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Alternatively Activated Macrophages Are the Primary Retinoic Acid-Producing Cells in Human Decidua.

Rajakumar A, Kane MA, Yu J, Jones JW, Qu H, Badell M, Taylor RN, Sidell N.

Reprod Sci. 2020 Jan;27(1):334-341. doi: 10.1007/s43032-019-00030-7. Epub 2020 Jan 1.


Development and bioanalytical method validation of an LC-MS/MS assay for simultaneous quantitation of 2-alkyl-4(1H)-quinolones for application in bacterial cell culture and lung tissue.

Brewer LK, Jones JW, Blackwood CB, Barbier M, Oglesby-Sherrouse A, Kane MA.

Anal Bioanal Chem. 2020 Mar;412(7):1521-1534. doi: 10.1007/s00216-019-02374-0. Epub 2020 Jan 29.


Role of Gold in Inflammation and Tristetraprolin Activity.

Ok K, Li W, Neu HM, Batelu S, Stemmler TL, Kane MA, Michel SLJ.

Chemistry. 2020 Feb 3;26(7):1535-1547. doi: 10.1002/chem.201904837. Epub 2020 Jan 16.


Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo.

Kwegyir-Afful AK, Ramalingam S, Ramamurthy VP, Purushottamachar P, Murigi FN, Vasaitis TS, Huang W, Kane MA, Zhang Y, Ambulos N, Tiwari S, Srivastava P, Nnane IP, Hussain A, Qiu Y, Weber DJ, Njar VCO.

Cancers (Basel). 2019 Oct 24;11(11). pii: E1637. doi: 10.3390/cancers11111637.


Modulation of retinoid signaling: therapeutic opportunities in organ fibrosis and repair.

Wang S, Yu J, Kane MA, Moise AR.

Pharmacol Ther. 2020 Jan;205:107415. doi: 10.1016/j.pharmthera.2019.107415. Epub 2019 Oct 16. Review.


cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury.

Li Y, Jones JW, M C Choi H, Sarkar C, Kane MA, Koh EY, Lipinski MM, Wu J.

Cell Death Dis. 2019 Jul 11;10(7):531. doi: 10.1038/s41419-019-1764-1.


Effects of ATP-competitive and function-selective ERK inhibitors on airway smooth muscle cell proliferation.

Defnet AE, Huang W, Polischak S, Yadav SK, Kane MA, Shapiro P, Deshpande DA.

FASEB J. 2019 Oct;33(10):10833-10843. doi: 10.1096/fj.201900680R. Epub 2019 Jul 26.


Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3.

Kim D, Chen R, Sheu M, Kim N, Kim S, Islam N, Wier EM, Wang G, Li A, Park A, Son W, Evans B, Yu V, Prizmic VP, Oh E, Wang Z, Yu J, Huang W, Archer NK, Hu Z, Clemetson N, Nelson AM, Chien A, Okoye GA, Miller LS, Ghiaur G, Kang S, Jones JW, Kane MA, Garza LA.

Nat Commun. 2019 Jun 26;10(1):2811. doi: 10.1038/s41467-019-10811-y.


PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.

Sarkar C, Jones JW, Hegdekar N, Thayer JA, Kumar A, Faden AI, Kane MA, Lipinski MM.

Autophagy. 2020 Mar;16(3):466-485. doi: 10.1080/15548627.2019.1628538. Epub 2019 Jun 25.


A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma.

Xie H, Yin J, Shah MH, Menefee ME, Bible KC, Reidy-Lagunes D, Kane MA, Quinn DI, Gandara DR, Erlichman C, Adjei AA.

Invest New Drugs. 2019 Aug;37(4):755-762. doi: 10.1007/s10637-019-00797-1. Epub 2019 Jun 6.


Proteomic Analysis of the Pseudomonas aeruginosa Iron Starvation Response Reveals PrrF Small Regulatory RNA-Dependent Iron Regulation of Twitching Motility, Amino Acid Metabolism, and Zinc Homeostasis Proteins.

Nelson CE, Huang W, Brewer LK, Nguyen AT, Kane MA, Wilks A, Oglesby-Sherrouse AG.

J Bacteriol. 2019 May 22;201(12). pii: e00754-18. doi: 10.1128/JB.00754-18. Print 2019 Jun 15.


Retinoic Acid Is a Negative Regulator of sFLT1 Expression in Decidual Stromal Cells, and Its Levels Are Reduced in Preeclamptic Decidua.

Deepak V, Sahu MB, Yu J, Jones JW, Kane MA, Taylor RN, Badell ML, Sidell N, Rajakumar A.

Hypertension. 2019 May;73(5):1104-1111. doi: 10.1161/HYPERTENSIONAHA.118.12564.


The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis.

Ramalingam S, Ramamurthy VP, Gediya LK, Murigi FN, Purushottamachar P, Huang W, Choi EY, Zhang Y, Vasaitis TS, Kane MA, Lapidus RG, Njar VCO.

Cancers (Basel). 2019 Mar 3;11(3). pii: E299. doi: 10.3390/cancers11030299.


Detection and Structural Characterization of Ether Glycerophosphoethanolamine from Cortical Lysosomes Following Traumatic Brain Injury Using UPLC-HDMSE.

Jones JW, Sarkar C, Lipinski MM, Kane MA.

Proteomics. 2019 Sep;19(18):e1800297. doi: 10.1002/pmic.201800297. Epub 2019 Mar 19.


ARS, DEARE, and Multiple-organ Injury: A Strategic and Tactical Approach to Link Radiation Effects, Animal Models, Medical Countermeasures, and Biomarker Development to Predict Clinical Outcome.

MacVittie TJ, Farese AM, Kane MA.

Health Phys. 2019 Apr;116(4):453. doi: 10.1097/HP.0000000000001050. No abstract available.


Set of Highly Stable Amine- and Carboxylate-Terminated Dendronized Au Nanoparticles with Dense Coating and Nontoxic Mixed-Dendronized Form.

Saha Ray A, Ghann WE, Tsoi PS, Szychowski B, Dockery LT, Pak YJ, Li W, Kane MA, Swaan P, Daniel MC.

Langmuir. 2019 Mar 5;35(9):3391-3403. doi: 10.1021/acs.langmuir.8b03196. Epub 2019 Feb 18.


Effect of Sex on Biomarker Response in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.

Jones JW, Alloush J, Sellamuthu R, Chua HL, MacVittie TJ, Orschell CM, Kane MA.

Health Phys. 2019 Apr;116(4):484-502. doi: 10.1097/HP.0000000000000961.


Characterizing the Natural History of Acute Radiation Syndrome of the Gastrointestinal Tract: Combining High Mass and Spatial Resolution Using MALDI-FTICR-MSI.

Carter CL, Hankey KG, Booth C, Tudor GL, Parker GA, Jones JW, Farese AM, MacVittie TJ, Kane MA.

Health Phys. 2019 Apr;116(4):454-472. doi: 10.1097/HP.0000000000000948.


Snapshots of Iron Speciation: Tracking the Fate of Iron Nanoparticle Drugs via a Liquid Chromatography-Inductively Coupled Plasma-Mass Spectrometric Approach.

Neu HM, Alexishin SA, Brandis JEP, Williams AMC, Li W, Sun D, Zheng N, Jiang W, Zimrin A, Fink JC, Polli JE, Kane MA, Michel SLJ.

Mol Pharm. 2019 Mar 4;16(3):1272-1281. doi: 10.1021/acs.molpharmaceut.8b01215. Epub 2019 Feb 14.


Acute Proteomic Changes in the Lung After WTLI in a Mouse Model: Identification of Potential Initiating Events for Delayed Effects of Acute Radiation Exposure.

Huang W, Yu J, Jones JW, Carter CL, Jackson IL, Vujaskovic Z, MacVittie TJ, Kane MA.

Health Phys. 2019 Apr;116(4):503-515. doi: 10.1097/HP.0000000000000956.


Proteomic Evaluation of the Acute Radiation Syndrome of the Gastrointestinal Tract in a Murine Total-body Irradiation Model.

Huang W, Yu J, Jones JW, Carter CL, Pierzchalski K, Tudor G, Booth C, MacVittie TJ, Kane MA.

Health Phys. 2019 Apr;116(4):516-528. doi: 10.1097/HP.0000000000000951.


Targeted Metabolomics Reveals Metabolomic Signatures Correlating Gastrointestinal Tissue to Plasma in a Mouse Total-body Irradiation Model.

Jones JW, Clifford Z, Li F, Tudor GL, Farese AM, Booth C, MacVittie TJ, Kane MA.

Health Phys. 2019 Apr;116(4):473-483. doi: 10.1097/HP.0000000000000955.


ARS, DEARE, and Multiple-organ Injury: A Strategic and Tactical Approach to Link Radiation Effects, Animal Models, Medical Countermeasures, and Biomarker Development to Predict Clinical Outcome.

MacVittie TJ, Farese AM, Kane MA.

Health Phys. 2019 Mar;116(3):297-304. doi: 10.1097/HP.0000000000001045. No abstract available.


Radiation Nephropathy in a Nonhuman Primate Model of Partial-body Irradiation with Minimal Bone Marrow Sparing-Part 1: Acute and Chronic Kidney Injury and the Influence of Neupogen.

Cohen EP, Hankey KG, Farese AM, Parker GA, Jones JW, Kane MA, Bennett A, MacVittie TJ.

Health Phys. 2019 Mar;116(3):401-408. doi: 10.1097/HP.0000000000000960. Erratum in: Health Phys. 2019 May;116(5):723.


Prenatal alcohol exposure prevalence as measured by direct ethanol metabolites in meconium in a Native American tribe of the southwest.

Bakhireva LN, Kane MA, Bearer CF, Bautista A, Jones JW, Garrison L, Begay MG, Ozechowski T, Lewis J.

Birth Defects Res. 2019 Jan 15;111(2):53-61. doi: 10.1002/bdr2.1427. Epub 2018 Dec 14.


Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium.

Teletin M, Vernet N, Yu J, Klopfenstein M, Jones JW, Féret B, Kane MA, Ghyselinck NB, Mark M.

Development. 2019 Jan 4;146(1). pii: dev170225. doi: 10.1242/dev.170225.


Erratum: Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5.

Wang H, Chauhan J, Hu A, Pendleton K, Yap JL, Sabato PE, Jones JW, Perri M, Yu J, Cione E, Kane MA, Fletcher S, Prochownik EV.

Oncotarget. 2018 Oct 12;9(80):35196. doi: 10.18632/oncotarget.26241. eCollection 2018 Oct 12.


Therapeutic potential of Bcl-xL/Mcl-1 synthetic inhibitor JY-1-106 and retinoids for human triple-negative breast cancer treatment.

Perri M, Yap JL, Fletcher S, Cione E, Kane MA.

Oncol Lett. 2018 May;15(5):7231-7236. doi: 10.3892/ol.2018.8258. Epub 2018 Mar 14.


Alterations in retinoic acid signaling affect the development of the mouse coronary vasculature.

Wang S, Huang W, Castillo HA, Kane MA, Xavier-Neto J, Trainor PA, Moise AR.

Dev Dyn. 2018 Aug;247(8):976-991. doi: 10.1002/dvdy.24639.


Commentary on Myomodulation with Injectable Fillers: An Innovative Approach to Addressing Facial Muscle Movement.

Kane MAC.

Aesthetic Plast Surg. 2018 Oct;42(5):1360-1363. doi: 10.1007/s00266-018-1140-z. Epub 2018 May 16. No abstract available.


A subset of mobilized human hematopoietic stem cells express germ layer lineage genes which can be modulated by culture conditions.

Makar T, Nimmagadda VK, Guda PR, Hampton B, Huang W, Kane MA, Fishman PS, Pessac B, Bever CT Jr, Trisler D.

Stem Cell Res Ther. 2018 May 2;9(1):127. doi: 10.1186/s13287-018-0858-5.


The Pseudomonas aeruginosa PrrF1 and PrrF2 Small Regulatory RNAs Promote 2-Alkyl-4-Quinolone Production through Redundant Regulation of the antR mRNA.

Djapgne L, Panja S, Brewer LK, Gans JH, Kane MA, Woodson SA, Oglesby-Sherrouse AG.

J Bacteriol. 2018 Apr 24;200(10). pii: e00704-17. doi: 10.1128/JB.00704-17. Print 2018 May 15.


The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation.

Handberg-Thorsager M, Gutierrez-Mazariegos J, Arold ST, Kumar Nadendla E, Bertucci PY, Germain P, Tomançak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V, Arendt D, Schubert M.

Sci Adv. 2018 Feb 21;4(2):eaao1261. doi: 10.1126/sciadv.aao1261. eCollection 2018 Feb.


Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells.

Wang S, Yu J, Jones JW, Pierzchalski K, Kane MA, Trainor PA, Xavier-Neto J, Moise AR.

FASEB J. 2018 Jul;32(7):3765-3781. doi: 10.1096/fj.201701038R. Epub 2018 Feb 15.


LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer.

Lo PK, Yao Y, Lee JS, Zhang Y, Huang W, Kane MA, Zhou Q.

Elife. 2018 Jan 19;7. pii: e31334. doi: 10.7554/eLife.31334.


Effect of Ibuprofen on Skeletal Muscle of Dysferlin-Null Mice.

Collier AF, Gumerson J, Lehtimäki K, Puoliväli J, Jones JW, Kane MA, Manne S, O'Neill A, Windish HP, Ahtoniemi T, Williams BA, Albrecht DE, Bloch RJ.

J Pharmacol Exp Ther. 2018 Mar;364(3):409-419. doi: 10.1124/jpet.117.244244. Epub 2017 Dec 28.


Novel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model.

McCarty DJ, Huang W, Kane MA, Purushottamachar P, Gediya LK, Njar VCO.

Oncotarget. 2017 Aug 1;8(51):88501-88516. doi: 10.18632/oncotarget.19762. eCollection 2017 Oct 24.


PAMDB: a comprehensive Pseudomonas aeruginosa metabolome database.

Huang W, Brewer LK, Jones JW, Nguyen AT, Marcu A, Wishart DS, Oglesby-Sherrouse AG, Kane MA, Wilks A.

Nucleic Acids Res. 2018 Jan 4;46(D1):D575-D580. doi: 10.1093/nar/gkx1061.


Neutrophil microparticle production and inflammasome activation by hyperglycemia due to cytoskeletal instability.

Thom SR, Bhopale VM, Yu K, Huang W, Kane MA, Margolis DJ.

J Biol Chem. 2017 Nov 3;292(44):18312-18324. doi: 10.1074/jbc.M117.802629. Epub 2017 Sep 25.


Targeted Metabolomics Identifies Pharmacodynamic Biomarkers for BIO 300 Mitigation of Radiation-Induced Lung Injury.

Jones JW, Jackson IL, Vujaskovic Z, Kaytor MD, Kane MA.

Pharm Res. 2017 Dec;34(12):2698-2709. doi: 10.1007/s11095-017-2200-9. Epub 2017 Oct 2.


Planar bile acids in health and disease.

Shiffka SJ, Kane MA, Swaan PW.

Biochim Biophys Acta Biomembr. 2017 Nov;1859(11):2269-2276. doi: 10.1016/j.bbamem.2017.08.019. Epub 2017 Sep 6. Review.


Lipidomic dysregulation within the lung parenchyma following whole-thorax lung irradiation: Markers of injury, inflammation and fibrosis detected by MALDI-MSI.

Carter CL, Jones JW, Farese AM, MacVittie TJ, Kane MA.

Sci Rep. 2017 Sep 4;7(1):10343. doi: 10.1038/s41598-017-10396-w.


Molecular Basis of Metabolism-Mediated Conversion of PK11195 from an Antagonist to an Agonist of the Constitutive Androstane Receptor.

Mackowiak B, Li L, Welch MA, Li D, Jones JW, Heyward S, Kane MA, Swaan PW, Wang H.

Mol Pharmacol. 2017 Jul;92(1):75-87. doi: 10.1124/mol.117.108621. Epub 2017 Apr 25.


The Practical Use of AbobotulinumtoxinA in Aesthetics.

Kane MA, Monheit G.

Aesthet Surg J. 2017 May 1;37(suppl_1):S12-S19. doi: 10.1093/asj/sjw285. Review.


The Pseudomonas aeruginosa PrrF Small RNAs Regulate Iron Homeostasis during Acute Murine Lung Infection.

Reinhart AA, Nguyen AT, Brewer LK, Bevere J, Jones JW, Kane MA, Damron FH, Barbier M, Oglesby-Sherrouse AG.

Infect Immun. 2017 Apr 21;85(5). pii: e00764-16. doi: 10.1128/IAI.00764-16. Print 2017 May.


Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.

Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA.

Science. 2016 Oct 14;354(6309):197-202.


Quantitation of the Noncovalent Cellular Retinol-Binding Protein, Type 1 Complex Through Native Mass Spectrometry.

Li W, Yu J, Kane MA.

J Am Soc Mass Spectrom. 2017 Jan;28(1):29-37. doi: 10.1007/s13361-016-1499-5. Epub 2016 Oct 5.


Ultraperformance convergence chromatography-high resolution tandem mass spectrometry for lipid biomarker profiling and identification.

Jones JW, Carter CL, Li F, Yu J, Pierzchalski K, Jackson IL, Vujaskovic Z, Kane MA.

Biomed Chromatogr. 2017 Mar;31(3). doi: 10.1002/bmc.3822. Epub 2016 Sep 29.


Cystic Fibrosis Isolates of Pseudomonas aeruginosa Retain Iron-Regulated Antimicrobial Activity against Staphylococcus aureus through the Action of Multiple Alkylquinolones.

Nguyen AT, Jones JW, Cámara M, Williams P, Kane MA, Oglesby-Sherrouse AG.

Front Microbiol. 2016 Jul 27;7:1171. doi: 10.3389/fmicb.2016.01171. eCollection 2016.

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