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Items: 1 to 50 of 73

1.

Risk factors for disease progression in idiopathic pulmonary fibrosis.

Raghu G, Ley B, Brown KK, Cottin V, Gibson KF, Kaner RJ, Lederer DJ, Noble PW, Song JW, Wells AU, Whelan TP, Lynch DA, Humphries SM, Moreau E, Goodman K, Patterson SD, Smith V, Gong Q, Sundy JS, O'Riordan TG, Martinez FJ.

Thorax. 2019 Oct 14. pii: thoraxjnl-2019-213620. doi: 10.1136/thoraxjnl-2019-213620. [Epub ahead of print]

PMID:
31611341
2.

Radiographic Lung Volumes Predict Progression to COPD in Smokers with Preserved Spirometry in SPIROMICS.

Arjomandi M, Zeng S, Barjaktarevic I, Barr RG, Bleecker ER, Bowler RP, Buhr RG, Criner GJ, Comellas AP, Cooper CB, Couper DJ, Curtis JL, Dransfield MT, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Kanner RE, Krishnan JA, Paine R 3rd, Peters SP, Rennard SI, Woodruff PG; SPIROMICS Investigators.

Eur Respir J. 2019 Aug 22. pii: 1802214. doi: 10.1183/13993003.02214-2018. [Epub ahead of print]

PMID:
31439683
3.

Role of KRAS in regulating normal human airway basal cell differentiation.

Ogawa F, Walters MS, Shafquat A, O'Beirne SL, Kaner RJ, Mezey JG, Zhang H, Leopold PL, Crystal RG.

Respir Res. 2019 Aug 9;20(1):181. doi: 10.1186/s12931-019-1129-4.

4.

Predictors of death or lung transplant after a diagnosis of idiopathic pulmonary fibrosis: insights from the IPF-PRO Registry.

Snyder L, Neely ML, Hellkamp AS, O'Brien E, de Andrade J, Conoscenti CS, Leonard T, Bender S, Gulati M, Culver DA, Kaner RJ, Palmer S, Kim HJ; IPF-PRO™ Registry investigators.

Respir Res. 2019 May 30;20(1):105. doi: 10.1186/s12931-019-1043-9.

5.

Design of Idiopathic Pulmonary Fibrosis Clinical Trials in the Era of Approved Therapies.

Kaner RJ, Bajwa EK, El-Amine M, Gorina E, Gupta R, Lazarus HM, Luckhardt TR, Mouded M, Posada K, Richeldi L, Stauffer J, Tutuncu A, Martinez FJ.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):133-139. doi: 10.1164/rccm.201903-0592PP. No abstract available.

PMID:
30985215
6.

Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes.

Zuo WL, Yang J, Strulovici-Barel Y, Salit J, Rostami M, Mezey JG, O'Beirne SL, Kaner RJ, Crystal RG.

Eur Respir J. 2019 May 18;53(5). pii: 1702553. doi: 10.1183/13993003.02553-2017. Print 2019 May.

PMID:
30705127
7.

Safety and Tolerability of Comprehensive Research Bronchoscopy in Chronic Obstructive Pulmonary Disease. Results from the SPIROMICS Bronchoscopy Substudy.

Wells JM, Arenberg DA, Barjaktarevic I, Bhatt SP, Bowler RP, Christenson SA, Couper DJ, Dransfield MT, Han MK, Hoffman EA, Kaner RJ, Kim V, Kleerup E, Martinez FJ, Moore WC, O'Beirne SL, Paine R 3rd, Putcha N, Raman SM, Barr RG, Rennard SI, Woodruff PG, Curtis JL.

Ann Am Thorac Soc. 2019 Apr;16(4):439-446. doi: 10.1513/AnnalsATS.201807-441OC.

PMID:
30653926
8.

Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene.

Wells JM, Parker MM, Oster RA, Bowler RP, Dransfield MT, Bhatt SP, Cho MH, Kim V, Curtis JL, Martinez FJ, Paine R 3rd, O'Neal W, Labaki WW, Kaner RJ, Barjaktarevic I, Han MK, Silverman EK, Crapo JD, Barr RG, Woodruff P, Castaldi PJ, Gaggar A, Investigators TSAC.

JCI Insight. 2018 Nov 15;3(22). pii: 123614. doi: 10.1172/jci.insight.123614.

9.

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.

Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R 3rd, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG.

J Clin Invest. 2019 Jan 2;129(1):169-181. doi: 10.1172/JCI121087. Epub 2018 Nov 26.

10.

Chronic Comorbid Illnesses Predict the Clinical Course of 866 Patients Requiring Prolonged Mechanical Ventilation in a Long-Term, Acute-Care Hospital.

Frengley JD, Sansone GR, Kaner RJ.

J Intensive Care Med. 2018 Oct 1:885066618783175. doi: 10.1177/0885066618783175. [Epub ahead of print]

PMID:
30270713
11.

Effects of Reinstitution of Prolonged Mechanical Ventilation on the Outcomes of 370 Patients in a Long-Term Acute Care Hospital.

Sansone GR, Frengley JD, Horland A, Vecchione JJ, Kaner RJ.

J Intensive Care Med. 2018 Sep;33(9):527-535. doi: 10.1177/0885066616683669. Epub 2016 Dec 14.

PMID:
30095035
12.

Ambient Pollution-related Reprogramming of the Human Small Airway Epithelial Transcriptome.

O'Beirne SL, Shenoy SA, Salit J, Strulovici-Barel Y, Kaner RJ, Visvanathan S, Fine JS, Mezey JG, Crystal RG.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1413-1422. doi: 10.1164/rccm.201712-2526OC.

PMID:
29897792
13.

Ontogeny and Biology of Human Small Airway Epithelial Club Cells.

Zuo WL, Shenoy SA, Li S, O'Beirne SL, Strulovici-Barel Y, Leopold PL, Wang G, Staudt MR, Walters MS, Mason C, Kaner RJ, Mezey JG, Crystal RG.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1375-1388. doi: 10.1164/rccm.201710-2107OC.

PMID:
29874100
14.

Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes.

Staudt MR, Salit J, Kaner RJ, Hollmann C, Crystal RG.

Respir Res. 2018 May 14;19(1):78. doi: 10.1186/s12931-018-0778-z.

15.

Seeing Deeply into the Lung in Interstitial Lung Disease.

Kaner RJ.

Am J Respir Crit Care Med. 2018 Apr 1;197(7):857-858. doi: 10.1164/rccm.201709-1798ED. No abstract available.

PMID:
28957640
16.

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.

Martinez CH, Li SX, Hirzel AJ, Stolberg VR, Alexis NE, Barr RG, Bleecker ER, Carretta EE, Christenson SA, Cooper CB, Couper DJ, Doerschuk CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Martinez FJ, Meyers DA, O'Neal WK, Paine R 3rd, Putcha N, Rennard SI, Woodruff PG, Zeidler M, Curtis JL, Freeman CM; SPIROMICS Investigators.

J Allergy Clin Immunol. 2018 Jan;141(1):429-432. doi: 10.1016/j.jaci.2017.07.039. Epub 2017 Sep 12. No abstract available.

17.

Role of OSGIN1 in mediating smoking-induced autophagy in the human airway epithelium.

Wang G, Zhou H, Strulovici-Barel Y, Al-Hijji M, Ou X, Salit J, Walters MS, Staudt MR, Kaner RJ, Crystal RG.

Autophagy. 2017 Jul 3;13(7):1205-1220. doi: 10.1080/15548627.2017.1301327. Epub 2017 May 26.

18.

HIV Reprograms Human Airway Basal Stem/Progenitor Cells to Acquire a Tissue-Destructive Phenotype.

Chung NPY, Ou X, Khan KMF, Salit J, Kaner RJ, Crystal RG.

Cell Rep. 2017 May 9;19(6):1091-1100. doi: 10.1016/j.celrep.2017.04.026.

19.

AJRCCM: 100-Year Anniversary. Progress in Interstitial Lung Disease.

Kaner RJ, Brown KK, Martinez FJ.

Am J Respir Crit Care Med. 2017 May 1;195(9):1104-1107. doi: 10.1164/rccm.201703-0584ED. No abstract available.

20.

Smoking-Dependent Distal-to-Proximal Repatterning of the Adult Human Small Airway Epithelium.

Yang J, Zuo WL, Fukui T, Chao I, Gomi K, Lee B, Staudt MR, Kaner RJ, Strulovici-Barel Y, Salit J, Crystal RG, Shaykhiev R.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):340-352. doi: 10.1164/rccm.201608-1672OC.

21.

Waterpipe smoking induces epigenetic changes in the small airway epithelium.

Walters MS, Salit J, Ju JH, Staudt MR, Kaner RJ, Rogalski AM, Sodeinde TB, Rahim R, Strulovici-Barel Y, Mezey JG, Almulla AM, Sattar H, Mahmoud M, Crystal RG.

PLoS One. 2017 Mar 8;12(3):e0171112. doi: 10.1371/journal.pone.0171112. eCollection 2017.

22.

Efficacy of simtuzumab versus placebo in patients with idiopathic pulmonary fibrosis: a randomised, double-blind, controlled, phase 2 trial.

Raghu G, Brown KK, Collard HR, Cottin V, Gibson KF, Kaner RJ, Lederer DJ, Martinez FJ, Noble PW, Song JW, Wells AU, Whelan TP, Wuyts W, Moreau E, Patterson SD, Smith V, Bayly S, Chien JW, Gong Q, Zhang JJ, O'Riordan TG.

Lancet Respir Med. 2017 Jan;5(1):22-32. doi: 10.1016/S2213-2600(16)30421-0. Epub 2016 Dec 7.

PMID:
27939076
23.

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ, Curtis JL, Doerschuk CM, Freeman CM, Gouskova NA, Han MK, Hanania NA, Hansel NN, Hersh CP, Hoffman EA, Kaner RJ, Kanner RE, Kleerup EC, Lutz S, Martinez FJ, Meyers DA, Peters SP, Regan EA, Rennard SI, Scholand MB, Silverman EK, Woodruff PG, O'Neal WK, Bowler RP; SPIROMICS Research Group; COPDGene Investigators.

PLoS Genet. 2016 Aug 17;12(8):e1006011. doi: 10.1371/journal.pgen.1006011. eCollection 2016 Aug.

24.

Persistence of circulating endothelial microparticles in COPD despite smoking cessation.

Strulovici-Barel Y, Staudt MR, Krause A, Gordon C, Tilley AE, Harvey BG, Kaner RJ, Hollmann C, Mezey JG, Bitter H, Pillai SG, Hilton H, Wolff G, Stevenson CS, Visvanathan S, Fine JS, Crystal RG.

Thorax. 2016 Dec;71(12):1137-1144. doi: 10.1136/thoraxjnl-2015-208274. Epub 2016 Jul 26.

25.

The Role of Interleukin-23 in the Early Development of Emphysema in HIV1(+) Smokers.

Barjaktarevic IZ, Crystal RG, Kaner RJ.

J Immunol Res. 2016;2016:3463104. doi: 10.1155/2016/3463104. Epub 2016 Jun 29.

26.

Progression to COPD in smokers with normal spirometry/low DLCO using different methods to determine normal levels.

Harvey BG, Strulovici-Barel Y, Kaner RJ, Sanders A, Vincent TL, Mezey JG, Crystal RG.

Eur Respir J. 2016 Jun;47(6):1888-9. doi: 10.1183/13993003.00435-2016. No abstract available.

27.

JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium.

Gomi K, Staudt MR, Salit J, Kaner RJ, Heldrich J, Rogalski AM, Arbelaez V, Crystal RG, Walters MS.

Stem Cell Rev Rep. 2016 Aug;12(4):454-63. doi: 10.1007/s12015-016-9656-6.

28.

Pulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers.

Strulovici-Barel Y, Shaykhiev R, Salit J, Deeb RS, Krause A, Kaner RJ, Vincent TL, Agosto-Perez F, Wang G, Hollmann C, Shanmugam V, Almulla AM, Sattar H, Mahmoud M, Mezey JG, Gross SS, Staudt MR, Walters MS, Crystal RG.

Am J Respir Crit Care Med. 2016 Sep 1;194(5):587-95. doi: 10.1164/rccm.201512-2470OC.

29.

POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes.

Zhou H, Brekman A, Zuo WL, Ou X, Shaykhiev R, Agosto-Perez FJ, Wang R, Walters MS, Salit J, Strulovici-Barel Y, Staudt MR, Kaner RJ, Mezey JG, Crystal RG, Wang G.

J Immunol. 2016 Apr 1;196(7):3159-67. doi: 10.4049/jimmunol.1502400. Epub 2016 Feb 29.

30.

Chronic Cough and Bilateral Pneumothoraces in a Nonsmoker.

O'Beirne SL, Escalon JG, Arkin JE, Stiles BM, Kaner RJ, Legasto AC, Narula N, King TC.

Chest. 2016 Feb;149(2):e49-e55. doi: 10.1016/j.chest.2015.10.070.

PMID:
26867855
31.

Relationship of the Duration of Ventilator Support to Successful Weaning and Other Clinical Outcomes in 437 Prolonged Mechanical Ventilation Patients.

Sansone GR, Frengley JD, Vecchione JJ, Manogaram MG, Kaner RJ.

J Intensive Care Med. 2017 May;32(4):283-291. doi: 10.1177/0885066615626897. Epub 2016 Jan 20.

PMID:
26792815
32.

Cigarette Smoking Induces Changes in Airway Epithelial Expression of Genes Associated with Monogenic Lung Disorders.

Tilley AE, Staudt MR, Salit J, Van de Graaf B, Strulovici-Barel Y, Kaner RJ, Vincent T, Agosto-Perez F, Mezey JG, Raby BA, Crystal RG.

Am J Respir Crit Care Med. 2016 Jan 15;193(2):215-7. doi: 10.1164/rccm.201412-2290LE. No abstract available.

33.

Risk of COPD with obstruction in active smokers with normal spirometry and reduced diffusion capacity.

Harvey BG, Strulovici-Barel Y, Kaner RJ, Sanders A, Vincent TL, Mezey JG, Crystal RG.

Eur Respir J. 2015 Dec;46(6):1589-1597. doi: 10.1183/13993003.02377-2014. Epub 2015 Nov 5.

34.

Severe Cavitary, Fistulating Mycobacterium avium-intracellulare Complex Disease in an Immunocompetent Host.

O'Beirne SL, Escalon JG, Momtahen S, Hissong E, Port JL, Schenck EJ, Legasto AC, Kaner RJ.

Am J Respir Crit Care Med. 2015 Dec 1;192(11):1387-8. doi: 10.1164/rccm.201506-1151IM. No abstract available.

PMID:
26244303
35.

The Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet): diagnostic and adjudication processes.

Andrade J, Schwarz M, Collard HR, Gentry-Bumpass T, Colby T, Lynch D, Kaner RJ; IPFnet Investigators.

Chest. 2015 Oct;148(4):1034-1042. doi: 10.1378/chest.14-2889.

36.

Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation.

Wang G, Wang R, Strulovici-Barel Y, Salit J, Staudt MR, Ahmed J, Tilley AE, Yee-Levin J, Hollmann C, Harvey BG, Kaner RJ, Mezey JG, Sridhar S, Pillai SG, Hilton H, Wolff G, Bitter H, Visvanathan S, Fine JS, Stevenson CS, Crystal RG.

PLoS One. 2015 Apr 17;10(4):e0120824. doi: 10.1371/journal.pone.0120824. eCollection 2015.

37.

Screening for Chronic Obstructive Pulmonary Disease (COPD) in an Urban HIV Clinic: A Pilot Study.

Shirley DK, Kaner RJ, Glesby MJ.

AIDS Patient Care STDS. 2015 May;29(5):232-9. doi: 10.1089/apc.2014.0265. Epub 2015 Feb 27.

38.

Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).

Freeman CM, Crudgington S, Stolberg VR, Brown JP, Sonstein J, Alexis NE, Doerschuk CM, Basta PV, Carretta EE, Couper DJ, Hastie AT, Kaner RJ, O'Neal WK, Paine R 3rd, Rennard SI, Shimbo D, Woodruff PG, Zeidler M, Curtis JL.

J Transl Med. 2015 Jan 27;13:19. doi: 10.1186/s12967-014-0374-z.

39.

Airway Basal stem/progenitor cells have diminished capacity to regenerate airway epithelium in chronic obstructive pulmonary disease.

Staudt MR, Buro-Auriemma LJ, Walters MS, Salit J, Vincent T, Shaykhiev R, Mezey JG, Tilley AE, Kaner RJ, Ho MW, Crystal RG.

Am J Respir Crit Care Med. 2014 Oct 15;190(8):955-8. doi: 10.1164/rccm.201406-1167LE. No abstract available.

40.

Smoking accelerates aging of the small airway epithelium.

Walters MS, De BP, Salit J, Buro-Auriemma LJ, Wilson T, Rogalski AM, Lief L, Hackett NR, Staudt MR, Tilley AE, Harvey BG, Kaner RJ, Mezey JG, Ashbridge B, Moore MA, Crystal RG.

Respir Res. 2014 Sep 24;15:94. doi: 10.1186/s12931-014-0094-1.

41.

Intraflagellar transport gene expression associated with short cilia in smoking and COPD.

Hessel J, Heldrich J, Fuller J, Staudt MR, Radisch S, Hollmann C, Harvey BG, Kaner RJ, Salit J, Yee-Levin J, Sridhar S, Pillai S, Hilton H, Wolff G, Bitter H, Visvanathan S, Fine J, Stevenson CS, Crystal RG, Tilley AE.

PLoS One. 2014 Jan 20;9(1):e85453. doi: 10.1371/journal.pone.0085453. eCollection 2014.

42.

Prolonged mechanical ventilation in 540 seriously ill older adults: effects of increasing age on clinical outcomes and survival.

Dermot Frengley J, Sansone GR, Shakya K, Kaner RJ.

J Am Geriatr Soc. 2014 Jan;62(1):1-9. doi: 10.1111/jgs.12597. Epub 2014 Jan 9.

PMID:
24404850
43.

Effects of smoking on non-AIDS-related morbidity in HIV-infected patients.

Shirley DK, Kaner RJ, Glesby MJ.

Clin Infect Dis. 2013 Jul;57(2):275-82. doi: 10.1093/cid/cit207. Epub 2013 Apr 9. Review.

44.

Mast cells: a pivotal role in pulmonary fibrosis.

Veerappan A, O'Connor NJ, Brazin J, Reid AC, Jung A, McGee D, Summers B, Branch-Elliman D, Stiles B, Worgall S, Kaner RJ, Silver RB.

DNA Cell Biol. 2013 Apr;32(4):206-18. doi: 10.1089/dna.2013.2005.

45.

A comparison of seriously ill patients with or without AIDS requiring prolonged mechanical ventilation.

Frengley JD, Sansone GR, Uppal K, Vecchione JJ, Kaner RJ.

J Crit Care. 2012 Dec;27(6):594-601. doi: 10.1016/j.jcrc.2012.05.010. Epub 2012 Jul 2.

PMID:
22762929
46.

A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis.

Noth I, Anstrom KJ, Calvert SB, de Andrade J, Flaherty KR, Glazer C, Kaner RJ, Olman MA; Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet).

Am J Respir Crit Care Med. 2012 Jul 1;186(1):88-95. doi: 10.1164/rccm.201202-0314OC. Epub 2012 May 3.

47.

Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.

Man M, Close SL, Shaw AD, Bernard GR, Douglas IS, Kaner RJ, Payen D, Vincent JL, Fossceco S, Janes JM, Leishman AG, O'Brien L, Williams MD, Garcia JG.

Pharmacogenomics J. 2013 Jun;13(3):218-26. doi: 10.1038/tpj.2012.1. Epub 2012 Feb 7.

PMID:
22310353
48.

Adenovirus vectors block human immunodeficiency virus-1 replication in human alveolar macrophages by inhibition of the long terminal repeat.

Kaner RJ, Santiago F, Rahaghi F, Michaels E, Moore JP, Crystal RG.

Am J Respir Cell Mol Biol. 2010 Aug;43(2):234-42. doi: 10.1165/rcmb.2008-0063OC. Epub 2009 Oct 5.

49.

Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema.

Kaner RJ, Santiago F, Crystal RG.

J Leukoc Biol. 2009 Oct;86(4):913-22. doi: 10.1189/jlb.0408240. Epub 2009 Jul 15.

50.

Acute exacerbations of idiopathic pulmonary fibrosis.

Collard HR, Moore BB, Flaherty KR, Brown KK, Kaner RJ, King TE Jr, Lasky JA, Loyd JE, Noth I, Olman MA, Raghu G, Roman J, Ryu JH, Zisman DA, Hunninghake GW, Colby TV, Egan JJ, Hansell DM, Johkoh T, Kaminski N, Kim DS, Kondoh Y, Lynch DA, Müller-Quernheim J, Myers JL, Nicholson AG, Selman M, Toews GB, Wells AU, Martinez FJ; Idiopathic Pulmonary Fibrosis Clinical Research Network Investigators.

Am J Respir Crit Care Med. 2007 Oct 1;176(7):636-43. Epub 2007 Jun 21. Review.

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