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Items: 1 to 50 of 127


Neurally mediated syncope diagnosis based on adenylate cyclase activity in Japanese patients.

Komiyama T, Nagata E, Hashida T, Sakama S, Ayabe K, Kamiguchi H, Sasaki A, Yoshioka K, Kobayashi H.

PLoS One. 2019 Apr 18;14(4):e0214733. doi: 10.1371/journal.pone.0214733. eCollection 2019.


Spatially restricted long-term transgene expression in the developing skin used for studying the interaction of epidermal development and sensory innervation.

Chan C, Kamiguchi H, Shimogori T.

Dev Growth Differ. 2019 May;61(4):276-282. doi: 10.1111/dgd.12603. Epub 2019 Apr 9.


Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid.

Otake K, Kamiguchi H, Hirozane Y.

BMC Med Genomics. 2019 Jan 10;12(1):7. doi: 10.1186/s12920-019-0473-z.


Preference for Glucose over Inositol Headgroup during Lysolipid Activation of G Protein-Coupled Receptor 55.

Guy AT, Kano K, Ohyama J, Kamiguchi H, Hirabayashi Y, Ito Y, Matsuo I, Greimel P.

ACS Chem Neurosci. 2019 Jan 16;10(1):716-727. doi: 10.1021/acschemneuro.8b00505. Epub 2018 Oct 29.


Squaryl group modified phosphoglycolipid analogs as potential modulators of GPR55.

Ding F, Guy AT, Greimel P, Hirabayashi Y, Kamiguchi H, Ito Y.

Chem Commun (Camb). 2018 Jul 26;54(61):8470-8473. doi: 10.1039/c8cc04467h.


Achievements of Japan neuroscience award winners.

Kamiguchi H.

Neurosci Res. 2018 Apr;129:1. doi: 10.1016/j.neures.2018.02.008. No abstract available.


Glucose uptake of the muscle and adipose tissues in diabetes and obesity disease models: evaluation of insulin and β3-adrenergic receptor agonist effects by 18F-FDG.

Ishino S, Sugita T, Kondo Y, Okai M, Tsuchimori K, Watanabe M, Mori I, Hosoya M, Horiguchi T, Kamiguchi H.

Ann Nucl Med. 2017 Jun;31(5):413-423. doi: 10.1007/s12149-017-1169-0. Epub 2017 Apr 11.


A PEGylated analog of short-length Neuromedin U with potent anorectic and anti-obesity effects.

Inooka H, Sakamoto K, Shinohara T, Masuda Y, Terada M, Kumano S, Yokoyama K, Noguchi J, Nishizawa N, Kamiguchi H, Fujita H, Asami T, Takekawa S, Ohtaki T.

Bioorg Med Chem. 2017 Apr 15;25(8):2307-2312. doi: 10.1016/j.bmc.2017.02.023. Epub 2017 Feb 21.


Editorial announcement - Welcome to the new journey of Neuroscience Research.

Kamiguchi H.

Neurosci Res. 2017 Jan;114:1-2. doi: 10.1016/j.neures.2017.01.001. No abstract available.


Analysis to Estimate Genetic Variations in the Idarubicin-Resistant Derivative MOLT-3.

Komiyama T, Ogura A, Hirokawa T, Zhijing M, Kamiguchi H, Asai S, Miyachi H, Kobayashi H.

Int J Mol Sci. 2016 Dec 22;18(1). pii: E12. doi: 10.3390/ijms18010012.


Mutations in the Mitochondrial ND1 Gene Are Associated with Postoperative Prognosis of Localized Renal Cell Carcinoma.

Kim H, Komiyama T, Inomoto C, Kamiguchi H, Kajiwara H, Kobayashi H, Nakamura N, Terachi T.

Int J Mol Sci. 2016 Dec 7;17(12). pii: E2049.


Visualization of Clathrin-Mediated Endocytosis During Semaphorin-Guided Axonal Growth.

Itofusa R, Tojima T, Kamiguchi H.

Methods Mol Biol. 2017;1493:287-298.


Biomarker discovery for drug-induced phospholipidosis: phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers.

Kamiguchi H, Murabayashi M, Mori I, Horinouchi A, Higaki K.

Biomarkers. 2017 Mar;22(2):178-188. doi: 10.1080/1354750X.2016.1252958. Epub 2016 Nov 21.


Production of a Locus- and Allele-Specific Monoclonal Antibody for the Characterization of SLA-1*0401 mRNA and Protein Expression Levels in MHC-Defined Microminipigs.

Kametani Y, Ohshima S, Miyamoto A, Shigenari A, Takasu M, Imaeda N, Matsubara T, Tanaka M, Shiina T, Kamiguchi H, Suzuki R, Kitagawa H, Kulski JK, Hirayama N, Inoko H, Ando A.

PLoS One. 2016 Oct 19;11(10):e0164995. doi: 10.1371/journal.pone.0164995. eCollection 2016.


Method development and validation for simultaneous quantitation of endogenous hippuric acid and phenylacetylglycine in rat urine using liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

Kamiguchi H, Yamaguchi M, Murabayashi M, Mori I, Horinouchi A.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 1;1035:76-83. doi: 10.1016/j.jchromb.2016.09.036. Epub 2016 Sep 28.


MicroRNA Stability in FFPE Tissue Samples: Dependence on GC Content.

Kakimoto Y, Tanaka M, Kamiguchi H, Ochiai E, Osawa M.

PLoS One. 2016 Sep 20;11(9):e0163125. doi: 10.1371/journal.pone.0163125. eCollection 2016.


Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats.

Gopalan V, Michael N, Ishino S, Lee SS, Yang AY, Bhanu Prakash KN, Yaligar J, Sadananthan SA, Kaneko M, Zhou Z, Satomi Y, Hirayama M, Kamiguchi H, Zhu B, Horiguchi T, Nishimoto T, Velan SS.

Sci Rep. 2016 May 20;6:26445. doi: 10.1038/srep26445.


Cyclic Nucleotide Control of Microtubule Dynamics for Axon Guidance.

Akiyama H, Fukuda T, Tojima T, Nikolaev VO, Kamiguchi H.

J Neurosci. 2016 May 18;36(20):5636-49. doi: 10.1523/JNEUROSCI.3596-15.2016.


Myosin Va and Endoplasmic Reticulum Calcium Channel Complex Regulates Membrane Export during Axon Guidance.

Wada F, Nakata A, Tatsu Y, Ooashi N, Fukuda T, Nabetani T, Kamiguchi H.

Cell Rep. 2016 May 10;15(6):1329-44. doi: 10.1016/j.celrep.2016.04.021. Epub 2016 Apr 28.


Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth.

Endo M, Hattori M, Toriyabe H, Ohno H, Kamiguchi H, Iino Y, Ozawa T.

Sci Rep. 2016 Apr 7;6:23976. doi: 10.1038/srep23976.


MicroRNA deep sequencing reveals chamber-specific miR-208 family expression patterns in the human heart.

Kakimoto Y, Tanaka M, Kamiguchi H, Hayashi H, Ochiai E, Osawa M.

Int J Cardiol. 2016 May 15;211:43-8. doi: 10.1016/j.ijcard.2016.02.145. Epub 2016 Mar 2.


Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin-microtubule interface.

Minoura I, Takazaki H, Ayukawa R, Saruta C, Hachikubo Y, Uchimura S, Hida T, Kamiguchi H, Shimogori T, Muto E.

Nat Commun. 2016 Jan 18;7:10058. doi: 10.1038/ncomms10058.


Introduction to glyco-neuroscience.

Kamiguchi H, Kadomatsu K.

Exp Neurol. 2015 Dec;274(Pt B):89. doi: 10.1016/j.expneurol.2015.11.008. No abstract available.


NEURONAL DEVELOPMENT. Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord.

Guy AT, Nagatsuka Y, Ooashi N, Inoue M, Nakata A, Greimel P, Inoue A, Nabetani T, Murayama A, Ohta K, Ito Y, Aoki J, Hirabayashi Y, Kamiguchi H.

Science. 2015 Aug 28;349(6251):974-7. doi: 10.1126/science.aab3516.


MicroRNA Stability in Postmortem FFPE Tissues: Quantitative Analysis Using Autoptic Samples from Acute Myocardial Infarction Patients.

Kakimoto Y, Kamiguchi H, Ochiai E, Satoh F, Osawa M.

PLoS One. 2015 Jun 5;10(6):e0129338. doi: 10.1371/journal.pone.0129338. eCollection 2015.


Exocytic and endocytic membrane trafficking in axon development.

Tojima T, Kamiguchi H.

Dev Growth Differ. 2015 May;57(4):291-304. doi: 10.1111/dgd.12218. Epub 2015 May 13. Review.


Relationship between human evolution and neurally mediated syncope disclosed by the polymorphic sites of the adrenergic receptor gene α2B-AR.

Komiyama T, Hirokawa T, Sato K, Oka A, Kamiguchi H, Nagata E, Sakura H, Otsuka K, Kobayashi H.

PLoS One. 2015 Apr 10;10(4):e0120788. doi: 10.1371/journal.pone.0120788. eCollection 2015.


Introduction: Second messengers in neural development.

Kamiguchi H, Borodinsky LN.

Dev Neurobiol. 2015 Apr;75(4):335-6. doi: 10.1002/dneu.22269. Epub 2015 Feb 18. No abstract available.


Cloning and transcriptional expression of mouse mannosyltransferase IV/V cDNA, which is involved in the synthesis of lipid-linked oligosaccharides.

Nishimura Y, Shimono N, Yoshimoto T, Kamiguchi H, Nishikawa Y.

Biosci Biotechnol Biochem. 2014;78(3):400-9. doi: 10.1080/09168451.2014.890026. Epub 2014 Apr 17.


Vasculogenic conditioning of peripheral blood mononuclear cells promotes endothelial progenitor cell expansion and phenotype transition of anti-inflammatory macrophage and T lymphocyte to cells with regenerative potential.

Masuda H, Tanaka R, Fujimura S, Ishikawa M, Akimaru H, Shizuno T, Sato A, Okada Y, Iida Y, Itoh J, Itoh Y, Kamiguchi H, Kawamoto A, Asahara T.

J Am Heart Assoc. 2014 Jun 25;3(3):e000743. doi: 10.1161/JAHA.113.000743.


Steering neuronal growth cones by shifting the imbalance between exocytosis and endocytosis.

Tojima T, Itofusa R, Kamiguchi H.

J Neurosci. 2014 May 21;34(21):7165-78. doi: 10.1523/JNEUROSCI.5261-13.2014.


Analysis of calcium signals in steering neuronal growth cones in vitro.

Akiyama H, Kamiguchi H.

Methods Mol Biol. 2014;1162:17-27. doi: 10.1007/978-1-4939-0777-9_2.


Second messenger networks for accurate growth cone guidance.

Akiyama H, Kamiguchi H.

Dev Neurobiol. 2015 Apr;75(4):411-22. doi: 10.1002/dneu.22157. Epub 2013 Dec 20. Review.


GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70.

Fujita A, Koinuma S, Yasuda S, Nagai H, Kamiguchi H, Wada N, Nakamura T.

PLoS One. 2013 Nov 4;8(11):e79689. doi: 10.1371/journal.pone.0079689. eCollection 2013.


Spatial gradients of chemotropic factors from immobilized patterns to guide axonal growth and regeneration.

Joddar B, Guy AT, Kamiguchi H, Ito Y.

Biomaterials. 2013 Dec;34(37):9593-601. doi: 10.1016/j.biomaterials.2013.08.019. Epub 2013 Sep 7.


Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration.

Kuboyama T, Luo X, Park K, Blackmore MG, Tojima T, Tohda C, Bixby JL, Lemmon VP, Kamiguchi H.

Exp Neurol. 2013 Oct;248:157-69. doi: 10.1016/j.expneurol.2013.06.011. Epub 2013 Jun 21.


Senescent case of cholesterol ester storage disease that progressed to liver cirrhosis with a novel mutation (N250H) of lysosomal acid lipase gene.

Kojima S, Watanabe N, Takashimizu S, Kagawa T, Shiraishi K, Koizumi J, Hirabayashi K, Ohkubo T, Kamiguchi H, Tsuda M, Mine T.

Hepatol Res. 2013 Dec;43(12):1361-7. doi: 10.1111/hepr.12087. Epub 2013 May 15.


Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors.

Kawakita Y, Seto M, Ohashi T, Tamura T, Yusa T, Miki H, Iwata H, Kamiguchi H, Tanaka T, Sogabe S, Ohta Y, Ishikawa T.

Bioorg Med Chem. 2013 Apr 15;21(8):2250-2261. doi: 10.1016/j.bmc.2013.02.014. Epub 2013 Feb 22.


[Mechanisms of neuronal growth cone navigation].

Akiyama H, Tojima T, Kamiguchi H.

Seikagaku. 2012 Oct;84(10):848-53. Review. Japanese. No abstract available.


Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacy.

Kawakita Y, Miwa K, Seto M, Banno H, Ohta Y, Tamura T, Yusa T, Miki H, Kamiguchi H, Ikeda Y, Tanaka T, Kamiyama K, Ishikawa T.

Bioorg Med Chem. 2012 Oct 15;20(20):6171-80. doi: 10.1016/j.bmc.2012.08.002. Epub 2012 Aug 25.


Porcine MHC classical class I genes are coordinately expressed in superantigen-activated mononuclear cells.

Kametani Y, Ohshima S, Kita YF, Shimada S, Kamiguchi H, Shiina T, Inoko H, Kulski JK, Ando A.

Vet Immunol Immunopathol. 2012 Aug 15;148(3-4):252-9. doi: 10.1016/j.vetimm.2012.05.005. Epub 2012 May 8.


LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner.

Takano T, Tomomura M, Yoshioka N, Tsutsumi K, Terasawa Y, Saito T, Kawano H, Kamiguchi H, Fukuda M, Hisanaga S.

J Neurosci. 2012 May 9;32(19):6587-99. doi: 10.1523/JNEUROSCI.5317-11.2012.


Establishment and validation of a rabbit model for in vivo pharmacodynamic screening of tachykinin NK2 antagonists.

Tanaka T, Matsumoto-Okano S, Inatomi N, Fujioka Y, Kamiguchi H, Yamaguchi M, Imanishi A, Kawamoto M, Miura K, Nishikawa Y, Tsukimi Y.

J Pharmacol Sci. 2012;118(4):487-95. Epub 2012 Mar 22.


Design and synthesis of pyrrolo[3,2-d]pyrimidine human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors: exploration of novel back-pocket binders.

Kawakita Y, Banno H, Ohashi T, Tamura T, Yusa T, Nakayama A, Miki H, Iwata H, Kamiguchi H, Tanaka T, Habuka N, Sogabe S, Ohta Y, Ishikawa T.

J Med Chem. 2012 Apr 26;55(8):3975-91. doi: 10.1021/jm300185p. Epub 2012 Apr 10.


Syntaxin 1C, a soluble form of syntaxin, attenuates membrane recycling by destabilizing microtubules.

Nakayama T, Kamiguchi H, Akagawa K.

J Cell Sci. 2012 Feb 15;125(Pt 4):817-30. doi: 10.1242/jcs.081943. Epub 2012 Mar 15.


Metabolic fate of sipoglitazar, a novel oral PPAR agonist with activities for PPAR-γ, -α and -δ, in rats and monkeys and comparison with humans in vitro.

Nishihara M, Sudo M, Kamiguchi H, Kawaguchi N, Maeshiba Y, Kiyota Y, Takahashi J, Tagawa Y, Kondo T, Asahi S.

Drug Metab Pharmacokinet. 2012;27(2):223-31. Epub 2011 Nov 29.


Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca2+/calmodulin-dependent protein kinases.

Nakamuta S, Funahashi Y, Namba T, Arimura N, Picciotto MR, Tokumitsu H, Soderling TR, Sakakibara A, Miyata T, Kamiguchi H, Kaibuchi K.

Sci Signal. 2011 Nov 15;4(199):ra76. doi: 10.1126/scisignal.2002011.


Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold.

Ishikawa T, Seto M, Banno H, Kawakita Y, Oorui M, Taniguchi T, Ohta Y, Tamura T, Nakayama A, Miki H, Kamiguchi H, Tanaka T, Habuka N, Sogabe S, Yano J, Aertgeerts K, Kamiyama K.

J Med Chem. 2011 Dec 8;54(23):8030-50. doi: 10.1021/jm2008634. Epub 2011 Nov 4.


Remarkable expression in the colon adenocarcinoma of Hmat-Xa, a human mannosyltransferase-like gene, that is homologous to drosophila gene GC15914.

Shimono N, Nishimura Y, Kamiguchi H, Nishikawa Y.

Biosci Biotechnol Biochem. 2011;75(8):1451-5. Epub 2011 Aug 7.

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