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Items: 42


The role of PAK1 in the sensitivity of kidney epithelial cells to ischemia-like conditions.

Zynda ER, Maloy MH, Kandel ES.

Cell Cycle. 2019 Mar;18(5):596-604. doi: 10.1080/15384101.2019.1578149. Epub 2019 Feb 11.


KLF9-dependent ROS regulate melanoma progression in stage-specific manner.

Bagati A, Moparthy S, Fink EE, Bianchi-Smiraglia A, Yun DH, Kolesnikova M, Udartseva OO, Wolff DW, Roll MV, Lipchick BC, Han Z, Kozlova NI, Jowdy P, Berman AE, Box NF, Rodriguez C, Bshara W, Kandel ES, Soengas MS, Paragh G, Nikiforov MA.

Oncogene. 2019 May;38(19):3585-3597. doi: 10.1038/s41388-019-0689-6. Epub 2019 Jan 21.


XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response.

Fink EE, Moparthy S, Bagati A, Bianchi-Smiraglia A, Lipchick BC, Wolff DW, Roll MV, Wang J, Liu S, Bakin AV, Kandel ES, Lee AH, Nikiforov MA.

Cell Rep. 2018 Oct 2;25(1):212-223.e4. doi: 10.1016/j.celrep.2018.09.013.


Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.

Bianchi-Smiraglia A, Bagati A, Fink EE, Affronti HC, Lipchick BC, Moparthy S, Long MD, Rosario SR, Lightman SM, Moparthy K, Wolff DW, Yun DH, Han Z, Polechetti A, Roll MV, Gitlin II, Leonova KI, Rowsam AM, Kandel ES, Gudkov AV, Bergsagel PL, Lee KP, Smiraglia DJ, Nikiforov MA.

J Clin Invest. 2018 Oct 1;128(10):4682-4696. doi: 10.1172/JCI70712. Epub 2018 Sep 10.


FOXQ1 controls the induced differentiation of melanocytic cells.

Bagati A, Bianchi-Smiraglia A, Moparthy S, Kolesnikova K, Fink EE, Kolesnikova M, Roll MV, Jowdy P, Wolff DW, Polechetti A, Yun DH, Lipchick BC, Paul LM, Wrazen B, Moparthy K, Mudambi S, Morozevich GE, Georgieva SG, Wang J, Shafirstein G, Liu S, Kandel ES, Berman AE, Box NF, Paragh G, Nikiforov MA.

Cell Death Differ. 2018 Jun;25(6):1040-1049. doi: 10.1038/s41418-018-0066-y. Epub 2018 Feb 20.


Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution.

Bianchi-Smiraglia A, Rana MS, Foley CE, Paul LM, Lipchick BC, Moparthy S, Moparthy K, Fink EE, Bagati A, Hurley E, Affronti HC, Bakin AV, Kandel ES, Smiraglia DJ, Feltri ML, Sousa R, Nikiforov MA.

Nat Methods. 2017 Oct;14(10):1003-1009. doi: 10.1038/nmeth.4404. Epub 2017 Sep 4.


The evidence for a microRNA product of human DROSHA gene.

Mechtler P, Johnson S, Slabodkin H, Cohanim AB, Brodsky L, Kandel ES.

RNA Biol. 2017 Nov 2;14(11):1508-1513. doi: 10.1080/15476286.2017.1342934. Epub 2017 Sep 5.


P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells.

Babagana M, Johnson S, Slabodkin H, Bshara W, Morrison C, Kandel ES.

Mol Carcinog. 2017 May;56(5):1515-1525. doi: 10.1002/mc.22611. Epub 2017 Feb 23.


An RNA interference screen identifies new avenues for nephroprotection.

Zynda ER, Schott B, Gruener S, Wernher E, Nguyen GD, Ebeling M, Kandel ES.

Cell Death Differ. 2017 Jul;24(7):1306. doi: 10.1038/cdd.2016.98. Epub 2016 Nov 18.


An RNA interference screen identifies new avenues for nephroprotection.

Zynda ER, Schott B, Babagana M, Gruener S, Wernher E, Nguyen GD, Ebeling M, Kandel ES.

Cell Death Differ. 2016 Apr;23(4):608-15. doi: 10.1038/cdd.2015.128. Epub 2015 Nov 13. Erratum in: Cell Death Differ. 2017 Jul;24(7):1306.


MicroRNA analysis suggests an additional level of feedback regulation in the NF-κB signaling cascade.

Mechtler P, Singhal R, Kichina JV, Bard JE, Buck MJ, Kandel ES.

Oncotarget. 2015 Jul 10;6(19):17097-106.


Protein kinase A type II-α regulatory subunit regulates the response of prostate cancer cells to taxane treatment.

Zynda ER, Matveev V, Makhanov M, Chenchik A, Kandel ES.

Cell Cycle. 2014;13(20):3292-301. doi: 10.4161/15384101.2014.949501.


Nrf2 amplifies oxidative stress via induction of Klf9.

Zucker SN, Fink EE, Bagati A, Mannava S, Bianchi-Smiraglia A, Bogner PN, Wawrzyniak JA, Foley C, Leonova KI, Grimm MJ, Moparthy K, Ionov Y, Wang J, Liu S, Sexton S, Kandel ES, Bakin AV, Zhang Y, Kaminski N, Segal BH, Nikiforov MA.

Mol Cell. 2014 Mar 20;53(6):916-928. doi: 10.1016/j.molcel.2014.01.033. Epub 2014 Mar 6.


ETV1 positively regulates transcription of tumor suppressor ARF.

Zynda E, Jackson MW, Bhattacharya P, Kandel ES.

Cancer Biol Ther. 2013 Dec;14(12):1167-73. doi: 10.4161/cbt.26883. Epub 2013 Oct 23.


FOXO1 regulates expression of a microRNA cluster on X chromosome.

Singhal R, Bard JE, Nowak NJ, Buck MJ, Kandel ES.

Aging (Albany NY). 2013 May;5(5):347-56.


Absence of XMRV and closely related viruses in primary prostate cancer tissues used to derive the XMRV-infected cell line 22Rv1.

Das Gupta J, Luk KC, Tang N, Gaughan C, Klein EA, Kandel ES, Hackett J Jr, Silverman RH.

PLoS One. 2012;7(5):e36072. doi: 10.1371/journal.pone.0036072. Epub 2012 May 16.


Long-distance effects of insertional mutagenesis.

Singhal R, Deng X, Chenchik AA, Kandel ES.

PLoS One. 2011 Jan 5;6(1):e15832. doi: 10.1371/journal.pone.0015832.


PAK1 as a therapeutic target.

Kichina JV, Goc A, Al-Husein B, Somanath PR, Kandel ES.

Expert Opin Ther Targets. 2010 Jul;14(7):703-25. doi: 10.1517/14728222.2010.492779. Review.


Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.

Lu T, Jackson MW, Singhi AD, Kandel ES, Yang M, Zhang Y, Gudkov AV, Stark GR.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16339-44. doi: 10.1073/pnas.0908560106. Epub 2009 Sep 1.


NFkappaB inhibition and more: a side-by-side comparison of the inhibitors of IKK and proteasome.

Kandel ES.

Cell Cycle. 2009 Jun 15;8(12):1819-20. Epub 2009 Jun 15. No abstract available.


The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt.

Somanath PR, Vijai J, Kichina JV, Byzova T, Kandel ES.

Oncogene. 2009 Jun 25;28(25):2365-9. doi: 10.1038/onc.2009.114. Epub 2009 May 4.


A natural human retrovirus efficiently complements vectors based on murine leukemia virus.

Dong B, Silverman RH, Kandel ES.

PLoS One. 2008 Sep 4;3(9):e3144. doi: 10.1371/journal.pone.0003144.


Transposon-based mutagenesis identifies short RIP1 as an activator of NFkappaB.

Dasgupta M, Agarwal MK, Varley P, Lu T, Stark GR, Kandel ES.

Cell Cycle. 2008 Jul 15;7(14):2249-56. Epub 2008 May 17.


miRNAs: Little known mediators of oncogenesis.

Gartel AL, Kandel ES.

Semin Cancer Biol. 2008 Apr;18(2):103-10. doi: 10.1016/j.semcancer.2008.01.008. Epub 2008 Jan 16. Review.


Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly.

Somanath PR, Kandel ES, Hay N, Byzova TV.

J Biol Chem. 2007 Aug 3;282(31):22964-76. Epub 2007 Jun 11.


RNA-mediated response to heat shock in mammalian cells.

Shamovsky I, Ivannikov M, Kandel ES, Gershon D, Nudler E.

Nature. 2006 Mar 23;440(7083):556-60.


RNA interference in cancer.

Gartel AL, Kandel ES.

Biomol Eng. 2006 Mar;23(1):17-34. Epub 2006 Feb 8. Review.


Mutagenesis by reversible promoter insertion to study the activation of NF-kappaB.

Kandel ES, Lu T, Wan Y, Agarwal MK, Jackson MW, Stark GR.

Proc Natl Acad Sci U S A. 2005 May 3;102(18):6425-30. Epub 2005 Apr 25.


Constitutive expression of E2F-1 leads to p21-dependent cell cycle arrest in S phase of the cell cycle.

Radhakrishnan SK, Feliciano CS, Najmabadi F, Haegebarth A, Kandel ES, Tyner AL, Gartel AL.

Oncogene. 2004 May 20;23(23):4173-6.


Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B.

Neznanov N, Neznanova L, Kondratov RV, Burdelya L, Kandel ES, O'Rourke DM, Ullrich A, Gudkov AV.

J Biol Chem. 2003 Feb 7;278(6):3809-15. Epub 2002 Nov 24.


Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage.

Kandel ES, Skeen J, Majewski N, Di Cristofano A, Pandolfi PP, Feliciano CS, Gartel A, Hay N.

Mol Cell Biol. 2002 Nov;22(22):7831-41.


The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

Kandel ES, Hay N.

Exp Cell Res. 1999 Nov 25;253(1):210-29. Review.


A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.

Chang BD, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y, Kandel ES, Lausch E, Christov K, Roninson IB.

Cancer Res. 1999 Aug 1;59(15):3761-7.


Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria.

Kennedy SG, Kandel ES, Cross TK, Hay N.

Mol Cell Biol. 1999 Aug;19(8):5800-10.


Applications of green fluorescent protein as a marker of retroviral vectors.

Kandel ES, Chang BD, Schott B, Shtil AA, Gudkov AV, Roninson IB.

Somat Cell Mol Genet. 1997 Sep;23(5):325-40.


Efficient recovery and regeneration of integrated retroviruses.

Schott B, Kandel ES, Roninson IB.

Nucleic Acids Res. 1997 Jul 15;25(14):2940-2.


Congenital determinants of violence.

Mednick SA, Kandel ES.

Bull Am Acad Psychiatry Law. 1988;16(2):101-9.


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