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Items: 1 to 50 of 84

1.

6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum.

Saepua S, Sadorn K, Vanichtanankul J, Anukunwithaya T, Rattanajak R, Vitsupakorn D, Kamchonwongpaisan S, Yuthavong Y, Thongpanchang C.

Bioorg Med Chem. 2019 Dec 15;27(24):115158. doi: 10.1016/j.bmc.2019.115158. Epub 2019 Oct 28.

PMID:
31685330
2.

(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities.

Promchai T, Thaima T, Rattanajak R, Kamchonwongpaisan S, Pyne SG, Limtharakul T.

Nat Prod Res. 2019 Oct 21:1-6. doi: 10.1080/14786419.2019.1679139. [Epub ahead of print]

PMID:
31631698
3.

Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target.

Aroonsri A, Posayapisit N, Kongsee J, Siripan O, Vitsupakorn D, Utaida S, Uthaipibull C, Kamchonwongpaisan S, Shaw PJ.

PeerJ. 2019 Apr 17;7:e6713. doi: 10.7717/peerj.6713. eCollection 2019.

4.

Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.

Tarnchompoo B, Chitnumsub P, Jaruwat A, Shaw PJ, Vanichtanankul J, Poen S, Rattanajak R, Wongsombat C, Tonsomboon A, Decharuangsilp S, Anukunwithaya T, Arwon U, Kamchonwongpaisan S, Yuthavong Y.

ACS Med Chem Lett. 2018 Nov 7;9(12):1235-1240. doi: 10.1021/acsmedchemlett.8b00389. eCollection 2018 Dec 13.

5.

Polyoxygenated Cyclohexenes and Their Chlorinated Derivatives from the Leaves of Uvaria cherrevensis.

Auranwiwat C, Wongsomboon P, Thaima T, Rattanajak R, Kamchonwongpaisan S, Willis AC, Laphookhieo S, Pyne SG, Limtharakul T.

J Nat Prod. 2019 Jan 25;82(1):101-110. doi: 10.1021/acs.jnatprod.8b00794. Epub 2019 Jan 4.

PMID:
30608167
6.

Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus.

Promchai T, Janhom P, Maneerat W, Rattanajak R, Kamchonwongpaisan S, Pyne SG, Limtharakul T.

Nat Prod Res. 2018 Dec 26:1-5. doi: 10.1080/14786419.2018.1512990. [Epub ahead of print]

PMID:
30587032
7.

Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis.

Auranwiwat C, Rattanajak R, Kamchonwongpaisan S, Laphookhieo S, Pyne SG, Limtharakul T.

Fitoterapia. 2018 Oct;130:198-202. doi: 10.1016/j.fitote.2018.08.020. Epub 2018 Aug 27.

PMID:
30165178
8.

The Plasmodium berghei RC strain is highly diverged and harbors putatively novel drug resistance variants.

Songsungthong W, Kulawonganunchai S, Wilantho A, Tongsima S, Koonyosying P, Uthaipibull C, Kamchonwongpaisan S, Shaw PJ.

PeerJ. 2017 Oct 5;5:e3766. doi: 10.7717/peerj.3766. eCollection 2017.

9.

Hematological parameters and red blood cell morphological abnormality of Glucose-6-Phosphate dehydrogenase deficiency co-inherited with thalassemia.

Pengon J, Svasti S, Kamchonwongpaisan S, Vattanaviboon P.

Hematol Oncol Stem Cell Ther. 2018 Mar;11(1):18-24. doi: 10.1016/j.hemonc.2017.05.029. Epub 2017 Jun 15.

10.

2-Phenylnaphthalenes and a polyoxygenated cyclohexene from the stem and root extracts of Uvaria cherrevensis (Annonaceae).

Auranwiwat C, Wongsomboon P, Thaima T, Rattanajak R, Kamchonwongpaisan S, Willis AC, Lie W, Pyne SG, Limtharakul Née Ritthiwigrom T.

Fitoterapia. 2017 Jul;120:103-107. doi: 10.1016/j.fitote.2017.06.002. Epub 2017 Jun 9.

PMID:
28596029
11.

Cytochrome c and c1 heme lyases are essential in Plasmodium berghei.

Posayapisit N, Songsungthong W, Koonyosying P, Falade MO, Uthaipibull C, Yuthavong Y, Shaw PJ, Kamchonwongpaisan S.

Mol Biochem Parasitol. 2016 Nov - Dec;210(1-2):32-36. doi: 10.1016/j.molbiopara.2016.08.003. Epub 2016 Aug 9.

PMID:
27520480
12.

Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates.

Lourens AC, Gravestock D, van Zyl RL, Hoppe HC, Kolesnikova N, Taweechai S, Yuthavong Y, Kamchonwongpaisan S, Rousseau AL.

Org Biomol Chem. 2016 Aug 16;14(33):7899-911. doi: 10.1039/c6ob01350c.

PMID:
27477595
13.

Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling.

Aroonsri A, Akinola O, Posayapisit N, Songsungthong W, Uthaipibull C, Kamchonwongpaisan S, Gbotosho GO, Yuthavong Y, Shaw PJ.

Int J Parasitol. 2016 Jul;46(8):527-35. doi: 10.1016/j.ijpara.2016.04.002. Epub 2016 May 2.

PMID:
27150044
14.

Inhibition of Glutathione Biosynthesis Sensitizes Plasmodium berghei to Antifolates.

Songsungthong W, Koonyosying P, Uthaipibull C, Kamchonwongpaisan S.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):3057-64. doi: 10.1128/AAC.01836-15. Print 2016 May.

15.

Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata.

Promchai T, Jaidee A, Cheenpracha S, Trisuwan K, Rattanajak R, Kamchonwongpaisan S, Laphookhieo S, Pyne SG, Ritthiwigrom T.

J Nat Prod. 2016 Apr 22;79(4):978-83. doi: 10.1021/acs.jnatprod.5b01054. Epub 2016 Mar 1.

PMID:
26928423
16.

Estimating mRNA lengths from Plasmodium falciparum genes by Virtual Northern RNA-seq analysis.

Shaw PJ, Kaewprommal P, Piriyapongsa J, Wongsombat C, Yuthavong Y, Kamchonwongpaisan S.

Int J Parasitol. 2016 Jan;46(1):7-12. doi: 10.1016/j.ijpara.2015.09.007. Epub 2015 Nov 10.

PMID:
26548960
17.

Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study.

Shaw PJ, Chaotheing S, Kaewprommal P, Piriyapongsa J, Wongsombat C, Suwannakitti N, Koonyosying P, Uthaipibull C, Yuthavong Y, Kamchonwongpaisan S.

BMC Genomics. 2015 Oct 21;16:830. doi: 10.1186/s12864-015-2040-0.

18.

Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green tea extract on growth of Plasmodium falciparum.

Thipubon P, Uthaipibull C, Kamchonwongpaisan S, Tipsuwan W, Srichairatanakool S.

Malar J. 2015 Sep 30;14:382. doi: 10.1186/s12936-015-0910-1.

19.

Cytotoxic and Antimalarial Alkaloids from the Twigs of Dasymaschalon obtusipetalum.

Jaidee A, Promchai T, Trisuwan K, Laphookhieo S, Rattanajak R, Kamchonwongpaisan S, Pyne SG, Ritthiwigrom T.

Nat Prod Commun. 2015 Jul;10(7):1175-7. Erratum in: Nat Prod Commun. 2015 Dec;10(12):2203.

PMID:
26411003
20.

Use of bacterial surrogates as a tool to explore antimalarial drug interaction: Synergism between inhibitors of malarial dihydrofolate reductase and dihydropteroate synthase.

Talawanich Y, Kamchonwongpaisan S, Sirawaraporn W, Yuthavong Y.

Acta Trop. 2015 Sep;149:64-9. doi: 10.1016/j.actatropica.2015.05.011. Epub 2015 May 18.

PMID:
25997881
21.

Molecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteins.

Wongsombat C, Aroonsri A, Kamchonwongpaisan S, Morgan HP, Walkinshaw MD, Yuthavong Y, Shaw PJ.

Mol Biochem Parasitol. 2014 Nov;198(1):1-10. doi: 10.1016/j.molbiopara.2014.10.005. Epub 2014 Nov 3.

PMID:
25447287
22.

Origin of robustness in generating drug-resistant malaria parasites.

Kümpornsin K, Modchang C, Heinberg A, Ekland EH, Jirawatcharadech P, Chobson P, Suwanakitti N, Chaotheing S, Wilairat P, Deitsch KW, Kamchonwongpaisan S, Fidock DA, Kirkman LA, Yuthavong Y, Chookajorn T.

Mol Biol Evol. 2014 Jul;31(7):1649-60. doi: 10.1093/molbev/msu140. Epub 2014 Apr 16.

23.

Molecular dynamics of interactions between rigid and flexible antifolates and dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium falciparum.

Mokmak W, Chunsrivirot S, Hannongbua S, Yuthavong Y, Tongsima S, Kamchonwongpaisan S.

Chem Biol Drug Des. 2014 Oct;84(4):450-61. doi: 10.1111/cbdd.12334. Epub 2014 Jun 4.

PMID:
24716467
24.

GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile.

Wangchuk P, Keller PA, Pyne SG, Taweechotipatr M, Kamchonwongpaisan S.

Nat Prod Commun. 2013 Sep;8(9):1305-8.

PMID:
24273872
25.

A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain.

Wangchuk P, Keller PA, Pyne SG, Lie W, Willis AC, Rattanajak R, Kamchonwongpaisan S.

J Ethnopharmacol. 2013 Dec 12;150(3):953-9. doi: 10.1016/j.jep.2013.09.052. Epub 2013 Oct 9. Erratum in: J Ethnopharmacol. 2014 May 14;153(3):934. Phurpa, Wangchuk [corrected to Wangchuk, Phurpa].

PMID:
24120516
26.

Inducible knockdown of Plasmodium gene expression using the glmS ribozyme.

Prommana P, Uthaipibull C, Wongsombat C, Kamchonwongpaisan S, Yuthavong Y, Knuepfer E, Holder AA, Shaw PJ.

PLoS One. 2013 Aug 30;8(8):e73783. doi: 10.1371/journal.pone.0073783. eCollection 2013.

27.

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.

Yuthavong Y, Tarnchompoo B, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Charman SA, McLennan DN, White KL, Vivas L, Bongard E, Thongphanchang C, Taweechai S, Vanichtanankul J, Rattanajak R, Arwon U, Fantauzzi P, Yuvaniyama J, Charman WN, Matthews D.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16823-8. doi: 10.1073/pnas.1204556109. Epub 2012 Oct 3.

28.

Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa.

Wangchuk P, Keller PA, Pyne SG, Sastraruji T, Taweechotipatr M, Rattanajak R, Tonsomboon A, Kamchonwongpaisan S.

Nat Prod Commun. 2012 May;7(5):575-80.

PMID:
22799079
29.

Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.

Wangchuk P, Keller PA, Pyne SG, Willis AC, Kamchonwongpaisan S.

J Ethnopharmacol. 2012 Aug 30;143(1):310-3. doi: 10.1016/j.jep.2012.06.037. Epub 2012 Jul 14.

PMID:
22796506
30.

Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil.

Vanichtanankul J, Taweechai S, Uttamapinant C, Chitnumsub P, Vilaivan T, Yuthavong Y, Kamchonwongpaisan S.

Antimicrob Agents Chemother. 2012 Jul;56(7):3928-35. doi: 10.1128/AAC.00301-12. Epub 2012 Apr 23.

31.

Flow cytometric enumeration of Plasmodium berghei-infected red blood cells stained with SYBR Green I.

Somsak V, Srichairatanakool S, Yuthavong Y, Kamchonwongpaisan S, Uthaipibull C.

Acta Trop. 2012 Apr;122(1):113-8. doi: 10.1016/j.actatropica.2011.12.010. Epub 2011 Dec 29.

PMID:
22222185
32.

Enhancement of DNA hybridization under acoustic streaming with three-piezoelectric-transducer system.

Maturos T, Pogfay T, Rodaree K, Chaotheing S, Jomphoak A, Wisitsoraat A, Suwanakitti N, Wongsombat C, Jaruwongrungsee K, Shaw P, Kamchonwongpaisan S, Tuantranont A.

Lab Chip. 2012 Jan 7;12(1):133-8. doi: 10.1039/c1lc20720b. Epub 2011 Nov 10.

PMID:
22072313
33.

Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening.

Somsak V, Uthaipibull C, Prommana P, Srichairatanakool S, Yuthavong Y, Kamchonwongpaisan S.

Malar J. 2011 Oct 7;10:291. doi: 10.1186/1475-2875-10-291.

34.

Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine.

Kritsiriwuthinan K, Chaotheing S, Shaw PJ, Wongsombat C, Chavalitshewinkoon-Petmitr P, Kamchonwongpaisan S.

Malar J. 2011 Aug 18;10:242. doi: 10.1186/1475-2875-10-242.

35.

Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities.

Wangchuk P, Keller PA, Pyne SG, Taweechotipatr M, Tonsomboon A, Rattanajak R, Kamchonwongpaisan S.

J Ethnopharmacol. 2011 Sep 1;137(1):730-42. doi: 10.1016/j.jep.2011.06.032. Epub 2011 Jun 28.

PMID:
21741462
36.

Trypanosomal dihydrofolate reductase reveals natural antifolate resistance.

Vanichtanankul J, Taweechai S, Yuvaniyama J, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Yuthavong Y.

ACS Chem Biol. 2011 Sep 16;6(9):905-11. doi: 10.1021/cb200124r. Epub 2011 Jun 16.

PMID:
21650210
37.

Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model.

Tipsuwan W, Srichairatanakool S, Kamchonwongpaisan S, Yuthavong Y, Uthaipibull C.

Malar J. 2011 May 10;10:119. doi: 10.1186/1475-2875-10-119.

38.

Small-scale in vitro culture and purification of Plasmodium berghei for transfection experiment.

Somsak V, Srichairatanakool S, Kamchonwongpaisan S, Yuthavong Y, Uthaipibull C.

Mol Biochem Parasitol. 2011 Jun;177(2):156-9. doi: 10.1016/j.molbiopara.2011.01.013. Epub 2011 Feb 1.

PMID:
21291917
39.

DNA hybridization enhancement using piezoelectric microagitation through a liquid coupling medium.

Rodaree K, Maturos T, Chaotheing S, Pogfay T, Suwanakitti N, Wongsombat C, Jaruwongrungsee K, Wisitsoraat A, Kamchonwongpaisan S, Lomas T, Tuantranont A.

Lab Chip. 2011 Mar 21;11(6):1059-64. doi: 10.1039/c0lc00419g. Epub 2011 Feb 2.

PMID:
21290049
40.

Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum.

Wangchuk P, Bremner JB, Samten, Skelton BW, White AH, Rattanajak R, Kamchonwongpaisan S.

J Ethnopharmacol. 2010 Aug 9;130(3):559-62. doi: 10.1016/j.jep.2010.05.057. Epub 2010 Jun 2.

PMID:
20561926
41.

Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.

Nzila A, Rottmann M, Chitnumsub P, Kiara SM, Kamchonwongpaisan S, Maneeruttanarungroj C, Taweechai S, Yeung BK, Goh A, Lakshminarayana SB, Zou B, Wong J, Ma NL, Weaver M, Keller TH, Dartois V, Wittlin S, Brun R, Yuthavong Y, Diagana TT.

Antimicrob Agents Chemother. 2010 Jun;54(6):2603-10. doi: 10.1128/AAC.01526-09. Epub 2010 Mar 29.

42.

Stepwise acquisition of pyrimethamine resistance in the malaria parasite.

Lozovsky ER, Chookajorn T, Brown KM, Imwong M, Shaw PJ, Kamchonwongpaisan S, Neafsey DE, Weinreich DM, Hartl DL.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12025-30. doi: 10.1073/pnas.0905922106. Epub 2009 Jul 8.

43.

Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha.

Wangchuk P, Bremner JB; Samten, Rattanajak R, Kamchonwongpaisan S.

Phytother Res. 2010 Apr;24(4):481-5. doi: 10.1002/ptr.2893.

PMID:
19496064
44.

Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review.

Cruz AK, de Toledo JS, Falade M, Terrão MC, Kamchonwongpaisan S, Kyle DE, Uthaipibull C.

Curr Drug Targets. 2009 Mar;10(3):178-92. Review.

PMID:
19275555
45.

Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases.

Maitarad P, Kamchonwongpaisan S, Vanichtanankul J, Vilaivan T, Yuthavong Y, Hannongbua S.

J Comput Aided Mol Des. 2009 Apr;23(4):241-52. doi: 10.1007/s10822-008-9254-z. Epub 2009 Jan 21.

PMID:
19156529
46.

Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria.

Dasgupta T, Chitnumsub P, Kamchonwongpaisan S, Maneeruttanarungroj C, Nichols SE, Lyons TM, Tirado-Rives J, Jorgensen WL, Yuthavong Y, Anderson KS.

ACS Chem Biol. 2009 Jan 16;4(1):29-40. doi: 10.1021/cb8002804.

47.

A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates.

Ganesan K, Ponmee N, Jiang L, Fowble JW, White J, Kamchonwongpaisan S, Yuthavong Y, Wilairat P, Rathod PK.

PLoS Pathog. 2008 Nov;4(11):e1000214. doi: 10.1371/journal.ppat.1000214. Epub 2008 Nov 21.

48.

Particular interaction between pyrimethamine derivatives and quadruple mutant type dihydrofolate reductase of Plasmodium falciparum: CoMFA and quantum chemical calculations studies.

Maitarad P, Saparpakorn P, Hannongbua S, Kamchonwongpaisan S, Tarnchompoo B, Yuthavong Y.

J Enzyme Inhib Med Chem. 2009 Apr;24(2):471-9. doi: 10.1080/14756360802201223 .

PMID:
18608776
49.

Characterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5' cap status.

Shaw PJ, Ponmee N, Karoonuthaisiri N, Kamchonwongpaisan S, Yuthavong Y.

Mol Biochem Parasitol. 2007 Oct;155(2):146-55. Epub 2007 Jul 10.

PMID:
17692399
50.

Folate metabolism as a source of molecular targets for antimalarials.

Yuthavong Y, Kamchonwongpaisan S, Leartsakulpanich U, Chitnumsub P.

Future Microbiol. 2006 Jun;1(1):113-25. Review.

PMID:
17661690

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