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Items: 33

1.

Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab.

Jassem S, Wang W, Sweet H, Manoukian R, Chow V, Kanakaraj P, Hutterer KM, Kuhns S, Foltz IN, Chen Q, Ferbas J, McBride HJ.

Pharm Res. 2019 Nov 6;36(12):177. doi: 10.1007/s11095-019-2702-8.

2.

Neuroendocrine and sympathetic responses to an orexin receptor antagonist, SB-649868, and alprazolam following insulin-induced hypoglycemia in humans.

Patel AX, Miller SR, Nathan PJ, Kanakaraj P, Napolitano A, Lawrence P, Koch A, Bullmore ET.

Psychopharmacology (Berl). 2014 Oct;231(19):3817-28. doi: 10.1007/s00213-014-3520-7. Epub 2014 Apr 26.

3.

Monoclonal antibody therapeutics with up to five specificities: functional enhancement through fusion of target-specific peptides.

LaFleur DW, Abramyan D, Kanakaraj P, Smith RG, Shah RR, Wang G, Yao XT, Kankanala S, Boyd E, Zaritskaya L, Nam V, Puffer BA, Buasen P, Kaithamana S, Burnette AF, Krishnamurthy R, Patel D, Roschke VV, Kiener PA, Hilbert DM, Barbas CF 3rd.

MAbs. 2013 Mar-Apr;5(2):208-18. doi: 10.4161/mabs.23043.

4.

Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis.

Kanakaraj P, Puffer BA, Yao XT, Kankanala S, Boyd E, Shah RR, Wang G, Patel D, Krishnamurthy R, Kaithamana S, Smith RG, LaFleur DW, Barbas CF 3rd, Hilbert DM, Kiener PA, Roschke VV.

MAbs. 2012 Sep-Oct;4(5):600-13. doi: 10.4161/mabs.21227. Epub 2012 Aug 6.

5.

Structural and functional characterization of CC chemokine CCL14.

Blain KY, Kwiatkowski W, Zhao Q, La Fleur D, Naik C, Chun TW, Tsareva T, Kanakaraj P, Laird MW, Shah R, George L, Sanyal I, Moore PA, Demeler B, Choe S.

Biochemistry. 2007 Sep 4;46(35):10008-15. Epub 2007 Aug 11.

PMID:
17691823
6.

HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo.

Pukac L, Kanakaraj P, Humphreys R, Alderson R, Bloom M, Sung C, Riccobene T, Johnson R, Fiscella M, Mahoney A, Carrell J, Boyd E, Yao XT, Zhang L, Zhong L, von Kerczek A, Shepard L, Vaughan T, Edwards B, Dobson C, Salcedo T, Albert V.

Br J Cancer. 2005 Apr 25;92(8):1430-41.

7.

Development of a long-acting insulin analog using albumin fusion technology.

Duttaroy A, Kanakaraj P, Osborn BL, Schneider H, Pickeral OK, Chen C, Zhang G, Kaithamana S, Singh M, Schulingkamp R, Crossan D, Bock J, Kaufman TE, Reavey P, Carey-Barber M, Krishnan SR, Garcia A, Murphy K, Siskind JK, McLean MA, Cheng S, Ruben S, Birse CE, Blondel O.

Diabetes. 2005 Jan;54(1):251-8.

8.

Pharmacokinetics and in vitro and in vivo anti-tumor response of an interleukin-2-human serum albumin fusion protein in mice.

Melder RJ, Osborn BL, Riccobene T, Kanakaraj P, Wei P, Chen G, Stolow D, Halpern WG, Migone TS, Wang Q, Grzegorzewski KJ, Gallant G.

Cancer Immunol Immunother. 2005 Jun;54(6):535-47. Epub 2004 Dec 8.

PMID:
15592670
9.

TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model.

Fiscella M, Perry JW, Teng B, Bloom M, Zhang C, Leung K, Pukac L, Florence K, Concepcion A, Liu B, Meng Y, Chen C, Elgin EC, Kanakaraj P, Kaufmann TE, Porter J, Cibotti R, Mei Y, Zhou J, Chen G, Roschke V, Komatsoulis G, Mansfield B, Ruben S, Sanyal I, Migone TS.

Nat Biotechnol. 2003 Mar;21(3):302-7. Epub 2003 Feb 24.

PMID:
12598909
10.

A TNF family member LIGHT transduces costimulatory signals into human T cells.

Wan X, Zhang J, Luo H, Shi G, Kapnik E, Kim S, Kanakaraj P, Wu J.

J Immunol. 2002 Dec 15;169(12):6813-21.

11.

NXY-059 maintains Akt activation and inhibits release of cytochrome C after focal cerebral ischemia.

Yoshimoto T, Kanakaraj P, Ying Ma J, Cheng M, Kerr I, Malaiyandi L, Watson JA, Siesjö BK, Maples KR.

Brain Res. 2002 Aug 30;947(2):191-8.

PMID:
12176160
12.

TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator.

Migone TS, Zhang J, Luo X, Zhuang L, Chen C, Hu B, Hong JS, Perry JW, Chen SF, Zhou JX, Cho YH, Ullrich S, Kanakaraj P, Carrell J, Boyd E, Olsen HS, Hu G, Pukac L, Liu D, Ni J, Kim S, Gentz R, Feng P, Moore PA, Ruben SM, Wei P.

Immunity. 2002 Mar;16(3):479-92.

13.

BLyS BINDS TO B CELLS WITH HIGH AFFINITY AND INDUCES ACTIVATION OF THE TRANSCRIPTION FACTORS NF-kappaB AND ELF-1.

Kanakaraj P, Migone TS, Nardelli B, Ullrich S, Li Y, Olsen HS, Salcedo TW, Kaufman T, Cochrane E, Gan Y, Hilbert DM, Giri J.

Cytokine. 2001 Jan 7;13(1):25-31.

PMID:
11145839
14.

Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS.

Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y, Cho YH, Garcia AD, Gollatz E, Dimke D, LaFleur D, Migone TS, Nardelli B, Wei P, Ruben SM, Ullrich SJ, Olsen HS, Kanakaraj P, Moore PA, Baker KP.

J Biol Chem. 2000 Nov 10;275(45):35478-85.

15.

Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice.

Kanakaraj P, Ngo K, Wu Y, Angulo A, Ghazal P, Harris CA, Siekierka JJ, Peterson PA, Fung-Leung WP.

J Exp Med. 1999 Apr 5;189(7):1129-38.

16.

Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells.

Azzoni L, Zatsepina O, Abebe B, Bennett IM, Kanakaraj P, Perussia B.

J Immunol. 1998 Oct 1;161(7):3493-500.

17.

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production.

Kanakaraj P, Schafer PH, Cavender DE, Wu Y, Ngo K, Grealish PF, Wadsworth SA, Peterson PA, Siekierka JJ, Harris CA, Fung-Leung WP.

J Exp Med. 1998 Jun 15;187(12):2073-9.

18.

The SH3 domain contributes to BCR/ABL-dependent leukemogenesis in vivo: role in adhesion, invasion, and homing.

Skorski T, Nieborowska-Skorska M, Wlodarski P, Wasik M, Trotta R, Kanakaraj P, Salomoni P, Antonyak M, Martinez R, Majewski M, Wong A, Perussia B, Calabretta B.

Blood. 1998 Jan 15;91(2):406-18.

PMID:
9427693
19.

IL-12-induced activation of NK and T cells occurs in the absence of immediate-early activation gene expression.

Azzoni L, Kanakaraj P, Zatsepina O, Perussia B.

J Immunol. 1996 Oct 15;157(8):3235-41.

PMID:
8871617
21.

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells.

Skorski T, Kanakaraj P, Nieborowska-Skorska M, Ratajczak MZ, Wen SC, Zon G, Gewirtz AM, Perussia B, Calabretta B.

Blood. 1995 Jul 15;86(2):726-36.

PMID:
7606002
22.

Characterization of a novel epidermal-growth-factor-receptor-related 200-kDa tyrosine kinase in tumor cells.

Panneerselvam K, Kanakaraj P, Raj S, Das M, Bishayee S.

Eur J Biochem. 1995 Jun 15;230(3):951-7.

23.

C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis.

Skorski T, Nieborowska-Skorska M, Szczylik C, Kanakaraj P, Perrotti D, Zon G, Gewirtz A, Perussia B, Calabretta B.

Cancer Res. 1995 Jun 1;55(11):2275-8.

24.

Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth.

Skorski T, Kanakaraj P, Ku DH, Nieborowska-Skorska M, Canaani E, Zon G, Perussia B, Calabretta B.

J Exp Med. 1994 Jun 1;179(6):1855-65.

25.

Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.

Kanakaraj P, Duckworth B, Azzoni L, Kamoun M, Cantley LC, Perussia B.

J Exp Med. 1994 Feb 1;179(2):551-8.

26.

p120 GAP requirement in normal and malignant human hematopoiesis.

Skorski T, Kanakaraj P, Nieborowska-Skorska M, Ratajczak M, Szczylik C, Zon G, Arlinghaus RB, Gewirtz A, Perussia B, Calabretta B.

J Exp Med. 1993 Dec 1;178(6):1923-33.

27.

Physical and functional association of p56lck with Fc gamma RIIIA (CD16) in natural killer cells.

Salcedo TW, Kurosaki T, Kanakaraj P, Ravetch JV, Perussia B.

J Exp Med. 1993 May 1;177(5):1475-80.

28.

Stimulation of Fc gamma RIIIA results in phospholipase C-gamma 1 tyrosine phosphorylation and p56lck activation.

Azzoni L, Kamoun M, Salcedo TW, Kanakaraj P, Perussia B.

J Exp Med. 1992 Dec 1;176(6):1745-50.

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Influence of hypercholesterolemia on morphological and rheological characteristics of erythrocytes.

Kanakaraj P, Singh M.

Atherosclerosis. 1989 Apr;76(2-3):209-18.

PMID:
2730718
33.

Hypocholesterolemic effect of onion extract on cholesterol-enriched erythrocytes.

Singh M, Kanakaraj P.

Indian J Exp Biol. 1985 Aug;23(8):456-9. No abstract available.

PMID:
4077145

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