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Prognostic significance of Wilms' tumor 1 expression in patients with pancreatic ductal adenocarcinoma.

Kanai T, Ito Z, Oji Y, Suka M, Nishida S, Takakura K, Kajihara M, Saruta M, Fujioka S, Misawa T, Akiba T, Yanagisawa H, Shimodaira S, Okamoto M, Sugiyama H, Koido S.

Oncol Lett. 2018 Aug;16(2):2682-2692. doi: 10.3892/ol.2018.8961. Epub 2018 Jun 13.


[Review of the small intestinal mucosal lesion].

Hosoe N, Ogata H, Kanai T.

Nihon Shokakibyo Gakkai Zasshi. 2018;115(7):605-611. doi: 10.11405/nisshoshi.115.605. Japanese. No abstract available.


Idiopathic Thrombocytopenic Purpura Responsive to Surgery for Crohn's Disease.

Mizuno S, Naganuma M, Kanai T.

Inflamm Bowel Dis. 2018 Jun 28. doi: 10.1093/ibd/izy233. [Epub ahead of print] No abstract available.


Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.

Maiti A, Myint W, Kanai T, Delviks-Frankenberry K, Sierra Rodriguez C, Pathak VK, Schiffer CA, Matsuo H.

Nat Commun. 2018 Jun 25;9(1):2460. doi: 10.1038/s41467-018-04872-8.


Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells.

Murakami Y, Sugiyama K, Ebinuma H, Nakamoto N, Ojiro K, Chu PS, Taniki N, Saito Y, Teratani T, Koda Y, Suzuki T, Saito K, Fukasawa M, Ikeda M, Kato N, Kanai T, Saito H.

BMC Cancer. 2018 Jun 25;18(1):680. doi: 10.1186/s12885-018-4588-y.


Intestinal barrier regulates immune responses in the liver via IL-10-producing macrophages.

Taniki N, Nakamoto N, Chu PS, Mikami Y, Amiya T, Teratani T, Suzuki T, Tsukimi T, Fukuda S, Yamaguchi A, Shiba S, Miyake R, Katayama T, Ebinuma H, Kanai T.

JCI Insight. 2018 Jun 21;3(12). pii: 91980. doi: 10.1172/jci.insight.91980. [Epub ahead of print]


Crystal structures of a [NiFe] hydrogenase large subunit HyhL in an immature state in complex with a Ni chaperone HypA.

Kwon S, Watanabe S, Nishitani Y, Kawashima T, Kanai T, Atomi H, Miki K.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7045-7050. doi: 10.1073/pnas.1801955115. Epub 2018 Jun 18.


Angioscopic differences of coronary intima between diffuse and focal coronary vasospasm: Comparison of optical coherence tomography findings.

Kitano D, Takayama T, Sudo M, Kogo T, Kojima K, Akutsu N, Nishida T, Haruta H, Fukamachi D, Kawano T, Kanai T, Hiro T, Saito S, Hirayma A.

J Cardiol. 2018 Jun 10. pii: S0914-5087(18)30136-9. doi: 10.1016/j.jjcc.2018.04.013. [Epub ahead of print]


Safety and efficacy of ultra-tapered mechanical dilator for EUS-guided hepaticogastrostomy and pancreatic duct drainage compared with electrocautery dilator (with video).

Honjo M, Itoi T, Tsuchiya T, Tanaka R, Tonozuka R, Mukai S, Sofuni A, Nagakawa Y, Iwasaki H, Kanai T.

Endosc Ultrasound. 2018 Jun 6. doi: 10.4103/eus.eus_2_18. [Epub ahead of print]


Evaluation of functionally weighted dose-volume parameters for thoracic stereotactic ablative radiotherapy (SABR) using CT ventilation.

Kanai T, Kadoya N, Nakajima Y, Miyasaka Y, Ieko Y, Kajikawa T, Ito K, Yamamoto T, Dobashi S, Takeda K, Nemoto K, Jingu K.

Phys Med. 2018 May;49:47-51. doi: 10.1016/j.ejmp.2018.05.001. Epub 2018 May 8.


Generation of sub-two-cycle CEP-stable optical pulses at 3.5  µm from a KTA-based optical parametric amplifier with multiple-plate compression.

Lu F, Xia P, Matsumoto Y, Kanai T, Ishii N, Itatani J.

Opt Lett. 2018 Jun 1;43(11):2720-2723. doi: 10.1364/OL.43.002720.


Establishment of a Novel Scoring System for Colon Capsule Endoscopy to Assess the Severity of Ulcerative Colitis-Capsule Scoring of Ulcerative Colitis.

Hosoe N, Nakano M, Takeuchi K, Endo Y, Matsuoka K, Abe T, Omori T, Hayashida M, Kobayashi T, Yoshida A, Mizuno S, Yoshihiro N, Naganuma M, Kanai T, Watanabe M, Ueno F, Suzuki Y, Hibi T, Ogata H.

Inflamm Bowel Dis. 2018 May 26. doi: 10.1093/ibd/izy193. [Epub ahead of print]


Crystal structures of an archaeal chitinase ChiD and its ligand complexes.

Nishitani Y, Horiuchi A, Aslam M, Kanai T, Atomi H, Miki K.

Glycobiology. 2018 Jun 1;28(6):418-426. doi: 10.1093/glycob/cwy024.


Burden of impaired sleep quality on work productivity in functional dyspepsia.

Matsuzaki J, Suzuki H, Togawa K, Yamane T, Mori H, Komori T, Masaoka T, Kanai T.

United European Gastroenterol J. 2018 Apr;6(3):398-406. doi: 10.1177/2050640617726466. Epub 2017 Aug 7.


Acquisition of double mutation in gyrA caused high resistance to sitafloxacin in Helicobacter pylori after unsuccessful eradication with sitafloxacin-containing regimens.

Mori H, Suzuki H, Matsuzaki J, Masaoka T, Kanai T.

United European Gastroenterol J. 2018 Apr;6(3):391-397. doi: 10.1177/2050640617737215. Epub 2017 Oct 8.


A decreased soluble Klotho level with normal eGFR, FGF23, serum phosphate, and FEP in an ADPKD patient with enlarged kidneys due to multiple cysts.

Kanai T, Shiizaki K, Betsui H, Aoyagi J, Yamagata T.

CEN Case Rep. 2018 May 16. doi: 10.1007/s13730-018-0339-9. [Epub ahead of print]


[Future perspectives on fecal microbiota transplantation].

Mizuno S, Nanki K, Kanai T.

Nihon Shokakibyo Gakkai Zasshi. 2018;115(5):449-459. doi: 10.11405/nisshoshi.115.449. Japanese. No abstract available.


Large Volume Fluid Resuscitation for Severe Acute Pancreatitis is Associated With Reduced Mortality: A Multicenter Retrospective Study.

Yamashita T, Horibe M, Sanui M, Sasaki M, Sawano H, Goto T, Ikeura T, Hamada T, Oda T, Yasuda H, Ogura Y, Miyazaki D, Hirose K, Kitamura K, Chiba N, Ozaki T, Koinuma T, Oshima T, Yamamoto T, Hirota M, Masuda Y, Tokuhira N, Kobayashi M, Saito S, Izai J, Lefor AK, Iwasaki E, Kanai T, Mayumi T.

J Clin Gastroenterol. 2018 Apr 23. doi: 10.1097/MCG.0000000000001046. [Epub ahead of print]


The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study.

Kurokawa S, Kishimoto T, Mizuno S, Masaoka T, Naganuma M, Liang KC, Kitazawa M, Nakashima M, Shindo C, Suda W, Hattori M, Kanai T, Mimura M.

J Affect Disord. 2018 Aug 1;235:506-512. doi: 10.1016/j.jad.2018.04.038. Epub 2018 Apr 12.


Initial Management of Colonic Diverticular Bleeding: Observational Study.

Wada M, Kato M, Hirai Y, Kubosawa Y, Sunata Y, Abe K, Hirata T, Takada Y, Banno S, Takatori Y, Kinoshita S, Mori H, Takabayashi K, Kikuchi M, Kikuchi M, Suzuki M, Kanai T, Uraoka T.

Digestion. 2018;98(1):41-47. doi: 10.1159/000487264. Epub 2018 Apr 19.


Long-term survival with extended lateral lymphadenectomy for lateral lymph node recurrence after laparoscopic abdominoperineal resection for rectal adenosquamous carcinoma: a case report.

Yokose T, Yamamoto S, Nagase T, Kanai T, Takano K, Fujii T, Tsutsui M, Nakagawa M, Ochiai H, Kameyama K.

Surg Case Rep. 2018 Apr 10;4(1):32. doi: 10.1186/s40792-018-0440-5.


Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study.

Kanai T, Akioka Y, Miura K, Hisano M, Koike J, Yamaguchi Y, Hattori M.

BMC Nephrol. 2018 Apr 6;19(1):82. doi: 10.1186/s12882-018-0874-9.


Expression and Dynamics of Podoplanin in Cultured Osteoblasts with Mechanostress and Mineralization Stimulus.

Takenawa T, Kanai T, Kitamura T, Yoshimura Y, Sawa Y, Iida J.

Acta Histochem Cytochem. 2018 Feb 27;51(1):41-52. doi: 10.1267/ahc.17031. Epub 2018 Jan 30.


Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia.

Namkoong H, Ishii M, Fujii H, Yagi K, Asami T, Asakura T, Suzuki S, Hegab AE, Kamata H, Tasaka S, Atarashi K, Nakamoto N, Iwata S, Honda K, Kanai T, Hasegawa N, Koyasu S, Betsuyaku T.

PLoS Pathog. 2018 Apr 5;14(4):e1006955. doi: 10.1371/journal.ppat.1006955. eCollection 2018 Apr.


Evidence for Ongoing Modeling-Based Bone Formation in Human Femoral Head Trabeculae via Forming Minimodeling Structures: A Study in Patients with Fractures and Arthritis.

Sano H, Kondo N, Shimakura T, Fujisawa J, Kijima Y, Kanai T, Poole KES, Yamamoto N, Takahashi HE, Endo N.

Front Endocrinol (Lausanne). 2018 Mar 19;9:88. doi: 10.3389/fendo.2018.00088. eCollection 2018.


The relative biological effectiveness for carbon, nitrogen, and oxygen ion beams using passive and scanning techniques evaluated with fully 3D silicon microdosimeters.

Tran LT, Bolst D, Guatelli S, Pogossov A, Petasecca M, Lerch MLF, Chartier L, Prokopovich DA, Reinhard MI, Povoli M, Kok A, Perevertaylo VL, Matsufuji N, Kanai T, Jackson M, Rosenfeld AB.

Med Phys. 2018 May;45(5):2299-2308. doi: 10.1002/mp.12874. Epub 2018 Apr 10.


Post-progression survival following second-line chemotherapy in patients with advanced pancreatic cancer previously treated with gemcitabine: a meta-analysis.

Kasuga A, Hamamoto Y, Takeuchi A, Okano N, Togasaki K, Aoki Y, Suzuki T, Kawasaki K, Hirata K, Sukawa Y, Kanai T, Takaishi H.

Invest New Drugs. 2018 Mar 23. doi: 10.1007/s10637-018-0589-6. [Epub ahead of print] Review.


Aortic carboxypeptidase-like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis.

Teratani T, Tomita K, Suzuki T, Furuhashi H, Irie R, Nishikawa M, Yamamoto J, Hibi T, Miura S, Minamino T, Oike Y, Hokari R, Kanai T.

J Clin Invest. 2018 Apr 2;128(4):1581-1596. doi: 10.1172/JCI92863. Epub 2018 Mar 19.


[Treatment strategy for inflammatory bowel disease with a focus on biologicals].

Fukuda T, Naganuma M, Kanai T.

Nihon Shokakibyo Gakkai Zasshi. 2018;115(3):272-282. doi: 10.11405/nisshoshi.115.272. Japanese. No abstract available.


Structure of a [NiFe] hydrogenase maturation protease HycI provides insights into its substrate selectivity.

Kwon S, Nishitani Y, Hirao Y, Kanai T, Atomi H, Miki K.

Biochem Biophys Res Commun. 2018 Apr 15;498(4):782-788. doi: 10.1016/j.bbrc.2018.03.058. Epub 2018 Mar 15.


Non-enhanced magnetic resonance imaging versus renal scintigraphy in acute pyelonephritis.

Aoyagi J, Kanai T, Odaka J, Ito T, Saito T, Betsui H, Furukawa R, Nakata W, Yamagata T.

Pediatr Int. 2018 Feb;60(2):200-203. doi: 10.1111/ped.13465.


Efficacy of Bifidobacterium breve Fermented Milk in Maintaining Remission of Ulcerative Colitis.

Matsuoka K, Uemura Y, Kanai T, Kunisaki R, Suzuki Y, Yokoyama K, Yoshimura N, Hibi T.

Dig Dis Sci. 2018 Jul;63(7):1910-1919. doi: 10.1007/s10620-018-4946-2. Epub 2018 Feb 15.


Evidence-based clinical practice guidelines for inflammatory bowel disease.

Matsuoka K, Kobayashi T, Ueno F, Matsui T, Hirai F, Inoue N, Kato J, Kobayashi K, Kobayashi K, Koganei K, Kunisaki R, Motoya S, Nagahori M, Nakase H, Omata F, Saruta M, Watanabe T, Tanaka T, Kanai T, Noguchi Y, Takahashi KI, Watanabe K, Hibi T, Suzuki Y, Watanabe M, Sugano K, Shimosegawa T.

J Gastroenterol. 2018 Mar;53(3):305-353. doi: 10.1007/s00535-018-1439-1. Epub 2018 Feb 10. Review.


Complications and outcomes of routine endoscopy in the very elderly.

Miyanaga R, Hosoe N, Naganuma M, Hirata K, Fukuhara S, Nakazato Y, Ojiro K, Iwasaki E, Yahagi N, Ogata H, Kanai T.

Endosc Int Open. 2018 Feb;6(2):E224-E229. doi: 10.1055/s-0043-120569. Epub 2018 Feb 7.


Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis.

Nanki K, Mizuno S, Matsuoka K, Ono K, Sugimoto S, Kiyohara H, Arai M, Nakashima M, Takeshita K, Saigusa K, Senoh M, Fukuda T, Naganuma M, Kato H, Suda W, Hattori M, Kanai T.

Intest Res. 2018 Jan;16(1):142-146. doi: 10.5217/ir.2018.16.1.142. Epub 2018 Jan 18.


Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report.

Mizuno S, Wakui M, Machida Y, Hosoe N, Hisamatsu T, Ishida T, Kameyama K, Naganuma M, Kanai T.

Medicine (Baltimore). 2017 Dec;96(51):e9237. doi: 10.1097/MD.0000000000009237. Review.


Evaluation of the accuracy and clinical practicality of a calculation system for patient positional displacement in carbon ion radiotherapy at five sites.

Kubota Y, Hayashi H, Abe S, Souda S, Okada R, Ishii T, Tashiro M, Torikoshi M, Kanai T, Ohno T, Nakano T.

J Appl Clin Med Phys. 2018 Mar;19(2):144-153. doi: 10.1002/acm2.12261. Epub 2018 Jan 25.


[Intestinal immune response is regulated by gut microbe].

Tanemoto S, Sujino T, Kanai T.

Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(6):408-415. doi: 10.2177/jsci.40.408. Review. Japanese.


Development of stereotactic radiosurgery using carbon beams (carbon-knife).

Keawsamur M, Matsumura A, Souda H, Kano Y, Torikoshi M, Nakano T, Kanai T.

Phys Med Biol. 2018 Feb 20;63(4):045024. doi: 10.1088/1361-6560/aaaa4d.


Gold cleaning methods for preparation of cell culture surfaces for self-assembled monolayers of zwitterionic oligopeptides.

Enomoto J, Kageyama T, Myasnikova D, Onishi K, Kobayashi Y, Taruno Y, Kanai T, Fukuda J.

J Biosci Bioeng. 2018 May;125(5):606-612. doi: 10.1016/j.jbiosc.2017.12.014. Epub 2018 Jan 17.


Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression.

Seino T, Kawasaki S, Shimokawa M, Tamagawa H, Toshimitsu K, Fujii M, Ohta Y, Matano M, Nanki K, Kawasaki K, Takahashi S, Sugimoto S, Iwasaki E, Takagi J, Itoi T, Kitago M, Kitagawa Y, Kanai T, Sato T.

Cell Stem Cell. 2018 Mar 1;22(3):454-467.e6. doi: 10.1016/j.stem.2017.12.009. Epub 2018 Jan 11.


Reconstruction of the Human Colon Epithelium In Vivo.

Sugimoto S, Ohta Y, Fujii M, Matano M, Shimokawa M, Nanki K, Date S, Nishikori S, Nakazato Y, Nakamura T, Kanai T, Sato T.

Cell Stem Cell. 2018 Feb 1;22(2):171-176.e5. doi: 10.1016/j.stem.2017.11.012. Epub 2017 Dec 28.


A carbon CT system: how to obtain accurate stopping power ratio using a Bragg peak reduction technique.

Lee SH, Sunaguchi N, Hirano Y, Kano Y, Liu C, Torikoshi M, Ohno T, Nakano T, Kanai T.

Phys Med Biol. 2018 Jan 31;63(3):035025. doi: 10.1088/1361-6560/aaa453.


The impact of visceral adipose tissue as best predictor for difficult colonoscopy and the clinical utility of a long small-caliber scope as rescue.

Kashiwagi K, Inoue N, Yoshida T, Bessho R, Yoneno K, Imaeda H, Ogata H, Kanai T, Sugino Y, Iwao Y.

PLoS One. 2017 Dec 21;12(12):e0189817. doi: 10.1371/journal.pone.0189817. eCollection 2017.


Possible function of the second RecJ-like protein in stalled replication fork repair by interacting with Hef.

Nagata M, Ishino S, Yamagami T, Simons JR, Kanai T, Atomi H, Ishino Y.

Sci Rep. 2017 Dec 5;7(1):16949. doi: 10.1038/s41598-017-17306-0.


Anastomotic Leakage Using Linear Stapling Device with Pre-attached Bioabsorbable Polyglycolic Acid Felt After Laparoscopic Anterior Resection.

Yamamoto S, Kanai T, Osumi K, Yo K, Takano K, Tsutsui M, Nakanishi R, Yoshikawa Y, Kaneko Y, Nakagawa M.

Anticancer Res. 2017 Dec;37(12):7083-7086.


Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis.

Yamada S, Kamada N, Amiya T, Nakamoto N, Nakaoka T, Kimura M, Saito Y, Ejima C, Kanai T, Saito H.

BMC Gastroenterol. 2017 Nov 29;17(1):136. doi: 10.1186/s12876-017-0689-3.


Reply to Gheorghe et al.

Naganuma M, Hosoe N, Nakazato Y, Ogata H, Kanai T.

Endoscopy. 2017 Dec;49(12):1286. doi: 10.1055/s-0043-120443. Epub 2017 Nov 29. No abstract available.


Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis.

Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T, Suzuki Y, Kanai T; INDIGO Study Group.

Gastroenterology. 2018 Mar;154(4):935-947. doi: 10.1053/j.gastro.2017.11.024. Epub 2017 Nov 22.


Dexmedetomidine vs propofol for gastrointestinal endoscopy: A meta-analysis.

Nishizawa T, Suzuki H, Hosoe N, Ogata H, Kanai T, Yahagi N.

United European Gastroenterol J. 2017 Nov;5(7):1037-1045. doi: 10.1177/2050640616688140. Epub 2017 Jan 12. Review.

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