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Items: 41


Application of model systems to study adaptive responses of Mycobacterium tuberculosis during infection and disease.

Gordhan BG, Peters J, Kana BD.

Adv Appl Microbiol. 2019;108:115-161. doi: 10.1016/bs.aambs.2019.08.001. Epub 2019 Aug 26.


L,D-Transpeptidase Specific Probe Reveals Spatial Activity of Peptidoglycan Cross-Linking.

Pidgeon SE, Apostolos AJ, Nelson JM, Shaku M, Rimal B, Islam MN, Crick DC, Kim SJ, Pavelka MS, Kana BD, Pires MM.

ACS Chem Biol. 2019 Oct 18;14(10):2185-2196. doi: 10.1021/acschembio.9b00427. Epub 2019 Sep 16.


Characterization of putative DD-carboxypeptidase-encoding genes in Mycobacterium smegmatis.

Ealand CS, Asmal R, Mashigo L, Campbell L, Kana BD.

Sci Rep. 2019 Mar 26;9(1):5194. doi: 10.1038/s41598-019-41001-x.


Remembering the Host in Tuberculosis Drug Development.

Frank DJ, Horne DJ, Dutta NK, Shaku MT, Madensein R, Hawn TR, Steyn AJC, Karakousis PC, Kana BD, Meintjes G, Laughon B, Tanvir Z.

J Infect Dis. 2019 Apr 19;219(10):1518-1524. doi: 10.1093/infdis/jiy712. Review.


Advances in the understanding of Mycobacterium tuberculosis transmission in HIV-endemic settings.

Peters JS, Andrews JR, Hatherill M, Hermans S, Martinez L, Schurr E, van der Heijden Y, Wood R, Rustomjee R, Kana BD.

Lancet Infect Dis. 2019 Mar;19(3):e65-e76. doi: 10.1016/S1473-3099(18)30477-8. Epub 2018 Dec 13. Review.


Breaking down walls.

Shaku MT, Kana BD.

Elife. 2018 Oct 24;7. pii: e42033. doi: 10.7554/eLife.42033.


Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe.

Kamariza M, Shieh P, Ealand CS, Peters JS, Chu B, Rodriguez-Rivera FP, Babu Sait MR, Treuren WV, Martinson N, Kalscheuer R, Kana BD, Bertozzi CR.

Sci Transl Med. 2018 Feb 28;10(430). pii: eaam6310. doi: 10.1126/scitranslmed.aam6310.


Genetic Mimetics of Mycobacterium tuberculosis and Methicillin-Resistant Staphylococcus aureus as Verification Standards for Molecular Diagnostics.

Machowski EE, Kana BD.

J Clin Microbiol. 2017 Dec;55(12):3384-3394. doi: 10.1128/JCM.01111-17. Epub 2017 Sep 20.


Relapse, re-infection and mixed infections in tuberculosis disease.

McIvor A, Koornhof H, Kana BD.

Pathog Dis. 2017 Apr 1;75(3). doi: 10.1093/femspd/ftx020. Review.


The essential mycobacterial amidotransferase GatCAB is a modulator of specific translational fidelity.

Su HW, Zhu JH, Li H, Cai RJ, Ealand C, Wang X, Chen YX, Kayani MU, Zhu TF, Moradigaravand D, Huang H, Kana BD, Javid B.

Nat Microbiol. 2016 Aug 26;1(11):16147. doi: 10.1038/nmicrobiol.2016.147.


Detection and Quantification of Differentially Culturable Tubercle Bacteria in Sputum from Patients with Tuberculosis.

Chengalroyen MD, Beukes GM, Gordhan BG, Streicher EM, Churchyard G, Hafner R, Warren R, Otwombe K, Martinson N, Kana BD.

Am J Respir Crit Care Med. 2016 Dec 15;194(12):1532-1540.


Activity of phosphino palladium(II) and platinum(II) complexes against HIV-1 and Mycobacterium tuberculosis.

Gama NH, Elkhadir AY, Gordhan BG, Kana BD, Darkwa J, Meyer D.

Biometals. 2016 Aug;29(4):637-50. doi: 10.1007/s10534-016-9940-6. Epub 2016 May 31.


A combinatorial role for MutY and Fpg DNA glycosylases in mutation avoidance in Mycobacterium smegmatis.

Hassim F, Papadopoulos AO, Kana BD, Gordhan BG.

Mutat Res. 2015 Sep;779:24-32. doi: 10.1016/j.mrfmmm.2015.06.002. Epub 2015 Jun 9.


Cleavage of the moaX-encoded fused molybdopterin synthase from Mycobacterium tuberculosis is necessary for activity.

Narrandes NC, Machowski EE, Mizrahi V, Kana BD.

BMC Microbiol. 2015 Feb 6;15:22. doi: 10.1186/s12866-015-0355-2.


Future target-based drug discovery for tuberculosis?

Kana BD, Karakousis PC, Parish T, Dick T.

Tuberculosis (Edinb). 2014 Dec;94(6):551-6. Review.


bis-Molybdopterin guanine dinucleotide is required for persistence of Mycobacterium tuberculosis in guinea pigs.

Williams MJ, Shanley CA, Zilavy A, Peixoto B, Manca C, Kaplan G, Orme IM, Mizrahi V, Kana BD.

Infect Immun. 2015 Feb;83(2):544-50. doi: 10.1128/IAI.02722-14. Epub 2014 Nov 17.


Comparative genomics for mycobacterial peptidoglycan remodelling enzymes reveals extensive genetic multiplicity.

Machowski EE, Senzani S, Ealand C, Kana BD.

BMC Microbiol. 2014 Mar 24;14:75. doi: 10.1186/1471-2180-14-75.


Energy metabolism and drug efflux in Mycobacterium tuberculosis.

Black PA, Warren RM, Louw GE, van Helden PD, Victor TC, Kana BD.

Antimicrob Agents Chemother. 2014 May;58(5):2491-503. doi: 10.1128/AAC.02293-13. Epub 2014 Mar 10. Review.


The contribution of Nth and Nei DNA glycosylases to mutagenesis in Mycobacterium smegmatis.

Moolla N, Goosens VJ, Kana BD, Gordhan BG.

DNA Repair (Amst). 2014 Jan;13:32-41. doi: 10.1016/j.dnarep.2013.11.003. Epub 2013 Dec 15.


Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.

Small JL, Park SW, Kana BD, Ioerger TR, Sacchettini JC, Ehrt S.

mBio. 2013 Sep 17;4(5):e00475-13. doi: 10.1128/mBio.00475-13.


Molybdenum cofactor: a key component of Mycobacterium tuberculosis pathogenesis?

Williams M, Mizrahi V, Kana BD.

Crit Rev Microbiol. 2014 Feb;40(1):18-29. doi: 10.3109/1040841X.2012.749211. Epub 2013 Jan 15. Review.


Dried culture spots for Xpert MTB/RIF external quality assessment: results of a phase 1 pilot study in South Africa.

Scott LE, Gous N, Cunningham BE, Kana BD, Perovic O, Erasmus L, Coetzee GJ, Koornhof H, Stevens W.

J Clin Microbiol. 2011 Dec;49(12):4356-60. doi: 10.1128/JCM.05167-11. Epub 2011 Oct 5.


Mycobacterium tuberculosis attenuated by multiple deletions of rpf genes effectively protects mice against TB infection.

Kondratieva T, Rubakova E, Kana BD, Biketov S, Potapov V, Kaprelyants A, Apt A.

Tuberculosis (Edinb). 2011 May;91(3):219-23. doi: 10.1016/ Epub 2011 Mar 17.


Functional analysis of molybdopterin biosynthesis in mycobacteria identifies a fused molybdopterin synthase in Mycobacterium tuberculosis.

Williams MJ, Kana BD, Mizrahi V.

J Bacteriol. 2011 Jan;193(1):98-106. doi: 10.1128/JB.00774-10. Epub 2010 Oct 22.


Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis.

Warner DF, Ndwandwe DE, Abrahams GL, Kana BD, Machowski EE, Venclovas C, Mizrahi V.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13093-8. doi: 10.1073/pnas.1002614107. Epub 2010 Jul 6.


Depletion of resuscitation-promoting factors has limited impact on the drug susceptibility of Mycobacterium tuberculosis.

Kana BD, Mizrahi V, Gordhan BG.

J Antimicrob Chemother. 2010 Aug;65(8):1583-5. doi: 10.1093/jac/dkq199. Epub 2010 Jun 11.


Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis.

Kana BD, Abrahams GL, Sung N, Warner DF, Gordhan BG, Machowski EE, Tsenova L, Sacchettini JC, Stoker NG, Kaplan G, Mizrahi V.

J Bacteriol. 2010 Apr;192(8):2220-7. doi: 10.1128/JB.01135-09. Epub 2010 Feb 5.


Resuscitation-promoting factors as lytic enzymes for bacterial growth and signaling.

Kana BD, Mizrahi V.

FEMS Immunol Med Microbiol. 2010 Feb;58(1):39-50. doi: 10.1111/j.1574-695X.2009.00606.x. Epub 2009 Sep 4. Review.


Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria.

Mowa MB, Warner DF, Kaplan G, Kana BD, Mizrahi V.

J Bacteriol. 2009 Feb;191(3):985-95. doi: 10.1128/JB.01409-08. Epub 2008 Nov 21.


The molecular and cellular basis of infection-Perspectives from the first advanced summer school in Africa.

Kana BD, Bonazzi M, Calzavara-Silva CE.

IUBMB Life. 2009 Feb;61(2):85-90. doi: 10.1002/iub.126. No abstract available.


Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids.

Savvi S, Warner DF, Kana BD, McKinney JD, Mizrahi V, Dawes SS.

J Bacteriol. 2008 Jun;190(11):3886-95. doi: 10.1128/JB.01767-07. Epub 2008 Mar 28.


The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro.

Kana BD, Gordhan BG, Downing KJ, Sung N, Vostroktunova G, Machowski EE, Tsenova L, Young M, Kaprelyants A, Kaplan G, Mizrahi V.

Mol Microbiol. 2008 Feb;67(3):672-84. doi: 10.1111/j.1365-2958.2007.06078.x.


Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration.

Shi L, Sohaskey CD, Kana BD, Dawes S, North RJ, Mizrahi V, Gennaro ML.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15629-34. Epub 2005 Oct 14.


Function of the cytochrome bc1-aa3 branch of the respiratory network in mycobacteria and network adaptation occurring in response to its disruption.

Matsoso LG, Kana BD, Crellin PK, Lea-Smith DJ, Pelosi A, Powell D, Dawes SS, Rubin H, Coppel RL, Mizrahi V.

J Bacteriol. 2005 Sep;187(18):6300-8.


Molecular genetics of Mycobacterium tuberculosis in relation to the discovery of novel drugs and vaccines.

Kana BD, Mizrahi V.

Tuberculosis (Edinb). 2004;84(1-2):63-75. Review.


Characterization of the cydAB-encoded cytochrome bd oxidase from Mycobacterium smegmatis.

Kana BD, Weinstein EA, Avarbock D, Dawes SS, Rubin H, Mizrahi V.

J Bacteriol. 2001 Dec;183(24):7076-86.

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