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Items: 31

1.

Therapeutic potential of PLK1 inhibition in triple-negative breast cancer.

Ueda A, Oikawa K, Fujita K, Ishikawa A, Sato E, Ishikawa T, Kuroda M, Kanekura K.

Lab Invest. 2019 Apr 17. doi: 10.1038/s41374-019-0247-4. [Epub ahead of print]

PMID:
30996295
2.

Genomic Comparison With Supercentenarians Identifies RNF213 as a Risk Gene for Pulmonary Arterial Hypertension.

Suzuki H, Kataoka M, Hiraide T, Aimi Y, Yamada Y, Katsumata Y, Chiba T, Kanekura K, Isobe S, Sato Y, Satoh T, Gamou S, Fukuda K, Kosaki K.

Circ Genom Precis Med. 2018 Dec;11(12):e002317. doi: 10.1161/CIRCGEN.118.002317. No abstract available.

PMID:
30562119
3.

Characterization of membrane penetration and cytotoxicity of C9orf72-encoding arginine-rich dipeptides.

Kanekura K, Harada Y, Fujimoto M, Yagi T, Hayamizu Y, Nagaoka K, Kuroda M.

Sci Rep. 2018 Aug 24;8(1):12740. doi: 10.1038/s41598-018-31096-z.

4.

SOX17 Mutations in Japanese Patients with Pulmonary Arterial Hypertension.

Hiraide T, Kataoka M, Suzuki H, Aimi Y, Chiba T, Kanekura K, Satoh T, Fukuda K, Gamou S, Kosaki K.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1231-1233. doi: 10.1164/rccm.201804-0766LE. No abstract available.

PMID:
30044643
5.

Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death.

Clark AL, Kanekura K, Lavagnino Z, Spears LD, Abreu D, Mahadevan J, Yagi T, Semenkovich CF, Piston DW, Urano F.

Sci Rep. 2017 Jul 17;7(1):5611. doi: 10.1038/s41598-017-05935-4.

6.

MicroRNA and gynecologic cancers.

Kanekura K, Nishi H, Isaka K, Kuroda M.

J Obstet Gynaecol Res. 2016 Jun;42(6):612-7. doi: 10.1111/jog.12995. Epub 2016 Apr 20. Review.

PMID:
27098274
7.

Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation.

Kanekura K, Yagi T, Cammack AJ, Mahadevan J, Kuroda M, Harms MB, Miller TM, Urano F.

Hum Mol Genet. 2016 May 1;25(9):1803-13. doi: 10.1093/hmg/ddw052. Epub 2016 Feb 29.

8.

Neuroimaging evidence of deficient axon myelination in Wolfram syndrome.

Lugar HM, Koller JM, Rutlin J, Marshall BA, Kanekura K, Urano F, Bischoff AN, Shimony JS, Hershey T; Washington University Wolfram Syndrome Research Study Group.

Sci Rep. 2016 Feb 18;6:21167. doi: 10.1038/srep21167.

9.

Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.

Vomund AN, Zinselmeyer BH, Hughes J, Calderon B, Valderrama C, Ferris ST, Wan X, Kanekura K, Carrero JA, Urano F, Unanue ER.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5496-502. doi: 10.1073/pnas.1515954112. Epub 2015 Aug 31.

10.

IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions.

Kanekura K, Ma X, Murphy JT, Zhu LJ, Diwan A, Urano F.

Sci Signal. 2015 Jun 23;8(382):ra62. doi: 10.1126/scisignal.aaa0341.

11.

Research resource: Monitoring endoplasmic reticulum membrane integrity in β-cells at the single-cell level.

Kanekura K, Ou J, Hara T, Zhu LJ, Urano F.

Mol Endocrinol. 2015 Mar;29(3):473-80. doi: 10.1210/me.2014-1260. Epub 2015 Jan 13.

12.

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.

Lu S, Kanekura K, Hara T, Mahadevan J, Spears LD, Oslowski CM, Martinez R, Yamazaki-Inoue M, Toyoda M, Neilson A, Blanner P, Brown CM, Semenkovich CF, Marshall BA, Hershey T, Umezawa A, Greer PA, Urano F.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5292-301. doi: 10.1073/pnas.1421055111. Epub 2014 Nov 24.

13.

Calcium efflux from the endoplasmic reticulum leads to β-cell death.

Hara T, Mahadevan J, Kanekura K, Hara M, Lu S, Urano F.

Endocrinology. 2014 Mar;155(3):758-68. doi: 10.1210/en.2013-1519. Epub 2013 Jan 1.

14.

Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells.

Kanekura K, Ishigaki S, Merksamer PI, Papa FR, Urano F.

Lab Invest. 2013 Nov;93(11):1254-8. doi: 10.1038/labinvest.2013.112. Epub 2013 Sep 16.

15.

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome.

Oslowski CM, Hara T, O'Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Zhu LJ, Hayashi E, Hui ST, Greiner D, Kaufman RJ, Bortell R, Urano F.

Cell Metab. 2012 Aug 8;16(2):265-73. doi: 10.1016/j.cmet.2012.07.005.

16.

ER stress and unfolded protein response in amyotrophic lateral sclerosis.

Kanekura K, Suzuki H, Aiso S, Matsuoka M.

Mol Neurobiol. 2009 Apr;39(2):81-9. doi: 10.1007/s12035-009-8054-3. Epub 2009 Jan 30. Review.

PMID:
19184563
17.

ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.

Suzuki H, Kanekura K, Levine TP, Kohno K, Olkkonen VM, Aiso S, Matsuoka M.

J Neurochem. 2009 Feb;108(4):973-985. doi: 10.1111/j.0022-3042.2008.05857.x.

18.

Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis.

Nakahara J, Kanekura K, Nawa M, Aiso S, Suzuki N.

J Clin Invest. 2009 Jan;119(1):169-81. doi: 10.1172/JCI35440. Epub 2008 Dec 22.

20.

Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal.

Kawasaki A, Torii K, Yamashita Y, Nishizawa K, Kanekura K, Katada M, Ito M, Nishimoto I, Terashita K, Aiso S, Matsuoka M.

Cell Signal. 2007 Dec;19(12):2498-506. Epub 2007 Aug 9.

PMID:
17804197
21.

Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8).

Kanekura K, Nishimoto I, Aiso S, Matsuoka M.

J Biol Chem. 2006 Oct 6;281(40):30223-33. Epub 2006 Aug 4.

22.

Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein.

Hashimoto Y, Chiba T, Yamada M, Nawa M, Kanekura K, Suzuki H, Terashita K, Aiso S, Nishimoto I, Matsuoka M.

Mol Cell Biol. 2005 Nov;25(21):9304-17.

23.

Expression of N19S-SOD1, an SOD1 mutant found in sporadic amyotrophic lateral sclerosis patients, induces low-grade motoneuronal toxicity.

Obata Y, Niikura T, Kanekura K, Hashimoto Y, Kawasumi M, Kita Y, Aiso S, Matsuoka M, Nishimoto I.

J Neurosci Res. 2005 Sep 1;81(5):720-9.

PMID:
16035108
24.
25.

Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin.

Hashimoto Y, Terashita K, Niikura T, Yamagishi Y, Ishizaka M, Kanekura K, Chiba T, Yamada M, Kita Y, Aiso S, Matsuoka M, Nishimoto I.

Eur J Neurosci. 2004 May;19(9):2356-64.

PMID:
15128389
26.

Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants.

Kanekura K, Hashimoto Y, Niikura T, Aiso S, Matsuoka M, Nishimoto I.

J Biol Chem. 2004 Apr 30;279(18):19247-56. Epub 2004 Feb 16.

27.

The Gtx homeodomain transcription factor exerts neuroprotection using its homeodomain.

Hashimoto Y, Tsuji O, Kanekura K, Aiso S, Niikura T, Matsuoka M, Nishimoto I.

J Biol Chem. 2004 Apr 16;279(16):16767-77. Epub 2004 Jan 29.

28.

Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells.

Tsukamoto E, Hashimoto Y, Kanekura K, Niikura T, Aiso S, Nishimoto I.

J Neurosci Res. 2003 Sep 1;73(5):627-36.

PMID:
12929130
29.

Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization.

Terashita K, Hashimoto Y, Niikura T, Tajima H, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Nawa M, Kita Y, Aiso S, Nishimoto I.

J Neurochem. 2003 Jun;85(6):1521-38.

30.

Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein-relevant insults.

Kawasumi M, Hashimoto Y, Chiba T, Kanekura K, Yamagishi Y, Ishizaka M, Tajima H, Niikura T, Nishimoto I.

Neurosignals. 2002 Sep-Oct;11(5):236-50. Review.

PMID:
12566925
31.

Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death.

Hashimoto Y, Tsuji O, Niikura T, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Tsukamoto E, Kouyama K, Terashita K, Aiso S, Lin A, Nishimoto I.

J Neurochem. 2003 Feb;84(4):864-77.

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