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Δ9-Tetrahydrocannabinol suppresses monocyte-mediated astrocyte production of MCP-1 and IL-6 in a TLR7-stimulated human co-culture.

Rizzo MD, Crawford RB, Bach A, Sermet S, Amalfitano A, Kaminski NE.

J Pharmacol Exp Ther. 2019 Aug 5. pii: jpet.119.260661. doi: 10.1124/jpet.119.260661. [Epub ahead of print]


Imiquimod and interferon-alpha augment monocyte-mediated astrocyte secretion of MCP-1, IL-6 and IP-10 in a human co-culture system.

Rizzo MD, Crawford RB, Bach A, Sermet S, Amalfitano A, Kaminski NE.

J Neuroimmunol. 2019 Aug 15;333:576969. doi: 10.1016/j.jneuroim.2019.576969. Epub 2019 May 20.


Suppression of CpG-ODN-mediated IFNα and TNFα response in human plasmacytoid dendritic cells (pDC) by cannabinoid receptor 2 (CB2)-specific agonists.

Henriquez JE, Crawford RB, Kaminski NE.

Toxicol Appl Pharmacol. 2019 Apr 15;369:82-89. doi: 10.1016/j.taap.2019.02.013. Epub 2019 Feb 23.



Aschner M, Autrup HN, Cohen SM, Dekant W, Eisenbrand G, Galli CL, Gori GB, Kaminski NE, Klaassen CD, Klaunig JE, Levy L, Lotti M, Marquardt HW, Pelkonen O, Schrenk DF, Yamazaki H.

Regul Toxicol Pharmacol. 2019 Feb;101:A1-A2. doi: 10.1016/j.yrtph.2018.12.015. No abstract available.


SLAMF7 Is a Critical Negative Regulator of IFN-α-Mediated CXCL10 Production in Chronic HIV Infection.

O'Connell P, Pepelyayeva Y, Blake MK, Hyslop S, Crawford RB, Rizzo MD, Pereira-Hicks C, Godbehere S, Dale L, Gulick P, Kaminski NE, Amalfitano A, Aldhamen YA.

J Immunol. 2019 Jan 1;202(1):228-238. doi: 10.4049/jimmunol.1800847. Epub 2018 Dec 10.


Characterizing Serpinb2 as a Modulator of TCDD-Induced Suppression of the B Cell.

Dornbos P, Warren M, Crawford RB, Kaminski NE, Threadgill DW, LaPres JJ.

Chem Res Toxicol. 2018 Nov 19;31(11):1248-1259. doi: 10.1021/acs.chemrestox.8b00225. Epub 2018 Oct 30.


Activated carbons of varying pore structure eliminate the bioavailability of 2,3,7,8-tetrachlorodibenzo-p-dioxin to a mammalian (mouse) model.

Sallach JB, Crawford R, Li H, Johnston CT, Teppen BJ, Kaminski NE, Boyd SA.

Sci Total Environ. 2019 Feb 10;650(Pt 2):2231-2238. doi: 10.1016/j.scitotenv.2018.09.270. Epub 2018 Sep 22.


Conflict of Interest Mitigation Procedures May Have Little Influence on the Perceived Procedural Fairness of Risk-Related Research.

Besley JC, Zahry NR, McCright A, Elliott KC, Kaminski NE, Martin JD.

Risk Anal. 2019 Mar;39(3):571-585. doi: 10.1111/risa.13182. Epub 2018 Sep 3.


Interferon-α-Mediated Activation of T Cells from Healthy and HIV-Infected Individuals Is Suppressed by Δ9-Tetrahydrocannabinol.

Henriquez JE, Rizzo MD, Crawford RB, Gulick P, Kaminski NE.

J Pharmacol Exp Ther. 2018 Oct;367(1):49-58. doi: 10.1124/jpet.118.250308. Epub 2018 Jul 19.


Obfuscating transparency?

Aschner M, Autrup H, Berry CL, Boobis AR, Cohen SM, Dekant W, Galli CL, Goodman JI, Gori GB, Greim HA, Kaminski NE, Klaassen CD, Klaunig JE, Lotti M, Marquardt HW, Moretto A, Pelkonen O, Sipes IG, Wallace KB, Yamazaki H.

Regul Toxicol Pharmacol. 2018 Aug;97:A1-A3. doi: 10.1016/j.yrtph.2018.07.004. Epub 2018 Jul 11.


Lymphocyte-Specific Protein Tyrosine Kinase (LCK) is Involved in the Aryl Hydrocarbon Receptor-Mediated Impairment of Immunoglobulin Secretion in Human Primary B Cells.

Zhou J, Zhang Q, Henriquez JE, Crawford RB, Kaminski NE.

Toxicol Sci. 2018 Oct 1;165(2):322-334. doi: 10.1093/toxsci/kfy133.


Immunotoxicity testing using human primary leukocytes: An adjunct approach for the evaluation of human risk.

Phadnis-Moghe AS, Kaminski NE.

Curr Opin Toxicol. 2017 Apr;3:25-29. doi: 10.1016/j.cotox.2017.04.005. Epub 2017 May 3.


CLARITY-BPA: Effects of chronic Bisphenol A exposure on the immune system: Part 1 - Quantification of the relative number and proportion of leukocyte populations in the spleen and thymus.

Li J, Bach A, Crawford RB, Phadnis-Moghe AS, Chen W, D'Ingillo S, Kovalova N, Suarez-Martinez JE, Zhou J, Kaplan BLF, Kaminski NE.

Toxicology. 2018 Mar 1;396-397:46-53. doi: 10.1016/j.tox.2018.01.004. Epub 2018 Feb 8.


CLARITY-BPA: Effects of chronic bisphenol A exposure on the immune system: Part 2 - Characterization of lymphoproliferative and immune effector responses by splenic leukocytes.

Li J, Bach A, Crawford RB, Phadnis-Moghe AS, Chen W, D'Ingillo S, Kovalova N, Suarez-Martinez JE, Zhou J, Kaplan BLF, Kaminski NE.

Toxicology. 2018 Mar 1;396-397:54-67. doi: 10.1016/j.tox.2018.02.004. Epub 2018 Feb 7.


HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-γ-inducible protein 10 levels compared with nonusing HIV patients.

Rizzo MD, Crawford RB, Henriquez JE, Aldhamen YA, Gulick P, Amalfitano A, Kaminski NE.

AIDS. 2018 Feb 20;32(4):419-429. doi: 10.1097/QAD.0000000000001704.


Aryl Hydrocarbon Receptor Activation Suppresses EBF1 and PAX5 and Impairs Human B Lymphopoiesis.

Li J, Bhattacharya S, Zhou J, Phadnis-Moghe AS, Crawford RB, Kaminski NE.

J Immunol. 2017 Nov 15;199(10):3504-3515. doi: 10.4049/jimmunol.1700289. Epub 2017 Oct 4.


Modulatory Influence of Segmented Filamentous Bacteria on Transcriptomic Response of Gnotobiotic Mice Exposed to TCDD.

Stedtfeld RD, Chai B, Crawford RB, Stedtfeld TM, Williams MR, Xiangwen S, Kuwahara T, Cole JR, Kaminski NE, Tiedje JM, Hashsham SA.

Front Microbiol. 2017 Sep 7;8:1708. doi: 10.3389/fmicb.2017.01708. eCollection 2017.


TCDD administered on activated carbon eliminates bioavailability and subsequent shifts to a key murine gut commensal.

Stedtfeld RD, Brett Sallach J, Crawford RB, Stedtfeld TM, Williams MR, Waseem H, Johnston CT, Li H, Teppen BJ, Kaminski NE, Boyd SA, Tiedje JM, Hashsham SA.

Appl Microbiol Biotechnol. 2017 Oct;101(19):7409-7415. doi: 10.1007/s00253-017-8460-9. Epub 2017 Aug 15.


Δ9-Tetrahydrocannabinol Suppresses Secretion of IFNα by Plasmacytoid Dendritic Cells From Healthy and HIV-Infected Individuals.

Henriquez JE, Rizzo MD, Schulz MA, Crawford RB, Gulick P, Kaminski NE.

J Acquir Immune Defic Syndr. 2017 Aug 15;75(5):588-596. doi: 10.1097/QAI.0000000000001449.


Perceived conflict of interest in health science partnerships.

Besley JC, McCright AM, Zahry NR, Elliott KC, Kaminski NE, Martin JD.

PLoS One. 2017 Apr 20;12(4):e0175643. doi: 10.1371/journal.pone.0175643. eCollection 2017. Erratum in: PLoS One. 2018 Aug 10;13(8):e0202392.


Sequestration of 2,3,7,8-tetrachlorodibenzo-p-dioxin by activated carbon eliminates bioavailability and the suppression of immune function in mice.

Boyd SA, Sallach JB, Zhang Y, Crawford R, Li H, Johnston CT, Teppen BJ, Kaminski NE.

Environ Toxicol Chem. 2017 Oct;36(10):2671-2678. doi: 10.1002/etc.3815. Epub 2017 Jun 15.


Aryl hydrocarbon receptor activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs human B lymphopoiesis.

Li J, Phadnis-Moghe AS, Crawford RB, Kaminski NE.

Toxicology. 2017 Mar 1;378:17-24. doi: 10.1016/j.tox.2016.12.010. Epub 2016 Dec 31.


Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells.

Kovalova N, Nault R, Crawford R, Zacharewski TR, Kaminski NE.

Toxicol Appl Pharmacol. 2017 Feb 1;316:95-106. doi: 10.1016/j.taap.2016.11.009. Epub 2016 Nov 30.


Pseuderanthemum palatiferum leaf extract inhibits the proinflammatory cytokines, TNF-α and IL-6 expression in LPS-activated macrophages.

Sittisart P, Chitsomboon B, Kaminski NE.

Food Chem Toxicol. 2016 Nov;97:11-22. doi: 10.1016/j.fct.2016.08.021. Epub 2016 Aug 19.


Immunological characterization of the aryl hydrocarbon receptor (AHR) knockout rat in the presence and absence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Phadnis-Moghe AS, Chen W, Li J, Crawford RB, Bach A, D'Ingillo S, Kovalova N, Suarez-Martinez JE, Kaplan BL, Harrill JA, Budinsky R, Rowlands JC, Thomas RS, Kaminski NE.

Toxicology. 2016 Aug 10;368-369:172-182. doi: 10.1016/j.tox.2016.08.019. Epub 2016 Aug 31.


Upholding science in health, safety and environmental risk assessments and regulations.

Aschner M, Autrup HN, Berry SC, Boobis AR, Cohen SM, Creppy EE, Dekant W, Doull J, Galli CL, Goodman JI, Gori GB, Greim HA, Joudrier P, Kaminski NE, Klaassen CD, Klaunig JE, Lotti M, Marquardt HW, Pelkonen O, Sipes IG, Wallace KB, Yamazaki H.

Toxicology. 2016 Sep 14;371:12-16. doi: 10.1016/j.tox.2016.09.005. Epub 2016 Sep 14.


SHP-1 is directly activated by the aryl hydrocarbon receptor and regulates BCL-6 in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Phadnis-Moghe AS, Li J, Crawford RB, Kaminski NE.

Toxicol Appl Pharmacol. 2016 Nov 1;310:41-50. doi: 10.1016/j.taap.2016.08.014. Epub 2016 Aug 18.


The Influence of Human Interindividual Variability on the Low-Dose Region of Dose-Response Curve Induced by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Primary B Cells.

Dornbos P, Crawford RB, Kaminski NE, Hession SL, LaPres JJ.

Toxicol Sci. 2016 Oct;153(2):352-60. doi: 10.1093/toxsci/kfw128. Epub 2016 Jul 29.


CRACC-targeting Fc-fusion protein induces activation of NK cells and DCs and improves T cell immune responses to antigenic targets.

Aldhamen YA, Rastall DPW, Chen W, Seregin SS, Pereira-Hicks C, Godbehere S, Kaminski NE, Amalfitano A.

Vaccine. 2016 Jun 8;34(27):3109-3118. doi: 10.1016/j.vaccine.2016.04.068. Epub 2016 May 3.


2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice.

Fader KA, Nault R, Ammendolia DA, Harkema JR, Williams KJ, Crawford RB, Kaminski NE, Potter D, Sharratt B, Zacharewski TR.

Toxicol Sci. 2015 Dec;148(2):567-80. doi: 10.1093/toxsci/kfv206. Epub 2015 Sep 16.


Macrophage depletion lowers blood pressure and restores sympathetic nerve α2-adrenergic receptor function in mesenteric arteries of DOCA-salt hypertensive rats.

Thang LV, Demel SL, Crawford R, Kaminski NE, Swain GM, Van Rooijen N, Galligan JJ.

Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1186-97. doi: 10.1152/ajpheart.00283.2015. Epub 2015 Aug 28.


Modulation of HIVGP120 Antigen-Specific Immune Responses In Vivo by Δ9-Tetrahydrocannabinol.

Chen W, Crawford RB, Kaplan BL, Kaminski NE.

J Neuroimmune Pharmacol. 2015 Jun;10(2):344-55. doi: 10.1007/s11481-015-9597-x. Epub 2015 Apr 22.


Suppression of human B cell activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin involves altered regulation of B cell lymphoma-6.

Phadnis-Moghe AS, Crawford RB, Kaminski NE.

Toxicol Sci. 2015 Mar;144(1):39-50. doi: 10.1093/toxsci/kfu257. Epub 2014 Dec 26.


Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses.

Zhang Q, Bhattacharya S, Conolly RB, Clewell HJ, Kaminski NE, Andersen ME.

Environ Health Perspect. 2014 Dec;122(12):1261-70. doi: 10.1289/ehp.1408244. Epub 2014 Aug 12. Review.


Induced T cell cytokine production is enhanced by engineered nanoparticles.

Chen W, Zhang Q, Kaplan BL, Baker GL, Kaminski NE.

Nanotoxicology. 2014 Aug;8 Suppl 1:11-23. doi: 10.3109/17435390.2013.848302. Epub 2013 Nov 21.


A survey of frameworks for best practices in weight-of-evidence analyses.

Rhomberg LR, Goodman JE, Bailey LA, Prueitt RL, Beck NB, Bevan C, Honeycutt M, Kaminski NE, Paoli G, Pottenger LH, Scherer RW, Wise KC, Becker RA.

Crit Rev Toxicol. 2013 Oct;43(9):753-84. doi: 10.3109/10408444.2013.832727. Review.


Impaired NFAT and NFκB activation are involved in suppression of CD40 ligand expression by Δ(9)-tetrahydrocannabinol in human CD4(+) T cells.

Ngaotepprutaram T, Kaplan BL, Kaminski NE.

Toxicol Appl Pharmacol. 2013 Nov 15;273(1):209-18. doi: 10.1016/j.taap.2013.08.023. Epub 2013 Aug 30.


Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice.

Brandenberger C, Rowley NL, Jackson-Humbles DN, Zhang Q, Bramble LA, Lewandowski RP, Wagner JG, Chen W, Kaplan BL, Kaminski NE, Baker GL, Worden RM, Harkema JR.

Part Fibre Toxicol. 2013 Jul 1;10:26. doi: 10.1186/1743-8977-10-26.


Suppression by Δ(9)-tetrahydrocannabinol of the primary immunoglobulin M response by human peripheral blood B cells is associated with impaired STAT3 activation.

Ngaotepprutaram T, Kaplan BL, Carney S, Crawford R, Kaminski NE.

Toxicology. 2013 Aug 9;310:84-91. doi: 10.1016/j.tox.2013.05.009. Epub 2013 May 29.


Improvement in middle cerebral artery structure and endothelial function in stroke-prone spontaneously hypertensive rats after macrophage depletion.

Pires PW, Girgla SS, McClain JL, Kaminski NE, van Rooijen N, Dorrance AM.

Microcirculation. 2013 Oct;20(7):650-61. doi: 10.1111/micc.12064.


All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Zhang Q, Kline DE, Bhattacharya S, Crawford RB, Conolly RB, Thomas RS, Andersen ME, Kaminski NE.

Toxicol Appl Pharmacol. 2013 Apr 1;268(1):17-26. doi: 10.1016/j.taap.2013.01.015. Epub 2013 Jan 26.


Cannabidiol (CBD) enhances lipopolysaccharide (LPS)-induced pulmonary inflammation in C57BL/6 mice.

Karmaus PW, Wagner JG, Harkema JR, Kaminski NE, Kaplan BL.

J Immunotoxicol. 2013 Jul-Sep;10(3):321-8. doi: 10.3109/1547691X.2012.741628. Epub 2012 Nov 23.


Δ9-tetrahydrocannabinol impairs the inflammatory response to influenza infection: role of antigen-presenting cells and the cannabinoid receptors 1 and 2.

Karmaus PW, Chen W, Crawford R, Kaplan BL, Kaminski NE.

Toxicol Sci. 2013 Feb;131(2):419-33. doi: 10.1093/toxsci/kfs315. Epub 2012 Nov 14.


Magnitude of stimulation dictates the cannabinoid-mediated differential T cell response to HIVgp120.

Chen W, Kaplan BL, Pike ST, Topper LA, Lichorobiec NR, Simmons SO, Ramabhadran R, Kaminski NE.

J Leukoc Biol. 2012 Nov;92(5):1093-102. doi: 10.1189/jlb.0212082. Epub 2012 Aug 16.


Differential modulation by delta9-tetrahydrocannabinol (∆9)-THC) of CD40 ligand (CD40L) expression in activated mouse splenic CD4+ T cells.

Ngaotepprutaram T, Kaplan BL, Crawford RB, Kaminski NE.

J Neuroimmune Pharmacol. 2012 Dec;7(4):969-80. doi: 10.1007/s11481-012-9390-z. Epub 2012 Aug 1.


Comparison of the D2 receptor regulation and neurotoxicant susceptibility of nigrostriatal dopamine neurons in wild-type and CB1/CB2 receptor knockout mice.

Simkins TJ, Janis KL, McClure AK, Behrouz B, Pappas SS, Lehner A, Kaminski NE, Goudreau JL, Lookingland KJ, Kaplan BL.

J Neuroimmune Pharmacol. 2012 Sep;7(3):533-8. doi: 10.1007/s11481-012-9375-y. Epub 2012 May 27.


Signal peptide and denaturing temperature are critical factors for efficient mammalian expression and immunoblotting of cannabinoid receptors.

Wang C, Wang Y, Wang M, Chen J, Yu N, Song S, Kaminski NE, Zhang W.

J Huazhong Univ Sci Technolog Med Sci. 2012 Apr;32(2):299-302. doi: 10.1007/s11596-012-0052-4. Epub 2012 Apr 20.


Suppression of humoral immune responses by 2,3,7,8-tetrachlorodibenzo-p-dioxin intercalated in smectite clay.

Boyd SA, Johnston CT, Pinnavaia TJ, Kaminski NE, Teppen BJ, Li H, Khan B, Crawford RB, Kovalova N, Kim SS, Shao H, Gu C, Kaplan BL.

Environ Toxicol Chem. 2011 Dec;30(12):2748-55. doi: 10.1002/etc.701.


Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection.

Karmaus PW, Chen W, Crawford RB, Harkema JR, Kaplan BL, Kaminski NE.

J Leukoc Biol. 2011 Nov;90(5):983-95. doi: 10.1189/jlb.0511219. Epub 2011 Aug 26.

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