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Antimicrob Agents Chemother. 2000 Dec;44(12):3441-3.

High-level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3206, USA.

Erratum in

  • Antimicrob Agents Chemother 2001 Feb;45(2):647.

Abstract

Immunoblotting with antibody against AcrA, an obligatory component of the AcrAB multidrug efflux system, showed that this protein was overexpressed by >/=170% in 9 of 10 clinical isolates of Esherichia coli with high-level ciprofloxacin resistance (MICs, >/=32 microg/ml) but not in any of the 15 isolates for which the MIC was </=1 microg/ml.

PMID:
11083655
PMCID:
PMC90220
DOI:
10.1128/aac.44.12.3441-3443.2000
[Indexed for MEDLINE]
Free PMC Article

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