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Items: 1 to 50 of 192

1.

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair.

Mardenborough YSN, Nitsenko K, Laffeber C, Duboc C, Sahin E, Quessada-Vial A, Winterwerp HHK, Sixma TK, Kanaar R, Friedhoff P, Strick TR, Lebbink JHG.

Nucleic Acids Res. 2019 Oct 10. pii: gkz834. doi: 10.1093/nar/gkz834. [Epub ahead of print]

PMID:
31598722
2.

Large Field Alpha Irradiation Setup for Radiobiological Experiments.

Roobol SJ, Kouwenberg JJM, Denkova AG, Kanaar R, Essers J.

Methods Protoc. 2019 Aug 28;2(3). pii: E75. doi: 10.3390/mps2030075.

3.

HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.

Brandsma I, Sato K, van Rossum-Fikkert SE, van Vliet N, Sleddens E, Reuter M, Odijk H, van den Tempel N, Dekkers DHW, Bezstarosti K, Demmers JAA, Maas A, Lebbink J, Wyman C, Essers J, van Gent DC, Baarends WM, Knipscheer P, Kanaar R, Zelensky AN.

Cell Rep. 2019 Jun 25;27(13):3790-3798.e7. doi: 10.1016/j.celrep.2019.05.096.

4.

Correction: Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects.

Meijer TG, Verkaik NS, Sieuwerts AM, van Riet J, Naipal KAT, van Deurzen CHM, den Bakker MA, Sleddens HFBM, Dubbink HJ, den Toom TD, Dinjens WNM, Lips E, Nederlof PM, Smid M, van de Werken HJG, Kanaar R, Martens JWM, Jager A, van Gent DC.

Clin Cancer Res. 2019 May 1;25(9):2935. doi: 10.1158/1078-0432.CCR-19-0936. No abstract available.

PMID:
31043383
5.

Fibulin-4 deficiency differentially affects cytoskeleton structure and dynamics as well as TGFβ signaling.

Burger J, van Vliet N, van Heijningen P, Kumra H, Kremers GJ, Alves M, van Cappellen G, Yanagisawa H, Reinhardt DP, Kanaar R, van der Pluijm I, Essers J.

Cell Signal. 2019 Jun;58:65-78. doi: 10.1016/j.cellsig.2019.02.008. Epub 2019 Mar 4. Review.

PMID:
30844428
6.

On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation.

van den Tempel N, Zelensky AN, Odijk H, Laffeber C, Schmidt CK, Brandsma I, Demmers J, Krawczyk PM, Kanaar R.

Cancers (Basel). 2019 Jan 15;11(1). pii: E97. doi: 10.3390/cancers11010097.

7.

Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy.

van der Zon NL, Kanaar R, Wyman C.

Version 2. F1000Res. 2018 Sep 12 [revised 2018 Jan 1];7. pii: F1000 Faculty Rev-1453. doi: 10.12688/f1000research.15650.2. eCollection 2018. Review.

8.

Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder.

van den Tempel N, Naipal KAT, Raams A, van Gent DC, Franckena M, Boormans JL, Kanaar R.

PLoS One. 2018 Dec 14;13(12):e0209101. doi: 10.1371/journal.pone.0209101. eCollection 2018.

9.

Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response.

Zhang W, van Weerden WM, de Ridder CMA, Erkens-Schulze S, Schönfeld E, Meijer TG, Kanaar R, van Gent DC, Nonnekens J.

Prostate. 2019 Mar;79(4):390-402. doi: 10.1002/pros.23745. Epub 2018 Dec 5.

10.

Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects.

Meijer TG, Verkaik NS, Sieuwerts AM, van Riet J, Naipal KAT, van Deurzen CHM, den Bakker MA, Sleddens HFBM, Dubbink HJ, den Toom TD, Dinjens WNM, Lips E, Nederlof PM, Smid M, van de Werken HJG, Kanaar R, Martens JWM, Jager A, van Gent DC.

Clin Cancer Res. 2018 Dec 15;24(24):6277-6287. doi: 10.1158/1078-0432.CCR-18-0063. Epub 2018 Aug 23. Erratum in: Clin Cancer Res. 2019 May 1;25(9):2935.

PMID:
30139880
11.

Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation.

van der Pluijm I, Burger J, van Heijningen PM, IJpma A, van Vliet N, Milanese C, Schoonderwoerd K, Sluiter W, Ringuette LJ, Dekkers DHW, Que I, Kaijzel EL, Te Riet L, MacFarlane EG, Das D, van der Linden R, Vermeij M, Demmers JA, Mastroberardino PG, Davis EC, Yanagisawa H, Dietz HC, Kanaar R, Essers J.

Cardiovasc Res. 2018 Nov 1;114(13):1776-1793. doi: 10.1093/cvr/cvy150.

12.

Genome editing by natural and engineered CRISPR-associated nucleases.

Wu WY, Lebbink JHG, Kanaar R, Geijsen N, van der Oost J.

Nat Chem Biol. 2018 Jul;14(7):642-651. doi: 10.1038/s41589-018-0080-x. Epub 2018 Jun 18. Review.

PMID:
29915237
13.

Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations.

Sun J, Shi L, Kinomura A, Fukuto A, Horikoshi Y, Oma Y, Harata M, Ikura M, Ikura T, Kanaar R, Tashiro S.

Elife. 2018 May 8;7. pii: e32222. doi: 10.7554/eLife.32222.

14.

Single-Molecule Dynamics and Localization of DNA Repair Proteins in Cells.

Paul MW, Zelensky AN, Wyman C, Kanaar R.

Methods Enzymol. 2018;600:375-406. doi: 10.1016/bs.mie.2017.11.015. Epub 2018 Feb 1.

PMID:
29458767
15.

Boosting the effects of hyperthermia-based anticancer treatments by HSP90 inhibition.

Vriend LEM, van den Tempel N, Oei AL, L'Acosta M, Pieterson FJ, Franken NAP, Kanaar R, Krawczyk PM.

Oncotarget. 2017 Oct 27;8(57):97490-97503. doi: 10.18632/oncotarget.22142. eCollection 2017 Nov 14.

16.

Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies.

van den Tempel N, Odijk H, van Holthe N, Naipal K, Raams A, Eppink B, van Gent DC, Hardillo J, Verduijn GM, Drooger JC, van Rhoon GC, Smedts DHPM, van Doorn HC, Boormans JL, Jager A, Franckena M, Kanaar R.

Int J Hyperthermia. 2018 Jun;34(4):407-414. doi: 10.1080/02656736.2017.1355487. Epub 2017 Jul 31.

PMID:
28705099
17.

Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA.

Zelensky AN, Schimmel J, Kool H, Kanaar R, Tijsterman M.

Nat Commun. 2017 Jul 7;8(1):66. doi: 10.1038/s41467-017-00124-3.

18.

The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination.

van den Tempel N, Laffeber C, Odijk H, van Cappellen WA, van Rhoon GC, Franckena M, Kanaar R.

Oncotarget. 2017 Jul 4;8(27):44593-44604. doi: 10.18632/oncotarget.17861.

19.

Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia.

Oei AL, van Leeuwen CM, Ahire VR, Rodermond HM, Ten Cate R, Westermann AM, Stalpers LJA, Crezee J, Kok HP, Krawczyk PM, Kanaar R, Franken NAP.

Oncotarget. 2017 Apr 25;8(17):28116-28124. doi: 10.18632/oncotarget.15922.

20.

Semi-quantitative proteomics of mammalian cells upon short-term exposure to non-ionizing electromagnetic fields.

Kuzniar A, Laffeber C, Eppink B, Bezstarosti K, Dekkers D, Woelders H, Zwamborn AP, Demmers J, Lebbink JH, Kanaar R.

PLoS One. 2017 Feb 24;12(2):e0170762. doi: 10.1371/journal.pone.0170762. eCollection 2017.

21.

Architectural plasticity of human BRCA2-RAD51 complexes in DNA break repair.

Sánchez H, Paul MW, Grosbart M, van Rossum-Fikkert SE, Lebbink JHG, Kanaar R, Houtsmuller AB, Wyman C.

Nucleic Acids Res. 2017 May 5;45(8):4507-4518. doi: 10.1093/nar/gkx084.

22.

Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling.

van der Pluijm I, van Vliet N, von der Thusen JH, Robertus JL, Ridwan Y, van Heijningen PM, van Thiel BS, Vermeij M, Hoeks SE, Buijs-Offerman RMGB, Verhagen HJM, Kanaar R, Bertoli-Avella AM, Essers J.

EBioMedicine. 2016 Oct;12:280-294. doi: 10.1016/j.ebiom.2016.09.006. Epub 2016 Sep 10.

23.

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.

Zambetti NA, Ping Z, Chen S, Kenswil KJG, Mylona MA, Sanders MA, Hoogenboezem RM, Bindels EMJ, Adisty MN, Van Strien PMH, van der Leije CS, Westers TM, Cremers EMP, Milanese C, Mastroberardino PG, van Leeuwen JPTM, van der Eerden BCJ, Touw IP, Kuijpers TW, Kanaar R, van de Loosdrecht AA, Vogl T, Raaijmakers MHGP.

Cell Stem Cell. 2016 Nov 3;19(5):613-627. doi: 10.1016/j.stem.2016.08.021. Epub 2016 Sep 22.

24.

Sensitizing thermochemotherapy with a PARP1-inhibitor.

Oei AL, Vriend LE, van Leeuwen CM, Rodermond HM, Ten Cate R, Westermann AM, Stalpers LJ, Crezee J, Kanaar R, Kok HP, Krawczyk PM, Franken NA.

Oncotarget. 2017 Mar 7;8(10):16303-16312. doi: 10.18632/oncotarget.11422.

25.

Exploiting DNA repair defects for novel cancer therapies.

van Gent DC, Kanaar R.

Mol Biol Cell. 2016 Jul 15;27(14):2145-8. doi: 10.1091/mbc.E15-10-0698.

26.

Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair.

Hermans N, Laffeber C, Cristovão M, Artola-Borán M, Mardenborough Y, Ikpa P, Jaddoe A, Winterwerp HH, Wyman C, Jiricny J, Kanaar R, Friedhoff P, Lebbink JH.

Nucleic Acids Res. 2016 Aug 19;44(14):6770-86. doi: 10.1093/nar/gkw411. Epub 2016 May 12.

27.

Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms.

van den Tempel N, Horsman MR, Kanaar R.

Int J Hyperthermia. 2016 Jun;32(4):446-54. doi: 10.3109/02656736.2016.1157216. Epub 2016 Apr 18. Review.

PMID:
27086587
28.

Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair.

Harnicek D, Kampmann E, Lauber K, Hennel R, Cardoso Martins AS, Guo Y, Belka C, Mörtl S, Gallmeier E, Kanaar R, Mansmann U, Hucl T, Lindner LH, Hiddemann W, Issels RD.

Int J Cancer. 2016 Jul 15;139(2):467-79. doi: 10.1002/ijc.30070. Epub 2016 Mar 25.

29.

Tumor slice culture system to assess drug response of primary breast cancer.

Naipal KA, Verkaik NS, Sánchez H, van Deurzen CH, den Bakker MA, Hoeijmakers JH, Kanaar R, Vreeswijk MP, Jager A, van Gent DC.

BMC Cancer. 2016 Feb 9;16:78. doi: 10.1186/s12885-016-2119-2.

30.

Hallmarks of hyperthermia in driving the future of clinical hyperthermia as targeted therapy: translation into clinical application.

Issels R, Kampmann E, Kanaar R, Lindner LH.

Int J Hyperthermia. 2016;32(1):89-95. doi: 10.3109/02656736.2015.1119317. Epub 2016 Jan 24. Review.

PMID:
26803991
31.

Mismatch repair and homeologous recombination.

Tham KC, Kanaar R, Lebbink JHG.

DNA Repair (Amst). 2016 Feb;38:75-83. doi: 10.1016/j.dnarep.2015.11.010. Epub 2015 Dec 7. Review.

PMID:
26739221
32.

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51.

Ameziane N, May P, Haitjema A, van de Vrugt HJ, van Rossum-Fikkert SE, Ristic D, Williams GJ, Balk J, Rockx D, Li H, Rooimans MA, Oostra AB, Velleuer E, Dietrich R, Bleijerveld OB, Maarten Altelaar AF, Meijers-Heijboer H, Joenje H, Glusman G, Roach J, Hood L, Galas D, Wyman C, Balling R, den Dunnen J, de Winter JP, Kanaar R, Gelinas R, Dorsman JC.

Nat Commun. 2015 Dec 18;6:8829. doi: 10.1038/ncomms9829.

33.

Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.

Ramnath NW, Hawinkels LJ, van Heijningen PM, te Riet L, Paauwe M, Vermeij M, Danser AH, Kanaar R, ten Dijke P, Essers J.

Sci Rep. 2015 Nov 26;5:16872. doi: 10.1038/srep16872.

34.

Attenuated XPC expression is not associated with impaired DNA repair in bladder cancer.

Naipal KA, Raams A, Bruens ST, Brandsma I, Verkaik NS, Jaspers NG, Hoeijmakers JH, van Leenders GJ, Pothof J, Kanaar R, Boormans J, van Gent DC.

PLoS One. 2015 Apr 30;10(4):e0126029. doi: 10.1371/journal.pone.0126029. eCollection 2015.

35.

BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells.

Reuter M, Zelensky A, Smal I, Meijering E, van Cappellen WA, de Gruiter HM, van Belle GJ, van Royen ME, Houtsmuller AB, Essers J, Kanaar R, Wyman C.

J Cell Biol. 2015 Mar 16;208(6):857. doi: 10.1083/jcb.20140501402182015c. No abstract available.

36.

Optical Imaging of Tumor Response to Hyperbaric Oxygen Treatment and Irradiation in an Orthotopic Mouse Model of Head and Neck Squamous Cell Carcinoma.

Braks JA, Spiegelberg L, Koljenovic S, Ridwan Y, Keereweer S, Kanaar R, Wolvius EB, Essers J.

Mol Imaging Biol. 2015 Oct;17(5):633-42. doi: 10.1007/s11307-015-0834-8.

37.

BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells.

Reuter M, Zelensky A, Smal I, Meijering E, van Cappellen WA, de Gruiter HM, van Belle GJ, van Royen ME, Houtsmuller AB, Essers J, Kanaar R, Wyman C.

J Cell Biol. 2014 Dec 8;207(5):599-613. doi: 10.1083/jcb.201405014. Erratum in: J Cell Biol. 2015 Mar 16;208(6):857.

38.

A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity.

Uringa EJ, Baldeyron C, Odijk H, Wassenaar E, van Cappellen WA, Maas A, Hoeijmakers JH, Baarends WM, Kanaar R, Essers J.

DNA Repair (Amst). 2015 Jan;25:27-40. doi: 10.1016/j.dnarep.2014.11.002. Epub 2014 Nov 18.

PMID:
25463395
39.

DNA damage response and anti-apoptotic proteins predict radiosensitization efficacy of HDAC inhibitors SAHA and LBH589 in patient-derived glioblastoma cells.

Pont LM, Naipal K, Kloezeman JJ, Venkatesan S, van den Bent M, van Gent DC, Dirven CM, Kanaar R, Lamfers ML, Leenstra S.

Cancer Lett. 2015 Jan 28;356(2 Pt B):525-35. doi: 10.1016/j.canlet.2014.09.049. Epub 2014 Oct 8.

PMID:
25305451
40.

Mediators of homologous DNA pairing.

Zelensky A, Kanaar R, Wyman C.

Cold Spring Harb Perspect Biol. 2014 Oct 9;6(12):a016451. doi: 10.1101/cshperspect.a016451. Review.

41.

Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema.

Ramnath NW, van de Luijtgaarden KM, van der Pluijm I, van Nimwegen M, van Heijningen PM, Swagemakers SM, van Thiel BS, Ridwan RY, van Vliet N, Vermeij M, Hawinkels LJ, de Munck A, Dzyubachyk O, Meijering E, van der Spek P, Rottier R, Yanagisawa H, Hendriks RW, Kanaar R, Rouwet EV, Kleinjan A, Essers J.

PLoS One. 2014 Sep 25;9(9):e106054. doi: 10.1371/journal.pone.0106054. eCollection 2014.

42.

Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment.

Naipal KA, Verkaik NS, Ameziane N, van Deurzen CH, Ter Brugge P, Meijers M, Sieuwerts AM, Martens JW, O'Connor MJ, Vrieling H, Hoeijmakers JH, Jonkers J, Kanaar R, de Winter JP, Vreeswijk MP, Jager A, van Gent DC.

Clin Cancer Res. 2014 Sep 15;20(18):4816-26. doi: 10.1158/1078-0432.CCR-14-0571. Epub 2014 Jun 24.

43.

PIQMIe: a web server for semi-quantitative proteomics data management and analysis.

Kuzniar A, Kanaar R.

Nucleic Acids Res. 2014 Jul;42(Web Server issue):W100-6. doi: 10.1093/nar/gku478. Epub 2014 May 26.

44.

Targeting homologous recombination-mediated DNA repair in cancer.

Carvalho JF, Kanaar R.

Expert Opin Ther Targets. 2014 Apr;18(4):427-58. doi: 10.1517/14728222.2014.882900. Epub 2014 Feb 4. Review.

PMID:
24491188
45.

Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage.

Shima H, Suzuki H, Sun J, Kono K, Shi L, Kinomura A, Horikoshi Y, Ikura T, Ikura M, Kanaar R, Igarashi K, Saitoh H, Kurumizaka H, Tashiro S.

J Cell Sci. 2013 Nov 15;126(Pt 22):5284-92. doi: 10.1242/jcs.133744. Epub 2013 Sep 17.

46.

Rad54 is required for the normal development of male and female germ cells and contributes to the maintainance of their genome integrity after genotoxic stress.

Messiaen S, Le Bras A, Duquenne C, Barroca V, Moison D, Déchamps N, Doussau M, Bauchet AL, Guerquin MJ, Livera G, Essers J, Kanaar R, Habert R, Bernardino-Sgherri J.

Cell Death Dis. 2013 Aug 15;4:e774. doi: 10.1038/cddis.2013.281.

47.

Mismatch repair inhibits homeologous recombination via coordinated directional unwinding of trapped DNA structures.

Tham KC, Hermans N, Winterwerp HH, Cox MM, Wyman C, Kanaar R, Lebbink JH.

Mol Cell. 2013 Aug 8;51(3):326-37. doi: 10.1016/j.molcel.2013.07.008.

48.

Combined optical and topographic imaging reveals different arrangements of human RAD54 with presynaptic and postsynaptic RAD51-DNA filaments.

Sanchez H, Kertokalio A, van Rossum-Fikkert S, Kanaar R, Wyman C.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11385-90. doi: 10.1073/pnas.1306467110. Epub 2013 Jun 25.

49.

Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation.

Zelensky AN, Sanchez H, Ristic D, Vidic I, van Rossum-Fikkert SE, Essers J, Wyman C, Kanaar R.

Nucleic Acids Res. 2013 Jul;41(13):6475-89. doi: 10.1093/nar/gkt375. Epub 2013 May 10.

50.

Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination.

Kikuchi K, Narita T, Pham VT, Iijima J, Hirota K, Keka IS, Mohiuddin, Okawa K, Hori T, Fukagawa T, Essers J, Kanaar R, Whitby MC, Sugasawa K, Taniguchi Y, Kitagawa K, Takeda S.

Cancer Res. 2013 Jul 15;73(14):4362-71. doi: 10.1158/0008-5472.CAN-12-3154. Epub 2013 Apr 10.

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