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Items: 30

1.

Enhancing FcγR-mediated antibody effector function during persistent viral infection.

Wieland A, Kamphorst AO, Valanparambil RM, Han JH, Xu X, Choudhury BP, Ahmed R.

Sci Immunol. 2018 Sep 21;3(27). pii: eaao3125. doi: 10.1126/sciimmunol.aao3125.

PMID:
30242080
2.

T cell receptor sequencing of activated CD8 T cells in the blood identifies tumor-infiltrating clones that expand after PD-1 therapy and radiation in a melanoma patient.

Wieland A, Kamphorst AO, Adsay NV, Masor JJ, Sarmiento J, Nasti TH, Darko S, Douek DC, Xue Y, Curran WJ, Lawson DH, Ahmed R.

Cancer Immunol Immunother. 2018 Aug 22. doi: 10.1007/s00262-018-2228-7. [Epub ahead of print]

PMID:
30167863
3.

CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions.

Hashimoto M, Kamphorst AO, Im SJ, Kissick HT, Pillai RN, Ramalingam SS, Araki K, Ahmed R.

Annu Rev Med. 2018 Jan 29;69:301-318. doi: 10.1146/annurev-med-012017-043208.

PMID:
29414259
4.

Immune checkpoint inhibitors in advanced non-small cell lung cancer.

Assi HI, Kamphorst AO, Moukalled NM, Ramalingam SS.

Cancer. 2018 Jan 15;124(2):248-261. doi: 10.1002/cncr.31105. Epub 2017 Dec 6. Review.

PMID:
29211297
5.

Comparison of the toxicity profile of PD-1 versus PD-L1 inhibitors in non-small cell lung cancer: A systematic analysis of the literature.

Pillai RN, Behera M, Owonikoko TK, Kamphorst AO, Pakkala S, Belani CP, Khuri FR, Ahmed R, Ramalingam SS.

Cancer. 2018 Jan 15;124(2):271-277. doi: 10.1002/cncr.31043. Epub 2017 Sep 28.

PMID:
28960263
6.

Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients.

Kamphorst AO, Pillai RN, Yang S, Nasti TH, Akondy RS, Wieland A, Sica GL, Yu K, Koenig L, Patel NT, Behera M, Wu H, McCausland M, Chen Z, Zhang C, Khuri FR, Owonikoko TK, Ahmed R, Ramalingam SS.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):4993-4998. doi: 10.1073/pnas.1705327114. Epub 2017 Apr 26.

7.

Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.

Kamphorst AO, Wieland A, Nasti T, Yang S, Zhang R, Barber DL, Konieczny BT, Daugherty CZ, Koenig L, Yu K, Sica GL, Sharpe AH, Freeman GJ, Blazar BR, Turka LA, Owonikoko TK, Pillai RN, Ramalingam SS, Araki K, Ahmed R.

Science. 2017 Mar 31;355(6332):1423-1427. doi: 10.1126/science.aaf0683. Epub 2017 Mar 9.

8.

Cardiac allograft rejection as a complication of PD-1 checkpoint blockade for cancer immunotherapy: a case report.

Owonikoko TK, Kumar M, Yang S, Kamphorst AO, Pillai RN, Akondy R, Nautiyal V, Chatwal MS, Book WM, Sahu A, Sica GL, Ahmed R, Ramalingam SS.

Cancer Immunol Immunother. 2017 Jan;66(1):45-50. doi: 10.1007/s00262-016-1918-2. Epub 2016 Oct 22.

9.

Dendritic Cells in Tolerance and Immunity against Pathogens.

Boscardin SB, Rosa DS, Kamphorst AO, Trumpfheller C.

J Immunol Res. 2016;2016:6438036. doi: 10.1155/2016/6438036. Epub 2016 Mar 31. No abstract available.

10.

Beyond adjuvants: immunomodulation strategies to enhance T cell immunity.

Kamphorst AO, Araki K, Ahmed R.

Vaccine. 2015 Jun 8;33 Suppl 2:B21-8. doi: 10.1016/j.vaccine.2014.12.082. Review.

11.

Antibody effector functions mediated by Fcγ-receptors are compromised during persistent viral infection.

Wieland A, Shashidharamurthy R, Kamphorst AO, Han JH, Aubert RD, Choudhury BP, Stowell SR, Lee J, Punkosdy GA, Shlomchik MJ, Selvaraj P, Ahmed R.

Immunity. 2015 Feb 17;42(2):367-378. doi: 10.1016/j.immuni.2015.01.009. Epub 2015 Feb 10.

12.

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.

Penaloza-MacMaster P, Kamphorst AO, Wieland A, Araki K, Iyer SS, West EE, O'Mara L, Yang S, Konieczny BT, Sharpe AH, Freeman GJ, Rudensky AY, Ahmed R.

J Exp Med. 2014 Aug 25;211(9):1905-18. doi: 10.1084/jem.20132577. Epub 2014 Aug 11.

13.

CD4 T-cell immunotherapy for chronic viral infections and cancer.

Kamphorst AO, Ahmed R.

Immunotherapy. 2013 Sep;5(9):975-87. doi: 10.2217/imt.13.91. Review.

14.

Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.

Guermonprez P, Helft J, Claser C, Deroubaix S, Karanje H, Gazumyan A, Darasse-Jèze G, Telerman SB, Breton G, Schreiber HA, Frias-Staheli N, Billerbeck E, Dorner M, Rice CM, Ploss A, Klein F, Swiecki M, Colonna M, Kamphorst AO, Meredith M, Niec R, Takacs C, Mikhail F, Hari A, Bosque D, Eisenreich T, Merad M, Shi Y, Ginhoux F, Rénia L, Urban BC, Nussenzweig MC.

Nat Med. 2013 Jun;19(6):730-8. doi: 10.1038/nm.3197. Epub 2013 May 19.

15.

Manipulating the PD-1 pathway to improve immunity.

Kamphorst AO, Ahmed R.

Curr Opin Immunol. 2013 Jun;25(3):381-8. doi: 10.1016/j.coi.2013.03.003. Epub 2013 Apr 9. Review.

16.

Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.

Meredith MM, Liu K, Kamphorst AO, Idoyaga J, Yamane A, Guermonprez P, Rihn S, Yao KH, Silva IT, Oliveira TY, Skokos D, Casellas R, Nussenzweig MC.

J Exp Med. 2012 Aug 27;209(9):1583-93. doi: 10.1084/jem.20121003. Epub 2012 Jul 30.

17.

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.

Meredith MM, Liu K, Darrasse-Jeze G, Kamphorst AO, Schreiber HA, Guermonprez P, Idoyaga J, Cheong C, Yao KH, Niec RE, Nussenzweig MC.

J Exp Med. 2012 Jun 4;209(6):1153-65. doi: 10.1084/jem.20112675. Epub 2012 May 21.

18.

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.

Aubert RD, Kamphorst AO, Sarkar S, Vezys V, Ha SJ, Barber DL, Ye L, Sharpe AH, Freeman GJ, Ahmed R.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21182-7. doi: 10.1073/pnas.1118450109. Epub 2011 Dec 12.

19.

A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center.

Schwickert TA, Victora GD, Fooksman DR, Kamphorst AO, Mugnier MR, Gitlin AD, Dustin ML, Nussenzweig MC.

J Exp Med. 2011 Jun 6;208(6):1243-52. doi: 10.1084/jem.20102477. Epub 2011 May 16.

20.

Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.

Victora GD, Schwickert TA, Fooksman DR, Kamphorst AO, Meyer-Hermann M, Dustin ML, Nussenzweig MC.

Cell. 2010 Nov 12;143(4):592-605. doi: 10.1016/j.cell.2010.10.032.

21.

Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes.

Kamphorst AO, Guermonprez P, Dudziak D, Nussenzweig MC.

J Immunol. 2010 Sep 15;185(6):3426-35. doi: 10.4049/jimmunol.1001205. Epub 2010 Aug 20.

22.

Innate profiles of cytokines implicated on oral tolerance correlate with low- or high-suppression of humoral response.

Silva MF, Kamphorst AO, Hayashi EA, Bellio M, Carvalho CR, Faria AM, Sabino KC, Coelho MG, Nobrega A, Tavares D, Silva AC.

Immunology. 2010 Jul;130(3):447-57. doi: 10.1111/j.1365-2567.2010.03248.x. Epub 2010 Mar 16.

23.

A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells.

Bougnères L, Helft J, Tiwari S, Vargas P, Chang BH, Chan L, Campisi L, Lauvau G, Hugues S, Kumar P, Kamphorst AO, Dumenil AM, Nussenzweig M, MacMicking JD, Amigorena S, Guermonprez P.

Immunity. 2009 Aug 21;31(2):232-44. doi: 10.1016/j.immuni.2009.06.022.

24.

Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation.

Obst R, van Santen HM, Melamed R, Kamphorst AO, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15460-5. Epub 2007 Sep 19.

25.

A mammalian microRNA expression atlas based on small RNA library sequencing.

Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T.

Cell. 2007 Jun 29;129(7):1401-14.

26.

Differential antigen processing by dendritic cell subsets in vivo.

Dudziak D, Kamphorst AO, Heidkamp GF, Buchholz VR, Trumpfheller C, Yamazaki S, Cheong C, Liu K, Lee HW, Park CG, Steinman RM, Nussenzweig MC.

Science. 2007 Jan 5;315(5808):107-11.

27.

The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions.

Faria AM, Levay A, Wang Y, Kamphorst AO, Rosa ML, Nussenzveig DR, Balkan W, Chook YM, Levy DE, Fontoura BM.

Immunity. 2006 Mar;24(3):295-304.

28.

Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses.

Boscardin SB, Hafalla JC, Masilamani RF, Kamphorst AO, Zebroski HA, Rai U, Morrot A, Zavala F, Steinman RM, Nussenzweig RS, Nussenzweig MC.

J Exp Med. 2006 Mar 20;203(3):599-606. Epub 2006 Feb 27.

29.

Genetic selection for resistance or susceptibility to oral tolerance to ovalbumin affects general mechanisms of tolerance induction in mice.

Kamphorst AO, da Silva MF, da Silva AC, Carvalho CR, Faria AM.

Ann N Y Acad Sci. 2004 Dec;1029:350-4.

PMID:
15681779
30.

Association complexes between ovalbumin and cyclodextrins have no effect on the immunological properties of ovalbumin.

Kamphorst AO, Mendes de Sá I, Faria AM, Sinisterra RD.

Eur J Pharm Biopharm. 2004 Mar;57(2):199-205.

PMID:
15018975

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