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Items: 32


Macrophage and T cell produced IL-10 promotes viral chronicity.

Richter K, Perriard G, Behrendt R, Schwendener RA, Sexl V, Dunn R, Kamanaka M, Flavell RA, Roers A, Oxenius A.

PLoS Pathog. 2013;9(11):e1003735. doi: 10.1371/journal.ppat.1003735. Epub 2013 Nov 7.


Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen.

Gagliani N, Jofra T, Valle A, Stabilini A, Morsiani C, Gregori S, Deng S, Rothstein DM, Atkinson M, Kamanaka M, Flavell RA, Roncarolo MG, Battaglia M.

Am J Transplant. 2013 Aug;13(8):1963-75. doi: 10.1111/ajt.12333. Epub 2013 Jul 8.


Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction.

Koni PA, Bolduc A, Takezaki M, Ametani Y, Huang L, Lee JR, Nutt SL, Kamanaka M, Flavell RA, Mellor AL, Tsubata T, Shimoda M.

J Immunol. 2013 Apr 1;190(7):3189-96. doi: 10.4049/jimmunol.1203364. Epub 2013 Feb 25.


IL-10 mediated regulation of liver inflammation during acute murine cytomegalovirus infection.

Gaddi PJ, Crane MJ, Kamanaka M, Flavell RA, Yap GS, Salazar-Mather TP.

PLoS One. 2012;7(8):e42850. doi: 10.1371/journal.pone.0042850. Epub 2012 Aug 3.


IL-10 suppression of NK/DC crosstalk leads to poor priming of MCMV-specific CD4 T cells and prolonged MCMV persistence.

Mandaric S, Walton SM, Rülicke T, Richter K, Girard-Madoux MJ, Clausen BE, Zurunic A, Kamanaka M, Flavell RA, Jonjic S, Oxenius A.

PLoS Pathog. 2012;8(8):e1002846. doi: 10.1371/journal.ppat.1002846. Epub 2012 Aug 2.


IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis.

Tao J, Kamanaka M, Hao J, Hao Z, Jiang X, Craft JE, Flavell RA, Wu Z, Hong Z, Zhao L, Yin Z.

Arthritis Res Ther. 2011;13(6):R212. doi: 10.1186/ar3545. Epub 2011 Dec 22.


Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology.

Kamanaka M, Huber S, Zenewicz LA, Gagliani N, Rathinam C, O'Connor W Jr, Wan YY, Nakae S, Iwakura Y, Hao L, Flavell RA.

J Exp Med. 2011 May 9;208(5):1027-40. doi: 10.1084/jem.20102149. Epub 2011 Apr 25.


Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.

Huber S, Gagliani N, Esplugues E, O'Connor W Jr, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA.

Immunity. 2011 Apr 22;34(4):554-65. doi: 10.1016/j.immuni.2011.01.020.


Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells.

Carter NA, Vasconcellos R, Rosser EC, Tulone C, Muñoz-Suano A, Kamanaka M, Ehrenstein MR, Flavell RA, Mauri C.

J Immunol. 2011 May 15;186(10):5569-79. doi: 10.4049/jimmunol.1100284. Epub 2011 Apr 4.


IL-10 signaling blockade controls murine West Nile virus infection.

Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E.

PLoS Pathog. 2009 Oct;5(10):e1000610. doi: 10.1371/journal.ppat.1000610. Epub 2009 Oct 9.


Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse.

Kamanaka M, Rainbow D, Schuster-Gossler K, Eynon EE, Chervonsky AV, Wicker LS, Flavell RA.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11236-40. doi: 10.1073/pnas.0904780106. Epub 2009 Jun 22.


Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity.

Sanjabi S, Zenewicz LA, Kamanaka M, Flavell RA.

Curr Opin Pharmacol. 2009 Aug;9(4):447-53. doi: 10.1016/j.coph.2009.04.008. Epub 2009 May 29. Review.


A protective function for interleukin 17A in T cell-mediated intestinal inflammation.

O'Connor W Jr, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK, Flavell RA.

Nat Immunol. 2009 Jun;10(6):603-9. doi: 10.1038/ni.1736.


IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection.

Couper KN, Blount DG, Wilson MS, Hafalla JC, Belkaid Y, Kamanaka M, Flavell RA, de Souza JB, Riley EM.

PLoS Pathog. 2008 Feb 29;4(2):e1000004. doi: 10.1371/journal.ppat.1000004.


A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.

Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL.

Nat Immunol. 2007 Dec;8(12):1380-9. Epub 2007 Nov 11.


IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice.

Wilson MS, Elnekave E, Mentink-Kane MM, Hodges MG, Pesce JT, Ramalingam TR, Thompson RW, Kamanaka M, Flavell RA, Keane-Myers A, Cheever AW, Wynn TA.

J Clin Invest. 2007 Oct;117(10):2941-51.


Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.

Jankovic D, Kullberg MC, Feng CG, Goldszmid RS, Collazo CM, Wilson M, Wynn TA, Kamanaka M, Flavell RA, Sher A.

J Exp Med. 2007 Feb 19;204(2):273-83. Epub 2007 Feb 5.


Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse.

Kamanaka M, Kim ST, Wan YY, Sutterwala FS, Lara-Tejero M, Galán JE, Harhaj E, Flavell RA.

Immunity. 2006 Dec;25(6):941-52. Epub 2006 Nov 30.


OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses.

Ishii N, Ndhlovu LC, Murata K, Sato T, Kamanaka M, Sugamura K.

Eur J Immunol. 2003 Sep;33(9):2372-81.


Increased susceptibility to airway responses in CD40-deficient mice.

Takahashi H, Ebihara S, Kanda A, Kamanaka M, Sato T, Habu S, Kikutani H, Sasaki H.

Clin Exp Immunol. 2003 Jul;133(1):22-9.


Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis.

Tanaka N, Kamanaka M, Enslen H, Dong C, Wysk M, Davis RJ, Flavell RA.

EMBO Rep. 2002 Aug;3(8):785-91. Epub 2002 Jul 15.


Effects of rhinovirus infection on histamine and cytokine production by cell lines from human mast cells and basophils.

Hosoda M, Yamaya M, Suzuki T, Yamada N, Kamanaka M, Sekizawa K, Butterfield JH, Watanabe T, Nishimura H, Sasaki H.

J Immunol. 2002 Aug 1;169(3):1482-91.


Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats.

Wang HD, Yamaya M, Okinaga S, Jia YX, Kamanaka M, Takahashi H, Guo LY, Ohrui T, Sasaki H.

Am J Respir Crit Care Med. 2002 Feb 1;165(3):406-11.


Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression.

Ishizuka S, Yamaya M, Suzuki T, Nakayama K, Kamanaka M, Ida S, Sekizawa K, Sasaki H.

Am J Respir Cell Mol Biol. 2001 Apr;24(4):459-68.


Type 2 rhinovirus infection of cultured human tracheal epithelial cells: role of LDL receptor.

Suzuki T, Yamaya M, Kamanaka M, Jia YX, Nakayama K, Hosoda M, Yamada N, Nishimura H, Sekizawa K, Sasaki H.

Am J Physiol Lung Cell Mol Physiol. 2001 Mar;280(3):L409-20.


Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development.

Kumanogoh A, Wang X, Lee I, Watanabe C, Kamanaka M, Shi W, Yoshida K, Sato T, Habu S, Itoh M, Sakaguchi N, Sakaguchi S, Kikutani H.

J Immunol. 2001 Jan 1;166(1):353-60.


Effects of dexamethasone on rhinovirus infection in cultured human tracheal epithelial cells.

Suzuki T, Yamaya M, Sekizawa K, Yamada N, Nakayama K, Ishizuka S, Kamanaka M, Morimoto T, Numazaki Y, Sasaki H.

Am J Physiol Lung Cell Mol Physiol. 2000 Mar;278(3):L560-71.


Cough reflex in the night.

Wang HD, Nakagawa T, Sekizawa K, Kamanaka M, Sasaki H.

Chest. 1998 Nov;114(5):1496-7. No abstract available.


Profound reduction of mature B cell numbers, reactivities and serum Ig levels in mice which simultaneously carry the XID and CD40 deficiency genes.

Oka Y, Rolink AG, Andersson J, Kamanaka M, Uchida J, Yasui T, Kishimoto T, Kikutani H, Melchers F.

Int Immunol. 1996 Nov;8(11):1675-85.


Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice.

Takeda K, Kamanaka M, Tanaka T, Kishimoto T, Akira S.

J Immunol. 1996 Oct 15;157(8):3220-2.


Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity.

Kamanaka M, Yu P, Yasui T, Yoshida K, Kawabe T, Horii T, Kishimoto T, Kikutani H.

Immunity. 1996 Mar;4(3):275-81.


The roles of CD40 and CD23 in IgE regulation.

Yasui T, Fujiwara H, Kamanaka M, Kawabe T, Yoshida N, Kishimoto T, Kikutani H.

Adv Exp Med Biol. 1996;409:349-54. Review. No abstract available.


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