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1.
2.

Associations of autozygosity with a broad range of human phenotypes.

Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK, Lin K, Zhao JH, Deelen P, Rohde R, Schurmann C, Guo X, Giulianini F, Zhang W, Medina-Gomez C, Karlsson R, Bao Y, Bartz TM, Baumbach C, Biino G, Bixley MJ, Brumat M, Chai JF, Corre T, Cousminer DL, Dekker AM, Eccles DA, van Eijk KR, Fuchsberger C, Gao H, Germain M, Gordon SD, de Haan HG, Harris SE, Hofer E, Huerta-Chagoya A, Igartua C, Jansen IE, Jia Y, Kacprowski T, Karlsson T, Kleber ME, Li SA, Li-Gao R, Mahajan A, Matsuda K, Meidtner K, Meng W, Montasser ME, van der Most PJ, Munz M, Nutile T, Palviainen T, Prasad G, Prasad RB, Priyanka TDS, Rizzi F, Salvi E, Sapkota BR, Shriner D, Skotte L, Smart MC, Smith AV, van der Spek A, Spracklen CN, Strawbridge RJ, Tajuddin SM, Trompet S, Turman C, Verweij N, Viberti C, Wang L, Warren HR, Wootton RE, Yanek LR, Yao J, Yousri NA, Zhao W, Adeyemo AA, Afaq S, Aguilar-Salinas CA, Akiyama M, Albert ML, Allison MA, Alver M, Aung T, Azizi F, Bentley AR, Boeing H, Boerwinkle E, Borja JB, de Borst GJ, Bottinger EP, Broer L, Campbell H, Chanock S, Chee ML, Chen G, Chen YI, Chen Z, Chiu YF, Cocca M, Collins FS, Concas MP, Corley J, Cugliari G, van Dam RM, Damulina A, Daneshpour MS, Day FR, Delgado GE, Dhana K, Doney ASF, Dörr M, Doumatey AP, Dzimiri N, Ebenesersdóttir SS, Elliott J, Elliott P, Ewert R, Felix JF, Fischer K, Freedman BI, Girotto G, Goel A, Gögele M, Goodarzi MO, Graff M, Granot-Hershkovitz E, Grodstein F, Guarrera S, Gudbjartsson DF, Guity K, Gunnarsson B, Guo Y, Hagenaars SP, Haiman CA, Halevy A, Harris TB, Hedayati M, van Heel DA, Hirata M, Höfer I, Hsiung CA, Huang J, Hung YJ, Ikram MA, Jagadeesan A, Jousilahti P, Kamatani Y, Kanai M, Kerrison ND, Kessler T, Khaw KT, Khor CC, de Kleijn DPV, Koh WP, Kolcic I, Kraft P, Krämer BK, Kutalik Z, Kuusisto J, Langenberg C, Launer LJ, Lawlor DA, Lee IT, Lee WJ, Lerch MM, Li L, Liu J, Loh M, London SJ, Loomis S, Lu Y, Luan J, Mägi R, Manichaikul AW, Manunta P, Másson G, Matoba N, Mei XW, Meisinger C, Meitinger T, Mezzavilla M, Milani L, Millwood IY, Momozawa Y, Moore A, Morange PE, Moreno-Macías H, Mori TA, Morrison AC, Muka T, Murakami Y, Murray AD, de Mutsert R, Mychaleckyj JC, Nalls MA, Nauck M, Neville MJ, Nolte IM, Ong KK, Orozco L, Padmanabhan S, Pálsson G, Pankow JS, Pattaro C, Pattie A, Polasek O, Poulter N, Pramstaller PP, Quintana-Murci L, Räikkönen K, Ralhan S, Rao DC, van Rheenen W, Rich SS, Ridker PM, Rietveld CA, Robino A, van Rooij FJA, Ruggiero D, Saba Y, Sabanayagam C, Sabater-Lleal M, Sala CF, Salomaa V, Sandow K, Schmidt H, Scott LJ, Scott WR, Sedaghati-Khayat B, Sennblad B, van Setten J, Sever PJ, Sheu WH, Shi Y, Shrestha S, Shukla SR, Sigurdsson JK, Sikka TT, Singh JR, Smith BH, Stančáková A, Stanton A, Starr JM, Stefansdottir L, Straker L, Sulem P, Sveinbjornsson G, Swertz MA, Taylor AM, Taylor KD, Terzikhan N, Tham YC, Thorleifsson G, Thorsteinsdottir U, Tillander A, Tracy RP, Tusié-Luna T, Tzoulaki I, Vaccargiu S, Vangipurapu J, Veldink JH, Vitart V, Völker U, Vuoksimaa E, Wakil SM, Waldenberger M, Wander GS, Wang YX, Wareham NJ, Wild S, Yajnik CS, Yuan JM, Zeng L, Zhang L, Zhou J, Amin N, Asselbergs FW, Bakker SJL, Becker DM, Lehne B, Bennett DA, van den Berg LH, Berndt SI, Bharadwaj D, Bielak LF, Bochud M, Boehnke M, Bouchard C, Bradfield JP, Brody JA, Campbell A, Carmi S, Caulfield MJ, Cesarini D, Chambers JC, Chandak GR, Cheng CY, Ciullo M, Cornelis M, Cusi D, Smith GD, Deary IJ, Dorajoo R, van Duijn CM, Ellinghaus D, Erdmann J, Eriksson JG, Evangelou E, Evans MK, Faul JD, Feenstra B, Feitosa M, Foisy S, Franke A, Friedlander Y, Gasparini P, Gieger C, Gonzalez C, Goyette P, Grant SFA, Griffiths LR, Groop L, Gudnason V, Gyllensten U, Hakonarson H, Hamsten A, van der Harst P, Heng CK, Hicks AA, Hochner H, Huikuri H, Hunt SC, Jaddoe VWV, De Jager PL, Johannesson M, Johansson Å, Jonas JB, Jukema JW, Junttila J, Kaprio J, Kardia SLR, Karpe F, Kumari M, Laakso M, van der Laan SW, Lahti J, Laudes M, Lea RA, Lieb W, Lumley T, Martin NG, März W, Matullo G, McCarthy MI, Medland SE, Merriman TR, Metspalu A, Meyer BF, Mohlke KL, Montgomery GW, Mook-Kanamori D, Munroe PB, North KE, Nyholt DR, O'connell JR, Ober C, Oldehinkel AJ, Palmas W, Palmer C, Pasterkamp GG, Patin E, Pennell CE, Perusse L, Peyser PA, Pirastu M, Polderman TJC, Porteous DJ, Posthuma D, Psaty BM, Rioux JD, Rivadeneira F, Rotimi C, Rotter JI, Rudan I, Den Ruijter HM, Sanghera DK, Sattar N, Schmidt R, Schulze MB, Schunkert H, Scott RA, Shuldiner AR, Sim X, Small N, Smith JA, Sotoodehnia N, Tai ES, Teumer A, Timpson NJ, Toniolo D, Tregouet DA, Tuomi T, Vollenweider P, Wang CA, Weir DR, Whitfield JB, Wijmenga C, Wong TY, Wright J, Yang J, Yu L, Zemel BS, Zonderman AB, Perola M, Magnusson PKE, Uitterlinden AG, Kooner JS, Chasman DI, Loos RJF, Franceschini N, Franke L, Haley CS, Hayward C, Walters RG, Perry JRB, Esko T, Helgason A, Stefansson K, Joshi PK, Kubo M, Wilson JF.

Nat Commun. 2019 Oct 31;10(1):4957. doi: 10.1038/s41467-019-12283-6.

3.

Clinical significance of TP53 variants as possible secondary findings in tumor-only next-generation sequencing.

Yamamoto Y, Kanai M, Kou T, Sugiyama A, Nakamura E, Miyake H, Yamada T, Nishigaki M, Kondo T, Murakami H, Torishima M, Matsumoto S, Kosugi S, Muto M.

J Hum Genet. 2019 Oct 18. doi: 10.1038/s10038-019-0681-6. [Epub ahead of print]

PMID:
31628423
4.

Association of Perceived Built Environment Attributes with Objectively Measured Physical Activity in Community-Dwelling Ambulatory Patients with Stroke.

Kanai M, Izawa KP, Kubo H, Nozoe M, Mase K, Koohsari MJ, Oka K, Shimada S.

Int J Environ Res Public Health. 2019 Oct 15;16(20). pii: E3908. doi: 10.3390/ijerph16203908.

5.

Polygenic burden in focal and generalized epilepsies.

Leu C, Stevelink R, Smith AW, Goleva SB, Kanai M, Ferguson L, Campbell C, Kamatani Y, Okada Y, Sisodiya SM, Cavalleri GL, Koeleman BPC, Lerche H, Jehi L, Davis LK, Najm IM, Palotie A, Daly MJ, Busch RM; Epi25 Consortium, Lal D.

Brain. 2019 Nov 1;142(11):3473-3481. doi: 10.1093/brain/awz292.

6.

Redox-Inactive CO2 Determines Atmospheric Stability of Electrical Properties of ZnO Nanowire Devices through a Room-Temperature Surface Reaction.

Nakamura K, Takahashi T, Hosomi T, Seki T, Kanai M, Zhang G, Nagashima K, Shibata N, Yanagida T.

ACS Appl Mater Interfaces. 2019 Oct 30;11(43):40260-40266. doi: 10.1021/acsami.9b13231. Epub 2019 Oct 17.

PMID:
31581773
7.

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.

Tin A, Marten J, Halperin Kuhns VL, Li Y, Wuttke M, Kirsten H, Sieber KB, Qiu C, Gorski M, Yu Z, Giri A, Sveinbjornsson G, Li M, Chu AY, Hoppmann A, O'Connor LJ, Prins B, Nutile T, Noce D, Akiyama M, Cocca M, Ghasemi S, van der Most PJ, Horn K, Xu Y, Fuchsberger C, Sedaghat S, Afaq S, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boerwinkle E, Bottinger EP, Boutin TS, Brumat M, Burkhardt R, Campana E, Campbell A, Campbell H, Carroll RJ, Catamo E, Chambers JC, Ciullo M, Concas MP, Coresh J, Corre T, Cusi D, Felicita SC, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Delgado G, Demirkan A, Devuyst O, Dittrich K, Eckardt KU, Ehret G, Endlich K, Evans MK, Gansevoort RT, Gasparini P, Giedraitis V, Gieger C, Girotto G, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V; German Chronic Kidney Disease Study, Haller T, Hamet P, Harris TB, Hayward C, Hicks AA, Hofer E, Holm H, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Lewis RM, Ingelsson E, Jakobsdottir J, Jonsdottir I, Jonsson H, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kanai M, Kerr SM, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Krämer BK, Kronenberg F, Kubo M, Kühnel B, La Bianca M, Lange LA, Lehne B, Lehtimäki T; Lifelines Cohort Study, Liu J, Loeffler M, Loos RJF, Lyytikäinen LP, Magi R, Mahajan A, Martin NG, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Metspalu A, Milaneschi Y; V. A. Million Veteran Program, O'Donnell CJ, Wilson OD, Gaziano JM, Mishra PP, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Müller-Nurasyid M, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell JR, Olafsson I, Padmanabhan S, Penninx BWJH, Perls T, Peters A, Pirastu M, Pirastu N, Pistis G, Polasek O, Ponte B, Porteous DJ, Poulain T, Preuss MH, Rabelink TJ, Raffield LM, Raitakari OT, Rettig R, Rheinberger M, Rice KM, Rizzi F, Robino A, Rudan I, Krajcoviechova A, Cifkova R, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Salvi E, Schmidt H, Schmidt R, Shaffer CM, Smith AV, Smith BH, Spracklen CN, Strauch K, Stumvoll M, Sulem P, Tajuddin SM, Teren A, Thiery J, Thio CHL, Thorsteinsdottir U, Toniolo D, Tönjes A, Tremblay J, Uitterlinden AG, Vaccargiu S, van der Harst P, van Duijn CM, Verweij N, Völker U, Vollenweider P, Waeber G, Waldenberger M, Whitfield JB, Wild SH, Wilson JF, Yang Q, Zhang W, Zonderman AB, Bochud M, Wilson JG, Pendergrass SA, Ho K, Parsa A, Pramstaller PP, Psaty BM, Böger CA, Snieder H, Butterworth AS, Okada Y, Edwards TL, Stefansson K, Susztak K, Scholz M, Heid IM, Hung AM, Teumer A, Pattaro C, Woodward OM, Vitart V, Köttgen A.

Nat Genet. 2019 Oct 2. doi: 10.1038/s41588-019-0504-x. [Epub ahead of print]

PMID:
31578528
8.

Substantial Narrowing on the Width of "Concentration Window" of Hydrothermal ZnO Nanowires via Ammonia Addition.

Sakai D, Nagashima K, Yoshida H, Kanai M, He Y, Zhang G, Zhao X, Takahashi T, Yasui T, Hosomi T, Uchida Y, Takeda S, Baba Y, Yanagida T.

Sci Rep. 2019 Oct 2;9(1):14160. doi: 10.1038/s41598-019-50641-y.

9.

Characterizing rare and low-frequency height-associated variants in the Japanese population.

Akiyama M, Ishigaki K, Sakaue S, Momozawa Y, Horikoshi M, Hirata M, Matsuda K, Ikegawa S, Takahashi A, Kanai M, Suzuki S, Matsui D, Naito M, Yamaji T, Iwasaki M, Sawada N, Tanno K, Sasaki M, Hozawa A, Minegishi N, Wakai K, Tsugane S, Shimizu A, Yamamoto M, Okada Y, Murakami Y, Kubo M, Kamatani Y.

Nat Commun. 2019 Sep 27;10(1):4393. doi: 10.1038/s41467-019-12276-5.

10.

Two Extremely Low Birth Weight Infants Who Survived Functional Pulmonary Atresia with Normal Intracardiac Anatomy.

Oka S, Kondo U, Oshima A, Matsumura S, Kanai M, Ishiguro A, Iwamoto Y, Ishido H, Omori I, Masutani S.

AJP Rep. 2019 Jul;9(3):e310-e314. doi: 10.1055/s-0039-1697960. Epub 2019 Sep 19.

11.

Safety and efficacy of transvenous lead extractions for noninfectious superfluous leads in a Japanese population: A single-center experience.

Higuchi S, Shoda M, Saito S, Kanai M, Kataoka S, Yazaki K, Yagishita D, Ejima K, Hagiwara N.

Pacing Clin Electrophysiol. 2019 Sep 17. doi: 10.1111/pace.13806. [Epub ahead of print]

PMID:
31531868
12.

Water-Organic Cosolvent Effect on Nucleation of Solution-Synthesized ZnO Nanowires.

Akihiro Y, Nagashima K, Hosomi T, Kanai M, Anzai H, Takahashi T, Zhang G, Yasui T, Baba Y, Yanagida T.

ACS Omega. 2019 May 8;4(5):8299-8304. doi: 10.1021/acsomega.9b00945. eCollection 2019 May 31.

13.

Maternal Exposure to Housing Renovation During Pregnancy and Risk of Offspring with Congenital Malformation: The Japan Environment and Children's Study.

Motoki N, Inaba Y, Shibazaki T, Misawa Y, Ohira S, Kanai M, Kurita H, Nakazawa Y, Tsukahara T, Nomiyama T; Japan Environment & Children’s Study (JECS) Group.

Sci Rep. 2019 Aug 9;9(1):11564. doi: 10.1038/s41598-019-47925-8.

14.

Photophysical properties and application in live cell imaging of B,B-fluoro-perfluoroalkyl BODIPYs.

Taniguchi A, Sawazaki T, Shimizu Y, Sohma Y, Kanai M.

Medchemcomm. 2019 Mar 16;10(7):1121-1125. doi: 10.1039/c9md00011a. eCollection 2019 Jul 1.

PMID:
31391884
15.

Copper(I)-Catalyzed Stereodivergent Propargylation of N-Acetyl Mannosamine for Protecting Group Minimal Synthesis of C3-Substituted Sialic Acids.

Ishizawa K, Majima S, Wei XF, Mitsunuma H, Shimizu Y, Kanai M.

J Org Chem. 2019 Sep 6;84(17):10615-10628. doi: 10.1021/acs.joc.9b00887. Epub 2019 Aug 22.

PMID:
31379168
16.

Persistent Activation of Calcium-Sensing Receptor Suppresses Bone Turnover, Increases Microcracks, and Decreases Bone Strength.

Dong B, Endo I, Ohnishi Y, Mitsui Y, Kurahashi K, Kanai M, Hiasa M, Teramachi J, Tenshin H, Fukumoto S, Abe M, Matsumoto T.

JBMR Plus. 2019 Mar 6;3(7):e10182. doi: 10.1002/jbm4.10182. eCollection 2019 Jul.

17.

Sawtooth fetal heart rate pattern associated with a favorable neurological outcome in an infant: a case report.

Ohira S, Yamanaka S, Asaka R, Ando H, Fuseya C, Kikuchi N, Miyamoto T, Kanai M, Shiozawa T.

J Med Case Rep. 2019 Jul 25;13(1):226. doi: 10.1186/s13256-019-2170-0.

18.

Alcohol Consumption During Pregnancy and Risk of Placental Abnormality: The Japan Environment and Children's Study.

Ohira S, Motoki N, Shibazaki T, Misawa Y, Inaba Y, Kanai M, Kurita H, Shiozawa T, Nakazawa Y, Tsukahara T, Nomiyama T; Japan Environment & Children’s Study (JECS) Group.

Sci Rep. 2019 Jul 16;9(1):10259. doi: 10.1038/s41598-019-46760-1.

19.

Successfully Treated Lung and Renal Metastases from Primary Chondrosarcoma of the Scapula with Radiofrequency Ablation and Surgical Resection.

Sekito S, Kato M, Nishikawa K, Yoshio Y, Kanai M, Kanda H, Arima K, Sugimura Y.

Case Rep Oncol Med. 2019 Jun 9;2019:6475356. doi: 10.1155/2019/6475356. eCollection 2019.

20.

Impact of inpatient cardiac rehabilitation on Barthel Index score and prognosis in patients with acute decompensated heart failure.

Motoki H, Nishimura M, Kanai M, Kimura K, Minamisawa M, Yamamoto S, Saigusa T, Ebisawa S, Okada A, Kuwahara K.

Int J Cardiol. 2019 Oct 15;293:125-130. doi: 10.1016/j.ijcard.2019.06.071. Epub 2019 Jun 28.

PMID:
31279661
21.

Association of renal function with ambulation in mild acute stroke patients.

Kubo H, Nozoe M, Kanai M, Yamamoto M, Kamo A, Noguchi M, Mase K, Shimada S.

Top Stroke Rehabil. 2019 Oct;26(7):538-543. doi: 10.1080/10749357.2019.1634361. Epub 2019 Jun 27.

PMID:
31246156
22.

Amine-tethered phenylboronic acid-enabling ring-opening strategy for carbon chain elongation from double aldol cyclic hemiacetals.

Kanzaki Y, Hirao Y, Mitsunuma H, Kanai M.

Org Biomol Chem. 2019 Jul 21;17(27):6562-6565. doi: 10.1039/c9ob01263j. Epub 2019 Jun 24.

PMID:
31233053
23.

Soybean (Glycine max L.) triacylglycerol lipase GmSDP1 regulates the quality and quantity of seed oil.

Kanai M, Yamada T, Hayashi M, Mano S, Nishimura M.

Sci Rep. 2019 Jun 20;9(1):8924. doi: 10.1038/s41598-019-45331-8.

24.

Prestroke sarcopenia and functional outcomes in elderly patients who have had an acute stroke: A prospective cohort study.

Nozoe M, Kanai M, Kubo H, Yamamoto M, Shimada S, Mase K.

Nutrition. 2019 Oct;66:44-47. doi: 10.1016/j.nut.2019.04.011. Epub 2019 Apr 25.

PMID:
31207438
25.

A Stable and Cleavable O-Linked Spacer for Drug Delivery Systems.

Ito K, Tatsumi T, Takahashi K, Shimizu Y, Yamatsugu K, Kanai M.

Chem Pharm Bull (Tokyo). 2019 Jun 12. doi: 10.1248/cpb.c19-00376. [Epub ahead of print]

26.

Association Between Preanalytical Factors and Tumor Mutational Burden Estimated by Next-Generation Sequencing-Based Multiplex Gene Panel Assay.

Quy PN, Kanai M, Fukuyama K, Kou T, Kondo T, Yamamoto Y, Matsubara J, Hiroshima A, Mochizuki H, Sakuma T, Kamada M, Nakatsui M, Eso Y, Seno H, Masui T, Takaori K, Minamiguchi S, Matsumoto S, Muto M.

Oncologist. 2019 Jun 11. pii: theoncologist.2018-0587. doi: 10.1634/theoncologist.2018-0587. [Epub ahead of print]

PMID:
31186376
27.

[Infrastructure Required for Implementing Genomic Medicine and Expert Panel].

Kanai M.

Gan To Kagaku Ryoho. 2019 Apr;46(4):622-625. Japanese.

PMID:
31164496
28.

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S; AFGen Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; International Genomics of Blood Pressure (iGEN-BP) Consortium; INVENT Consortium; STARNET, Bis JC, Pastinen T, Ruusalepp A, Schadt EE, Koplev S, Björkegren JLM, Codoni V, Civelek M, Smith NL, Trégouët DA, Christophersen IE, Roselli C, Lubitz SA, Ellinor PT, Tai ES, Kooner JS, Kato N, He J, van der Harst P, Elliott P, Chambers JC, Takeuchi F, Johnson AD; BioBank Japan Cooperative Hospital Group; COMPASS Consortium; EPIC-CVD Consortium; EPIC-InterAct Consortium; International Stroke Genetics Consortium (ISGC); METASTROKE Consortium; Neurology Working Group of the CHARGE Consortium; NINDS Stroke Genetics Network (SiGN); UK Young Lacunar DNA Study; MEGASTROKE Consortium, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT Jr, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M.

Nat Genet. 2019 Jul;51(7):1192-1193. doi: 10.1038/s41588-019-0449-0.

29.

A catalog of genetic loci associated with kidney function from analyses of a million individuals.

Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, Tin A, Wang L, Chu AY, Hoppmann A, Kirsten H, Giri A, Chai JF, Sveinbjornsson G, Tayo BO, Nutile T, Fuchsberger C, Marten J, Cocca M, Ghasemi S, Xu Y, Horn K, Noce D, van der Most PJ, Sedaghat S, Yu Z, Akiyama M, Afaq S, Ahluwalia TS, Almgren P, Amin N, Ärnlöv J, Bakker SJL, Bansal N, Baptista D, Bergmann S, Biggs ML, Biino G, Boehnke M, Boerwinkle E, Boissel M, Bottinger EP, Boutin TS, Brenner H, Brumat M, Burkhardt R, Butterworth AS, Campana E, Campbell A, Campbell H, Canouil M, Carroll RJ, Catamo E, Chambers JC, Chee ML, Chee ML, Chen X, Cheng CY, Cheng Y, Christensen K, Cifkova R, Ciullo M, Concas MP, Cook JP, Coresh J, Corre T, Sala CF, Cusi D, Danesh J, Daw EW, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Delgado G, Demirkan A, Di Angelantonio E, Dittrich K, Divers J, Dorajoo R, Eckardt KU, Ehret G, Elliott P, Endlich K, Evans MK, Felix JF, Foo VHX, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Friedlander Y, Froguel P, Gansevoort RT, Gao H, Gasparini P, Gaziano JM, Giedraitis V, Gieger C, Girotto G, Giulianini F, Gögele M, Gordon SD, Gudbjartsson DF, Gudnason V, Haller T, Hamet P, Harris TB, Hartman CA, Hayward C, Hellwege JN, Heng CK, Hicks AA, Hofer E, Huang W, Hutri-Kähönen N, Hwang SJ, Ikram MA, Indridason OS, Ingelsson E, Ising M, Jaddoe VWV, Jakobsdottir J, Jonas JB, Joshi PK, Josyula NS, Jung B, Kähönen M, Kamatani Y, Kammerer CM, Kanai M, Kastarinen M, Kerr SM, Khor CC, Kiess W, Kleber ME, Koenig W, Kooner JS, Körner A, Kovacs P, Kraja AT, Krajcoviechova A, Kramer H, Krämer BK, Kronenberg F, Kubo M, Kühnel B, Kuokkanen M, Kuusisto J, La Bianca M, Laakso M, Lange LA, Langefeld CD, Lee JJ, Lehne B, Lehtimäki T, Lieb W; Lifelines Cohort Study, Lim SC, Lind L, Lindgren CM, Liu J, Liu J, Loeffler M, Loos RJF, Lucae S, Lukas MA, Lyytikäinen LP, Mägi R, Magnusson PKE, Mahajan A, Martin NG, Martins J, März W, Mascalzoni D, Matsuda K, Meisinger C, Meitinger T, Melander O, Metspalu A, Mikaelsdottir EK, Milaneschi Y, Miliku K, Mishra PP; V. A. Million Veteran Program, Mohlke KL, Mononen N, Montgomery GW, Mook-Kanamori DO, Mychaleckyj JC, Nadkarni GN, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Noordam R, O'Connell J, O'Donoghue ML, Olafsson I, Oldehinkel AJ, Orho-Melander M, Ouwehand WH, Padmanabhan S, Palmer ND, Palsson R, Penninx BWJH, Perls T, Perola M, Pirastu M, Pirastu N, Pistis G, Podgornaia AI, Polasek O, Ponte B, Porteous DJ, Poulain T, Pramstaller PP, Preuss MH, Prins BP, Province MA, Rabelink TJ, Raffield LM, Raitakari OT, Reilly DF, Rettig R, Rheinberger M, Rice KM, Ridker PM, Rivadeneira F, Rizzi F, Roberts DJ, Robino A, Rossing P, Rudan I, Rueedi R, Ruggiero D, Ryan KA, Saba Y, Sabanayagam C, Salomaa V, Salvi E, Saum KU, Schmidt H, Schmidt R, Schöttker B, Schulz CA, Schupf N, Shaffer CM, Shi Y, Smith AV, Smith BH, Soranzo N, Spracklen CN, Strauch K, Stringham HM, Stumvoll M, Svensson PO, Szymczak S, Tai ES, Tajuddin SM, Tan NYQ, Taylor KD, Teren A, Tham YC, Thiery J, Thio CHL, Thomsen H, Thorleifsson G, Toniolo D, Tönjes A, Tremblay J, Tzoulaki I, Uitterlinden AG, Vaccargiu S, van Dam RM, van der Harst P, van Duijn CM, Velez Edward DR, Verweij N, Vogelezang S, Völker U, Vollenweider P, Waeber G, Waldenberger M, Wallentin L, Wang YX, Wang C, Waterworth DM, Bin Wei W, White H, Whitfield JB, Wild SH, Wilson JF, Wojczynski MK, Wong C, Wong TY, Xu L, Yang Q, Yasuda M, Yerges-Armstrong LM, Zhang W, Zonderman AB, Rotter JI, Bochud M, Psaty BM, Vitart V, Wilson JG, Dehghan A, Parsa A, Chasman DI, Ho K, Morris AP, Devuyst O, Akilesh S, Pendergrass SA, Sim X, Böger CA, Okada Y, Edwards TL, Snieder H, Stefansson K, Hung AM, Heid IM, Scholz M, Teumer A, Köttgen A, Pattaro C.

Nat Genet. 2019 Jun;51(6):957-972. doi: 10.1038/s41588-019-0407-x. Epub 2019 May 31.

30.

Prestroke Sarcopenia and Stroke Severity in Elderly Patients with Acute Stroke.

Nozoe M, Kanai M, Kubo H, Yamamoto M, Shimada S, Mase K.

J Stroke Cerebrovasc Dis. 2019 Aug;28(8):2228-2231. doi: 10.1016/j.jstrokecerebrovasdis.2019.05.001. Epub 2019 May 22.

PMID:
31129104
31.

Site-Selective Synthetic Acylation of a Target Protein in Living Cells Promoted by a Chemical Catalyst/Donor System.

Hamajima W, Fujimura A, Fujiwara Y, Yamatsugu K, Kawashima SA, Kanai M.

ACS Chem Biol. 2019 Jun 21;14(6):1102-1109. doi: 10.1021/acschembio.9b00102. Epub 2019 May 24.

PMID:
31117394
32.

Unusual dual-loop reentry during cavo-tricuspid isthmus-dependent atrial flutter.

Higuchi S, Shoda M, Kanai M, Yazaki K, Yagishita D, Ejima K, Hagiwara N.

J Interv Card Electrophysiol. 2019 Oct;56(1):93. doi: 10.1007/s10840-019-00558-3. Epub 2019 May 14. No abstract available.

PMID:
31089942
33.

GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture.

Matoba N, Akiyama M, Ishigaki K, Kanai M, Takahashi A, Momozawa Y, Ikegawa S, Ikeda M, Iwata N, Hirata M, Matsuda K, Kubo M, Okada Y, Kamatani Y.

Nat Hum Behav. 2019 May;3(5):471-477. doi: 10.1038/s41562-019-0557-y. Epub 2019 Mar 25.

PMID:
31089300
34.

Factors delaying the progress of early rehabilitation of elderly Japanese patients with heart failure.

Kubo I, Izawa KP, Kajisa N, Ogura A, Kanai M, Matsumoto D.

Aging Clin Exp Res. 2019 May 10. doi: 10.1007/s40520-019-01213-7. [Epub ahead of print]

PMID:
31076966
35.

Photo-oxygenation inhibits tau amyloid formation.

Suzuki T, Hori Y, Sawazaki T, Shimizu Y, Nemoto Y, Taniguchi A, Ozawa S, Sohma Y, Kanai M, Tomita T.

Chem Commun (Camb). 2019 May 28;55(44):6165-6168. doi: 10.1039/c9cc01728c.

PMID:
31049495
36.

Catalytic asymmetric allylation of aldehydes with alkenes through allylic C(sp3)-H functionalization mediated by organophotoredox and chiral chromium hybrid catalysis.

Mitsunuma H, Tanabe S, Fuse H, Ohkubo K, Kanai M.

Chem Sci. 2019 Jan 17;10(12):3459-3465. doi: 10.1039/c8sc05677c. eCollection 2019 Mar 28.

37.

Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.

Nakatochi M, Kanai M, Nakayama A, Hishida A, Kawamura Y, Ichihara S, Akiyama M, Ikezaki H, Furusyo N, Shimizu S, Yamamoto K, Hirata M, Okada R, Kawai S, Kawaguchi M, Nishida Y, Shimanoe C, Ibusuki R, Takezaki T, Nakajima M, Takao M, Ozaki E, Matsui D, Nishiyama T, Suzuki S, Takashima N, Kita Y, Endoh K, Kuriki K, Uemura H, Arisawa K, Oze I, Matsuo K, Nakamura Y, Mikami H, Tamura T, Nakashima H, Nakamura T, Kato N, Matsuda K, Murakami Y, Matsubara T, Naito M, Kubo M, Kamatani Y, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H.

Commun Biol. 2019 Apr 8;2:115. doi: 10.1038/s42003-019-0339-0. eCollection 2019.

38.

Paper-Based Disposable Molecular Sensor Constructed from Oxide Nanowires, Cellulose Nanofibers, and Pencil-Drawn Electrodes.

Koga H, Nagashima K, Huang Y, Zhang G, Wang C, Takahashi T, Inoue A, Yan H, Kanai M, He Y, Uetani K, Nogi M, Yanagida T.

ACS Appl Mater Interfaces. 2019 Apr 24;11(16):15044-15050. doi: 10.1021/acsami.9b01287. Epub 2019 Apr 15.

PMID:
30942067
39.

Clinical use of current polygenic risk scores may exacerbate health disparities.

Martin AR, Kanai M, Kamatani Y, Okada Y, Neale BM, Daly MJ.

Nat Genet. 2019 Apr;51(4):584-591. doi: 10.1038/s41588-019-0379-x. Epub 2019 Mar 29. Review.

40.

Rational Method of Monitoring Molecular Transformations on Metal-Oxide Nanowire Surfaces.

Wang C, Hosomi T, Nagashima K, Takahashi T, Zhang G, Kanai M, Zeng H, Mizukami W, Shioya N, Shimoaka T, Tamaoka T, Yoshida H, Takeda S, Yasui T, Baba Y, Aoki Y, Terao J, Hasegawa T, Yanagida T.

Nano Lett. 2019 Apr 10;19(4):2443-2449. doi: 10.1021/acs.nanolett.8b05180. Epub 2019 Mar 26.

PMID:
30888179
41.

Unusual Oxygen Partial Pressure Dependence of Electrical Transport of Single-Crystalline Metal Oxide Nanowires Grown by the Vapor-Liquid-Solid Process.

Anzai H, Takahashi T, Suzuki M, Kanai M, Zhang G, Hosomi T, Seki T, Nagashima K, Shibata N, Yanagida T.

Nano Lett. 2019 Mar 13;19(3):1675-1681. doi: 10.1021/acs.nanolett.8b04668. Epub 2019 Mar 5.

PMID:
30827116
42.

Clinical Practice of Postoperative Adjuvant Chemotherapy in Patients with Colorectal Liver Metastases: Impact of the Completion for Six Months.

Nishino H, Hatano E, Okuno M, Toda R, Seo S, Taura K, Horimatsu T, Kanai M, Hasegawa S, Matsumoto S, Sakai Y, Uemoto S.

Am Surg. 2019 Feb 1;85(2):e111-e114. No abstract available.

PMID:
30819321
43.

[A case of spinal and bulbar muscular atrophy with improved walking ability following gait training using the hybrid assistive limb (HAL)].

Mizui D, Nakai Y, Okada H, Kanai M, Yamaguchi K.

Rinsho Shinkeigaku. 2019 Mar 28;59(3):157-159. doi: 10.5692/clinicalneurol.cn-001223. Epub 2019 Feb 28. Japanese.

PMID:
30814446
44.

Molecular mechanism of lysophosphatidic acid-induced hypertensive response.

Kano K, Matsumoto H, Inoue A, Yukiura H, Kanai M, Chun J, Ishii S, Shimizu T, Aoki J.

Sci Rep. 2019 Feb 25;9(1):2662. doi: 10.1038/s41598-019-39041-4.

45.

Engineering Nanowire-Mediated Cell Lysis for Microbial Cell Identification.

Yasui T, Yanagida T, Shimada T, Otsuka K, Takeuchi M, Nagashima K, Rahong S, Naito T, Takeshita D, Yonese A, Magofuku R, Zhu Z, Kaji N, Kanai M, Kawai T, Baba Y.

ACS Nano. 2019 Feb 26;13(2):2262-2273. doi: 10.1021/acsnano.8b08959. Epub 2019 Feb 13.

PMID:
30758938
46.

Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma.

Mizumoto A, Ohashi S, Kamada M, Saito T, Nakai Y, Baba K, Hirohashi K, Mitani Y, Kikuchi O, Matsubara J, Yamada A, Takahashi T, Lee H, Okuno Y, Kanai M, Muto M.

J Gastroenterol. 2019 Aug;54(8):687-698. doi: 10.1007/s00535-019-01549-x. Epub 2019 Feb 8.

47.

Design and properties of [Met35(O)]Aβ42-lactam(Asp23/Lys28) possessing a lactam tether as a salt-bridge surrogate.

Yamamoto M, Shinoda K, Sasaki D, Kanai M, Sohma Y.

Bioorg Med Chem. 2019 Mar 1;27(5):888-893. doi: 10.1016/j.bmc.2019.01.038. Epub 2019 Jan 30.

PMID:
30733085
48.

Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.

Suzuki K, Akiyama M, Ishigaki K, Kanai M, Hosoe J, Shojima N, Hozawa A, Kadota A, Kuriki K, Naito M, Tanno K, Ishigaki Y, Hirata M, Matsuda K, Iwata N, Ikeda M, Sawada N, Yamaji T, Iwasaki M, Ikegawa S, Maeda S, Murakami Y, Wakai K, Tsugane S, Sasaki M, Yamamoto M, Okada Y, Kubo M, Kamatani Y, Horikoshi M, Yamauchi T, Kadowaki T.

Nat Genet. 2019 Mar;51(3):379-386. doi: 10.1038/s41588-018-0332-4. Epub 2019 Feb 4.

PMID:
30718926
49.

Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population.

Hirata J, Hosomichi K, Sakaue S, Kanai M, Nakaoka H, Ishigaki K, Suzuki K, Akiyama M, Kishikawa T, Ogawa K, Masuda T, Yamamoto K, Hirata M, Matsuda K, Momozawa Y, Inoue I, Kubo M, Kamatani Y, Okada Y.

Nat Genet. 2019 Mar;51(3):470-480. doi: 10.1038/s41588-018-0336-0. Epub 2019 Jan 28.

PMID:
30692682
50.

Breeding of a cordycepin-resistant and adenosine kinase-deficient sake yeast strain that accumulates high levels of S-adenosylmethionine.

Kanai M, Yasuda N, Morimoto T, Yoshida S, Nishibori N, Mizunuma M, Fujii T, Iefuji H.

Biosci Biotechnol Biochem. 2019 Aug;83(8):1530-1537. doi: 10.1080/09168451.2019.1571896. Epub 2019 Jan 27.

PMID:
30686113

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