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Items: 1 to 50 of 118

1.

Biomechanics of the peafowl's crest reveals frequencies tuned to social displays.

Kane SA, Van Beveren D, Dakin R.

PLoS One. 2018 Nov 28;13(11):e0207247. doi: 10.1371/journal.pone.0207247. eCollection 2018.

2.

Paroxysmal eye-head movements in Glut1 deficiency syndrome.

Pearson TS, Pons R, Engelstad K, Kane SA, Goldberg ME, De Vivo DC.

Neurology. 2017 Apr 25;88(17):1666-1673. doi: 10.1212/WNL.0000000000003867. Epub 2017 Mar 24.

3.

Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.

Wolkenberg SE, Nolt MB, Bilodeau MT, Trotter BW, Manley PJ, Kett NR, Nanda KK, Wu Z, Cato MJ, Kane SA, Kiss L, Spencer RH, Wang J, Lynch JJ, Regan CP, Stump GL, Li B, White R, Yeh S, Dinsmore CJ, Lindsley CW, Hartman GD.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):1062-1069. doi: 10.1016/j.bmcl.2016.12.054. Epub 2017 Jan 16.

PMID:
28131713
4.

Accuracy of pulse interval timing in ambulatory blood pressure measurement.

Kane SA, Blake JR, McArdle FJ, Langley P, Sims AJ.

Sci Rep. 2016 Nov 23;6:37472. doi: 10.1038/srep37472.

5.

Opportunistic detection of atrial fibrillation using blood pressure monitors: a systematic review.

Kane SA, Blake JR, McArdle FJ, Langley P, Sims AJ.

Open Heart. 2016 Apr 12;3(1):e000362. doi: 10.1136/openhrt-2015-000362. eCollection 2016. Erratum in: Open Heart. 2016;3(1):e000362corr1.

6.

Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine.

Crowley BM, Stump CA, Nguyen DN, Potteiger CM, McWherter MA, Paone DV, Quigley AG, Bruno JG, Cui D, Culberson JC, Danziger A, Fandozzi C, Gauvreau D, Kemmerer AL, Menzel K, Moore EL, Mosser SD, Reddy V, White RB, Salvatore CA, Kane SA, Bell IM, Selnick HG, Fraley ME, Burgey CS.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4777-4781. doi: 10.1016/j.bmcl.2015.07.021. Epub 2015 Jul 14.

PMID:
26231160
7.

When hawks attack: animal-borne video studies of goshawk pursuit and prey-evasion strategies.

Kane SA, Fulton AH, Rosenthal LJ.

J Exp Biol. 2015 Jan 15;218(Pt 2):212-22. doi: 10.1242/jeb.108597.

8.

Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain.

Stachel SJ, Sanders JM, Henze DA, Rudd MT, Su HP, Li Y, Nanda KK, Egbertson MS, Manley PJ, Jones KL, Brnardic EJ, Green A, Grobler JA, Hanney B, Leitl M, Lai MT, Munshi V, Murphy D, Rickert K, Riley D, Krasowska-Zoladek A, Daley C, Zuck P, Kane SA, Bilodeau MT.

J Med Chem. 2014 Jul 10;57(13):5800-16. doi: 10.1021/jm5006429. Epub 2014 Jun 19.

PMID:
24914455
9.

[(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor.

Bell IM, Gallicchio SN, Stump CA, Bruno JG, Fan H, Gantert LT, Hostetler ED, Kemmerer AL, McWherter M, Moore EL, Mosser SD, Purcell ML, Riffel K, Salvatore CA, Sanabria-Bohórquez S, Staas DD, White RB, Williams M, Zartman CB, Cook JJ, Hargreaves RJ, Kane SA, Graham SL, Selnick HG.

ACS Med Chem Lett. 2013 Jul 18;4(9):863-8. doi: 10.1021/ml400199p. eCollection 2013 Sep 12.

10.

Microbubbles are detected prior to larger bubbles following decompression.

Swan JG, Wilbur JC, Moodie KL, Kane SA, Knaus DA, Phillips SD, Beach TL, Fellows AM, Magari PJ, Buckey JC.

J Appl Physiol (1985). 2014 Apr 1;116(7):790-6. doi: 10.1152/japplphysiol.01156.2013. Epub 2014 Jan 16.

11.

Falcons pursue prey using visual motion cues: new perspectives from animal-borne cameras.

Kane SA, Zamani M.

J Exp Biol. 2014 Jan 15;217(Pt 2):225-34. doi: 10.1242/jeb.092403.

12.

In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232.

Hostetler ED, Joshi AD, Sanabria-Bohórquez S, Fan H, Zeng Z, Purcell M, Gantert L, Riffel K, Williams M, O'Malley S, Miller P, Selnick HG, Gallicchio SN, Bell IM, Salvatore CA, Kane SA, Li CC, Hargreaves RJ, de Groot T, Bormans G, Van Hecken A, Derdelinckx I, de Hoon J, Reynders T, Declercq R, De Lepeleire I, Kennedy WP, Blanchard R, Marcantonio EE, Sur C, Cook JJ, Van Laere K, Evelhoch JL.

J Pharmacol Exp Ther. 2013 Nov;347(2):478-86. doi: 10.1124/jpet.113.206458. Epub 2013 Aug 23.

PMID:
23975906
13.

Late-recognized primary congenital glaucoma.

Walton DS, Nagao K, Yeung HH, Kane SA.

J Pediatr Ophthalmol Strabismus. 2013 Jul-Aug;50(4):234-8. doi: 10.3928/01913913-20130423-02. Epub 2013 Apr 30.

PMID:
23614468
14.

MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.

Bell IM, Stump CA, Gallicchio SN, Staas DD, Zartman CB, Moore EL, Sain N, Urban M, Bruno JG, Calamari A, Kemmerer AL, Mosser SD, Fandozzi C, White RB, Zrada MM, Selnick HG, Graham SL, Vacca JP, Kane SA, Salvatore CA.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):3941-5. doi: 10.1016/j.bmcl.2012.04.105. Epub 2012 Apr 30.

PMID:
22607672
15.

Biophysical model of prokaryotic diversity in geothermal hot springs.

Klales A, Duncan J, Nett EJ, Kane SA.

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Feb;85(2 Pt 1):021911. Epub 2012 Feb 14.

PMID:
22463248
16.

To eat or not to eat red meat. A closer look at the relationship between restrained eating and vegetarianism in college females.

Forestell CA, Spaeth AM, Kane SA.

Appetite. 2012 Feb;58(1):319-25. doi: 10.1016/j.appet.2011.10.015. Epub 2011 Nov 2.

PMID:
22079892
17.

Identification of a novel RAMP-independent CGRP receptor antagonist.

Zartman CB, Bell IM, Gallicchio SN, Graham SL, Kane SA, Mallee JJ, Rutledge RZ, Salvatore CA, Vacca JP, Williams TM.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6705-8. doi: 10.1016/j.bmcl.2011.09.056. Epub 2011 Sep 21.

PMID:
21982500
18.

Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3).

Kuduk SD, Chang RK, Di Marco CN, Dipardo RM, Cook SP, Cato MJ, Jovanovska A, Urban MO, Leitl M, Spencer RH, Kane SA, Hartman GD, Bilodeau MT.

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4255-8. doi: 10.1016/j.bmcl.2011.05.064. Epub 2011 May 27.

PMID:
21669528
19.

CGRP receptor antagonists: toward a novel migraine therapy.

Salvatore CA, Kane SA.

Curr Pharm Biotechnol. 2011 Oct;12(10):1671-80. Review.

PMID:
21466447
20.

Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.

Trotter BW, Nanda KK, Burgey CS, Potteiger CM, Deng JZ, Green AI, Hartnett JC, Kett NR, Wu Z, Henze DA, Della Penna K, Desai R, Leitl MD, Lemaire W, White RB, Yeh S, Urban MO, Kane SA, Hartman GD, Bilodeau MT.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2354-8. doi: 10.1016/j.bmcl.2011.02.082. Epub 2011 Mar 1.

PMID:
21420860
21.

Decahydroquinoline amides as highly selective CB2 agonists: role of selectivity on in vivo efficacy in a rodent model of analgesia.

Manley PJ, Zartman A, Paone DV, Burgey CS, Henze DA, Della Penna K, Desai R, Leitl MD, Lemaire W, White RB, Yeh S, Urban MO, Kane SA, Hartman GD, Bilodeau MT, Trotter BW.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2359-64. doi: 10.1016/j.bmcl.2011.02.078. Epub 2011 Feb 26.

PMID:
21420857
22.

High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors.

Wolkenberg SE, Zhao Z, Mulhearn JJ, Harrison ST, Sanders JM, Cato MJ, Jovanovska A, Panigel J, Cook SP, Henze DA, Kane SA, Hartman GD, Barrow JC.

Bioorg Med Chem Lett. 2011 May 1;21(9):2646-9. doi: 10.1016/j.bmcl.2010.12.115. Epub 2010 Dec 28.

PMID:
21257308
23.

Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918.

Paone DV, Nguyen DN, Shaw AW, Burgey CS, Potteiger CM, Deng JZ, Mosser SD, Salvatore CA, Yu S, Roller S, Kane SA, Selnick HG, Vacca JP, Williams TM.

Bioorg Med Chem Lett. 2011 May 1;21(9):2683-6. doi: 10.1016/j.bmcl.2010.12.054. Epub 2010 Dec 30.

PMID:
21251825
24.

Effect of calcitonin gene-related peptide receptor antagonism on the systemic blood pressure responses to mechanistically diverse vasomodulators in conscious rats.

Lynch JJ Jr, Detwiler TJ, Kane SA, Regan CP.

J Cardiovasc Pharmacol. 2010 Nov;56(5):518-25. doi: 10.1097/FJC.0b013e3181f5d414.

PMID:
20729756
25.

Characterization of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) in human isolated coronary arteries.

Chan KY, Edvinsson L, Eftekhari S, Kimblad PO, Kane SA, Lynch J, Hargreaves RJ, de Vries R, Garrelds IM, van den Bogaerdt AJ, Danser AH, Maassenvandenbrink A.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):746-52. doi: 10.1124/jpet.110.165993. Epub 2010 Jun 23.

PMID:
20573757
26.

Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion.

Eftekhari S, Salvatore CA, Calamari A, Kane SA, Tajti J, Edvinsson L.

Neuroscience. 2010 Aug 25;169(2):683-96. doi: 10.1016/j.neuroscience.2010.05.016. Epub 2010 May 22. Erratum in: Neuroscience. 2010 Nov 10;170(4):1346.

PMID:
20472035
27.

Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist.

Bell IM, Gallicchio SN, Wood MR, Quigley AG, Stump CA, Zartman CB, Fay JF, Li CC, Lynch JJ, Moore EL, Mosser SD, Prueksaritanont T, Regan CP, Roller S, Salvatore CA, Kane SA, Vacca JP, Selnick HG.

ACS Med Chem Lett. 2010 Jan 12;1(1):24-9. doi: 10.1021/ml900016y. eCollection 2010 Apr 8.

28.

Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel.

Beshore DC, Liverton NJ, McIntyre CJ, Claiborne CF, Libby B, Culberson JC, Salata JJ, Regan CP, Lynch JJ, Kiss L, Spencer RH, Kane SA, White RB, Yeh S, Hartman GD, Dinsmore CJ.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2493-6. doi: 10.1016/j.bmcl.2010.03.005. Epub 2010 Mar 4.

PMID:
20304642
29.

Identification of potent, highly constrained CGRP receptor antagonists.

Stump CA, Bell IM, Bednar RA, Fay JF, Gallicchio SN, Hershey JC, Jelley R, Kreatsoulas C, Moore EL, Mosser SD, Quigley AG, Roller SA, Salvatore CA, Sharik SS, Theberge CR, Zartman CB, Kane SA, Graham SL, Selnick HG, Vacca JP, Williams TM.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2572-6. doi: 10.1016/j.bmcl.2010.02.086. Epub 2010 Feb 25.

PMID:
20299218
30.

Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding.

Moore EL, Gingell JJ, Kane SA, Hay DL, Salvatore CA.

Biochem Biophys Res Commun. 2010 Mar 26;394(1):141-5. doi: 10.1016/j.bbrc.2010.02.131. Epub 2010 Feb 24.

PMID:
20188075
31.

Comparison of the vasoconstrictor effects of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) and zolmitriptan in human isolated coronary arteries.

Lynch JJ Jr, Regan CP, Edvinsson L, Hargreaves RJ, Kane SA.

J Cardiovasc Pharmacol. 2010 May;55(5):518-21. doi: 10.1097/FJC.0b013e3181d7665f.

PMID:
20164785
32.

Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567.

Kuduk SD, Di Marco CN, Bodmer-Narkevitch V, Cook SP, Cato MJ, Jovanovska A, Urban MO, Leitl M, Sain N, Liang A, Spencer RH, Kane SA, Hartman GD, Bilodeau MT.

ACS Chem Neurosci. 2010 Jan 20;1(1):19-24. doi: 10.1021/cn9000186. Epub 2009 Oct 6.

33.

Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).

Sinclair SR, Kane SA, Van der Schueren BJ, Xiao A, Willson KJ, Boyle J, de Lepeleire I, Xu Y, Hickey L, Denney WS, Li CC, Palcza J, Vanmolkot FH, Depré M, Van Hecken A, Murphy MG, Ho TW, de Hoon JN.

Br J Clin Pharmacol. 2010 Jan;69(1):15-22. doi: 10.1111/j.1365-2125.2009.03543.x.

34.

Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist.

Salvatore CA, Moore EL, Calamari A, Cook JJ, Michener MS, O'Malley S, Miller PJ, Sur C, Williams DL Jr, Zeng Z, Danziger A, Lynch JJ, Regan CP, Fay JF, Tang YS, Li CC, Pudvah NT, White RB, Bell IM, Gallicchio SN, Graham SL, Selnick HG, Vacca JP, Kane SA.

J Pharmacol Exp Ther. 2010 Apr;333(1):152-60. doi: 10.1124/jpet.109.163816. Epub 2010 Jan 11.

PMID:
20065019
35.

Telemedical diagnosis of retinopathy of prematurity: accuracy of expert versus non-expert graders.

Williams SL, Wang L, Kane SA, Lee TC, Weissgold DJ, Berrocal AM, Rabinowitz D, Starren J, Flynn JT, Chiang MF.

Br J Ophthalmol. 2010 Mar;94(3):351-6. doi: 10.1136/bjo.2009.166348. Epub 2009 Dec 2.

36.

Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.

Burgey CS, Potteiger CM, Deng JZ, Mosser SD, Salvatore CA, Yu S, Roller S, Kane SA, Vacca JP, Williams TM.

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6368-72. doi: 10.1016/j.bmcl.2009.09.066. Epub 2009 Sep 22.

PMID:
19818613
37.

Effects of the prototype serotonin 5-HT(1B/1D) receptor agonist sumatriptan and the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37) on myocardial reactive hyperemic response in conscious dogs.

Lynch JJ, Shen YT, Pittman TJ, Anderson KD, Koblan KS, Gould RJ, Regan CP, Kane SA.

Eur J Pharmacol. 2009 Nov 25;623(1-3):96-102. doi: 10.1016/j.ejphar.2009.09.018. Epub 2009 Sep 17.

PMID:
19766109
38.

Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility.

Wood MR, Schirripa KM, Kim JJ, Quigley AG, Stump CA, Bell IM, Bednar RA, Fay JF, Bruno JG, Moore EL, Mosser SD, Roller S, Salvatore CA, Kane SA, Vacca JP, Selnick HG.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5787-90. doi: 10.1016/j.bmcl.2009.07.134. Epub 2009 Aug 6.

PMID:
19703767
39.

The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.

Bell IM, Bednar RA, Corcoran HA, Fay JF, Gallicchio SN, Johnston VK, Hershey JC, Miller-Stein CM, Moore EL, Mosser SD, Roller SA, Salvatore CA, Theberge CR, Wong BK, Blair Zartman C, Kane SA, Williams TM, Graham SL, Vacca JP.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4740-2. doi: 10.1016/j.bmcl.2009.06.057. Epub 2009 Jun 17.

PMID:
19577468
40.

Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3).

Kuduk SD, Chang RK, Wai JM, Di Marco CN, Cofre V, DiPardo RM, Cook SP, Cato MJ, Jovanovska A, Urban MO, Leitl M, Spencer RH, Kane SA, Hartman GD, Bilodeau MT.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4059-63. doi: 10.1016/j.bmcl.2009.06.021. Epub 2009 Jun 13.

PMID:
19553111
41.

Antinociceptive effects of the non-selective cannabinoid receptor agonist CP 55,940 are absent in CB1(-/-) and not CB2(-/-) mice in models of acute and persistent pain.

Sain NM, Liang A, Kane SA, Urban MO.

Neuropharmacology. 2009 Sep;57(3):235-41. doi: 10.1016/j.neuropharm.2009.06.004. Epub 2009 Jun 16.

PMID:
19538975
42.

The prototype serotonin 5-HT 1B/1D agonist sumatriptan increases the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.

Lynch JJ Jr, Stump GL, Kane SA, Regan CP.

J Cardiovasc Pharmacol. 2009 Jun;53(6):474-9. doi: 10.1097/FJC.0b013e3181a71a61.

PMID:
19430309
43.

Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K+ channel.

Karczewski J, Wang J, Kane SA, Kiss L, Koblan KS, Culberson JC, Spencer RH.

Biochem Pharmacol. 2009 May 15;77(10):1602-11. doi: 10.1016/j.bcp.2009.02.011. Epub 2009 Feb 27.

PMID:
19426697
44.

Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).

Kuduk SD, Di Marco CN, Chang RK, Dipardo RM, Cook SP, Cato MJ, Jovanovska A, Urban MO, Leitl M, Spencer RH, Kane SA, Bilodeau MT, Hartman GD, Bock MG.

Bioorg Med Chem Lett. 2009 May 1;19(9):2514-8. doi: 10.1016/j.bmcl.2009.03.029. Epub 2009 Mar 14.

PMID:
19339181
45.

Examining the binding properties of MK-0974: a CGRP receptor antagonist for the acute treatment of migraine.

Moore EL, Burgey CS, Paone DV, Shaw AW, Tang YS, Kane SA, Salvatore CA.

Eur J Pharmacol. 2009 Jan 14;602(2-3):250-4. doi: 10.1016/j.ejphar.2008.11.050. Epub 2008 Dec 3.

PMID:
19084002
46.

The discovery of highly potent CGRP receptor antagonists.

Stump CA, Bell IM, Bednar RA, Bruno JG, Fay JF, Gallicchio SN, Johnston VK, Moore EL, Mosser SD, Quigley AG, Salvatore CA, Theberge CR, Blair Zartman C, Zhang XF, Kane SA, Graham SL, Vacca JP, Williams TM.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):214-7. doi: 10.1016/j.bmcl.2008.10.106. Epub 2008 Oct 31.

PMID:
19010673
47.

Calcitonin gene-related peptide receptor antagonism does not affect the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.

Regan CP, Stump GL, Kane SA, Lynch JJ Jr.

J Pharmacol Exp Ther. 2009 Feb;328(2):571-8. doi: 10.1124/jpet.108.144220. Epub 2008 Nov 7.

PMID:
18997059
48.

Sol-gel carbon composite electrode as an amperometric detector for liquid chromatography.

Pamidi PV, Parrado C, Kane SA, Wang J, Smyth MR, Pingarrón J.

Talanta. 1997 Nov;44(11):1929-34.

PMID:
18966936
49.

High-throughput analysis of drug binding interactions for the human cardiac channel, Kv1.5.

Karczewski J, Kiss L, Kane SA, Koblan KS, Lynch RJ, Spencer RH.

Biochem Pharmacol. 2009 Jan 15;77(2):177-85. doi: 10.1016/j.bcp.2008.09.035. Epub 2008 Oct 8.

PMID:
18955031
50.

HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity.

Eid SR, Crown ED, Moore EL, Liang HA, Choong KC, Dima S, Henze DA, Kane SA, Urban MO.

Mol Pain. 2008 Oct 27;4:48. doi: 10.1186/1744-8069-4-48.

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