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Items: 1 to 50 of 54

1.

Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways.

Christensen KR, Beach TG, Serrano GE, Kanaan NM.

Acta Neuropathol Commun. 2019 Feb 28;7(1):29. doi: 10.1186/s40478-019-0675-9.

2.

Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease.

Tiernan CT, Ginsberg SD, He B, Ward SM, Guillozet-Bongaarts AL, Kanaan NM, Mufson EJ, Counts SE.

Neurobiol Dis. 2018 Sep;117:125-136. doi: 10.1016/j.nbd.2018.05.021. Epub 2018 May 31.

3.

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

Duffy MF, Collier TJ, Patterson JR, Kemp CJ, Luk KC, Tansey MG, Paumier KL, Kanaan NM, Fischer DL, Polinski NK, Barth OL, Howe JW, Vaikath NN, Majbour NK, El-Agnaf OMA, Sortwell CE.

J Neuroinflammation. 2018 May 29;15(1):169. doi: 10.1186/s12974-018-1202-9.

4.

Tau Kinetics in Neurons and the Human Central Nervous System.

Sato C, Barthélemy NR, Mawuenyega KG, Patterson BW, Gordon BA, Jockel-Balsarotti J, Sullivan M, Crisp MJ, Kasten T, Kirmess KM, Kanaan NM, Yarasheski KE, Baker-Nigh A, Benzinger TLS, Miller TM, Karch CM, Bateman RJ.

Neuron. 2018 May 16;98(4):861-864. doi: 10.1016/j.neuron.2018.04.035. No abstract available.

5.

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

Duffy MF, Collier TJ, Patterson JR, Kemp CJ, Luk KC, Tansey MG, Paumier KL, Kanaan NM, Fischer DL, Polinski NK, Barth OL, Howe JW, Vaikath NN, Majbour NK, El-Agnaf OMA, Sortwell CE.

J Neuroinflammation. 2018 May 1;15(1):129. doi: 10.1186/s12974-018-1171-z. Erratum in: J Neuroinflammation. 2018 May 29;15(1):169.

6.

Tau Kinetics in Neurons and the Human Central Nervous System.

Sato C, Barthélemy NR, Mawuenyega KG, Patterson BW, Gordon BA, Jockel-Balsarotti J, Sullivan M, Crisp MJ, Kasten T, Kirmess KM, Kanaan NM, Yarasheski KE, Baker-Nigh A, Benzinger TLS, Miller TM, Karch CM, Bateman RJ.

Neuron. 2018 Mar 21;97(6):1284-1298.e7. doi: 10.1016/j.neuron.2018.02.015. Erratum in: Neuron. 2018 May 16;98 (4):861-864.

7.

Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization.

Shirafuji N, Hamano T, Yen SH, Kanaan NM, Yoshida H, Hayashi K, Ikawa M, Yamamura O, Kuriyama M, Nakamoto Y.

Int J Mol Sci. 2018 Mar 17;19(3). pii: E891. doi: 10.3390/ijms19030891.

8.

Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.

Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA.

J Neuroimmune Pharmacol. 2018 Jun;13(2):254-264. doi: 10.1007/s11481-018-9781-x. Epub 2018 Mar 7.

9.

Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease.

Tiernan CT, Mufson EJ, Kanaan NM, Counts SE.

J Neuropathol Exp Neurol. 2018 Mar 1;77(3):246-259. doi: 10.1093/jnen/nlx120.

10.

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.

Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B.

Nat Neurosci. 2018 Jan;21(1):72-80. doi: 10.1038/s41593-017-0022-z. Epub 2017 Nov 20.

11.

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms.

Kneynsberg A, Combs B, Christensen K, Morfini G, Kanaan NM.

Front Neurosci. 2017 Oct 17;11:572. doi: 10.3389/fnins.2017.00572. eCollection 2017. Review.

12.

Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS.

Kanaan NM, Sellnow RC, Boye SL, Coberly B, Bennett A, Agbandje-McKenna M, Sortwell CE, Hauswirth WW, Boye SE, Manfredsson FP.

Mol Ther Nucleic Acids. 2017 Sep 15;8:184-197. doi: 10.1016/j.omtn.2017.06.011. Epub 2017 Jun 21.

13.

Production of recombinant tau oligomers in vitro.

Combs B, Tiernan CT, Hamel C, Kanaan NM.

Methods Cell Biol. 2017;141:45-64. doi: 10.1016/bs.mcb.2017.06.005. Epub 2017 Jul 14.

14.

Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats.

Kneynsberg A, Kanaan NM.

eNeuro. 2017 Jul 21;4(4). pii: ENEURO.0043-17.2017. doi: 10.1523/ENEURO.0043-17.2017. eCollection 2017 Jul-Aug.

15.

Aging and Parkinson's disease: Different sides of the same coin?

Collier TJ, Kanaan NM, Kordower JH.

Mov Disord. 2017 Jul;32(7):983-990. doi: 10.1002/mds.27037. Epub 2017 May 18. Review.

16.

Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies.

Combs B, Kanaan NM.

Am J Pathol. 2017 Jun;187(6):1222-1229. doi: 10.1016/j.ajpath.2017.01.019. Epub 2017 Apr 14.

17.

Novel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 Regulation.

Grabinski T, Kanaan NM.

Front Mol Neurosci. 2016 Nov 17;9:123. eCollection 2016.

18.

Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study.

Mufson EJ, Perez SE, Nadeem M, Mahady L, Kanaan NM, Abrahamson EE, Ikonomovic MD, Crawford F, Alvarez V, Stein T, McKee AC.

Brain Inj. 2016;30(12):1399-1413.

19.

Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition.

Cox K, Combs B, Abdelmesih B, Morfini G, Brady ST, Kanaan NM.

Neurobiol Aging. 2016 Nov;47:113-126. doi: 10.1016/j.neurobiolaging.2016.07.015. Epub 2016 Jul 29.

20.

Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline.

Koss DJ, Jones G, Cranston A, Gardner H, Kanaan NM, Platt B.

Acta Neuropathol. 2016 Dec;132(6):875-895. Epub 2016 Oct 21.

21.

Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons.

Imamura K, Sahara N, Kanaan NM, Tsukita K, Kondo T, Kutoku Y, Ohsawa Y, Sunada Y, Kawakami K, Hotta A, Yawata S, Watanabe D, Hasegawa M, Trojanowski JQ, Lee VM, Suhara T, Higuchi M, Inoue H.

Sci Rep. 2016 Oct 10;6:34904. doi: 10.1038/srep34904.

22.

Pioglitazone prevents tau oligomerization.

Hamano T, Shirafuji N, Makino C, Yen SH, Kanaan NM, Ueno A, Suzuki J, Ikawa M, Matsunaga A, Yamamura O, Kuriyama M, Nakamoto Y.

Biochem Biophys Res Commun. 2016 Sep 23;478(3):1035-42. doi: 10.1016/j.bbrc.2016.08.016. Epub 2016 Aug 16.

PMID:
27543203
23.

Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport.

Tiernan CT, Combs B, Cox K, Morfini G, Brady ST, Counts SE, Kanaan NM.

Exp Neurol. 2016 Sep;283(Pt A):318-29. doi: 10.1016/j.expneurol.2016.06.030. Epub 2016 Jun 30.

24.

Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies.

Combs B, Hamel C, Kanaan NM.

Neurobiol Dis. 2016 Oct;94:18-31. doi: 10.1016/j.nbd.2016.05.016. Epub 2016 May 31.

25.

Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease.

Tiernan CT, Ginsberg SD, Guillozet-Bongaarts AL, Ward SM, He B, Kanaan NM, Mufson EJ, Binder LI, Counts SE.

Neurobiol Aging. 2016 Jun;42:80-90. doi: 10.1016/j.neurobiolaging.2016.02.031. Epub 2016 Mar 8.

26.

Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures.

Kneynsberg A, Collier TJ, Manfredsson FP, Kanaan NM.

J Neurosci Methods. 2016 Jun 15;266:32-41. doi: 10.1016/j.jneumeth.2016.03.004. Epub 2016 Mar 28.

27.

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.

Fá M, Puzzo D, Piacentini R, Staniszewski A, Zhang H, Baltrons MA, Li Puma DD, Chatterjee I, Li J, Saeed F, Berman HL, Ripoli C, Gulisano W, Gonzalez J, Tian H, Costa JA, Lopez P, Davidowitz E, Yu WH, Haroutunian V, Brown LM, Palmeri A, Sigurdsson EM, Duff KE, Teich AF, Honig LS, Sierks M, Moe JG, D'Adamio L, Grassi C, Kanaan NM, Fraser PE, Arancio O.

Sci Rep. 2016 Jan 20;6:19393. doi: 10.1038/srep19393.

28.

Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy.

Kanaan NM, Cox K, Alvarez VE, Stein TD, Poncil S, McKee AC.

J Neuropathol Exp Neurol. 2016 Jan;75(1):19-34.

29.

Gene Therapy Models of Alzheimer's Disease and Other Dementias.

Combs B, Kneynsberg A, Kanaan NM.

Methods Mol Biol. 2016;1382:339-66. doi: 10.1007/978-1-4939-3271-9_25.

30.

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration.

Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, Lee VM, Sortwell CE.

Neurobiol Dis. 2015 Oct;82:185-199. doi: 10.1016/j.nbd.2015.06.003. Epub 2015 Jun 17.

31.

The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes.

Kanaan NM, Collier TJ, Cole-Strauss A, Grabinski T, Mattingly ZR, Winn ME, Steece-Collier K, Sortwell CE, Manfredsson FP, Lipton JW.

PLoS One. 2015 May 20;10(5):e0127768. doi: 10.1371/journal.pone.0127768. eCollection 2015.

32.

A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures.

Grabinski TM, Kneynsberg A, Manfredsson FP, Kanaan NM.

PLoS One. 2015 Mar 20;10(3):e0120120. doi: 10.1371/journal.pone.0120120. eCollection 2015.

33.

Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain.

Polinski NK, Gombash SE, Manfredsson FP, Lipton JW, Kemp CJ, Cole-Strauss A, Kanaan NM, Steece-Collier K, Kuhn NC, Wohlgenant SL, Sortwell CE.

Neurobiol Aging. 2015 Feb;36(2):1110-20. doi: 10.1016/j.neurobiolaging.2014.07.047. Epub 2014 Oct 13.

34.

Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system.

Kanaan NM, Pigino GF, Brady ST, Lazarov O, Binder LI, Morfini GA.

Exp Neurol. 2013 Aug;246:44-53. doi: 10.1016/j.expneurol.2012.06.003. Epub 2012 Jun 19. Review.

35.

Loss of functional alpha-synuclein: a toxic event in Parkinson's disease?

Kanaan NM, Manfredsson FP.

J Parkinsons Dis. 2012;2(4):249-67. doi: 10.3233/JPD-012138. Review.

36.

Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.

Patterson KR, Ward SM, Combs B, Voss K, Kanaan NM, Morfini G, Brady ST, Gamblin TC, Binder LI.

Biochemistry. 2011 Nov 29;50(47):10300-10. doi: 10.1021/bi2009147. Epub 2011 Nov 8.

37.

Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.

Vana L, Kanaan NM, Ugwu IC, Wuu J, Mufson EJ, Binder LI.

Am J Pathol. 2011 Nov;179(5):2533-50. doi: 10.1016/j.ajpath.2011.07.044. Epub 2011 Sep 23.

38.

Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.

Kanaan NM, Morfini G, Pigino G, LaPointe NE, Andreadis A, Song Y, Leitman E, Binder LI, Brady ST.

Neurobiol Aging. 2012 Apr;33(4):826.e15-30. doi: 10.1016/j.neurobiolaging.2011.06.006. Epub 2011 Jul 27.

39.

Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases.

Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI.

J Neurosci. 2011 Jul 6;31(27):9858-68. doi: 10.1523/JNEUROSCI.0560-11.2011.

40.

Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates.

Collier TJ, Kanaan NM, Kordower JH.

Nat Rev Neurosci. 2011 Jun;12(6):359-66. doi: 10.1038/nrn3039. Epub 2011 May 18. Review.

41.

Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

Patterson KR, Remmers C, Fu Y, Brooker S, Kanaan NM, Vana L, Ward S, Reyes JF, Philibert K, Glucksman MJ, Binder LI.

J Biol Chem. 2011 Jul 1;286(26):23063-76. doi: 10.1074/jbc.M111.237974. Epub 2011 May 6.

42.

Tyrosine nitration within the proline-rich region of Tau in Alzheimer's disease.

Reyes JF, Fu Y, Vana L, Kanaan NM, Binder LI.

Am J Pathol. 2011 May;178(5):2275-85. doi: 10.1016/j.ajpath.2011.01.030.

43.

Peroxynitrite-induced nitrative and oxidative modifications alter tau filament formation.

Vana L, Kanaan NM, Hakala K, Weintraub ST, Binder LI.

Biochemistry. 2011 Feb 22;50(7):1203-12. doi: 10.1021/bi101735m. Epub 2011 Jan 26.

44.

Axonal transport defects in neurodegenerative diseases.

Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH Jr, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST.

J Neurosci. 2009 Oct 14;29(41):12776-86. doi: 10.1523/JNEUROSCI.3463-09.2009. Review.

45.

Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys.

Kanaan NM, Kordower JH, Collier TJ.

Neurobiol Aging. 2010 Jun;31(6):937-52. doi: 10.1016/j.neurobiolaging.2008.07.006. Epub 2008 Aug 19.

46.
48.

Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerability.

Kanaan NM, Kordower JH, Collier TJ.

J Comp Neurol. 2007 Jun 10;502(5):683-700. Erratum in: J Comp Neurol. 2007 Aug 1;503(4):592.

PMID:
17436290
49.

MDMA administration to pregnant Sprague-Dawley rats results in its passage to the fetal compartment.

Campbell NG, Koprich JB, Kanaan NM, Lipton JW.

Neurotoxicol Teratol. 2006 Jul-Aug;28(4):459-65. Epub 2006 Jun 8.

PMID:
16905291
50.

Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.

Kordower JH, Kanaan NM, Chu Y, Suresh Babu R, Stansell J 3rd, Terpstra BT, Sortwell CE, Steece-Collier K, Collier TJ.

Ann Neurol. 2006 Aug;60(2):264-8.

PMID:
16862579

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