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Items: 7


Biosynthesis of an Anti-Addiction Agent from the Iboga Plant.

Farrow SC, Kamileen MO, Caputi L, Bussey K, Mundy JEA, McAtee RC, Stephenson CRJ, O'Connor SE.

J Am Chem Soc. 2019 Aug 21;141(33):12979-12983. doi: 10.1021/jacs.9b05999. Epub 2019 Aug 6.


Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.

Lichman BR, Kamileen MO, Titchiner GR, Saalbach G, Stevenson CEM, Lawson DM, O'Connor SE.

Nat Chem Biol. 2019 Jan;15(1):71-79. doi: 10.1038/s41589-018-0185-2. Epub 2018 Dec 10.


Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from Tabernanthe iboga.

Farrow SC, Kamileen MO, Meades J, Ameyaw B, Xiao Y, O'Connor SE.

J Biol Chem. 2018 Sep 7;293(36):13821-13833. doi: 10.1074/jbc.RA118.004060. Epub 2018 Jul 20.


Identification of iridoid synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry.

Sherden NH, Lichman B, Caputi L, Zhao D, Kamileen MO, Buell CR, O'Connor SE.

Phytochemistry. 2018 Jan;145:48-56. doi: 10.1016/j.phytochem.2017.10.004. Epub 2017 Nov 5.


Inverted stereocontrol of iridoid synthase in snapdragon.

Kries H, Kellner F, Kamileen MO, O'Connor SE.

J Biol Chem. 2017 Sep 1;292(35):14659-14667. doi: 10.1074/jbc.M117.800979. Epub 2017 Jul 12.


Differential iridoid production as revealed by a diversity panel of 84 cultivated and wild blueberry species.

Leisner CP, Kamileen MO, Conway ME, O'Connor SE, Buell CR.

PLoS One. 2017 Jun 13;12(6):e0179417. doi: 10.1371/journal.pone.0179417. eCollection 2017.


Structural determinants of reductive terpene cyclization in iridoid biosynthesis.

Kries H, Caputi L, Stevenson CEM, Kamileen MO, Sherden NH, Geu-Flores F, Lawson DM, O'Connor SE.

Nat Chem Biol. 2016 Jan;12(1):6-8. doi: 10.1038/nchembio.1955. Epub 2015 Nov 9.

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