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Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients.

Amrun SN, Yee WX, Abu Bakar F, Lee B, Kam YW, Lum FM, Tan JJ, Lim VW, Watthanaworawit W, Ling C, Nosten F, Renia L, Leo YS, Ng LF.

Clin Transl Immunology. 2019 Jul 26;8(7):e1066. doi: 10.1002/cti2.1066. eCollection 2019.


Ocular infarction following ethanol sclerotherapy of an arteriovenous malformation.

Link T, Kam Y, Ajlan R.

Am J Ophthalmol Case Rep. 2019 Apr 25;15:100457. doi: 10.1016/j.ajoc.2019.100457. eCollection 2019 Sep.


ZIKV-Specific NS1 Epitopes as Serological Markers of Acute Zika Virus Infection.

Kam YW, Leite JA, Amrun SN, Lum FM, Yee WX, Bakar FA, Eng KE, Lye DC, Leo YS, Chong CY, Freitas ARR, Milanez GP, Proença-Modena JL, Rénia L, Costa FTM, Ng LFP; Zika-Unicamp Network .

J Infect Dis. 2019 Jun 19;220(2):203-212. doi: 10.1093/infdis/jiz092.


Bisphosphonate-induced orbital inflammation in a patient on chronic immunosuppressive therapy.

Herrera I, Kam Y, Whittaker TJ, Champion M, Ajlan RS.

BMC Ophthalmol. 2019 Feb 14;19(1):51. doi: 10.1186/s12886-019-1063-8.


Multimodal assessments of Zika virus immune pathophysiological responses in marmosets.

Lum FM, Zhang W, Lim KC, Malleret B, Teo TH, Koh JJ, Lee KJ, Chua TK, Kam YW, Yee WX, Huen I, Tan JJL, Amrun SN, Prakash Kn B, Cozzone PJ, Renia L, Lee PTH, Ng LFP.

Sci Rep. 2018 Nov 20;8(1):17125. doi: 10.1038/s41598-018-35481-6.


Enhanced salt tolerance of euryhaline tadpoles depends on increased Na+, K+-ATPase expression after salinity acclimation.

Lai JC, Kam YC, Lin HC, Wu CS.

Comp Biochem Physiol A Mol Integr Physiol. 2019 Jan;227:84-91. doi: 10.1016/j.cbpa.2018.09.025. Epub 2018 Oct 9.


The 2016 Singapore Zika virus outbreak did not cause a surge in Guillain-Barré syndrome.

Umapathi T, Kam YW, Ohnmar O, Ng BCJ, Ng Y, Premikha M, Leo YS, Ng LFP.

J Peripher Nerv Syst. 2018 Sep;23(3):197-201. doi: 10.1111/jns.12284. Epub 2018 Aug 21.


New Endoscopic Surgical Approach for Anterior Hyaloid Dissection in Phakic and Pseudophakic Patients.

Kam YW, Funk RO, Barnard L, Ajlan RS.

Retina. 2019 Oct;39 Suppl 1:S129-S132. doi: 10.1097/IAE.0000000000002193. No abstract available.


The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations.

O'Connor RS, Guo L, Ghassemi S, Snyder NW, Worth AJ, Weng L, Kam Y, Philipson B, Trefely S, Nunez-Cruz S, Blair IA, June CH, Milone MC.

Sci Rep. 2018 Apr 19;8(1):6289. doi: 10.1038/s41598-018-24676-6.


Longitudinal Study of Cellular and Systemic Cytokine Signatures to Define the Dynamics of a Balanced Immune Environment During Disease Manifestation in Zika Virus-Infected Patients.

Lum FM, Lye DCB, Tan JJL, Lee B, Chia PY, Chua TK, Amrun SN, Kam YW, Yee WX, Ling WP, Lim VWX, Pang VJX, Lee LK, Mok EWH, Chong CY, Leo YS, Ng LFP.

J Infect Dis. 2018 Jul 24;218(5):814-824. doi: 10.1093/infdis/jiy225.


Efficient detection of Zika virus RNA in patients' blood from the 2016 outbreak in Campinas, Brazil.

Judice CC, Tan JJL, Parise PL, Kam YW, Milanez GP, Leite JA, Caserta LC, Arns CW, Resende MR, Angerami R, Amaral E, Junior RP, Freitas ARR, Costa FTM, Proenca-Modena JL, Ng LFP; Zika-Unicamp Network.

Sci Rep. 2018 Mar 5;8(1):4012. doi: 10.1038/s41598-018-22159-2.


Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity.

Lum FM, Couderc T, Chia BS, Ong RY, Her Z, Chow A, Leo YS, Kam YW, Rénia L, Lecuit M, Ng LFP.

Sci Rep. 2018 Jan 30;8(1):1860. doi: 10.1038/s41598-018-20305-4.


Seroprevalence of antibodies against chikungunya virus in Singapore resident adult population.

Ang LW, Kam YW, Lin C, Krishnan PU, Tay J, Ng LC, James L, Lee VJM, Goh KT, Ng LFP, Lin RTP.

PLoS Negl Trop Dis. 2017 Dec 27;11(12):e0006163. doi: 10.1371/journal.pntd.0006163. eCollection 2017 Dec.


Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil.

Kam YW, Leite JA, Lum FM, Tan JJL, Lee B, Judice CC, Teixeira DAT, Andreata-Santos R, Vinolo MA, Angerami R, Resende MR, Freitas ARR, Amaral E, Junior RP, Costa ML, Guida JP, Arns CW, Ferreira LCS, Rénia L, Proença-Modena JL, Ng LFP, Costa FTM; Zika-Unicamp Network.

J Infect Dis. 2017 Jul 15;216(2):172-181. doi: 10.1093/infdis/jix261.


Utilization of Starch-Enriched Brewery (Rice Wine) Waste for Mixotrophic Cultivation of Ettlia Sp. YC001 Used in Biodiesel Production.

Kam Y, Sung M, Cho H, Kang CM, Kim J, Han JI.

Appl Biochem Biotechnol. 2017 Dec;183(4):1478-1487. doi: 10.1007/s12010-017-2515-3. Epub 2017 May 27.


Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections.

Kam YW, Lee CY, Teo TH, Howland SW, Amrun SN, Lum FM, See P, Kng NQ, Huber RG, Xu MH, Tan HL, Choo A, Maurer-Stroh S, Ginhoux F, Fink K, Wang CI, Ng LF, Rénia L.

JCI Insight. 2017 Apr 20;2(8). pii: 92428. doi: 10.1172/jci.insight.92428. eCollection 2017 Apr 20.


Structural Optimizations of Thieno[3,2-b]pyrrole Derivatives for the Development of Metabolically Stable Inhibitors of Chikungunya Virus.

Ching KC, Tran TN, Amrun SN, Kam YW, Ng LF, Chai CL.

J Med Chem. 2017 Apr 13;60(7):3165-3186. doi: 10.1021/acs.jmedchem.7b00180. Epub 2017 Apr 4.


Clinical features of patients with Zika and dengue virus co-infection in Singapore.

Chia PY, Yew HS, Ho H, Chow A, Sadarangani SP, Chan M, Kam YW, Chong CY, Thoon KC, Yung CF, Li JH, Lye DC, De PP, Ng LFP, Yeo TW, Leo YS.

J Infect. 2017 Jun;74(6):611-615. doi: 10.1016/j.jinf.2017.03.007. Epub 2017 Mar 23. No abstract available.


Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection.

Her Z, Kam YW, Gan VC, Lee B, Thein TL, Tan JJ; SIgN Immunomonitoring Platform, Lee LK, Fink K, Lye DC, Rénia L, Leo YS, Ng LF.

J Infect Dis. 2017 Jan 1;215(1):42-51. doi: 10.1093/infdis/jiw494. Epub 2016 Oct 17.


HYP-17, a novel voltage-gated sodium channel blocker, relieves inflammatory and neuropathic pain in rats.

Lee JY, Kam YL, Oh J, Kim DH, Choi JS, Choi HY, Han S, Youn I, Choo HP, Yune TY.

Pharmacol Biochem Behav. 2017 Feb;153:116-129. doi: 10.1016/j.pbb.2016.12.013. Epub 2016 Dec 24.


Early clearance of Chikungunya virus in children is associated with a strong innate immune response.

Simarmata D, Ng DC, Kam YW, Lee B, Sum MS, Her Z, Chow A, Leo YS, Cardosa J, Perera D, Ooi MH, Ng LF.

Sci Rep. 2016 May 16;6:26097. doi: 10.1038/srep26097.


Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer.

Enriquez-Navas PM, Kam Y, Das T, Hassan S, Silva A, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA.

Sci Transl Med. 2016 Feb 24;8(327):327ra24. doi: 10.1126/scitranslmed.aad7842.


Trisubstituted Thieno[3,2-b]pyrrole 5-Carboxamides as Potent Inhibitors of Alphaviruses.

Ching KC, Kam YW, Merits A, Ng LF, Chai CL.

J Med Chem. 2015 Dec 10;58(23):9196-213. doi: 10.1021/acs.jmedchem.5b01047. Epub 2015 Nov 19.


A sensitive epitope-blocking ELISA for the detection of Chikungunya virus-specific antibodies in patients.

Goh LY, Kam YW, Metz SW, Hobson-Peters J, Prow NA, McCarthy S, Smith DW, Pijlman GP, Ng LF, Hall RA.

J Virol Methods. 2015 Sep 15;222:55-61. doi: 10.1016/j.jviromet.2015.05.011. Epub 2015 May 27.


Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology.

Teo TH, Her Z, Tan JJ, Lum FM, Lee WW, Chan YH, Ong RY, Kam YW, Leparc-Goffart I, Gallian P, Rénia L, de Lamballerie X, Ng LF.

J Virol. 2015 Aug;89(15):7955-69. doi: 10.1128/JVI.00909-15. Epub 2015 May 20.


Expanding regulatory T cells alleviates chikungunya virus-induced pathology in mice.

Lee WW, Teo TH, Her Z, Lum FM, Kam YW, Haase D, Rénia L, Rötzschke O, Ng LF.

J Virol. 2015 Aug 1;89(15):7893-7904. Epub 2015 May 20.


Correction: Parentage of overlapping offspring of an arboreal-breeding frog with no nest defense: implications for nest site selection and reproductive strategy.

Tung WP, Chen YH, Cheng WC, Chuang MF, Hsu WT, Kam YC, Lehtinen RM.

PLoS One. 2015 May 11;10(5):e0128483. doi: 10.1371/journal.pone.0128483. eCollection 2015. No abstract available.


Parentage of overlapping offspring of an arboreal-breeding frog with no nest defense: implications for nest site selection and reproductive strategy.

Tung WP, Chen YH, Cheng WC, Chuang MF, Hsu WT, Kam YC, Lehtinen RM.

PLoS One. 2015 Apr 2;10(4):e0123221. doi: 10.1371/journal.pone.0123221. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0128483.


A Systematic Meta-analysis of Immune Signatures in Patients With Acute Chikungunya Virus Infection.

Teng TS, Kam YW, Lee B, Hapuarachchi HC, Wimal A, Ng LC, Ng LF.

J Infect Dis. 2015 Jun 15;211(12):1925-35. doi: 10.1093/infdis/jiv049. Epub 2015 Jan 29.


Sero-prevalence and cross-reactivity of chikungunya virus specific anti-E2EP3 antibodies in arbovirus-infected patients.

Kam YW, Pok KY, Eng KE, Tan LK, Kaur S, Lee WW, Leo YS, Ng LC, Ng LF.

PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3445. doi: 10.1371/journal.pntd.0003445. eCollection 2015 Jan.


Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response.

Her Z, Teng TS, Tan JJ, Teo TH, Kam YW, Lum FM, Lee WW, Gabriel C, Melchiotti R, Andiappan AK, Lulla V, Lulla A, Win MK, Chow A, Biswas SK, Leo YS, Lecuit M, Merits A, Rénia L, Ng LF.

EMBO Mol Med. 2015 Jan;7(1):24-41. doi: 10.15252/emmm.201404459.


Evolutionary strategy for systemic therapy of metastatic breast cancer: balancing response with suppression of resistance.

Kam Y, Das T, Minton S, Gatenby RA.

Womens Health (Lond). 2014 Jul;10(4):423-30. doi: 10.2217/whe.14.23. Review.


Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges".

Kam Y, Das T, Tian H, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA.

Int J Cancer. 2015 Feb 15;136(4):E188-96. doi: 10.1002/ijc.29158. Epub 2014 Sep 2.


Preventing shoulder-surfing attack with the concept of concealing the password objects' information.

Ho PF, Kam YH, Wee MC, Chong YN, Por LY.

ScientificWorldJournal. 2014;2014:838623. doi: 10.1155/2014/838623. Epub 2014 May 27.


Unique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development.

Kam YW, Lee WW, Simarmata D, Le Grand R, Tolou H, Merits A, Roques P, Ng LF.

PLoS One. 2014 Apr 22;9(4):e95647. doi: 10.1371/journal.pone.0095647. eCollection 2014.


Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study.

Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD.

Dement Geriatr Cogn Disord. 2014;38(1-2):39-45. doi: 10.1159/000357793. Epub 2014 Feb 20.


Short amplexus duration in a territorial anuran: a possible adaptation in response to male-male competition.

Chuang MF, Bee MA, Kam YC.

PLoS One. 2013 Dec 10;8(12):e83116. doi: 10.1371/journal.pone.0083116. eCollection 2013.


Salinity acclimation enhances salinity tolerance in tadpoles living in brackish water through increased Na⁺ , K⁺ -ATPase expression.

Wu CS, Yang WK, Lee TH, Gomez-Mestre I, Kam YC.

J Exp Zool A Ecol Genet Physiol. 2014 Jan;321(1):57-64. doi: 10.1002/jez.1837. Epub 2013 Oct 8.


An essential role of antibodies in the control of Chikungunya virus infection.

Lum FM, Teo TH, Lee WW, Kam YW, Rénia L, Ng LF.

J Immunol. 2013 Jun 15;190(12):6295-302. doi: 10.4049/jimmunol.1300304. Epub 2013 May 13.


Synthesis and characterization of near IR fluorescent albumin nanoparticles for optical detection of colon cancer.

Cohen S, Pellach M, Kam Y, Grinberg I, Corem-Salkmon E, Rubinstein A, Margel S.

Mater Sci Eng C Mater Biol Appl. 2013 Mar 1;33(2):923-31. doi: 10.1016/j.msec.2012.11.022. Epub 2012 Nov 21.


Detection of a long non-coding RNA (CCAT1) in living cells and human adenocarcinoma of colon tissues using FIT-PNA molecular beacons.

Kam Y, Rubinstein A, Naik S, Djavsarov I, Halle D, Ariel I, Gure AO, Stojadinovic A, Pan H, Tsivin V, Nissan A, Yavin E.

Cancer Lett. 2014 Sep 28;352(1):90-6. doi: 10.1016/j.canlet.2013.02.014. Epub 2013 Feb 14.


Minimization of thermodynamic costs in cancer cell invasion.

Liu L, Duclos G, Sun B, Lee J, Wu A, Kam Y, Sontag ED, Stone HA, Sturm JC, Gatenby RA, Austin RH.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1686-91. doi: 10.1073/pnas.1221147110. Epub 2013 Jan 14.


Evolutionary approaches to prolong progression-free survival in breast cancer.

Silva AS, Kam Y, Khin ZP, Minton SE, Gillies RJ, Gatenby RA.

Cancer Res. 2012 Dec 15;72(24):6362-70. doi: 10.1158/0008-5472.CAN-12-2235. Epub 2012 Oct 12.


The relative roles of charge and a recognition peptide in luminal targeting of colorectal cancer by fluorescent polyacrylamide.

Bloch M, Kam Y, Yavin E, Moradov D, Nissan A, Ariel I, Rubinstein A.

Eur J Pharm Sci. 2012 Dec 18;47(5):904-13. doi: 10.1016/j.ejps.2012.09.003. Epub 2012 Sep 25.


Longitudinal analysis of the human antibody response to Chikungunya virus infection: implications for serodiagnosis and vaccine development.

Kam YW, Lee WW, Simarmata D, Harjanto S, Teng TS, Tolou H, Chow A, Lin RT, Leo YS, Rénia L, Ng LF.

J Virol. 2012 Dec;86(23):13005-15. doi: 10.1128/JVI.01780-12. Epub 2012 Sep 26.


HYP-1, a novel diamide compound, relieves inflammatory and neuropathic pain in rats.

Kam YL, Back SK, Kang B, Kim YY, Kim HJ, Rhim H, Nah SY, Chung JM, Kim DH, Choi JS, Na HS, Choo HY.

Pharmacol Biochem Behav. 2012 Nov;103(1):33-42.


Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection.

Kam YW, Simarmata D, Chow A, Her Z, Teng TS, Ong EK, Rénia L, Leo YS, Ng LF.

J Infect Dis. 2012 Apr 1;205(7):1147-54. doi: 10.1093/infdis/jis033. Epub 2012 Mar 1.


Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein.

Kam YW, Lum FM, Teo TH, Lee WW, Simarmata D, Harjanto S, Chua CL, Chan YF, Wee JK, Chow A, Lin RT, Leo YS, Le Grand R, Sam IC, Tong JC, Roques P, Wiesmüller KH, Rénia L, Rötzschke O, Ng LF.

EMBO Mol Med. 2012 Apr;4(4):330-43. doi: 10.1002/emmm.201200213. Epub 2012 Mar 5.

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