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Items: 1 to 50 of 104


Autophagy regulates lipid metabolism through selective turnover of NCoR1.

Saito T, Kuma A, Sugiura Y, Ichimura Y, Obata M, Kitamura H, Okuda S, Lee HC, Ikeda K, Kanegae Y, Saito I, Auwerx J, Motohashi H, Suematsu M, Soga T, Yokomizo T, Waguri S, Mizushima N, Komatsu M.

Nat Commun. 2019 Apr 5;10(1):1567. doi: 10.1038/s41467-019-08829-3.


Forced expression of DYRK2 exerts anti-tumor effects via apoptotic induction in liver cancer.

Yokoyama-Mashima S, Yogosawa S, Kanegae Y, Hirooka S, Yoshida S, Horiuchi T, Ohashi T, Yanaga K, Saruta M, Oikawa T, Yoshida K.

Cancer Lett. 2019 Jun 1;451:100-109. doi: 10.1016/j.canlet.2019.02.046. Epub 2019 Mar 6.


NF-κB signaling activation via increases in BRD2 and BRD4 confers resistance to the bromodomain inhibitor I-BET151 in U937 cells.

Hishiki K, Akiyama M, Kanegae Y, Ozaki K, Ohta M, Tsuchitani E, Kaito K, Yamada H.

Leuk Res. 2018 Nov;74:57-63. doi: 10.1016/j.leukres.2018.09.016. Epub 2018 Oct 2.


The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy.

Nakamoto FK, Okamoto S, Mitsui J, Sone T, Ishikawa M, Yamamoto Y, Kanegae Y, Nakatake Y, Imaizumi K, Ishiura H, Tsuji S, Okano H.

Sci Rep. 2018 Sep 21;8(1):14215. doi: 10.1038/s41598-018-32573-1.


Critical role of CREBH-mediated induction of transforming growth factor β2 by hepatitis C virus infection in fibrogenic responses in hepatic stellate cells.

Chida T, Ito M, Nakashima K, Kanegae Y, Aoshima T, Takabayashi S, Kawata K, Nakagawa Y, Yamamoto M, Shimano H, Matsuura T, Kobayashi Y, Suda T, Suzuki T.

Hepatology. 2017 Nov;66(5):1430-1443. doi: 10.1002/hep.29319. Epub 2017 Sep 29.


Adenovirus vector expressing keratinocyte growth factor using CAG promoter impairs pulmonary function of mice with elastase-induced emphysema.

Oki H, Yazawa T, Baba Y, Kanegae Y, Sato H, Sakamoto S, Goto T, Saito I, Kurahashi K.

Microbiol Immunol. 2017 Jul;61(7):264-271. doi: 10.1111/1348-0421.12492.


Efficient genome replication of hepatitis B virus using adenovirus vector: a compact pregenomic RNA-expression unit.

Suzuki M, Kondo S, Yamasaki M, Matsuda N, Nomoto A, Suzuki T, Saito I, Kanegae Y.

Sci Rep. 2017 Feb 3;7:41851. doi: 10.1038/srep41851.


Establishment of a tamoxifen-inducible Cre-driver mouse strain for widespread and temporal genetic modification in adult mice.

Ichise H, Hori A, Shiozawa S, Kondo S, Kanegae Y, Saito I, Ichise T, Yoshida N.

Exp Anim. 2016 Jul 29;65(3):231-44. doi: 10.1538/expanim.15-0126. Epub 2016 Feb 29.


Single-domain intrabodies against hepatitis C virus core inhibit viral propagation and core-induced NFκB activation.

Suzuki R, Saito K, Matsuda M, Sato M, Kanegae Y, Shi G, Watashi K, Aizaki H, Chiba J, Saito I, Wakita T, Suzuki T.

J Gen Virol. 2016 Apr;97(4):887-92. doi: 10.1099/jgv.0.000423. Epub 2016 Feb 9.


CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins.

Suzuki T, Kikuguchi C, Sharma S, Sasaki T, Tokumasu M, Adachi S, Natsume T, Kanegae Y, Yamamoto T.

Sci Rep. 2015 Oct 6;5:14779. doi: 10.1038/srep14779.


Preferable sites and orientations of transgene inserted in the adenovirus vector genome: The E3 site may be unfavorable for transgene position.

Suzuki M, Kondo S, Pei Z, Maekawa A, Saito I, Kanegae Y.

Gene Ther. 2015 May;22(5):421-9. doi: 10.1038/gt.2014.124. Epub 2015 Jan 15.


Adenovirus-encoding virus-associated RNAs suppress HDGF gene expression to support efficient viral replication.

Kondo S, Yoshida K, Suzuki M, Saito I, Kanegae Y.

PLoS One. 2014 Oct 2;9(9):e108627. doi: 10.1371/journal.pone.0108627. eCollection 2014.


Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.

Lystad AH, Ichimura Y, Takagi K, Yang Y, Pankiv S, Kanegae Y, Kageyama S, Suzuki M, Saito I, Mizushima T, Komatsu M, Simonsen A.

EMBO Rep. 2014 May;15(5):557-65. doi: 10.1002/embr.201338003. Epub 2014 Mar 25.


Adenovirus vectors lacking virus-associated RNA expression enhance shRNA activity to suppress hepatitis C virus replication.

Pei Z, Shi G, Kondo S, Ito M, Maekawa A, Suzuki M, Saito I, Suzuki T, Kanegae Y.

Sci Rep. 2013 Dec 20;3:3575. doi: 10.1038/srep03575.


Efficient production of adenovirus vector lacking genes of virus-associated RNAs that disturb cellular RNAi machinery.

Maekawa A, Pei Z, Suzuki M, Fukuda H, Ono Y, Kondo S, Saito I, Kanegae Y.

Sci Rep. 2013;3:1136. doi: 10.1038/srep01136. Epub 2013 Jan 25.


[Recent progress in adenovirus vectors: focusing on VA-deleted AdV].

Kondo S, Maekawa A, Saito I, Kanegae Y.

Uirusu. 2013;63(2):155-64. Review. Japanese.


Influence of loxP insertion upstream of the cis-acting packaging domain on adenovirus packaging efficiency.

Kanegae Y, Ishimura M, Kondo S, Saito I.

Microbiol Immunol. 2012 Jul;56(7):447-55. doi: 10.1111/j.1348-0421.2012.00454.x.


Trans-complemented hepatitis C virus particles as a versatile tool for study of virus assembly and infection.

Suzuki R, Saito K, Kato T, Shirakura M, Akazawa D, Ishii K, Aizaki H, Kanegae Y, Matsuura Y, Saito I, Wakita T, Suzuki T.

Virology. 2012 Oct 10;432(1):29-38. doi: 10.1016/j.virol.2012.05.033. Epub 2012 Jun 22.


Copy number of adenoviral vector genome transduced into target cells can be measured using quantitative PCR: application to vector titration.

Pei Z, Kondo S, Kanegae Y, Saito I.

Biochem Biophys Res Commun. 2012 Jan 20;417(3):945-50. doi: 10.1016/j.bbrc.2011.12.016. Epub 2011 Dec 19.


Comparison of efficiency between FLPe and Cre for recombinase-mediated cassette exchange in vitro and in adenovirus vector production.

Takata Y, Kondo S, Goda N, Kanegae Y, Saito I.

Genes Cells. 2011 Jul;16(7):765-77. doi: 10.1111/j.1365-2443.2011.01526.x.


Conditional gene expression in hepatitis C virus transgenic mice without induction of severe liver injury using a non-inflammatory Cre-expressing adenovirus.

Chiyo T, Sekiguchi S, Hayashi M, Tobita Y, Kanegae Y, Saito I, Kohara M.

Virus Res. 2011 Sep;160(1-2):89-97. doi: 10.1016/j.virusres.2011.05.019. Epub 2011 May 30.


BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity.

Ishijima N, Suzuki M, Ashida H, Ichikawa Y, Kanegae Y, Saito I, Borén T, Haas R, Sasakawa C, Mimuro H.

J Biol Chem. 2011 Jul 15;286(28):25256-64. doi: 10.1074/jbc.M111.233601. Epub 2011 May 19.


Keratinocyte growth factor gene transduction ameliorates pulmonary fibrosis induced by bleomycin in mice.

Sakamoto S, Yazawa T, Baba Y, Sato H, Kanegae Y, Hirai T, Saito I, Goto T, Kurahashi K.

Am J Respir Cell Mol Biol. 2011 Sep;45(3):489-97. doi: 10.1165/rcmb.2010-0092OC. Epub 2010 Dec 3.


High-level expression by tissue/cancer-specific promoter with strict specificity using a single-adenoviral vector.

Kanegae Y, Terashima M, Kondo S, Fukuda H, Maekawa A, Pei Z, Saito I.

Nucleic Acids Res. 2011 Jan;39(2):e7. doi: 10.1093/nar/gkq966. Epub 2010 Nov 4.


Activities of various FLP recombinases expressed by adenovirus vectors in mammalian cells.

Kondo S, Takata Y, Nakano M, Saito I, Kanegae Y.

J Mol Biol. 2009 Jul 10;390(2):221-30. doi: 10.1016/j.jmb.2009.04.057. Epub 2009 May 3.


[Gene engineering of the adenovirus vector].

Kondo S, Terashima M, Fukuda H, Saito I, Kanegae Y.

Uirusu. 2007 Jun;57(1):37-45. Review. Japanese.


Alpha-catenin is essential in intestinal adenoma formation.

Shibata H, Takano H, Ito M, Shioya H, Hirota M, Matsumoto H, Kakudo Y, Ishioka C, Akiyama T, Kanegae Y, Saito I, Noda T.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18199-204. Epub 2007 Nov 7.


Expression of pIX gene induced by transgene promoter: possible cause of host immune response in first-generation adenoviral vectors.

Nakai M, Komiya K, Murata M, Kimura T, Kanaoka M, Kanegae Y, Saito I.

Hum Gene Ther. 2007 Oct;18(10):925-36.


[Development and application of adenovirus vector].

Kondo S, Fukuda H, Saito I, Kanegae Y.

Tanpakushitsu Kakusan Koso. 2007 Aug;52(10 Suppl):1281-7. Review. Japanese. No abstract available.


Keratinocyte growth factor gene transduction ameliorates acute lung injury and mortality in mice.

Baba Y, Yazawa T, Kanegae Y, Sakamoto S, Saito I, Morimura N, Goto T, Yamada Y, Kurahashi K.

Hum Gene Ther. 2007 Feb;18(2):130-41.


Efficient sequential gene regulation via FLP-and Cre-recombinase using adenovirus vector in mammalian cells including mouse ES cells.

Kondo S, Takahashi Y, Shiozawa S, Ichise H, Yoshida N, Kanegae Y, Saito I.

Microbiol Immunol. 2006;50(10):831-43.


Possible mechanism of adenovirus generation from a cloned viral genome tagged with nucleotides at its ends.

Fukuda H, Terashima M, Koshikawa M, Kanegae Y, Saito I.

Microbiol Immunol. 2006;50(8):643-54.


Production of viral vectors using recombinase-mediated cassette exchange.

Nakano M, Odaka K, Takahashi Y, Ishimura M, Saito I, Kanegae Y.

Nucleic Acids Res. 2005 May 5;33(8):e76.


[Adenovirus vectors for gene therapy].

Nakano M, Kondo S, Kanegae Y, Saito I.

Uirusu. 2003 Dec;53(2):147-53. Review. Japanese. No abstract available.


Simultaneous on/off regulation of transgenes located on a mammalian chromosome with Cre-expressing adenovirus and a mutant loxP.

Kondo S, Okuda A, Sato H, Tachikawa N, Terashima M, Kanegae Y, Saito I.

Nucleic Acids Res. 2003 Jul 15;31(14):e76.


Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells.

Horie R, Watanabe T, Morishita Y, Ito K, Ishida T, Kanegae Y, Saito I, Higashihara M, Mori S, Kadin ME, Watanabe T.

Oncogene. 2002 Apr 11;21(16):2493-503.


Induction of photoreceptor-specific phenotypes in adult mammalian iris tissue.

Haruta M, Kosaka M, Kanegae Y, Saito I, Inoue T, Kageyama R, Nishida A, Honda Y, Takahashi M.

Nat Neurosci. 2001 Dec;4(12):1163-4.


DNA substrates influence the recombination efficiency mediated by FLP recombinase expressed in mammalian cells.

Nakano M, Ishimura M, Chiba J, Kanegae Y, Saito I.

Microbiol Immunol. 2001;45(9):657-65.


Successful gene therapy via intraarticular injection of adenovirus vector containing CTLA4IgG in a murine model of type II collagen-induced arthritis.

Ijima K, Murakami M, Okamoto H, Inobe M, Chikuma S, Saito I, Kanegae Y, Kawaguchi Y, Kitabatake A, Uede T.

Hum Gene Ther. 2001 Jun 10;12(9):1063-77.


Efficient gene activation in cultured mammalian cells mediated by FLP recombinase-expressing recombinant adenovirus.

Nakano M, Odaka K, Ishimura M, Kondo S, Tachikawa N, Chiba J, Kanegae Y, Saito I.

Nucleic Acids Res. 2001 Apr 1;29(7):E40.


Long-term acceptance of allografts by in vivo gene transfer of regulatable adenovirus vector containing CTLA4IgG and loxP.

Takehara M, Murakami M, Inobe M, Tanaka K, Chikuma S, Saito I, Kanegae Y, Yasunami Y, Nakano M, Yamashita K, Todo S, Uede T.

Hum Gene Ther. 2001 Mar 1;12(4):415-26.


Gene therapy for hepatocellular carcinoma using two recombinant adenovirus vectors with alpha-fetoprotein promoter and Cre/lox P system.

Sakai Y, Kaneko S, Sato Y, Kanegae Y, Tamaoki T, Saito I, Kobayashi K.

J Virol Methods. 2001 Mar;92(1):5-17.


[Patching of the raw surface of the posterior right ventricular wall in Ross procedure to prevent bleeding and to confirm anastomosis of the conduit].

Murakami J, Imoto Y, Shiokawa Y, Kanegae Y, Tokunaga S, Minami K, Kajihara N, Kado H.

Kyobu Geka. 2000 Nov;53(12):1016-8. Japanese.


Possible role of cytotoxic T cells in acute liver injury in hepatitis C virus cDNA transgenic mice mediated by Cre/loxP system.

Wakita T, Katsume A, Kato J, Taya C, Yonekawa H, Kanegae Y, Saito I, Hayashi Y, Koike M, Miyamoto M, Hiasa Y, Kohara M.

J Med Virol. 2000 Nov;62(3):308-17.


The differential cardioprotective effects of nucleoside transport inhibitor on moderate and deep hypothermic ischemia with cold cardioplegia.

Nishida T, Masuda M, Kanegae Y, Miyamoto K, Tominaga R, Kawachi Y, Yasui H.

Surg Today. 2000;30(9):805-10.


[Progress of adenovirus vector development].

Kanegae Y, Nakai M, Saito I.

Tanpakushitsu Kakusan Koso. 2000 Mar;45(4):549-58. Review. Japanese. No abstract available.


Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts.

Miyazaki T, Katagiri H, Kanegae Y, Takayanagi H, Sawada Y, Yamamoto A, Pando MP, Asano T, Verma IM, Oda H, Nakamura K, Tanaka S.

J Cell Biol. 2000 Jan 24;148(2):333-42.


Cancer gene therapy using a pro-apoptotic gene, caspase-3.

Yamabe K, Shimizu S, Ito T, Yoshioka Y, Nomura M, Narita M, Saito I, Kanegae Y, Matsuda H.

Gene Ther. 1999 Dec;6(12):1952-9.


Induction of apoptosis after switch-on of the hepatitis B virus X gene mediated by the Cre/loxP recombination system.

Shintani Y, Yotsuyanagi H, Moriya K, Fujie H, Tsutsumi T, Kanegae Y, Kimura S, Saito I, Koike K.

J Gen Virol. 1999 Dec;80 ( Pt 12):3257-65.


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