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Items: 1 to 50 of 63

1.

Novel neuroprotective hydroquinones with a vinyl alkyne from the fungus, Pestalotiopsis microspora.

Kanno K, Tsurukawa Y, Kamisuki S, Shibasaki H, Iguchi K, Murakami H, Uchiyama J, Kuramochi K.

J Antibiot (Tokyo). 2019 Jul 24. doi: 10.1038/s41429-019-0213-9. [Epub ahead of print]

PMID:
31341274
2.

Design, Synthesis, and Biological Evaluation of EdAP, a 4'-Ethynyl-2'-Deoxyadenosine 5'-Monophosphate Analog, as a Potent Influenza a Inhibitor.

Takeuchi T, Sriwilaijaroen N, Sakuraba A, Hayashi E, Kamisuki S, Suzuki Y, Ohrui H, Sugawara F.

Molecules. 2019 Jul 17;24(14). pii: E2603. doi: 10.3390/molecules24142603.

3.

Chloramphenicol inhibits eukaryotic Ser/Thr phosphatase and infection-specific cell differentiation in the rice blast fungus.

Nozaka A, Nishiwaki A, Nagashima Y, Endo S, Kuroki M, Nakajima M, Narukawa M, Kamisuki S, Arazoe T, Taguchi H, Sugawara F, Kamakura T.

Sci Rep. 2019 Jun 26;9(1):9283. doi: 10.1038/s41598-019-41039-x.

4.

Identification, characterization, and structural analyses of a fungal endo-β-1,2-glucanase reveal a new glycoside hydrolase family.

Tanaka N, Nakajima M, Narukawa-Nara M, Matsunaga H, Kamisuki S, Aramasa H, Takahashi Y, Sugimoto N, Abe K, Terada T, Miyanaga A, Yamashita T, Sugawara F, Kamakura T, Komba S, Nakai H, Taguchi H.

J Biol Chem. 2019 May 10;294(19):7942-7965. doi: 10.1074/jbc.RA118.007087. Epub 2019 Mar 29.

PMID:
30926603
5.

The aryl hydrocarbon receptor-cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly.

Ohashi H, Nishioka K, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Muramatsu M, Wakita T, Watashi K.

J Biol Chem. 2018 Dec 21;293(51):19559-19571. doi: 10.1074/jbc.RA118.005033. Epub 2018 Oct 31.

PMID:
30381393
6.

Distribution and metabolism of 14C-sulfoquinovosylacylpropanediol (14C-SQAP) after a single intravenous administration in tumor-bearing mice.

Ruike T, Kanai Y, Iwabata K, Matsumoto Y, Murata H, Ishima M, Ohta K, Oshige M, Katsura S, Kuramochi K, Kamisuki S, Sahara H, Miura M, Sugawara F, Sakaguchi K.

Xenobiotica. 2019 Mar;49(3):346-362. doi: 10.1080/00498254.2018.1448949. Epub 2018 Apr 24.

PMID:
29543539
7.

Identification of proteins that bind to the neuroprotective agent neoechinulin A.

Kamisuki S, Himeno N, Tsurukawa Y, Kusayanagi T, Takeno M, Kamakura T, Kuramochi K, Sugawara F.

Biosci Biotechnol Biochem. 2018 Mar;82(3):442-448. doi: 10.1080/09168451.2018.1433018. Epub 2018 Feb 15.

PMID:
29447077
8.

TRPA1-dependent reversible opening of tight junction by natural compounds with an α,β-unsaturated moiety and capsaicin.

Kanda Y, Yamasaki Y, Sasaki-Yamaguchi Y, Ida-Koga N, Kamisuki S, Sugawara F, Nagumo Y, Usui T.

Sci Rep. 2018 Feb 2;8(1):2251. doi: 10.1038/s41598-018-20526-7.

9.

Biochemical and structural analyses of a bacterial endo-β-1,2-glucanase reveal a new glycoside hydrolase family.

Abe K, Nakajima M, Yamashita T, Matsunaga H, Kamisuki S, Nihira T, Takahashi Y, Sugimoto N, Miyanaga A, Nakai H, Arakawa T, Fushinobu S, Taguchi H.

J Biol Chem. 2017 May 5;292(18):7487-7506. doi: 10.1074/jbc.M116.762724. Epub 2017 Mar 7.

10.

MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane.

Kanda Y, Yamasaki Y, Shimura S, Kamisuki S, Sugawara F, Nagumo Y, Usui T.

J Antibiot (Tokyo). 2017 May;70(5):691-694. doi: 10.1038/ja.2016.168. Epub 2017 Jan 18.

PMID:
28096546
11.

Neoechinulin A induced memory improvements and antidepressant-like effects in mice.

Sasaki-Hamada S, Hoshi M, Niwa Y, Ueda Y, Kokaji A, Kamisuki S, Kuramochi K, Sugawara F, Oka J.

Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 3;71:155-61. doi: 10.1016/j.pnpbp.2016.08.002. Epub 2016 Aug 2.

PMID:
27495355
12.

Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System.

Nakajima S, Watashi K, Ohashi H, Kamisuki S, Izaguirre-Carbonell J, Kwon AT, Suzuki H, Kataoka M, Tsukuda S, Okada M, Moi ML, Takeuchi T, Arita M, Suzuki R, Aizaki H, Kato T, Suzuki T, Hasegawa H, Takasaki T, Sugawara F, Wakita T.

J Virol. 2016 Sep 29;90(20):9058-74. doi: 10.1128/JVI.00856-16. Print 2016 Oct 15.

13.

Identification of a Chlamydomonas plastidial 2-lysophosphatidic acid acyltransferase and its use to engineer microalgae with increased oil content.

Yamaoka Y, Achard D, Jang S, Legéret B, Kamisuki S, Ko D, Schulz-Raffelt M, Kim Y, Song WY, Nishida I, Li-Beisson Y, Lee Y.

Plant Biotechnol J. 2016 Nov;14(11):2158-2167. doi: 10.1111/pbi.12572. Epub 2016 May 23.

14.

Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity.

Nakajima Y, Iguchi H, Kamisuki S, Sugawara F, Furuichi T, Shinoda Y.

J Toxicol Sci. 2016 Apr;41(2):311-9. doi: 10.2131/jts.41.311.

15.

Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei.

Nishikori S, Takemoto K, Kamisuki S, Nakajima S, Kuramochi K, Tsukuda S, Iwamoto M, Katayama Y, Suzuki T, Kobayashi S, Watashi K, Sugawara F.

J Nat Prod. 2016 Feb 26;79(2):442-6. doi: 10.1021/acs.jnatprod.5b00555. Epub 2016 Feb 5.

PMID:
26848504
16.

Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity.

Izaguirre-Carbonell J, Kawakubo H, Murata H, Tanabe A, Takeuchi T, Kusayanagi T, Tsukuda S, Hirakawa T, Iwabata K, Kanai Y, Ohta K, Miura M, Sakaguchi K, Matsunaga S, Sahara H, Kamisuki S, Sugawara F.

Sci Rep. 2015 Oct 12;5:15136. doi: 10.1038/srep15136.

17.

A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide.

Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T.

J Virol. 2015 Dec;89(23):11945-53. doi: 10.1128/JVI.01855-15. Epub 2015 Sep 16.

18.

Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors.

Ikeda K, Kamisuki S, Uetake S, Mizusawa A, Ota N, Sasaki T, Tsukuda S, Kusayanagi T, Takakusagi Y, Morohashi K, Yamori T, Dan S, Shiina I, Sugawara F.

Bioorg Med Chem. 2015 Sep 15;23(18):6118-24. doi: 10.1016/j.bmc.2015.08.001. Epub 2015 Aug 5.

PMID:
26314924
19.

Isolation and structure of vanitaracin A, a novel anti-hepatitis B virus compound from Talaromyces sp.

Matsunaga H, Kamisuki S, Kaneko M, Yamaguchi Y, Takeuchi T, Watashi K, Sugawara F.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4325-8. doi: 10.1016/j.bmcl.2015.07.067. Epub 2015 Jul 26.

20.

Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces "angiogenic switch off" in a hepatoma mouse model.

Iwamoto H, Nakamura T, Koga H, Izaguirre-Carbonell J, Kamisuki S, Sugawara F, Abe M, Iwabata K, Ikezono Y, Sakaue T, Masuda A, Yano H, Ohta K, Nakano M, Shimose S, Shirono T, Torimura T.

Mol Ther Oncolytics. 2015 Dec 2;2:15020. doi: 10.1038/mto.2015.20. eCollection 2015.

21.

EpsinR, a target for pyrenocine B, role in endogenous MHC-II-restricted antigen presentation.

Shishido T, Hachisuka M, Ryuzaki K, Miura Y, Tanabe A, Tamura Y, Kusayanagi T, Takeuchi T, Kamisuki S, Sugawara F, Sahara H.

Eur J Immunol. 2014 Nov;44(11):3220-31. doi: 10.1002/eji.201444475. Epub 2014 Oct 30.

22.

Bioactive dihydronaphthoquinone derivatives from Fusarium solani.

Takemoto K, Kamisuki S, Chia PT, Kuriyama I, Mizushina Y, Sugawara F.

J Nat Prod. 2014 Sep 26;77(9):1992-6. doi: 10.1021/np500175j. Epub 2014 Aug 28.

PMID:
25163667
23.

Inhibition of mammalian DNA polymerases and the suppression of inflammatory and allergic responses by tyrosol from used activated charcoal waste generated during sake production.

Mizushina Y, Ogawa Y, Onodera T, Kuriyama I, Sakamoto Y, Nishikori S, Kamisuki S, Sugawara F.

J Agric Food Chem. 2014 Aug 6;62(31):7779-86. doi: 10.1021/jf502095p. Epub 2014 Jul 28.

PMID:
25029297
24.

Cytotoxic alkylated hydroquinone, phenol, and cyclohexenone derivatives from Aspergillus violaceofuscus Gasperini.

Myobatake Y, Takemoto K, Kamisuki S, Inoue N, Takasaki A, Takeuchi T, Mizushina Y, Sugawara F.

J Nat Prod. 2014 May 23;77(5):1236-40. doi: 10.1021/np401017g. Epub 2014 May 1.

PMID:
24786915
25.

Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.

Mizushina Y, Suzuki-Fukudome H, Takeuchi T, Takemoto K, Kuriyama I, Yoshida H, Kamisuki S, Sugawara F.

Bioorg Med Chem. 2014 Feb 1;22(3):1070-6. doi: 10.1016/j.bmc.2013.12.038. Epub 2013 Dec 25.

PMID:
24411199
26.

Total synthesis and anti-hepatitis C virus activity of MA026.

Shimura S, Ishima M, Nakajima S, Fujii T, Himeno N, Ikeda K, Izaguirre-Carbonell J, Murata H, Takeuchi T, Kamisuki S, Suzuki T, Kuramochi K, Watashi K, Kobayashi S, Sugawara F.

J Am Chem Soc. 2013 Dec 18;135(50):18949-56. doi: 10.1021/ja410145x. Epub 2013 Dec 6.

PMID:
24251365
27.

Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives.

Nakajima S, Watashi K, Kamisuki S, Tsukuda S, Takemoto K, Matsuda M, Suzuki R, Aizaki H, Sugawara F, Wakita T.

Biochem Biophys Res Commun. 2013 Nov 1;440(4):515-20. doi: 10.1016/j.bbrc.2013.09.100. Epub 2013 Oct 5.

PMID:
24099774
28.

Synthesis, structure, and cytotoxicity studies of some fungal isochromanes.

Kuramochi K, Tsubaki K, Kuriyama I, Mizushina Y, Yoshida H, Takeuchi T, Kamisuki S, Sugawara F, Kobayashi S.

J Nat Prod. 2013 Sep 27;76(9):1737-45. doi: 10.1021/np400460m. Epub 2013 Sep 13.

PMID:
24033077
29.

Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2.

Tsukuda S, Kusayanagi T, Umeda E, Watanabe C, Tosaki YT, Kamisuki S, Takeuchi T, Takakusagi Y, Shiina I, Sugawara F.

Bioorg Med Chem. 2013 Jan 1;21(1):311-20. doi: 10.1016/j.bmc.2012.10.037. Epub 2012 Oct 29.

PMID:
23199482
30.

The antitumor agent doxorubicin binds to Fanconi anemia group F protein.

Kusayanagi T, Tsukuda S, Shimura S, Manita D, Iwakiri K, Kamisuki S, Takakusagi Y, Takeuchi T, Kuramochi K, Nakazaki A, Sakaguchi K, Kobayashi S, Sugawara F.

Bioorg Med Chem. 2012 Nov 1;20(21):6248-55. doi: 10.1016/j.bmc.2012.09.015. Epub 2012 Sep 16.

PMID:
23026082
31.

Total synthesis of (+)-Sch 725680: inhibitor of mammalian A-, B-, and Y-family DNA polymerases.

Takeuchi T, Mizushina Y, Takaichi S, Inoue N, Kuramochi K, Shimura S, Myobatake Y, Katayama Y, Takemoto K, Endo S, Kamisuki S, Sugawara F.

Org Lett. 2012 Sep 7;14(17):4303-5. Epub 2012 Aug 28.

PMID:
22928597
32.

Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen.

Miyano Y, Tsukuda S, Sakimoto I, Takeuchi R, Shimura S, Takahashi N, Kusayanagi T, Takakusagi Y, Okado M, Matsumoto Y, Takakusagi K, Takeuchi T, Kamisuki S, Nakazaki A, Ohta K, Miura M, Kuramochi K, Mizushina Y, Kobayashi S, Sugawara F, Sakaguchi K.

Bioorg Med Chem. 2012 Jul 1;20(13):3985-90. doi: 10.1016/j.bmc.2012.05.016. Epub 2012 May 15.

PMID:
22658539
33.

Camptothecin (CPT) directly binds to human heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and inhibits the hnRNP A1/topoisomerase I interaction.

Manita D, Toba Y, Takakusagi Y, Matsumoto Y, Kusayanagi T, Takakusagi K, Tsukuda S, Takada K, Kanai Y, Kamisuki S, Sakaguchi K, Sugawara F.

Bioorg Med Chem. 2011 Dec 15;19(24):7690-7. doi: 10.1016/j.bmc.2011.09.059. Epub 2011 Oct 5.

PMID:
22071521
34.

Catch and release of alkyne-tagged molecules in water by a polymer-supported cobalt complex.

Egami H, Kamisuki S, Dodo K, Asanuma M, Hamashima Y, Sodeoka M.

Org Biomol Chem. 2011 Oct 26;9(22):7667-70. doi: 10.1039/c1ob06123b. Epub 2011 Sep 20.

PMID:
21935565
35.

Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.

Kamisuki S, Shirakawa T, Kugimiya A, Abu-Elheiga L, Choo HY, Yamada K, Shimogawa H, Wakil SJ, Uesugi M.

J Med Chem. 2011 Jul 14;54(13):4923-7. doi: 10.1021/jm200304y. Epub 2011 Jun 8.

36.

Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors.

Kuramochi K, Fukudome K, Kuriyama I, Takeuchi T, Sato Y, Kamisuki S, Tsubaki K, Sugawara F, Yoshida H, Mizushina Y.

Bioorg Med Chem. 2009 Oct 15;17(20):7227-38. doi: 10.1016/j.bmc.2009.08.051. Epub 2009 Aug 31.

PMID:
19767211
37.

A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.

Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M.

Chem Biol. 2009 Aug 28;16(8):882-92. doi: 10.1016/j.chembiol.2009.07.007.

38.

Wrenchnolol derivative optimized for gene activation in cells.

Jung D, Shimogawa H, Kwon Y, Mao Q, Sato S, Kamisuki S, Kigoshi H, Uesugi M.

J Am Chem Soc. 2009 Apr 8;131(13):4774-82. doi: 10.1021/ja900669k.

PMID:
19290630
39.

Chlorogenic acid facilitates root hair formation in lettuce seedlings.

Narukawa M, Kanbara K, Tominaga Y, Aitani Y, Fukuda K, Kodama T, Murayama N, Nara Y, Arai T, Konno M, Kamisuki S, Sugawara F, Iwai M, Inoue Y.

Plant Cell Physiol. 2009 Mar;50(3):504-14. doi: 10.1093/pcp/pcp010. Epub 2009 Jan 23. Erratum in: Plant Cell Physiol. 2009 Apr;50(4):909.

PMID:
19168456
40.

The specific inhibitory effect of demethoxydehydroaltenusin, a derivative of dehydroaltenusin, on mammalian DNA polymerase alpha.

Kuriyama I, Fukudome K, Kamisuki S, Kuramochi K, Tsubaki K, Sakaguchi K, Sugawara F, Yoshida H, Mizushina Y.

Int J Mol Med. 2008 Dec;22(6):793-9.

PMID:
19020778
41.

Hymenoic acid, a novel specific inhibitor of human DNA polymerase lambda from a fungus of Hymenochaetaceae sp.

Nishida M, Ida N, Horio M, Takeuchi T, Kamisuki S, Murata H, Kuramochi K, Sugawara F, Yoshida H, Mizushina Y.

Bioorg Med Chem. 2008 May 1;16(9):5115-22. doi: 10.1016/j.bmc.2008.03.021. Epub 2008 Mar 10.

PMID:
18364258
42.

[Discovering high-affinity ligands for proteins: SAR by NMR].

Kamisuki S, Uesugi M.

Tanpakushitsu Kakusan Koso. 2007 Oct;52(13 Suppl):1818-9. Review. Japanese. No abstract available.

PMID:
18051441
43.

Structure-activity relationships of neoechinulin A analogues with cytoprotection against peroxynitrite-induced PC12 cell death.

Kimoto K, Aoki T, Shibata Y, Kamisuki S, Sugawara F, Kuramochi K, Nakazaki A, Kobayashi S, Kuroiwa K, Watanabe N, Arai T.

J Antibiot (Tokyo). 2007 Oct;60(10):614-21.

PMID:
17965477
44.

An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress.

Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F, Froines JR, Kumagai Y.

Free Radic Biol Med. 2007 Sep 1;43(5):789-99. Epub 2007 May 24.

PMID:
17664142
45.

Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp.

Kamisuki S, Ishimaru C, Onoda K, Kuriyama I, Ida N, Sugawara F, Yoshida H, Mizushina Y.

Bioorg Med Chem. 2007 May 1;15(9):3109-14. Epub 2007 Mar 3.

PMID:
17363259
46.

Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin.

Sato S, Kwon Y, Kamisuki S, Srivastava N, Mao Q, Kawazoe Y, Uesugi M.

J Am Chem Soc. 2007 Jan 31;129(4):873-80.

PMID:
17243824
47.

Synthesis of synthetic small molecule transcription factors (STF).

Sato A, Kawazoe Y, Kamisuki S, Uesugi M.

Nucleic Acids Symp Ser (Oxf). 2006;(50):29-30.

PMID:
17150801
48.

Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha.

Maeda N, Kokai Y, Ohtani S, Sahara H, Kuriyama I, Kamisuki S, Takahashi S, Sakaguchi K, Sugawara F, Yoshida H, Sato N, Mizushina Y.

Biochem Biophys Res Commun. 2007 Jan 12;352(2):390-6. Epub 2006 Nov 14.

PMID:
17118336
49.

Site-directed mutational analysis of structural interactions of low molecule compounds binding to the N-terminal 8 kDa domain of DNA polymerase beta.

Murakami S, Kamisuki S, Takata K, Kasai N, Kimura S, Mizushina Y, Ohta K, Sugawara F, Sakaguchi K.

Biochem Biophys Res Commun. 2006 Nov 10;350(1):7-16. Epub 2006 Sep 15.

PMID:
16996474
50.

Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin.

Uchiyama Y, Tagami J, Kamisuki S, Kasai N, Oshige M, Chiku H, Ibe S, Koiwai O, Sugawara F, Sakaguchi K.

Biochim Biophys Acta. 2005 Oct 10;1725(3):298-304.

PMID:
16099107

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