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Items: 1 to 50 of 157


LPA1/3 signaling mediates tumor lymphangiogenesis through promoting CRT expression in prostate cancer.

Lin YC, Chen CC, Chen WM, Lu KY, Shen TL, Jou YC, Shen CH, Ohbayashi N, Kanaho Y, Huang YL, Lee H.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1305-1315. doi: 10.1016/j.bbalip.2018.07.005. Epub 2018 Jul 24.


Physiological function of phospholipase D2 in anti-tumor immunity: regulation of CD8+ T lymphocyte proliferation.

Ngo Thai Bich V, Hongu T, Miura Y, Katagiri N, Ohbayashi N, Yamashita-Kanemaru Y, Shibuya A, Funakoshi Y, Kanaho Y.

Sci Rep. 2018 Apr 19;8(1):6283. doi: 10.1038/s41598-018-24512-x.


Phospholipase D2 promotes disease progression of renal cell carcinoma through the induction of angiogenin.

Kandori S, Kojima T, Matsuoka T, Yoshino T, Sugiyama A, Nakamura E, Shimazui T, Funakoshi Y, Kanaho Y, Nishiyama H.

Cancer Sci. 2018 Jun;109(6):1865-1875. doi: 10.1111/cas.13609. Epub 2018 May 25.


Oxidized LDL phagocytosis during foam cell formation in atherosclerotic plaques relies on a PLD2-CD36 functional interdependence.

Ganesan R, Henkels KM, Wrenshall LE, Kanaho Y, Di Paolo G, Frohman MA, Gomez-Cambronero J.

J Leukoc Biol. 2018 May;103(5):867-883. doi: 10.1002/JLB.2A1017-407RR. Epub 2018 Apr 14.


ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex.

Miura Y, Kanaho Y.

Biochem Biophys Res Commun. 2017 Nov 18;493(2):1089-1094. doi: 10.1016/j.bbrc.2017.09.076. Epub 2017 Sep 15.


Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration.

Lin YC, Ohbayashi N, Hongu T, Katagiri N, Funakoshi Y, Lee H, Kanaho Y.

Sci Rep. 2017 Sep 12;7(1):11431. doi: 10.1038/s41598-017-11240-x.


Regulation of HGF-induced hepatocyte proliferation by the small GTPase Arf6 through the PIP2-producing enzyme PIP5K1A.

Tsai MT, Katagiri N, Ohbayashi N, Iwasaki K, Ohkohchi N, Ding ST, Kanaho Y, Funakoshi Y.

Sci Rep. 2017 Aug 25;7(1):9438. doi: 10.1038/s41598-017-09633-z.


Rab32 subfamily small GTPases: pleiotropic Rabs in endosomal trafficking.

Ohbayashi N, Fukuda M, Kanaho Y.

J Biochem. 2017 Aug 1;162(2):65-71. doi: 10.1093/jb/mvx027. Review.


The small G protein Arf6 expressed in keratinocytes by HGF stimulation is a regulator for skin wound healing.

Miura Y, Ngo Thai Bich V, Furuya M, Hasegawa H, Takahashi S, Katagiri N, Hongu T, Funakoshi Y, Ohbayashi N, Kanaho Y.

Sci Rep. 2017 Apr 21;7:46649. doi: 10.1038/srep46649.


Machineries regulating the activity of the small GTPase Arf6 in cancer cells are potential targets for developing innovative anti-cancer drugs.

Yamauchi Y, Miura Y, Kanaho Y.

Adv Biol Regul. 2017 Jan;63:115-121. doi: 10.1016/j.jbior.2016.10.004. Epub 2016 Oct 18. Review.


ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons.

Miura Y, Hongu T, Yamauchi Y, Funakoshi Y, Katagiri N, Ohbayashi N, Kanaho Y.

Biochem J. 2016 Sep 1;473(17):2591-602. doi: 10.1042/BCJ20160183. Epub 2016 Jun 21.


[Versatile in vivo functions of the small GTPase Arf6].

Hongu T, Kanaho Y.

Seikagaku. 2016 Feb;88(1):78-85. Review. Japanese. No abstract available.


Pathological functions of the small GTPase Arf6 in cancer progression: Tumor angiogenesis and metastasis.

Hongu T, Yamauchi Y, Funakoshi Y, Katagiri N, Ohbayashi N, Kanaho Y.

Small GTPases. 2016 Apr 2;7(2):47-53. doi: 10.1080/21541248.2016.1154640. Epub 2016 Feb 24. Review.


PKN3 is the major regulator of angiogenesis and tumor metastasis in mice.

Mukai H, Muramatsu A, Mashud R, Kubouchi K, Tsujimoto S, Hongu T, Kanaho Y, Tsubaki M, Nishida S, Shioi G, Danno S, Mehruba M, Satoh R, Sugiura R.

Sci Rep. 2016 Jan 8;6:18979. doi: 10.1038/srep18979.


Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking.

Huang Y, Joshi S, Xiang B, Kanaho Y, Li Z, Bouchard BA, Moncman CL, Whiteheart SW.

Blood. 2016 Mar 17;127(11):1459-67. doi: 10.1182/blood-2015-05-648550. Epub 2016 Jan 6.


PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination.

Kim JD, Park KE, Ishida J, Kako K, Hamada J, Kani S, Takeuchi M, Namiki K, Fukui H, Fukuhara S, Hibi M, Kobayashi M, Kanaho Y, Kasuya Y, Mochizuki N, Fukamizu A.

Sci Adv. 2015 Dec 4;1(11):e1500615. doi: 10.1126/sciadv.1500615. eCollection 2015 Dec.


Activation of the Small G Protein Arf6 by Dynamin2 through Guanine Nucleotide Exchange Factors in Endocytosis.

Okada R, Yamauchi Y, Hongu T, Funakoshi Y, Ohbayashi N, Hasegawa H, Kanaho Y.

Sci Rep. 2015 Oct 27;5:14919. doi: 10.1038/srep14919.


Physiological functions of the small GTPase Arf6 in the nervous system.

Akiyama M, Kanaho Y.

Small GTPases. 2015;6(3):160-4. doi: 10.1080/21541248.2015.1043041. Epub 2015 Aug 20.


Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling.

Hongu T, Funakoshi Y, Fukuhara S, Suzuki T, Sakimoto S, Takakura N, Ema M, Takahashi S, Itoh S, Kato M, Hasegawa H, Mochizuki N, Kanaho Y.

Nat Commun. 2015 Aug 4;6:7925. doi: 10.1038/ncomms8925.


Phospholipase D1 facilitates second-phase myoblast fusion and skeletal muscle regeneration.

Teng S, Stegner D, Chen Q, Hongu T, Hasegawa H, Chen L, Kanaho Y, Nieswandt B, Frohman MA, Huang P.

Mol Biol Cell. 2015 Feb 1;26(3):506-17. doi: 10.1091/mbc.E14-03-0802. Epub 2014 Nov 26.


TRE17/USP6 regulates ubiquitylation and trafficking of cargo proteins that enter cells by clathrin-independent endocytosis.

Funakoshi Y, Chou MM, Kanaho Y, Donaldson JG.

J Cell Sci. 2014 Nov 1;127(Pt 21):4750-61. doi: 10.1242/jcs.156786. Epub 2014 Sep 1.


Trans-regulation of oligodendrocyte myelination by neurons through small GTPase Arf6-regulated secretion of fibroblast growth factor-2.

Akiyama M, Hasegawa H, Hongu T, Frohman MA, Harada A, Sakagami H, Kanaho Y.

Nat Commun. 2014 Aug 21;5:4744. doi: 10.1038/ncomms5744.


Garcinia vilersiana bark extract activates the Nrf2/HO-1 signaling pathway in RAW264.7 cells.

Shinkai Y, Yamanaka I, Duong HH, Quynh NT, Kanaho Y, Kumagai Y.

J Toxicol Sci. 2013;38(6):875-8.


Activation machinery of the small GTPase Arf6.

Hongu T, Kanaho Y.

Adv Biol Regul. 2014 Jan;54:59-66. doi: 10.1016/j.jbior.2013.09.014. Epub 2013 Oct 8. Review.


[Physiological significance of phosphatidylinositol 4-phosphate 5-kinase in mammals].

Haswgawa H, Kanaho Y.

Seikagaku. 2013 May;85(5):362-7. Review. Japanese. No abstract available.


Phosphatidylinositol 4-phosphate 5-kinase β regulates growth cone morphology and semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons.

Yamazaki M, Yamauchi Y, Goshima Y, Kanaho Y.

Neurosci Lett. 2013 Jun 28;547:59-64. doi: 10.1016/j.neulet.2013.04.062. Epub 2013 May 14.


Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.

Ali WH, Chen Q, Delgiorno KE, Su W, Hall JC, Hongu T, Tian H, Kanaho Y, Di Paolo G, Crawford HC, Frohman MA.

PLoS One. 2013;8(1):e55325. doi: 10.1371/journal.pone.0055325. Epub 2013 Jan 28.


Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.

Sanematsu F, Nishikimi A, Watanabe M, Hongu T, Tanaka Y, Kanaho Y, Côté JF, Fukui Y.

J Biol Chem. 2013 Mar 22;288(12):8092-100. doi: 10.1074/jbc.M112.410423. Epub 2013 Jan 29.


Phosphatidylinositol 4-phosphate 5-kinase α facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location.

Nguyen TT, Kim YM, Kim TD, Le OT, Kim JJ, Kang HC, Hasegawa H, Kanaho Y, Jou I, Lee SY.

J Biol Chem. 2013 Feb 22;288(8):5645-59. doi: 10.1074/jbc.M112.410126. Epub 2013 Jan 7.


Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.

Neely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, Novatchkova M, Gibson D, Maixner W, Pospisilik JA, Hirsch E, Whishaw IQ, Zimmer A, Gupta V, Sasaki J, Kanaho Y, Sasaki T, Kress M, Woolf CJ, Penninger JM.

PLoS Genet. 2012;8(12):e1003071. doi: 10.1371/journal.pgen.1003071. Epub 2012 Dec 6.


Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis.

Chen Q, Hongu T, Sato T, Zhang Y, Ali W, Cavallo JA, van der Velden A, Tian H, Di Paolo G, Nieswandt B, Kanaho Y, Frohman MA.

Sci Signal. 2012 Nov 6;5(249):ra79. doi: 10.1126/scisignal.2003257.


Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable.

Sato T, Hongu T, Sakamoto M, Funakoshi Y, Kanaho Y.

Mol Cell Biol. 2013 Jan;33(1):136-45. doi: 10.1128/MCB.00869-12. Epub 2012 Oct 29.


Molecular mechanisms of fMLP-induced superoxide generation and degranulation in mouse neutrophils.

Kanaho Y, Sato T, Hongu T, Funakoshi Y.

Adv Biol Regul. 2013 Jan;53(1):128-34. doi: 10.1016/j.jbior.2012.09.001. Epub 2012 Sep 28.


Regulation of the cell proliferation and migration as extra-pituitary functions of GnRH.

Park MK, Kanaho Y, Enomoto M.

Gen Comp Endocrinol. 2013 Jan 15;181:259-64. doi: 10.1016/j.ygcen.2012.09.023. Epub 2012 Sep 29.


Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis.

Makyio H, Ohgi M, Takei T, Takahashi S, Takatsu H, Katoh Y, Hanai A, Ueda T, Kanaho Y, Xie Y, Shin HW, Kamikubo H, Kataoka M, Kawasaki M, Kato R, Wakatsuki S, Nakayama K.

EMBO J. 2012 May 30;31(11):2590-603. doi: 10.1038/emboj.2012.89. Epub 2012 Apr 20.


Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis.

Hasegawa H, Noguchi J, Yamashita M, Okada R, Sugimoto R, Furuya M, Unoki T, Funakoshi Y, Baba T, Kanaho Y.

Biol Reprod. 2012 May 3;86(5):136, 1-12. doi: 10.1095/biolreprod.110.089896. Print 2012 May.


NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂ is essential for AMPA receptor endocytosis during LTD.

Unoki T, Matsuda S, Kakegawa W, Van NT, Kohda K, Suzuki A, Funakoshi Y, Hasegawa H, Yuzaki M, Kanaho Y.

Neuron. 2012 Jan 12;73(1):135-48. doi: 10.1016/j.neuron.2011.09.034.


Regulation and functions of the lipid kinase PIP5K g661 at synapses.

Kanaho Y, Unoki T.

Adv Biol Regul. 2012 Jan;52(1):59-65. No abstract available.


Phospholipase D2 activation by p38 MAP kinase is involved in neurite outgrowth.

Watanabe H, Hongu T, Yamazaki M, Kanaho Y.

Biochem Biophys Res Commun. 2011 Sep 23;413(2):288-93. doi: 10.1016/j.bbrc.2011.08.088. Epub 2011 Aug 27.


Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice.

Huang P, Yeku O, Zong H, Tsang P, Su W, Yu X, Teng S, Osisami M, Kanaho Y, Pessin JE, Frohman MA.

Diabetes. 2011 Feb;60(2):454-63. doi: 10.2337/db10-0614.


Tissue- and development-dependent expression of the small GTPase Arf6 in mice.

Akiyama M, Zhou M, Sugimoto R, Hongu T, Furuya M, Funakoshi Y, Kato M, Hasegawa H, Kanaho Y.

Dev Dyn. 2010 Dec;239(12):3416-35. doi: 10.1002/dvdy.22481.


Regulation of PIP5K activity by Arf6 and its physiological significance.

Funakoshi Y, Hasegawa H, Kanaho Y.

J Cell Physiol. 2011 Apr;226(4):888-95. doi: 10.1002/jcp.22482. Review.


The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition.

Hada K, Asahina M, Hasegawa H, Kanaho Y, Slack FJ, Niwa R.

Dev Biol. 2010 Aug 15;344(2):1100-9. doi: 10.1016/j.ydbio.2010.05.508. Epub 2010 Jun 2.


SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals.

Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M.

PLoS One. 2010 Jul 23;5(7):e11755. doi: 10.1371/journal.pone.0011755.


Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain.

Volpicelli-Daley LA, Lucast L, Gong LW, Liu L, Sasaki J, Sasaki T, Abrams CS, Kanaho Y, De Camilli P.

J Biol Chem. 2010 Sep 10;285(37):28708-14. doi: 10.1074/jbc.M110.132191. Epub 2010 Jul 9.


The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons.

Suzuki A, Arikawa C, Kuwahara Y, Itoh K, Watanabe M, Watanabe H, Suzuki T, Funakoshi Y, Hasegawa H, Kanaho Y.

FEBS Lett. 2010 Jul 2;584(13):2801-6. doi: 10.1016/j.febslet.2010.05.020. Epub 2010 May 21.


Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation.

Nishida M, Suda R, Nagamatsu Y, Tanabe S, Onohara N, Nakaya M, Kanaho Y, Shibata T, Uchida K, Sumimoto H, Sato Y, Kurose H.

J Biol Chem. 2010 May 14;285(20):15268-77. doi: 10.1074/jbc.M109.076232. Epub 2010 Mar 15.


Activation mechanisms of PIP5K isozymes by the small GTPase ARF6.

Funakoshi Y, Hasegawa H, Kanaho Y.

Adv Enzyme Regul. 2010;50(1):72-80. doi: 10.1016/j.advenzreg.2009.11.001. Epub 2009 Nov 5. No abstract available.


The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration.

Itoh T, Hasegawa J, Tsujita K, Kanaho Y, Takenawa T.

Sci Signal. 2009 Sep 8;2(87):ra52. doi: 10.1126/scisignal.2000393.


Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6.

Anthonio EA, Brees C, Baumgart-Vogt E, Hongu T, Huybrechts SJ, Van Dijck P, Mannaerts GP, Kanaho Y, Van Veldhoven PP, Fransen M.

BMC Cell Biol. 2009 Aug 17;10:58. doi: 10.1186/1471-2121-10-58.

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