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Items: 1 to 50 of 117

1.

A Novel Deep Learning Framework on Brain Functional Networks for Early MCI Diagnosis.

Kam TE, Zhang H, Shen D.

Med Image Comput Comput Assist Interv. 2018 Sep;11072:293-301. doi: 10.1007/978-3-030-00931-1_34. Epub 2018 Sep 13.

2.

Reactions of Anodically Generated Methoxystilbene Cation Radicals: The Influence of Ortho-Substituted Vinyl and Formyl Groups.

Chong KW, Thomas NF, Low YY, Kam TS.

J Org Chem. 2019 Jun 7;84(11):7279-7290. doi: 10.1021/acs.joc.9b00939. Epub 2019 May 14.

PMID:
31056921
3.

Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.

Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, Anantharam V, Kanthasamy AG, Kanthasamy A.

J Exp Med. 2019 Jun 3;216(6):1411-1430. doi: 10.1084/jem.20182191. Epub 2019 Apr 29.

PMID:
31036561
4.

Conolodinines A-D, Aspidosperma- Aspidosperma Bisindole Alkaloids with Antiproliferative Activity from Tabernaemontana corymbosa.

Sim DS, Navanesan S, Sim KS, Gurusamy S, Lim SH, Low YY, Kam TS.

J Nat Prod. 2019 Apr 26;82(4):850-858. doi: 10.1021/acs.jnatprod.8b00919. Epub 2019 Mar 14.

PMID:
30869890
5.

Utilization of stereotactic ablative radiotherapy in oligometastatic & oligoprogressive skeletal metastases: Results and pattern of failure.

Kam TY, Chan OSH, Hung AWM, Yeung RMW.

Asia Pac J Clin Oncol. 2019 Mar;15 Suppl 2:14-19. doi: 10.1111/ajco.13115. Epub 2019 Mar 12.

PMID:
30859749
6.

Lycopodium Alkaloids: Lycoplatyrine A, an Unusual Lycodine-Piperidine Adduct from Lycopodium platyrhizoma and the Absolute Configurations of Lycoplanine D and Lycogladine H.

Yeap JS, Lim KH, Yong KT, Lim SH, Kam TS, Low YY.

J Nat Prod. 2019 Feb 22;82(2):324-329. doi: 10.1021/acs.jnatprod.8b00754. Epub 2019 Jan 30.

PMID:
30698428
7.

Amelioration of amyloid β-FcγRIIb neurotoxicity and tau pathologies by targeting LYN.

Gwon Y, Kim SH, Kim HT, Kam TI, Park J, Lim B, Cha H, Chang HJ, Hong YR, Jung YK.

FASEB J. 2019 Mar;33(3):4300-4313. doi: 10.1096/fj.201800926R. Epub 2018 Dec 12.

PMID:
30540497
8.

Reactivity of Anodically Generated 4-Methoxystilbene Cation Radicals: The Influence of Ortho-Substituted Hydroxymethyl, Aminomethyl, and Carboxylic Acid Groups.

Chong KW, Thomas NF, Low YY, Kam TS.

J Org Chem. 2018 Dec 21;83(24):15087-15100. doi: 10.1021/acs.joc.8b02360. Epub 2018 Dec 6.

PMID:
30488699
9.

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.

Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL.

Science. 2018 Nov 2;362(6414). pii: eaat8407. doi: 10.1126/science.aat8407.

10.

TOM1 Regulates Neuronal Accumulation of Amyloid-β Oligomers by FcγRIIb2 Variant in Alzheimer's Disease.

Gwon Y, Kam TI, Kim SH, Song S, Park H, Lim B, Lee H, Lee W, Jo DG, Jung YK.

J Neurosci. 2018 Oct 17;38(42):9001-9018. doi: 10.1523/JNEUROSCI.1996-17.2018. Epub 2018 Sep 5.

11.

Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.

Smedley CJ, Stanley PA, Qazzaz ME, Prota AE, Olieric N, Collins H, Eastman H, Barrow AS, Lim KH, Kam TS, Smith BJ, Duivenvoorden HM, Parker BS, Bradshaw TD, Steinmetz MO, Moses JE.

Sci Rep. 2018 Jul 13;8(1):10617. doi: 10.1038/s41598-018-28880-2.

12.

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease.

Yun SP, Kam TI, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, Mao X, Lee JH, Kumar M, An D, Kang SU, Lee Y, Lee KC, Na DH, Kim D, Lee SH, Roschke VV, Liddelow SA, Mari Z, Barres BA, Dawson VL, Lee S, Dawson TM, Ko HS.

Nat Med. 2018 Jul;24(7):931-938. doi: 10.1038/s41591-018-0051-5. Epub 2018 Jun 11.

13.

Ajmaline, Oxindole, and Cytotoxic Macroline-Akuammiline Bisindole Alkaloids from Alstonia penangiana.

Yeap JS, Navanesan S, Sim KS, Yong KT, Gurusamy S, Lim SH, Low YY, Kam TS.

J Nat Prod. 2018 May 25;81(5):1266-1277. doi: 10.1021/acs.jnatprod.8b00170. Epub 2018 May 10.

PMID:
29746134
14.

Corrigendum to "Endoscopic resection with adjuvant chemo-radiotherapy for superficial esophageal squamous cell carcinoma: A critical review" [Crit. Rev. Oncol./Hematol. 124, April (2018), 61-65].

Kam TY, Kountouri M, Roth A, Frossard JL, Huber O, Mönig S, Zilli T.

Crit Rev Oncol Hematol. 2018 Aug;128:139. doi: 10.1016/j.critrevonc.2018.04.004. Epub 2018 May 4. No abstract available.

PMID:
29731124
15.

Endoscopic resection with adjuvant chemo-radiotherapy for superficial esophageal squamous cell carcinoma: A critical review.

Kam TY, Kountouri M, Roth A, Frossard JL, Huber O, Mönig S, Zilli T.

Crit Rev Oncol Hematol. 2018 Apr;124:61-65. doi: 10.1016/j.critrevonc.2018.02.011. Epub 2018 Mar 2. Review. Erratum in: Crit Rev Oncol Hematol. 2018 May 3;:.

PMID:
29548487
16.

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism.

Yun SP, Kim D, Kim S, Kim S, Karuppagounder SS, Kwon SH, Lee S, Kam TI, Lee S, Ham S, Park JH, Dawson VL, Dawson TM, Lee Y, Ko HS.

Mol Neurodegener. 2018 Jan 8;13(1):1. doi: 10.1186/s13024-017-0233-5.

17.

Biosynthetic Enantiodivergence in the Eburnane Alkaloids from Kopsia.

Chong KW, Yeap JS, Lim SH, Weber JF, Low YY, Kam TS.

J Nat Prod. 2017 Nov 22;80(11):3014-3024. doi: 10.1021/acs.jnatprod.7b00621. Epub 2017 Oct 31.

PMID:
29087707
18.

A Bis-benzopyrroloisoquinoline Alkaloid Incorporating a Cyclobutane Core and a Chlorophenanthroindolizidine Alkaloid with Cytotoxic Activity from Ficus fistulosa var. tengerensis.

Al-Khdhairawi AAQ, Krishnan P, Mai CW, Chung FF, Leong CO, Yong KT, Chong KW, Low YY, Kam TS, Lim KH.

J Nat Prod. 2017 Oct 27;80(10):2734-2740. doi: 10.1021/acs.jnatprod.7b00500. Epub 2017 Sep 19.

PMID:
28926237
19.

Multiple functional networks modeling for autism spectrum disorder diagnosis.

Kam TE, Suk HI, Lee SW.

Hum Brain Mapp. 2017 Nov;38(11):5804-5821. doi: 10.1002/hbm.23769. Epub 2017 Aug 28.

PMID:
28845892
20.

Electrochemically Mediated Oxidative Transformations of Substituted 4-Methoxystilbenes: Effect of Ortho-Substituted Nucleophilic Groups.

Chong KW, Hong FJ, Thomas NF, Low YY, Kam TS.

J Org Chem. 2017 Jun 16;82(12):6172-6191. doi: 10.1021/acs.joc.7b00753. Epub 2017 Jun 8.

PMID:
28552001
21.

Enhancement of apoptotic activities on brain cancer cells via the combination of γ-tocotrienol and jerantinine A.

Abubakar IB, Lim KH, Kam TS, Loh HS.

Phytomedicine. 2017 Jul 1;30:74-84. doi: 10.1016/j.phymed.2017.03.004. Epub 2017 Mar 10.

PMID:
28545672
22.

Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1).

Chung FF, Tan PF, Raja VJ, Tan BS, Lim KH, Kam TS, Hii LW, Tan SH, See SJ, Tan YF, Wong LZ, Yam WK, Mai CW, Bradshaw TD, Leong CO.

Sci Rep. 2017 Feb 15;7:42504. doi: 10.1038/srep42504.

23.

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival.

Lee Y, Stevens DA, Kang SU, Jiang H, Lee YI, Ko HS, Scarffe LA, Umanah GE, Kang H, Ham S, Kam TI, Allen K, Brahmachari S, Kim JW, Neifert S, Yun SP, Fiesel FC, Springer W, Dawson VL, Shin JH, Dawson TM.

Cell Rep. 2017 Jan 24;18(4):918-932. doi: 10.1016/j.celrep.2016.12.090.

24.

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.

Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim B, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam TI, Jeong JS, Xie Z, Neifert S, Qian J, Andrabi SA, Blackshaw S, Zhu H, Song H, Ming GL, Dawson VL, Dawson TM.

Science. 2016 Oct 7;354(6308). pii: aad6872.

25.

FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model.

Kam TI, Park H, Gwon Y, Song S, Kim SH, Moon SW, Jo DG, Jung YK.

Elife. 2016 Nov 11;5. pii: e18691. doi: 10.7554/eLife.18691.

27.

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.

Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM.

Science. 2016 Sep 30;353(6307). pii: aah3374.

28.

Adherence to a Clinical Pathway for Video-Assisted Thoracic Surgery: Predictors and Clinical Importance.

Sihoe AD, Yu PS, Kam TH, Lee SY, Liu X.

Innovations (Phila). 2016 May-Jun;11(3):179-86. doi: 10.1097/IMI.0000000000000279.

PMID:
27537191
29.

Ibogan, Aspidosperman, Vincamine, and Bisindole Alkaloids from a Malayan Tabernaemontana corymbosa: Iboga Alkaloids with C-20α Substitution.

Nge CE, Chong KW, Thomas NF, Lim SH, Low YY, Kam TS.

J Nat Prod. 2016 May 27;79(5):1388-99. doi: 10.1021/acs.jnatprod.6b00129. Epub 2016 Apr 14.

PMID:
27077800
30.

Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity.

Xu JC, Fan J, Wang X, Eacker SM, Kam TI, Chen L, Yin X, Zhu J, Chi Z, Jiang H, Chen R, Dawson TM, Dawson VL.

Sci Transl Med. 2016 Apr 6;8(333):333ra48. doi: 10.1126/scitranslmed.aad0623.

31.

Arborisidine and Arbornamine, Two Monoterpenoid Indole Alkaloids with New Polycyclic Carbon-Nitrogen Skeletons Derived from a Common Pericine Precursor.

Wong SP, Chong KW, Lim KH, Lim SH, Low YY, Kam TS.

Org Lett. 2016 Apr 1;18(7):1618-21. doi: 10.1021/acs.orglett.6b00478. Epub 2016 Mar 22.

PMID:
27033525
32.

Synergistic cytotoxic effects of combined δ-tocotrienol and jerantinine B on human brain and colon cancers.

Abubakar IB, Lim KH, Kam TS, Loh HS.

J Ethnopharmacol. 2016 May 26;184:107-18. doi: 10.1016/j.jep.2016.03.004. Epub 2016 Mar 3.

PMID:
26947901
33.

Vobatensines A-F, Cytotoxic Iboga-Vobasine Bisindoles from Tabernaemontana corymbosa.

Sim DS, Teoh WY, Sim KS, Lim SH, Thomas NF, Low YY, Kam TS.

J Nat Prod. 2016 Apr 22;79(4):1048-55. doi: 10.1021/acs.jnatprod.5b01117. Epub 2016 Feb 26.

PMID:
26918761
34.

Aspidofractinine and Eburnane Alkaloids from a North Borneo Kopsia. Ring-Contracted, Additional Ring-Fused, and Paucidactine-Type Aspidofractinine Alkaloids from K. pauciflora.

Yap WS, Gan CY, Sim KS, Lim SH, Low YY, Kam TS.

J Nat Prod. 2016 Jan 22;79(1):230-9. doi: 10.1021/acs.jnatprod.5b00992. Epub 2015 Dec 30.

PMID:
26717050
35.

Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model.

Kim Y, Choi H, Lee W, Park H, Kam TI, Hong SH, Nah J, Jung S, Shin B, Lee H, Choi TY, Choo H, Kim KK, Choi SY, Kayed R, Jung YK.

Neurobiol Dis. 2016 Mar;87:19-28. doi: 10.1016/j.nbd.2015.12.006. Epub 2015 Dec 17.

PMID:
26704708
36.

Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity.

Choi S, Kim D, Kam TI, Yun S, Kim S, Park H, Hwang H, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS.

PLoS One. 2015 Dec 2;10(12):e0143854. doi: 10.1371/journal.pone.0143854. eCollection 2015.

37.

Human visual cortical responses to specular and matte motion flows.

Kam TE, Mannion DJ, Lee SW, Doerschner K, Kersten DJ.

Front Hum Neurosci. 2015 Oct 21;9:579. doi: 10.3389/fnhum.2015.00579. eCollection 2015.

38.

In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B.

Qazzaz ME, Raja VJ, Lim KH, Kam TS, Lee JB, Gershkovich P, Bradshaw TD.

Cancer Lett. 2016 Jan 28;370(2):185-97. doi: 10.1016/j.canlet.2015.10.013. Epub 2015 Oct 26.

PMID:
26515390
39.

Arboridinine, a Pentacyclic Indole Alkaloid with a New Cage Carbon-Nitrogen Skeleton Derived from a Pericine Precursor.

Wong SP, Gan CY, Lim KH, Ting KN, Low YY, Kam TS.

Org Lett. 2015 Jul 17;17(14):3628-31. doi: 10.1021/acs.orglett.5b01757. Epub 2015 Jul 8.

PMID:
26183592
40.

Biologically active vallesamine, strychnan, and rhazinilam alkaloids from Alstonia: Pneumatophorine, a nor-secovallesamine with unusual incorporation of a 3-ethylpyridine moiety.

Lim JL, Sim KS, Yong KT, Loong BJ, Ting KN, Lim SH, Low YY, Kam TS.

Phytochemistry. 2015 Sep;117:317-324. doi: 10.1016/j.phytochem.2015.06.024. Epub 2015 Jun 27.

PMID:
26125941
41.

Transformations of Ferric Chloride-Generated Stilbene Cation Radicals. The Effect of Aromatic Substitution and a Comparison with Anodic Oxidation.

Hong FJ, Chong KW, Low YY, Thomas NF, Kam TS.

Chem Asian J. 2015 Oct;10(10):2207-20. doi: 10.1002/asia.201500488. Epub 2015 Jul 7.

PMID:
26097065
42.

Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition.

Kim Y, Park H, Nah J, Moon S, Lee W, Hong SH, Kam TI, Jung YK.

Biochem Biophys Res Commun. 2015 Jun 26;462(2):112-8. doi: 10.1016/j.bbrc.2015.04.084. Epub 2015 Apr 27.

PMID:
25930997
43.

Ibogan, tacaman, and cytotoxic bisindole alkaloids from tabernaemontana. Cononusine, an iboga alkaloid with unusual incorporation of a pyrrolidone moiety.

Lim KH, Raja VJ, Bradshaw TD, Lim SH, Low YY, Kam TS.

J Nat Prod. 2015 May 22;78(5):1129-38. doi: 10.1021/acs.jnatprod.5b00117. Epub 2015 Apr 28.

PMID:
25919190
44.

Hispidacine, an unusual 8,4'-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.

Yap VA, Loong BJ, Ting KN, Loh SH, Yong KT, Low YY, Kam TS, Lim KH.

Phytochemistry. 2015 Jan;109:96-102. doi: 10.1016/j.phytochem.2014.10.032. Epub 2014 Nov 19.

PMID:
25468714
45.

Criofolinine and vernavosine, new pentacyclic indole alkaloids incorporating pyrroloazepine and pyridopyrimidine moieties derived from a common yohimbine precursor.

Nge CE, Gan CY, Lim KH, Ting KN, Low YY, Kam TS.

Org Lett. 2014 Dec 19;16(24):6330-3. doi: 10.1021/ol503072g. Epub 2014 Dec 2.

PMID:
25454201
46.

Corynanthean, eburnan, secoleuconoxine, and pauciflorine alkaloids from Kopsia pauciflora.

Gan CY, Yoganathan K, Sim KS, Low YY, Lim SH, Kam TS.

Phytochemistry. 2014 Dec;108:234-42. doi: 10.1016/j.phytochem.2014.09.014. Epub 2014 Oct 17.

PMID:
25442910
47.

Cytotoxic vobasine, tacaman, and corynanthe-tryptamine bisindole alkaloids from Tabernaemontana and structure revision of tronoharine.

Sim DS, Chong KW, Nge CE, Low YY, Sim KS, Kam TS.

J Nat Prod. 2014 Nov 26;77(11):2504-12. doi: 10.1021/np500589u. Epub 2014 Oct 21.

PMID:
25333996
48.

Oxidized derivatives of macroline, sarpagine, and pleiocarpamine alkaloids from Alstonia angustifolia.

Tan SJ, Lim JL, Low YY, Sim KS, Lim SH, Kam TS.

J Nat Prod. 2014 Sep 26;77(9):2068-80. doi: 10.1021/np500439u. Epub 2014 Sep 11.

PMID:
25211145
49.

Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's disease.

Kam TI, Gwon Y, Jung YK.

Cell Mol Life Sci. 2014 Dec;71(24):4803-13. doi: 10.1007/s00018-014-1706-0. Epub 2014 Aug 24. Review.

PMID:
25151011
50.

Drug-induced immune thrombocytopenia.

Kam T, Alexander M.

J Pharm Pract. 2014 Oct;27(5):430-9. doi: 10.1177/0897190014546099. Epub 2014 Aug 17. Review.

PMID:
25134884

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