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Items: 22

1.

Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended-release tablets.

Inoue Y, Morita H, Nozawa K, Kanazu T.

Biopharm Drug Dispos. 2019 Sep;40(8):282-293. doi: 10.1002/bdd.2201. Epub 2019 Aug 7.

2.

Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine.

Akazawa T, Yoshida S, Ohnishi S, Kanazu T, Kawai M, Takahashi K.

Drug Metab Dispos. 2018 Nov;46(11):1497-1506. doi: 10.1124/dmd.118.083246. Epub 2018 Aug 22.

PMID:
30135242
3.

Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation.

Kobayashi M, Kodama M, Noshi T, Yoshida R, Kanazu T, Nomura N, Soda K, Isoda N, Okamatsu M, Sakoda Y, Yamano Y, Sato A, Kida H.

Antiviral Res. 2017 Mar;139:41-48. doi: 10.1016/j.antiviral.2016.12.011. Epub 2016 Dec 22.

PMID:
28012921
4.

In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans.

Sekiguchi K, Kanazu T, Murayama N, Yamazaki H, Yamaguchi Y.

Xenobiotica. 2016;46(6):495-502. doi: 10.3109/00498254.2015.1091114. Epub 2015 Dec 18.

PMID:
26677906
5.

The metabolism and pharmacokinetics of [14C]-S-777469, a new cannabinoid receptor 2 selective agonist, in healthy human subjects.

Sekiguchi K, Fukumura K, Hasegawa H, Kanazu T.

Xenobiotica. 2015 Feb;45(2):150-7. doi: 10.3109/00498254.2014.956158. Epub 2014 Sep 2.

PMID:
25180977
6.

The relationship between in vivo antiviral activity and pharmacokinetic parameters of peramivir in influenza virus infection model in mice.

Kodama M, Yoshida R, Hasegawa T, Izawa M, Kitano M, Baba K, Noshi T, Seki T, Okazaki K, Tsuji M, Kanazu T, Kamimori H, Homma T, Kobayashi M, Sakoda Y, Kida H, Sato A, Yamano Y.

Antiviral Res. 2014 Sep;109:110-5. doi: 10.1016/j.antiviral.2014.06.016. Epub 2014 Jul 2.

PMID:
24997412
7.

Non-clinical evaluation of the metabolism, pharmacokinetics and excretion of S-777469, a new cannabinoid receptor 2 selective agonist.

Sekiguchi K, Kanazu T, Takeuchi M, Hasegawa H, Yamaguchi Y.

Xenobiotica. 2014 Jan;44(1):48-58. doi: 10.3109/00498254.2013.805853. Epub 2013 Jun 13.

PMID:
23763649
8.

Efficacy of repeated intravenous injection of peramivir against influenza A (H1N1) 2009 virus infection in immunosuppressed mice.

Kitano M, Kodama M, Itoh Y, Kanazu T, Kobayashi M, Yoshida R, Sato A.

Antimicrob Agents Chemother. 2013 May;57(5):2286-94. doi: 10.1128/AAC.02324-12. Epub 2013 Mar 11.

9.

Investigation of drug-drug interaction via mechanism-based inhibition of cytochrome P450 3A by macrolides in dexamethasone-treated female rats.

Kanazu T, Sato N, Kadono K, Touchi A, Takeda Y, Yamaguchi Y, Baba T.

Biopharm Drug Dispos. 2012 May;33(4):195-206. doi: 10.1002/bdd.1785. Epub 2012 Apr 20.

PMID:
22447511
10.

Efficacy of single intravenous injection of peramivir against influenza B virus infection in ferrets and cynomolgus macaques.

Kitano M, Itoh Y, Kodama M, Ishigaki H, Nakayama M, Ishida H, Baba K, Noda T, Sato K, Nihashi Y, Kanazu T, Yoshida R, Torii R, Sato A, Ogasawara K.

Antimicrob Agents Chemother. 2011 Nov;55(11):4961-70. doi: 10.1128/AAC.00412-11. Epub 2011 Aug 15.

12.

Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action.

Sakamoto S, Kusuhara H, Miyata K, Shimaoka H, Kanazu T, Matsuo Y, Nomura K, Okamura N, Hara S, Horie K, Baba T, Sugiyama Y.

J Pharmacol Exp Ther. 2007 Aug;322(2):610-8. Epub 2007 Apr 30.

PMID:
17470645
13.

Assessment of the hepatic and intestinal first-pass metabolism of midazolam in a CYP3A drug-drug interaction model rats.

Kanazu T, Okamura N, Yamaguchi Y, Baba T, Koike M.

Xenobiotica. 2005 Apr;35(4):305-17.

PMID:
16019953
14.
15.
16.

Distribution and excretion of boron after intravenous administration of disodium mercaptoundecahydro-closo-dodecaborate to rats.

Yamaguchi T, Nakajima Y, Miyamoto H, Mizobuchi M, Kanazu T, Kadono K, Nakamoto K, Ikeuchi I.

J Toxicol Sci. 1998 Oct;23 Suppl 4:577-85.

PMID:
9836183
17.

Disposition and metabolism of the new hypocholesterolemic compound S-8921 in rats and dogs.

Yamaguchi T, Nakajima Y, Mizobuchi M, Inazawa K, Kanazu T, Kadono K, Ohkawa T, Iwatani K.

Arzneimittelforschung. 1998 Oct;48(10):995-1006.

PMID:
9825117
18.
19.

Aldehyde reductase is a major protein associated with 3-deoxyglucosone reductase activity in rat, pig and human livers.

Kanazu T, Shinoda M, Nakayama T, Deyashiki Y, Hara A, Sawada H.

Biochem J. 1991 Nov 1;279 ( Pt 3):903-6.

20.

Inhibition of dimeric dihydrodiol dehydrogenases of rabbit and pig lens by ascorbic acid.

Hara A, Shinoda M, Kanazu T, Nakayama T, Deyashiki Y, Sawada H.

Biochem J. 1991 Apr 1;275 ( Pt 1):121-6.

21.

Distribution and characterization of dihydrodiol dehydrogenases in mammalian ocular tissues.

Hara A, Nakayama T, Harada T, Kanazu T, Shinoda M, Deyashiki Y, Sawada H.

Biochem J. 1991 Apr 1;275 ( Pt 1):113-9.

22.

Distribution of dimeric dihydrodiol dehydrogenase in pig tissues and its role in carbonyl metabolism.

Nakayama T, Sawada H, Deyashiki Y, Kanazu T, Hara A, Shinoda M, Matsuura K, Bunai Y, Ohya I.

Adv Exp Med Biol. 1991;284:187-96. No abstract available.

PMID:
1905099

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