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Items: 37


Ligand-induced genetic degradation as a tool for target validation.

Yesbolatova A, Tominari Y, Kanemaki MT.

Drug Discov Today Technol. 2019 Apr;31:91-98. doi: 10.1016/j.ddtec.2018.11.001. Epub 2018 Nov 24. Review.


HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates.

Yoshiba S, Tsuchiya Y, Ohta M, Gupta A, Shiratsuchi G, Nozaki Y, Ashikawa T, Fujiwara T, Natsume T, Kanemaki MT, Kitagawa D.

J Cell Sci. 2019 Jun 20;132(12). pii: jcs217521. doi: 10.1242/jcs.217521.


Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole.

Yesbolatova A, Natsume T, Hayashi KI, Kanemaki MT.

Methods. 2019 Apr 24. pii: S1046-2023(18)30331-1. doi: 10.1016/j.ymeth.2019.04.010. [Epub ahead of print]


Single nucleosome imaging reveals loose genome chromatin networks via active RNA polymerase II.

Nagashima R, Hibino K, Ashwin SS, Babokhov M, Fujishiro S, Imai R, Nozaki T, Tamura S, Tani T, Kimura H, Shribak M, Kanemaki MT, Sasai M, Maeshima K.

J Cell Biol. 2019 May 6;218(5):1511-1530. doi: 10.1083/jcb.201811090. Epub 2019 Mar 1.


Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib.

Morii I, Iwabuchi Y, Mori S, Suekuni M, Natsume T, Yoshida K, Sugimoto N, Kanemaki MT, Fujita M.

Cancer Sci. 2019 Mar;110(3):1044-1053. doi: 10.1111/cas.13941. Epub 2019 Feb 14.


Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell cycle progression.

Goto H, Natsume T, Kanemaki MT, Kaito A, Wang S, Gabazza EC, Inagaki M, Mizoguchi A.

J Cell Sci. 2019 Jan 25;132(2). pii: jcs223123. doi: 10.1242/jcs.223123.


Publisher Correction: Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.

Takahashi A, Okada R, Nagao K, Kawamata Y, Hanyu A, Yoshimoto S, Takasugi M, Watanabe S, Kanemaki MT, Obuse C, Hara E.

Nat Commun. 2018 Oct 8;9(1):4109. doi: 10.1038/s41467-018-06613-3.


Temporal Regulation of ESCO2 Degradation by the MCM Complex, the CUL4-DDB1-VPRBP Complex, and the Anaphase-Promoting Complex.

Minamino M, Tei S, Negishi L, Kanemaki MT, Yoshimura A, Sutani T, Bando M, Shirahige K.

Curr Biol. 2018 Aug 20;28(16):2665-2672.e5. doi: 10.1016/j.cub.2018.06.037. Epub 2018 Aug 9.


Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble.

Okumura M, Natsume T, Kanemaki MT, Kiyomitsu T.

Elife. 2018 May 31;7. pii: e36559. doi: 10.7554/eLife.36559.


Seh1 targets GATOR2 and Nup153 to mitotic chromosomes.

Platani M, Samejima I, Samejima K, Kanemaki MT, Earnshaw WC.

J Cell Sci. 2018 May 1;131(9). pii: jcs213140. doi: 10.1242/jcs.213140.


TAGing for destruction.

Yesbolatova A, Kanemaki MT.

Nat Chem Biol. 2018 May;14(5):414-415. doi: 10.1038/s41589-018-0024-5. No abstract available.


Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms.

Takagi M, Ono T, Natsume T, Sakamoto C, Nakao M, Saitoh N, Kanemaki MT, Hirano T, Imamoto N.

J Cell Sci. 2018 Mar 22;131(6). pii: jcs212092. doi: 10.1242/jcs.212092.


Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity.

Eaton JD, Davidson L, Bauer DLV, Natsume T, Kanemaki MT, West S.

Genes Dev. 2018 Jan 15;32(2):127-139. doi: 10.1101/gad.308528.117. Epub 2018 Feb 8.


Replication stress induces accumulation of FANCD2 at central region of large fragile genes.

Okamoto Y, Iwasaki WM, Kugou K, Takahashi KK, Oda A, Sato K, Kobayashi W, Kawai H, Sakasai R, Takaori-Kondo A, Yamamoto T, Kanemaki MT, Taoka M, Isobe T, Kurumizaka H, Innan H, Ohta K, Ishiai M, Takata M.

Nucleic Acids Res. 2018 Apr 6;46(6):2932-2944. doi: 10.1093/nar/gky058.


Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis.

Samejima K, Booth DG, Ogawa H, Paulson JR, Xie L, Watson CA, Platani M, Kanemaki MT, Earnshaw WC.

J Cell Sci. 2018 Feb 22;131(4). pii: jcs210187. doi: 10.1242/jcs.210187.


Endosomal Rab cycles regulate Parkin-mediated mitophagy.

Yamano K, Wang C, Sarraf SA, M√ľnch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ.

Elife. 2018 Jan 23;7. pii: e31326. doi: 10.7554/eLife.31326.


A pathway for mitotic chromosome formation.

Gibcus JH, Samejima K, Goloborodko A, Samejima I, Naumova N, Nuebler J, Kanemaki MT, Xie L, Paulson JR, Earnshaw WC, Mirny LA, Dekker J.

Science. 2018 Feb 9;359(6376). pii: eaao6135. doi: 10.1126/science.aao6135. Epub 2018 Jan 18.


Conditional Degrons for Controlling Protein Expression at the Protein Level.

Natsume T, Kanemaki MT.

Annu Rev Genet. 2017 Nov 27;51:83-102. doi: 10.1146/annurev-genet-120116-024656. Review.


Dynamic Organization of Chromatin Domains Revealed by Super-Resolution Live-Cell Imaging.

Nozaki T, Imai R, Tanbo M, Nagashima R, Tamura S, Tani T, Joti Y, Tomita M, Hibino K, Kanemaki MT, Wendt KS, Okada Y, Nagai T, Maeshima K.

Mol Cell. 2017 Jul 20;67(2):282-293.e7. doi: 10.1016/j.molcel.2017.06.018. Epub 2017 Jul 14.


Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.

Takahashi A, Okada R, Nagao K, Kawamata Y, Hanyu A, Yoshimoto S, Takasugi M, Watanabe S, Kanemaki MT, Obuse C, Hara E.

Nat Commun. 2017 May 16;8:15287. doi: 10.1038/ncomms15287. Erratum in: Nat Commun. 2018 Oct 8;9(1):4109.


Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis.

Natsume T, Nishimura K, Minocherhomji S, Bhowmick R, Hickson ID, Kanemaki MT.

Genes Dev. 2017 Apr 15;31(8):816-829. doi: 10.1101/gad.297663.117. Epub 2017 May 9.


Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1.

Ode KL, Ukai H, Susaki EA, Narumi R, Matsumoto K, Hara J, Koide N, Abe T, Kanemaki MT, Kiyonari H, Ueda HR.

Mol Cell. 2017 Jan 5;65(1):176-190. doi: 10.1016/j.molcel.2016.11.022. Epub 2016 Dec 22.


Perichromosomal protein Ki67 supports mitotic chromosome architecture.

Takagi M, Natsume T, Kanemaki MT, Imamoto N.

Genes Cells. 2016 Oct;21(10):1113-1124. doi: 10.1111/gtc.12420. Epub 2016 Sep 9.


Chromatin folding and DNA replication inhibition mediated by a highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex.

Imai R, Komeda S, Shimura M, Tamura S, Matsuyama S, Nishimura K, Rogge R, Matsunaga A, Hiratani I, Takata H, Uemura M, Iida Y, Yoshikawa Y, Hansen JC, Yamauchi K, Kanemaki MT, Maeshima K.

Sci Rep. 2016 Apr 20;6:24712. doi: 10.1038/srep24712.


Rapid Protein Depletion in Human Cells by Auxin-Inducible Degron Tagging with Short Homology Donors.

Natsume T, Kiyomitsu T, Saga Y, Kanemaki MT.

Cell Rep. 2016 Apr 5;15(1):210-218. doi: 10.1016/j.celrep.2016.03.001. Epub 2016 Mar 24.


Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines.

Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma H.

Genes Cells. 2015 Dec;20(12):1059-76. doi: 10.1111/gtc.12310. Epub 2015 Nov 2.


Conditional Budding Yeast Mutants with Temperature-Sensitive and Auxin-Inducible Degrons for Screening of Suppressor Genes.

Devrekanli A, Kanemaki MT.

Methods Mol Biol. 2016;1369:257-78. doi: 10.1007/978-1-4939-3145-3_18.


RecQ4 promotes the conversion of the pre-initiation complex at a site-specific origin for DNA unwinding in Xenopus egg extracts.

Sanuki Y, Kubota Y, Kanemaki MT, Takahashi TS, Mimura S, Takisawa H.

Cell Cycle. 2015;14(7):1010-23. doi: 10.1080/15384101.2015.1007003.


Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module.

Samejima K, Ogawa H, Ageichik AV, Peterson KL, Kaufmann SH, Kanemaki MT, Earnshaw WC.

J Biol Chem. 2014 Nov 7;289(45):31617-23. doi: 10.1074/jbc.M114.583542. Epub 2014 Sep 23.


Rapid Depletion of Budding Yeast Proteins via the Fusion of an Auxin-Inducible Degron (AID).

Nishimura K, Kanemaki MT.

Curr Protoc Cell Biol. 2014 Sep 2;64:20.9.1-16. doi: 10.1002/0471143030.cb2009s64. Review.


[Structure and function of the MCM family proteins].

Kanemaki MT.

Seikagaku. 2014 Apr;86(2):249-54. Review. Japanese. No abstract available.


Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor.

Rodriguez-Bravo V, Maciejowski J, Corona J, Buch HK, Collin P, Kanemaki MT, Shah JV, Jallepalli PV.

Cell. 2014 Feb 27;156(5):1017-31. doi: 10.1016/j.cell.2014.01.010.


The dimeric Mcm8-9 complex of Xenopus laevis likely has a conserved function for resistance to DNA damage.

Kanemaki MT.

Cell Cycle. 2013 May 1;12(9):1338-9. doi: 10.4161/cc.24670. Epub 2013 Apr 15. No abstract available.


The Elg1 replication factor C-like complex functions in PCNA unloading during DNA replication.

Kubota T, Nishimura K, Kanemaki MT, Donaldson AD.

Mol Cell. 2013 Apr 25;50(2):273-80. doi: 10.1016/j.molcel.2013.02.012. Epub 2013 Mar 14.


Frontiers of protein expression control with conditional degrons.

Kanemaki MT.

Pflugers Arch. 2013 Mar;465(3):419-25. doi: 10.1007/s00424-012-1203-y. Epub 2012 Dec 28. Review.


Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.

Nishimura K, Ishiai M, Horikawa K, Fukagawa T, Takata M, Takisawa H, Kanemaki MT.

Mol Cell. 2012 Aug 24;47(4):511-22. doi: 10.1016/j.molcel.2012.05.047. Epub 2012 Jul 5.


Mcm10 plays a role in functioning of the eukaryotic replicative DNA helicase, Cdc45-Mcm-GINS.

Watase G, Takisawa H, Kanemaki MT.

Curr Biol. 2012 Feb 21;22(4):343-9. doi: 10.1016/j.cub.2012.01.023. Epub 2012 Jan 26.

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