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Items: 28


Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.

Woodard JL, Huntsman AC, Patel PA, Chai HB, Kanagasabai R, Karmahapatra S, Young AN, Ren Y, Cole MS, Herrera D, Yalowich JC, Kinghorn AD, Burdette JE, Fuchs JR.

Bioorg Med Chem. 2018 May 15;26(9):2354-2364. doi: 10.1016/j.bmc.2018.03.033. Epub 2018 Mar 23.


The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIα (TOP2α/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2α/170 Isoform.

Kanagasabai R, Karmahapatra S, Kientz CA, Yu Y, Hernandez VA, Kania EE, Yalowich JC, Elton TS.

Mol Pharmacol. 2018 May;93(5):515-525. doi: 10.1124/mol.117.111567. Epub 2018 Mar 7.


An unusual case of partial Anterior Cruciate ligament (ACL) tear secondary to a glass foreign body in an adolescent knee joint.

S M S, K AH, R K, Gnanadoss JJ.

J Orthop Case Rep. 2016 Jul-Aug;6(3):13-15. doi: 10.13107/jocr.2250-0685.478.


Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform.

Kanagasabai R, Serdar L, Karmahapatra S, Kientz CA, Ellis J, Ritke MK, Elton TS, Yalowich JC.

J Pharmacol Exp Ther. 2017 Jan;360(1):152-163. Epub 2016 Nov 10.


Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform.

Hasinoff BB, Wu X, Patel D, Kanagasabai R, Karmahapatra S, Yalowich JC.

J Pharmacol Exp Ther. 2016 Feb;356(2):397-409. doi: 10.1124/jpet.115.228650. Epub 2015 Dec 11.


TRIM72 modulates caveolar endocytosis in repair of lung cells.

Nagre N, Wang S, Kellett T, Kanagasabai R, Deng J, Nishi M, Shilo K, Oeckler RA, Yalowich JC, Takeshima H, Christman J, Hubmayr RD, Zhao X.

Am J Physiol Lung Cell Mol Physiol. 2016 Mar 1;310(5):L452-64. doi: 10.1152/ajplung.00089.2015. Epub 2015 Dec 4.


Predebridement wound culture in open fractures does not predict postoperative wound infection: A pilot study.

Lingaraj R, Santoshi JA, Devi S, Najimudeen S, Gnanadoss JJ, Kanagasabai R, Kanungo R.

J Nat Sci Biol Med. 2015 Aug;6(Suppl 1):S63-8. doi: 10.4103/0976-9668.166088.


Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis.

Ren Y, Yuan C, Deng Y, Kanagasabai R, Ninh TN, Tu VT, Chai HB, Soejarto DD, Fuchs JR, Yalowich JC, Yu J, Kinghorn AD.

Phytochemistry. 2015 Mar;111:132-40. doi: 10.1016/j.phytochem.2014.12.014. Epub 2015 Jan 14.


Potent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilanei.

Ren Y, Lantvit DD, Deng Y, Kanagasabai R, Gallucci JC, Ninh TN, Chai HB, Soejarto DD, Fuchs JR, Yalowich JC, Yu J, Swanson SM, Kinghorn AD.

J Nat Prod. 2014 Jun 27;77(6):1494-504. doi: 10.1021/np5002785. Epub 2014 Jun 12.


Diabetes of the brain: computational approaches and interventional strategies.

Narasimhan K, Govindasamy M, Gauthaman K, Kamal MA, Abuzenadeh AM, Al-Qahtani M, Kanagasabai R.

CNS Neurol Disord Drug Targets. 2014 Apr;13(3):408-17. Review.


Unusual presentation of a radial neck fracture in a child.

Poduval M, Kanagasabai R, Abraham VT, Marimuthu C.

Indian J Orthop. 2013 Mar;47(2):204-6. doi: 10.4103/0019-5413.108923.


The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II.

Hasinoff BB, Wu X, Nitiss JL, Kanagasabai R, Yalowich JC.

Biochem Pharmacol. 2012 Dec 15;84(12):1617-26. doi: 10.1016/j.bcp.2012.09.023. Epub 2012 Oct 5.


Heat shock factor-1 knockout induces multidrug resistance gene, MDR1b, and enhances P-glycoprotein (ABCB1)-based drug extrusion in the heart.

Krishnamurthy K, Vedam K, Kanagasabai R, Druhan LJ, Ilangovan G.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9023-8. doi: 10.1073/pnas.1200731109. Epub 2012 May 21.


The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα.

Yalowich JC, Wu X, Zhang R, Kanagasabai R, Hornbaker M, Hasinoff BB.

Biochem Pharmacol. 2012 Jul 1;84(1):52-8. doi: 10.1016/j.bcp.2012.03.021. Epub 2012 Apr 4.


Heat shock protein 25-enriched plasma transfusion preconditions the heart against doxorubicin-induced dilated cardiomyopathy in mice.

Krishnamurthy K, Kanagasabai R, Druhan LJ, Ilangovan G.

J Pharmacol Exp Ther. 2012 Jun;341(3):829-39. doi: 10.1124/jpet.112.192245. Epub 2012 Mar 21.


Forced expression of heat shock protein 27 (Hsp27) reverses P-glycoprotein (ABCB1)-mediated drug efflux and MDR1 gene expression in Adriamycin-resistant human breast cancer cells.

Kanagasabai R, Krishnamurthy K, Druhan LJ, Ilangovan G.

J Biol Chem. 2011 Sep 23;286(38):33289-300. doi: 10.1074/jbc.M111.249102. Epub 2011 Jul 22.


Purification, characterization and inhibition of sterol C24-methyltransferase from Candida albicans.

Ganapathy K, Kanagasabai R, Nguyen TT, Nes WD.

Arch Biochem Biophys. 2011 Jan 15;505(2):194-201. doi: 10.1016/ Epub 2010 Oct 12.


Hsp27 protects adenocarcinoma cells from UV-induced apoptosis by Akt and p21-dependent pathways of survival.

Kanagasabai R, Karthikeyan K, Vedam K, Qien W, Zhu Q, Ilangovan G.

Mol Cancer Res. 2010 Oct;8(10):1399-412. doi: 10.1158/1541-7786.MCR-10-0181. Epub 2010 Sep 21.


Ubiquitin-family modifications of topoisomerase I in camptothecin-treated human breast cancer cells.

Kanagasabai R, Liu S, Salama S, Yamasaki EF, Zhang L, Greenchurch KB, Snapka RM.

Biochemistry. 2009 Apr 14;48(14):3176-85. doi: 10.1021/bi802179t.


Mining to find the lipid interaction networks involved in Ovarian Cancers.

Kanagasabai R, Narasimhan K, Low HS, Ang WT, Fernandis AZ, Wenk MR, Choolani MA, Baker CJ.

Summit Transl Bioinform. 2009 Mar 1;2009:61-5.


MotifVoter: a novel ensemble method for fine-grained integration of generic motif finders.

Wijaya E, Yiu SM, Son NT, Kanagasabai R, Sung WK.

Bioinformatics. 2008 Oct 15;24(20):2288-95. doi: 10.1093/bioinformatics/btn420. Epub 2008 Aug 12.


Ontology-centric integration and navigation of the dengue literature.

Rajapakse M, Kanagasabai R, Ang WT, Veeramani A, Schreiber MJ, Baker CJ.

J Biomed Inform. 2008 Oct;41(5):806-15. doi: 10.1016/j.jbi.2008.04.004. Epub 2008 May 5.


Towards ontology-driven navigation of the lipid bibliosphere.

Baker CJ, Kanagasabai R, Ang WT, Veeramani A, Low HS, Wenk MR.

BMC Bioinformatics. 2008;9 Suppl 1:S5. doi: 10.1186/1471-2105-9-S1-S5.


A workflow for mutation extraction and structure annotation.

Kanagasabai R, Choo KH, Ranganathan S, Baker CJ.

J Bioinform Comput Biol. 2007 Dec;5(6):1319-37.


Mechanism-based enzyme inactivators of phytosterol biosynthesis.

Zhou W, Song Z, Kanagasabai R, Liu J, Jayasimha P, Sinha A, Veeramachanemi P, Miller MB, Nes WD.

Molecules. 2004 Mar 31;9(4):185-203. Review.


Evaluation of Anti-inflammatory activity and toxicity studies of Chloroxylon sweitenia in Rats.

Kumar K, Ganesh M, Baskar S, Srinivasan K, Kanagasabai R, Sambathkumar R, Kumar SS, Sivakumar T.

Anc Sci Life. 2006 Jan;25(3-4):33-43.


Sterol methyltransferase: functional analysis of highly conserved residues by site-directed mutagenesis.

Nes WD, Jayasimha P, Zhou W, Kanagasabai R, Jin C, Jaradat TT, Shaw RW, Bujnicki JM.

Biochemistry. 2004 Jan 20;43(2):569-76.


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