excretion and metabolites analysis of DL0410, a dual‑acting cholinesterase inhibitor and histamine‑3 receptor antagonist.

Pang X, Zhao Y, Song J, Kang, Wu S, Wang L, Liu A, Du G.

Mol Med Rep. 2019 Aug;20(2):1103-1112. doi: 10.3892/mmr.2019.10306. Epub 2019 May 28.


Reduction of total, organic, and inorganic arsenic content in Hizikia fusiforme (Hijiki).

Park GY, Kang DE, Davaatseren M, Shin C, Kang GJ, Chung MS.

Food Sci Biotechnol. 2018 Nov 2;28(2):615-622. doi: 10.1007/s10068-018-0501-3. eCollection 2019 Apr.


Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics.

Woo JA, Liu T, Fang CC, Cazzaro S, Kee T, LePochat P, Yrigoin K, Penn C, Zhao X, Wang X, Liggett SB, Kang DE.

Commun Biol. 2019 Mar 22;2:112. doi: 10.1038/s42003-019-0359-9. eCollection 2019.


Depressive symptom-associated IL-1β and TNF-α release correlates with impaired bronchodilator response and neutrophilic airway inflammation in asthma.

Zhang L, Zhang X, Zheng J, Liu Y, Wang J, Wang G, Zhang HP, Kang Y, Peng ZG, Ji YL, Wang L, Gibson PG, Wang G.

Clin Exp Allergy. 2019 Jun;49(6):770-780. doi: 10.1111/cea.13346. Epub 2019 Feb 18.


The sphingosine kinase-1/sphingosine-1-phosphate axis in cancer: Potential target for anticancer therapy.

Zheng X, Li W, Ren L, Liu J, Pang X, Chen X, Kang, Wang J, Du G.

Pharmacol Ther. 2019 Mar;195:85-99. doi: 10.1016/j.pharmthera.2018.10.011. Epub 2018 Oct 19. Review.


Identification of Estrogen Receptor α Antagonists from Natural Products via In Vitro and In Silico Approaches.

Pang X, Fu W, Wang J, Kang, Xu L, Zhao Y, Liu AL, Du GH.

Oxid Med Cell Longev. 2018 May 10;2018:6040149. doi: 10.1155/2018/6040149. eCollection 2018.


Network pharmacology-based analysis of Chinese herbal Naodesheng formula for application to Alzheimer's disease.

Pang XC, Kang, Fang JS, Zhao Y, Xu LJ, Lian WW, Liu AL, DU GH.

Chin J Nat Med. 2018 Jan;16(1):53-62. doi: 10.1016/S1875-5364(18)30029-3.


The Bioinformatic Analysis of the Dysregulated Genes and MicroRNAs in Entorhinal Cortex, Hippocampus, and Blood for Alzheimer's Disease.

Pang X, Zhao Y, Wang J, Zhou Q, Xu L, Kang, Liu AL, Du GH.

Biomed Res Int. 2017;2017:9084507. doi: 10.1155/2017/9084507. Epub 2017 Nov 21.


Systemic inflammation mediates the detrimental effects of obesity on asthma control.

Zhang X, Zheng J, Zhang L, Liu Y, Chen GP, Zhang HP, Wang L, Kang Y, Wood LG, Wang G.

Allergy Asthma Proc. 2018 Jan 2;39(1):43-50. doi: 10.2500/aap.2018.39.4096.


Multi-Protection of DL0410 in Ameliorating Cognitive Defects in D-Galactose Induced Aging Mice.

Lian W, Jia H, Xu L, Zhou W, Kang, Liu A, Du G.

Front Aging Neurosci. 2017 Dec 8;9:409. doi: 10.3389/fnagi.2017.00409. eCollection 2017.


Corticosteroid plus β2-agonist in a single inhaler as reliever therapy in intermittent and mild asthma: a proof-of-concept systematic review and meta-analysis.

Wang G, Zhang X, Zhang HP, Wang L, Kang Y, Barnes PJ, Wang G.

Respir Res. 2017 Dec 6;18(1):203. doi: 10.1186/s12931-017-0687-6. Review.


Enhanced tau pathology via RanBP9 and Hsp90/Hsc70 chaperone complexes.

Woo JA, Liu T, Zhao X, Trotter C, Yrigoin K, Cazzaro S, Narvaez E, Khan H, Witas R, Bukhari A, Makati K, Wang X, Dickey C, Kang DE.

Hum Mol Genet. 2017 Oct 15;26(20):3973-3988. doi: 10.1093/hmg/ddx284.


Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation.

Liu T, Wang F, LePochat P, Woo JA, Bukhari MZ, Hong KW, Trotter C, Kang DE.

Sci Rep. 2017 Sep 14;7(1):11532. doi: 10.1038/s41598-017-09996-3.


Members of FOX family could be drug targets of cancers.

Wang J, Li W, Zhao Y, Kang, Fu W, Zheng X, Pang X, Du G.

Pharmacol Ther. 2018 Jan;181:183-196. doi: 10.1016/j.pharmthera.2017.08.003. Epub 2017 Aug 19. Review.


Effects of P-Glycoprotein on the Transport of DL0410, a Potential Multifunctional Anti-Alzheimer Agent.

Pang X, Wang L, Kang, Zhao Y, Wu S, Liu AL, Du GH.

Molecules. 2017 Jul 25;22(8). pii: E1246. doi: 10.3390/molecules22081246.


Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.

Woo JA, Liu T, Trotter C, Fang CC, De Narvaez E, LePochat P, Maslar D, Bukhari A, Zhao X, Deonarine A, Westerheide SD, Kang DE.

Nat Commun. 2017 Jun 6;8:15558. doi: 10.1038/ncomms15558.


DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice.

Lian W, Fang J, Xu L, Zhou W, Kang, Xiong W, Jia H, Liu AL, Du GH.

Molecules. 2017 Mar 6;22(3). pii: E410. doi: 10.3390/molecules22030410.


A new manufacturing process to remove thrombogenic factors (II, VII, IX, X, and XI) from intravenous immunoglobulin gamma preparations.

Park DH, Kang GB, Kang DE, Hong JW, Lee MG, Kim KY, Han JW.

Biologicals. 2017 Jan;45:1-8. doi: 10.1016/j.biologicals.2016.11.002. Epub 2016 Nov 18.


Two-Photon Tracer for Human Epidermal Growth Factor Receptor-2: Detection of Breast Cancer in a Live Tissue.

Choi JW, Hong ST, Kang DE, Paik KC, Han MS, Lim CS, Cho BR.

Anal Chem. 2016 Oct 4;88(19):9412-9418. Epub 2016 Sep 20.


[Network pharmacology study of effective constituents of traditional Chinese medicine for Alzheimer’s disease treatment].

Pang XC, Wang Z, Fang JS, Lian WW, Zhao Y, Kang D, Liu AL, Du GH.

Yao Xue Xue Bao. 2016 May;51(5):725-31. Chinese.


Effect of ATorvastatin On Chronic subdural Hematoma (ATOCH): a study protocol for a randomized controlled trial.

Jiang R, Wang D, Poon WS, Lu YC, Li XG, Zhao SG, Wang RZ, You C, Yuan XR, Zhang JM, Feng H, Fei Z, Yu XG, Zhao YL, Hu J, Kang DZ, Yu RT, Gao GD, Zhu XD, Sun T, Hao JH, Liu XZ, Su N, Yue SY, Zhang JN.

Trials. 2015 Nov 18;16:528. doi: 10.1186/s13063-015-1045-y.


Two-Photon Probes for Lysosomes and Mitochondria: Simultaneous Detection of Lysosomes and Mitochondria in Live Tissues by Dual-Color Two-Photon Microscopy Imaging.

Lim CS, Hong ST, Ryu SS, Kang DE, Cho BR.

Chem Asian J. 2015 Oct;10(10):2240-9. doi: 10.1002/asia.201500314. Epub 2015 Jul 14.


Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers.

Woo JA, Zhao X, Khan H, Penn C, Wang X, Joly-Amado A, Weeber E, Morgan D, Kang DE.

Cell Death Differ. 2015 Jun;22(6):1069-70. doi: 10.1038/cdd.2015.41.


RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction.

Woo JA, Boggess T, Uhlar C, Wang X, Khan H, Cappos G, Joly-Amado A, De Narvaez E, Majid S, Minamide LS, Bamburg JR, Morgan D, Weeber E, Kang DE.

Cell Death Dis. 2015 Mar 5;6:1676. doi: 10.1038/cddis.2015.37.


Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers.

Woo JA, Zhao X, Khan H, Penn C, Wang X, Joly-Amado A, Weeber E, Morgan D, Kang DE.

Cell Death Differ. 2015 Jun;22(6):921-34. doi: 10.1038/cdd.2015.5. Epub 2015 Feb 20. Erratum in: Cell Death Differ. 2015 Jun;22(6):1069-70.


Liquid core photonic crystal fiber with low-refractive-index liquids for optofluidic applications.

Park J, Kang DE, Paulson B, Nazari T, Oh K.

Opt Express. 2014 Jul 14;22(14):17320-30. doi: 10.1364/OE.22.017320.


RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease.

Wang R, Palavicini JP, Wang H, Maiti P, Bianchi E, Xu S, Lloyd BN, Dawson-Scully K, Kang DE, Lakshmana MK.

Neurobiol Dis. 2014 Sep;69:169-79. doi: 10.1016/j.nbd.2014.05.029. Epub 2014 Jun 2.


Two-photon probe for Cu²⁺ with an internal reference: quantitative estimation of Cu²⁺ in human tissues by two-photon microscopy.

Kang DE, Lim CS, Kim JY, Kim ES, Chun HJ, Cho BR.

Anal Chem. 2014 Jun 3;86(11):5353-9. doi: 10.1021/ac500329k. Epub 2014 May 13.


Interaction of toxin-1 and T lymphocytes in toxic shock syndrome.

Kang D, Lin CH, Chen G, Guo SG, Wu YS, Zheng ZP, Shi CH, Chen GL, Ji X.

Front Biosci (Landmark Ed). 2014 Jan 1;19:571-7. Review.


Two-photon fluorescent probes for metal ions in live tissues.

Sarkar AR, Kang DE, Kim HM, Cho BR.

Inorg Chem. 2014 Feb 17;53(4):1794-803. doi: 10.1021/ic402475f. Epub 2013 Dec 12. Review.


Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation.

Almenar-Queralt A, Kim SN, Benner C, Herrera CM, Kang DE, Garcia-Bassets I, Goldstein LS.

J Biol Chem. 2013 Dec 6;288(49):35222-36. doi: 10.1074/jbc.M113.513705. Epub 2013 Oct 21.


How does cancer cell metabolism affect tumor migration and invasion?

Han T, Kang D, Ji D, Wang X, Zhan W, Fu M, Xin HB, Wang JB.

Cell Adh Migr. 2013 Sep-Oct;7(5):395-403. doi: 10.4161/cam.26345. Epub 2013 Oct 8. Review.


Activation of TRPC4β by Gαi subunit increases Ca2+ selectivity and controls neurite morphogenesis in cultured hippocampal neuron.

Jeon JP, Roh SE, Wie J, Kim J, Kim H, Lee KP, Yang D, Jeon JH, Cho NH, Kim IG, Kang DE, Kim HJ, So I.

Cell Calcium. 2013 Oct;54(4):307-19. doi: 10.1016/j.ceca.2013.07.006. Epub 2013 Aug 14.


Mitochondrial dysfunction and calcium deregulation by the RanBP9-cofilin pathway.

Roh SE, Woo JA, Lakshmana MK, Uhlar C, Ankala V, Boggess T, Liu T, Hong YH, Mook-Jung I, Kim SJ, Kang DE.

FASEB J. 2013 Dec;27(12):4776-89. doi: 10.1096/fj.13-234765. Epub 2013 Aug 27.


RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice.

Palavicini JP, Lloyd BN, Hayes CD, Bianchi E, Kang DE, Dawson-Scully K, Lakshmana MK.

PLoS One. 2013 Jun 26;8(6):e66908. doi: 10.1371/journal.pone.0066908. Print 2013.


RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes.

Palavicini JP, Wang H, Bianchi E, Xu S, Rao JS, Kang DE, Lakshmana MK.

Cell Death Dis. 2013 Jun 13;4:e667. doi: 10.1038/cddis.2013.183.


Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis.

Liu T, Roh SE, Woo JA, Ryu H, Kang DE.

Cell Death Dis. 2013 Jan 24;4:e476. doi: 10.1038/cddis.2012.203.


Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis.

Song H, Boo JH, Kim KH, Kim C, Kim YE, Ahn JH, Jeon GS, Ryu H, Kang DE, Mook-Jung I.

Cell Death Differ. 2013 Apr;20(4):639-48. doi: 10.1038/cdd.2012.162. Epub 2013 Jan 11.


Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration.

Woo JA, Jung AR, Lakshmana MK, Bedrossian A, Lim Y, Bu JH, Park SA, Koo EH, Mook-Jung I, Kang DE.

Cell Death Differ. 2012 Sep;19(9):1413-23. doi: 10.1038/cdd.2012.14. Epub 2012 Feb 24.


XMRV Discovery and Prostate Cancer-Related Research.

Kang DE, Lee MC, Das Gupta J, Klein EA, Silverman RH.

Adv Virol. 2011;2011:432837. doi: 10.1155/2011/432837. Epub 2011 Jun 21.


Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels.

Shilling D, Mak DO, Kang DE, Foskett JK.

J Biol Chem. 2012 Mar 30;287(14):10933-44. doi: 10.1074/jbc.M111.300491. Epub 2012 Feb 6.


Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain.

Lakshmana MK, Hayes CD, Bennett SP, Bianchi E, Reddy KM, Koo EH, Kang DE.

FASEB J. 2012 May;26(5):2072-83. doi: 10.1096/fj.11-196709. Epub 2012 Jan 31. Erratum in: FASEB J. 2015 Mar;29(3):1124.


Pivotal role of RanBP9 in integrin-dependent focal adhesion signaling and assembly.

Woo JA, Roh SE, Lakshmana MK, Kang DE.

FASEB J. 2012 Apr;26(4):1672-81. doi: 10.1096/fj.11-194423. Epub 2012 Jan 5.


The Interface between Cytoskeletal Aberrations and Mitochondrial Dysfunction in Alzheimer's Disease and Related Disorders.

Kang DE, Roh SE, Woo JA, Liu T, Bu JH, Jung AR, Lim Y.

Exp Neurobiol. 2011 Jun;20(2):67-80. doi: 10.5607/en.2011.20.2.67. Epub 2011 Jun 30.


Both basic and acidic amino acid residues of IpTx(a) are involved in triggering substate of RyR1.

Seo IR, Kang DE, Song DW, Kim DH.

J Biomed Biotechnol. 2011;2011:386384. doi: 10.1155/2011/386384. Epub 2011 Oct 5.


Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons.

Cheung KH, Mei L, Mak DO, Hayashi I, Iwatsubo T, Kang DE, Foskett JK.

Sci Signal. 2010 Mar 23;3(114):ra22. doi: 10.1126/scisignal.2000818.


A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation.

Lakshmana MK, Chung JY, Wickramarachchi S, Tak E, Bianchi E, Koo EH, Kang DE.

FASEB J. 2010 Jan;24(1):119-27. doi: 10.1096/fj.09-136457. Epub 2009 Sep 3.


Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.

Lakshmana MK, Yoon IS, Chen E, Bianchi E, Koo EH, Kang DE.

J Biol Chem. 2009 May 1;284(18):11863-72. doi: 10.1074/jbc.M807345200. Epub 2009 Feb 27.


Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cells.

Boo JH, Song H, Kim JE, Kang DE, Mook-Jung I.

PLoS One. 2009;4(1):e4172. doi: 10.1371/journal.pone.0004172. Epub 2009 Jan 12.


Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

Kwan P, Poon WS, Ng HK, Kang DE, Wong V, Ng PW, Lui CH, Sin NC, Wong KS, Baum L.

Pharmacogenet Genomics. 2008 Nov;18(11):989-98. doi: 10.1097/FPC.0b013e3283117d67.


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