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Migration of vascular endothelial cells in monolayers under hypoxic exposure.

Tabata Y, Yoshino D, Funamoto K, Koens R, Kamm RD, Funamoto K.

Integr Biol (Camb). 2019 Jan 1;11(1):26-35. doi: 10.1093/intbio/zyz002.


Quantitative screening of the effects of hyper-osmotic stress on cancer cells cultured in 2- or 3-dimensional settings.

Miermont A, Lee SWL, Adriani G, Kamm RD.

Sci Rep. 2019 Sep 24;9(1):13782. doi: 10.1038/s41598-019-50198-w.


Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution.

Offeddu GS, Possenti L, Loessberg-Zahl JT, Zunino P, Roberts J, Han X, Hickman D, Knutson CG, Kamm RD.

Small. 2019 Sep 9:e1902393. doi: 10.1002/smll.201902393. [Epub ahead of print]


Balance of interstitial flow magnitude and vascular endothelial growth factor concentration modulates three-dimensional microvascular network formation.

Abe Y, Watanabe M, Chung S, Kamm RD, Tanishita K, Sudo R.

APL Bioeng. 2019 Jul 30;3(3):036102. doi: 10.1063/1.5094735. eCollection 2019 Sep.


Studying nucleic envelope and plasma membrane mechanics of eukaryotic cells using confocal reflectance interferometric microscopy.

Singh VR, Yang YA, Yu H, Kamm RD, Yaqoob Z, So PTC.

Nat Commun. 2019 Aug 13;10(1):3652. doi: 10.1038/s41467-019-11645-4.


Publisher Correction: Microfluidic assessment of metastatic potential.

Wan Z, Kamm RD.

Nat Biomed Eng. 2019 Aug;3(8):670. doi: 10.1038/s41551-019-0444-x.


Microfluidic assessment of metastatic potential.

Wan Z, Kamm RD.

Nat Biomed Eng. 2019 Jun;3(6):423-424. doi: 10.1038/s41551-019-0412-5. No abstract available. Erratum in: Nat Biomed Eng. 2019 Aug;3(8):670.


An on-chip model of protein paracellular and transcellular permeability in the microcirculation.

Offeddu GS, Haase K, Gillrie MR, Li R, Morozova O, Hickman D, Knutson CG, Kamm RD.

Biomaterials. 2019 Aug;212:115-125. doi: 10.1016/j.biomaterials.2019.05.022. Epub 2019 May 13.


Perspective: The promise of multi-cellular engineered living systems.

Kamm RD, Bashir R, Arora N, Dar RD, Gillette MU, Griffith LG, Kemp ML, Kinlaw K, Levin M, Martin AC, McDevitt TC, Nerem RM, Powers MJ, Saif TA, Sharpe J, Takayama S, Takeuchi S, Weiss R, Ye K, Yevick HG, Zaman MH.

APL Bioeng. 2018 Oct 11;2(4):040901. doi: 10.1063/1.5038337. eCollection 2018 Dec.


Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos.

Mercurio A, Sharples L, Corbo F, Franchini C, Vacca A, Catalano A, Carocci A, Kamm RD, Pavesi A, Adriani G.

Front Pharmacol. 2019 Apr 17;10:349. doi: 10.3389/fphar.2019.00349. eCollection 2019.


Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation.

Escribano J, Chen MB, Moeendarbary E, Cao X, Shenoy V, Garcia-Aznar JM, Kamm RD, Spill F.

PLoS Comput Biol. 2019 May 2;15(5):e1006395. doi: 10.1371/journal.pcbi.1006395. eCollection 2019 May.


Self-organization of hepatocyte morphogenesis depending on the size of collagen microbeads relative to hepatocytes.

Ajoudanian M, Enomoto K, Tokunaga Y, Minami H, Chung S, Tanishita K, Kamm RD, Sudo R.

Biofabrication. 2019 Apr 26;11(3):035007. doi: 10.1088/1758-5090/ab145d.


Remodeling of the Tumor Microenvironment by a Chemokine/Anti-PD-L1 Nanobody Fusion Protein.

Fang T, Li R, Li Z, Cho J, Guzman JS, Kamm RD, Ploegh HL.

Mol Pharm. 2019 Jun 3;16(6):2838-2844. doi: 10.1021/acs.molpharmaceut.9b00078. Epub 2019 Apr 29.


Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices.

Malandrino A, Trepat X, Kamm RD, Mak M.

PLoS Comput Biol. 2019 Apr 8;15(4):e1006684. doi: 10.1371/journal.pcbi.1006684. eCollection 2019 Apr.


Quantification of human neuromuscular function through optogenetics.

Vila OF, Uzel SGM, Ma SP, Williams D, Pak J, Kamm RD, Vunjak-Novakovic G.

Theranostics. 2019 Jan 31;9(5):1232-1246. doi: 10.7150/thno.25735. eCollection 2019.


Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models.

Papa AL, Jiang A, Korin N, Chen MB, Langan ET, Waterhouse A, Nash E, Caroff J, Graveline A, Vernet A, Mammoto A, Mammoto T, Jain A, Kamm RD, Gounis MJ, Ingber DE.

Sci Transl Med. 2019 Feb 13;11(479). pii: eaau5898. doi: 10.1126/scitranslmed.aau5898.


Biohybrid valveless pump-bot powered by engineered skeletal muscle.

Li Z, Seo Y, Aydin O, Elhebeary M, Kamm RD, Kong H, Saif MTA.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1543-1548. doi: 10.1073/pnas.1817682116. Epub 2019 Jan 11.


A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines.

Song J, Miermont A, Lim CT, Kamm RD.

Sci Rep. 2018 Dec 18;8(1):17949. doi: 10.1038/s41598-018-36381-5.


A combined microfluidic-transcriptomic approach to characterize the extravasation potential of cancer cells.

Bersini S, Miermont A, Pavesi A, Kamm RD, Thiery JP, Moretti M, Adriani G.

Oncotarget. 2018 Nov 16;9(90):36110-36125. doi: 10.18632/oncotarget.26306. eCollection 2018 Nov 16.


Cooperative Effects of Vascular Angiogenesis and Lymphangiogenesis.

Osaki T, Serrano JC, Kamm RD.

Regen Eng Transl Med. 2018 Sep;4(3):120-132. doi: 10.1007/s40883-018-0054-2. Epub 2018 Apr 23.


Engineered Models of Metastasis with Application to Study Cancer Biomechanics.

Chen MB, Kamm RD, Moeendarbary E.

Adv Exp Med Biol. 2018;1092:189-207. doi: 10.1007/978-3-319-95294-9_10. Review.


Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons.

Osaki T, Uzel SGM, Kamm RD.

Sci Adv. 2018 Oct 10;4(10):eaat5847. doi: 10.1126/sciadv.aat5847. eCollection 2018 Oct.


Construction of Continuous Capillary Networks Stabilized by Pericyte-like Perivascular Cells.

Yamamoto K, Tanimura K, Watanabe M, Sano H, Uwamori H, Mabuchi Y, Matsuzaki Y, Chung S, Kamm RD, Tanishita K, Sudo R.

Tissue Eng Part A. 2019 Mar;25(5-6):499-510. doi: 10.1089/ten.TEA.2018.0186. Epub 2018 Oct 27.


3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade.

Aref AR, Campisi M, Ivanova E, Portell A, Larios D, Piel BP, Mathur N, Zhou C, Coakley RV, Bartels A, Bowden M, Herbert Z, Hill S, Gilhooley S, Carter J, Cañadas I, Thai TC, Kitajima S, Chiono V, Paweletz CP, Barbie DA, Kamm RD, Jenkins RW.

Lab Chip. 2018 Oct 9;18(20):3129-3143. doi: 10.1039/c8lc00322j.


Complex mechanics of the heterogeneous extracellular matrix in cancer.

Malandrino A, Mak M, Kamm RD, Moeendarbary E.

Extreme Mech Lett. 2018 May;21:25-34. doi: 10.1016/j.eml.2018.02.003. Review.


Corrigendum: Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model.

Lee SWL, Adriani G, Ceccarello E, Pavesi A, Tan AT, Bertoletti A, Kamm RD, Wong SC.

Front Immunol. 2018 Jul 24;9:1719. doi: 10.3389/fimmu.2018.01719. eCollection 2018.


Epithelial-Mesenchymal Transition Induces Podocalyxin to Promote Extravasation via Ezrin Signaling.

Fröse J, Chen MB, Hebron KE, Reinhardt F, Hajal C, Zijlstra A, Kamm RD, Weinberg RA.

Cell Rep. 2018 Jul 24;24(4):962-972. doi: 10.1016/j.celrep.2018.06.092.


Hydrogel-incorporating unit in a well: 3D cell culture for high-throughput analysis.

Yu YJ, Kim YH, Na K, Min SY, Hwang OK, Park DK, Kim DY, Choi SH, Kamm RD, Chung S, Kim JA.

Lab Chip. 2018 Aug 21;18(17):2604-2613. doi: 10.1039/c8lc00525g.


Studying TCR T cell anti-tumor activity in a microfluidic intrahepatic tumor model.

Adriani G, Pavesi A, Kamm RD.

Methods Cell Biol. 2018;146:199-214. doi: 10.1016/bs.mcb.2018.05.009. Epub 2018 Jul 12.


3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes.

Campisi M, Shin Y, Osaki T, Hajal C, Chiono V, Kamm RD.

Biomaterials. 2018 Oct;180:117-129. doi: 10.1016/j.biomaterials.2018.07.014. Epub 2018 Jul 12.


Interstitial flow promotes macrophage polarization toward an M2 phenotype.

Li R, Serrano JC, Xing H, Lee TA, Azizgolshani H, Zaman M, Kamm RD.

Mol Biol Cell. 2018 Aug 8;29(16):1927-1940. doi: 10.1091/mbc.E18-03-0164. Epub 2018 Jul 11.


Influence of protein corona and caveolae-mediated endocytosis on nanoparticle uptake and transcytosis.

Ho YT, Kamm RD, Kah JCY.

Nanoscale. 2018 Jul 9;10(26):12386-12397. doi: 10.1039/c8nr02393j.


Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation.

Chen MB, Hajal C, Benjamin DC, Yu C, Azizgolshani H, Hynes RO, Kamm RD.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7022-7027. doi: 10.1073/pnas.1715932115. Epub 2018 Jun 18.


In vitro models of molecular and nano-particle transport across the blood-brain barrier.

Hajal C, Campisi M, Mattu C, Chiono V, Kamm RD.

Biomicrofluidics. 2018 May 31;12(4):042213. doi: 10.1063/1.5027118. eCollection 2018 Jul.


Evidence from ITIR-FCS Diffusion Studies that the Amyloid-Beta (Aβ) Peptide Does Not Perturb Plasma Membrane Fluidity in Neuronal Cells.

Ng J, Kamm RD, Wohland T, Kraut RS.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3439-3453. doi: 10.1016/j.jmb.2018.04.030. Epub 2018 May 7.


Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering.

Osaki T, Sivathanu V, Kamm RD.

Curr Opin Biotechnol. 2018 Aug;52:116-123. doi: 10.1016/j.copbio.2018.03.011. Epub 2018 Apr 12. Review.


Cell contraction induces long-ranged stress stiffening in the extracellular matrix.

Han YL, Ronceray P, Xu G, Malandrino A, Kamm RD, Lenz M, Broedersz CP, Guo M.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4075-4080. doi: 10.1073/pnas.1722619115. Epub 2018 Apr 4.


Engineered 3D vascular and neuronal networks in a microfluidic platform.

Osaki T, Sivathanu V, Kamm RD.

Sci Rep. 2018 Mar 26;8(1):5168. doi: 10.1038/s41598-018-23512-1.


Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model.

Lee SWL, Adriani G, Ceccarello E, Pavesi A, Tan AT, Bertoletti A, Kamm RD, Wong SC.

Front Immunol. 2018 Mar 6;9:416. doi: 10.3389/fimmu.2018.00416. eCollection 2018. Erratum in: Front Immunol. 2018 Jul 24;9:1719.


The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model.

Boussommier-Calleja A, Atiyas Y, Haase K, Headley M, Lewis C, Kamm RD.

Biomaterials. 2019 Apr;198:180-193. doi: 10.1016/j.biomaterials.2018.03.005. Epub 2018 Mar 5.


In Vitro Modeling of Mechanics in Cancer Metastasis.

Malandrino A, Kamm RD, Moeendarbary E.

ACS Biomater Sci Eng. 2018 Feb 12;4(2):294-301. doi: 10.1021/acsbiomaterials.7b00041. Epub 2017 May 16. Review.


Computational modeling of three-dimensional ECM-rigidity sensing to guide directed cell migration.

Kim MC, Silberberg YR, Abeyaratne R, Kamm RD, Asada HH.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E390-E399. doi: 10.1073/pnas.1717230115. Epub 2018 Jan 2.


Crosstalk between developing vasculature and optogenetically engineered skeletal muscle improves muscle contraction and angiogenesis.

Osaki T, Sivathanu V, Kamm RD.

Biomaterials. 2018 Feb;156:65-76. doi: 10.1016/j.biomaterials.2017.11.041. Epub 2017 Nov 25.


Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research.

Holle AW, Young JL, Van Vliet KJ, Kamm RD, Discher D, Janmey P, Spatz JP, Saif T.

Nano Lett. 2018 Jan 10;18(1):1-8. doi: 10.1021/acs.nanolett.7b04982. Epub 2017 Dec 6.


Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Jenkins RW, Aref AR, Lizotte PH, Ivanova E, Stinson S, Zhou CW, Bowden M, Deng J, Liu H, Miao D, He MX, Walker W, Zhang G, Tian T, Cheng C, Wei Z, Palakurthi S, Bittinger M, Vitzthum H, Kim JW, Merlino A, Quinn M, Venkataramani C, Kaplan JA, Portell A, Gokhale PC, Phillips B, Smart A, Rotem A, Jones RE, Keogh L, Anguiano M, Stapleton L, Jia Z, Barzily-Rokni M, Cañadas I, Thai TC, Hammond MR, Vlahos R, Wang ES, Zhang H, Li S, Hanna GJ, Huang W, Hoang MP, Piris A, Eliane JP, Stemmer-Rachamimov AO, Cameron L, Su MJ, Shah P, Izar B, Thakuria M, LeBoeuf NR, Rabinowits G, Gunda V, Parangi S, Cleary JM, Miller BC, Kitajima S, Thummalapalli R, Miao B, Barbie TU, Sivathanu V, Wong J, Richards WG, Bueno R, Yoon CH, Miret J, Herlyn M, Garraway LA, Van Allen EM, Freeman GJ, Kirschmeier PT, Lorch JH, Ott PA, Hodi FS, Flaherty KT, Kamm RD, Boland GM, Wong KK, Dornan D, Paweletz CP, Barbie DA.

Cancer Discov. 2018 Feb;8(2):196-215. doi: 10.1158/2159-8290.CD-17-0833. Epub 2017 Nov 3.


ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP-9 expression and transendothelial migration in breast cancer cells.

Conrad C, Götte M, Schlomann U, Roessler M, Pagenstecher A, Anderson P, Preston J, Pruessmeyer J, Ludwig A, Li R, Kamm RD, Ritz R, Carl B, Nimsky C, Bartsch JW.

Int J Cancer. 2018 Feb 15;142(4):779-791. doi: 10.1002/ijc.31090. Epub 2017 Oct 31.


In Vitro Microfluidic Models for Neurodegenerative Disorders.

Osaki T, Shin Y, Sivathanu V, Campisi M, Kamm RD.

Adv Healthc Mater. 2018 Jan;7(2). doi: 10.1002/adhm.201700489. Epub 2017 Sep 7. Review.


A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors.

Pavesi A, Tan AT, Koh S, Chia A, Colombo M, Antonecchia E, Miccolis C, Ceccarello E, Adriani G, Raimondi MT, Kamm RD, Bertoletti A.

JCI Insight. 2017 Jun 15;2(12). pii: 89762. doi: 10.1172/jci.insight.89762. eCollection 2017 Jun 15.


Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation.

Alvarez MM, Aizenberg J, Analoui M, Andrews AM, Bisker G, Boyden ES, Kamm RD, Karp JM, Mooney DJ, Oklu R, Peer D, Stolzoff M, Strano MS, Trujillo-de Santiago G, Webster TJ, Weiss PS, Khademhosseini A.

ACS Nano. 2017 Jun 27;11(6):5195-5214. doi: 10.1021/acsnano.7b01493. Epub 2017 May 19. Review.


Integrated Analysis of Intracellular Dynamics of MenaINV Cancer Cells in a 3D Matrix.

Mak M, Anderson S, McDonough MC, Spill F, Kim JE, Boussommier-Calleja A, Zaman MH, Kamm RD.

Biophys J. 2017 May 9;112(9):1874-1884. doi: 10.1016/j.bpj.2017.03.030.

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