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An Advanced ICTVSS Model for Real-Time Vehicle Traffic Applications.

Chen YS, Lin CK, Kan YW.

Sensors (Basel). 2019 Sep 24;19(19). pii: E4134. doi: 10.3390/s19194134.


The CRISPR/Cas9-mediated gene deletion efficiently retards the progression of Philadelphia-positive acute lymphoblastic leukemia in a p210 BCR-ABL1T315I mutation mouse model.

Tan YT, Ye L, Xie F, Wang J, Müschen M, Chen SJ, Kan YW, Liu H.

Haematologica. 2019 Sep 19. pii: haematol.2019.229013. doi: 10.3324/haematol.2019.229013. [Epub ahead of print]


Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor.

Tan YT, Ye L, Xie F, Beyer AI, Muench MO, Wang J, Chen Z, Liu H, Chen SJ, Kan YW.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2180-2185. doi: 10.1073/pnas.1718446115. Epub 2018 Jan 31.


Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia.

Ye L, Wang J, Tan Y, Beyer AI, Xie F, Muench MO, Kan YW.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10661-5. doi: 10.1073/pnas.1612075113. Epub 2016 Sep 6.


Reversible Immortalization Enables Seamless Transdifferentiation of Primary Fibroblasts into Other Lineage Cells.

Xie F, Gong K, Li K, Zhang M, Chang JC, Jiang S, Ye L, Wang J, Tan Y, Kan YW.

Stem Cells Dev. 2016 Aug 15;25(16):1243-8. doi: 10.1089/scd.2016.0035. Epub 2016 Jul 28.


TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs.

Suzuki S, Sargent RG, Illek B, Fischer H, Esmaeili-Shandiz A, Yezzi MJ, Lee A, Yang Y, Kim S, Renz P, Qi Z, Yu J, Muench MO, Beyer AI, Guimarães AO, Ye L, Chang J, Fine EJ, Cradick TJ, Bao G, Rahdar M, Porteus MH, Shuto T, Kai H, Kan YW, Gruenert DC.

Mol Ther Nucleic Acids. 2016 Jan 5;5:e273. doi: 10.1038/mtna.2015.43.


Nrf2 in health and disease: current and future clinical implications.

Al-Sawaf O, Clarner T, Fragoulis A, Kan YW, Pufe T, Streetz K, Wruck CJ.

Clin Sci (Lond). 2015 Dec;129(12):989-99. doi: 10.1042/CS20150436. Review.


Nrf2 augments skeletal muscle regeneration after ischaemia-reperfusion injury.

Al-Sawaf O, Fragoulis A, Rosen C, Keimes N, Liehn EA, Hölzle F, Kan YW, Pufe T, Sönmez TT, Wruck CJ.

J Pathol. 2014 Dec;234(4):538-47. doi: 10.1002/path.4418. Epub 2014 Sep 16.


Nrf2 deficiency impairs fracture healing in mice.

Lippross S, Beckmann R, Streubesand N, Ayub F, Tohidnezhad M, Campbell G, Kan YW, Horst F, Sönmez TT, Varoga D, Lichte P, Jahr H, Pufe T, Wruck CJ.

Calcif Tissue Int. 2014 Oct;95(4):349-61. doi: 10.1007/s00223-014-9900-5. Epub 2014 Aug 6.


Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac.

Xie F, Ye L, Chang JC, Beyer AI, Wang J, Muench MO, Kan YW.

Genome Res. 2014 Sep;24(9):1526-33. doi: 10.1101/gr.173427.114. Epub 2014 Aug 5.


Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection.

Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, Chang JC, Bao G, Muench MO, Yu J, Levy JA, Kan YW.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9591-6. doi: 10.1073/pnas.1407473111. Epub 2014 Jun 9.


Interplay between nuclear factor erythroid 2-related factor 2 and amphiregulin during mechanical ventilation.

Reiss LK, Fragoulis A, Siegl S, Platen C, Kan YW, Nautiyal J, Parker M, Pufe T, Uhlig U, Martin C, Uhlig S, Wruck CJ.

Am J Respir Cell Mol Biol. 2014 Nov;51(5):668-77. doi: 10.1165/rcmb.2013-0279OC.


Nrf2 protects against TWEAK-mediated skeletal muscle wasting.

Al-Sawaf O, Fragoulis A, Rosen C, Kan YW, Sönmez TT, Pufe T, Wruck CJ.

Sci Rep. 2014 Jan 10;4:3625. doi: 10.1038/srep03625.


Blood cell-derived induced pluripotent stem cells free of reprogramming factors generated by Sendai viral vectors.

Ye L, Muench MO, Fusaki N, Beyer AI, Wang J, Qi Z, Yu J, Kan YW.

Stem Cells Transl Med. 2013 Aug;2(8):558-66. doi: 10.5966/sctm.2013-0006. Epub 2013 Jul 11.


The prevention of thalassemia.

Cao A, Kan YW.

Cold Spring Harb Perspect Med. 2013 Feb 1;3(2):a011775. doi: 10.1101/cshperspect.a011775. Review.


Coexpression of VEGF and angiopoietin-1 promotes angiogenesis and cardiomyocyte proliferation reduces apoptosis in porcine myocardial infarction (MI) heart.

Tao Z, Chen B, Tan X, Zhao Y, Wang L, Zhu T, Cao K, Yang Z, Kan YW, Su H.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2064-9. doi: 10.1073/pnas.1018925108. Epub 2011 Jan 18.


Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice.

Wruck CJ, Fragoulis A, Gurzynski A, Brandenburg LO, Kan YW, Chan K, Hassenpflug J, Freitag-Wolf S, Varoga D, Lippross S, Pufe T.

Ann Rheum Dis. 2011 May;70(5):844-50. doi: 10.1136/ard.2010.132720. Epub 2010 Dec 20.


Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter.

Wruck CJ, Streetz K, Pavic G, Götz ME, Tohidnezhad M, Brandenburg LO, Varoga D, Eickelberg O, Herdegen T, Trautwein C, Cha K, Kan YW, Pufe T.

J Biol Chem. 2011 Feb 11;286(6):4493-9. doi: 10.1074/jbc.M110.162008. Epub 2010 Dec 2.


Generation of induced pluripotent stem cells using site-specific integration with phage integrase.

Ye L, Chang JC, Lin C, Qi Z, Yu J, Kan YW.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19467-72. doi: 10.1073/pnas.1012677107. Epub 2010 Oct 25.


Molecular diagnosis of hemoglobinopathies and thalassemia.

Kan YW, Chang JC.

Prenat Diagn. 2010 Jul;30(7):608-10. doi: 10.1002/pd.2479. No abstract available.


Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice.

Yu S, Khor TO, Cheung KL, Li W, Wu TY, Huang Y, Foster BA, Kan YW, Kong AN.

PLoS One. 2010 Jan 5;5(1):e8579. doi: 10.1371/journal.pone.0008579.


Signalling molecules involved in mouse bladder smooth muscle cellular differentiation.

Liu B, Feng D, Lin G, Cao M, Kan YW, Cunha GR, Baskin LS.

Int J Dev Biol. 2010;54(1):175-80. doi: 10.1387/ijdb.082610bl.


Combining angiogenic gene and stem cell therapies for myocardial infarction.

Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H.

J Gene Med. 2009 Sep;11(9):743-53. doi: 10.1002/jgm.1362.


Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases.

Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9826-30. doi: 10.1073/pnas.0904689106. Epub 2009 May 29.


Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte.

Chen PC, Vargas MR, Pani AK, Smeyne RJ, Johnson DA, Kan YW, Johnson JA.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2933-8. doi: 10.1073/pnas.0813361106. Epub 2009 Feb 5.


Permanent coronary artery occlusion: cardiovascular MR imaging is platform for percutaneous transendocardial delivery and assessment of gene therapy in canine model.

Saeed M, Martin A, Jacquier A, Bucknor M, Saloner D, Do L, Ursell P, Su H, Kan YW, Higgins CB.

Radiology. 2008 Nov;249(2):560-71. doi: 10.1148/radiol.2491072068. Epub 2008 Sep 9.


Development of human single-chain antibodies against SARS-associated coronavirus.

Leung KM, Feng DX, Lou J, Zhou Y, Fung KP, Waye MM, Tsui SK, Chan PK, Marks JD, Pang SF, Kan YW.

Intervirology. 2008;51(3):173-81. doi: 10.1159/000151530. Epub 2008 Aug 25.


The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis.

Xu W, Hellerbrand C, Köhler UA, Bugnon P, Kan YW, Werner S, Beyer TA.

Lab Invest. 2008 Oct;88(10):1068-78. doi: 10.1038/labinvest.2008.75. Epub 2008 Aug 4.


Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart.

Su H, Takagawa J, Huang Y, Arakawa-Hoyt J, Pons J, Grossman W, Kan YW.

Int J Cardiol. 2009 Apr 3;133(2):191-7. doi: 10.1016/j.ijcard.2007.12.034. Epub 2008 Mar 4.


High oxygen environment during pregnancy rescues sickle cell anemia mice from prenatal death.

Ye L, Chang JC, Lu R, Kan YW.

Blood Cells Mol Dis. 2008 Jul-Aug;41(1):67-72. doi: 10.1016/j.bcmd.2007.12.002. Epub 2008 Jan 22.


Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance.

Beyer TA, Xu W, Teupser D, auf dem Keller U, Bugnon P, Hildt E, Thiery J, Kan YW, Werner S.

EMBO J. 2008 Jan 9;27(1):212-23. Epub 2007 Dec 6.


AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid.

Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, Grossman W, Kan YW.

J Gene Med. 2008 Jan;10(1):33-41.


Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage.

Zhao X, Sun G, Zhang J, Strong R, Dash PK, Kan YW, Grotta JC, Aronowski J.

Stroke. 2007 Dec;38(12):3280-6. Epub 2007 Oct 25.


Fetal gene therapy of alpha-thalassemia in a mouse model.

Han XD, Lin C, Chang J, Sadelain M, Kan YW.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):9007-11. Epub 2007 May 11.


Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element.

Kraft AD, Lee JM, Johnson DA, Kan YW, Johnson JA.

J Neurochem. 2006 Sep;98(6):1852-65.


AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect.

Su H, Huang Y, Takagawa J, Barcena A, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW.

Gene Ther. 2006 Nov;13(21):1495-502. Epub 2006 Jun 15.


Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain.

Shen F, Su H, Liu W, Kan YW, Young WL, Yang GY.

Front Biosci. 2006 Sep 1;11:3190-8.


Yuet Wai Kan, MD: sickle cell and thalassemia pioneer. Interview by Tracy Hampton.

Kan YW.

JAMA. 2006 Mar 1;295(9):991. No abstract available.


Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice.

Hu X, Roberts JR, Apopa PL, Kan YW, Ma Q.

Mol Cell Biol. 2006 Feb;26(3):940-54.


Correction of the sickle cell mutation in embryonic stem cells.

Chang JC, Ye L, Kan YW.

Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1036-40. Epub 2006 Jan 11.


Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription.

Calkins MJ, Jakel RJ, Johnson DA, Chan K, Kan YW, Johnson JA.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):244-9. Epub 2004 Dec 20.


Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts.

Su H, Joho S, Huang Y, Barcena A, Arakawa-Hoyt J, Grossman W, Kan YW.

Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16280-5. Epub 2004 Nov 8.


Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia.

Lee JM, Chan K, Kan YW, Johnson JA.

Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9751-6. Epub 2004 Jun 21.


Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation.

Marini MG, Asunis I, Chan K, Chan JY, Kan YW, Porcu L, Cao A, Moi P.

Blood Cells Mol Dis. 2002 Sep-Oct;29(2):145-58.


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