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Items: 39


T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces.

Jin W, Tamzalit F, Chaudhuri PK, Black CT, Huse M, Kam LC.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):19835-19840. doi: 10.1073/pnas.1906986116. Epub 2019 Sep 16.


Cutting Edge: Synapse Propensity of Human Memory CD8 T Cells Confers Competitive Advantage over Naive Counterparts.

Mayya V, Judokusumo E, Abu-Shah E, Neiswanger W, Sachar C, Depoil D, Kam LC, Dustin ML.

J Immunol. 2019 Aug 1;203(3):601-606. doi: 10.4049/jimmunol.1801687. Epub 2019 Jun 14.


Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells.

Tamzalit F, Wang MS, Jin W, Tello-Lafoz M, Boyko V, Heddleston JM, Black CT, Kam LC, Huse M.

Sci Immunol. 2019 Mar 22;4(33). pii: eaav5445. doi: 10.1126/sciimmunol.aav5445.


Ex vivo induction of regulatory T cells from conventional CD4+ T cells is sensitive to substrate rigidity.

Nataraj NM, Dang AP, Kam LC, Lee JH.

J Biomed Mater Res A. 2018 Dec;106(12):3001-3008. doi: 10.1002/jbm.a.36489. Epub 2018 Oct 10.


Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation.

Morrell AE, Brown GN, Robinson ST, Sattler RL, Baik AD, Zhen G, Cao X, Bonewald LF, Jin W, Kam LC, Guo XE.

Bone Res. 2018 Mar 19;6:6. doi: 10.1038/s41413-018-0007-x. eCollection 2018.


Enhanced activation and expansion of T cells using mechanically soft elastomer fibers.

Dang A, De Leo S, Bogdanowicz DR, Yuan DJ, Fernandes SM, Brown JR, Lu HH, Kam LC.

Adv Biosyst. 2018 Feb;2(2). pii: 1700167. doi: 10.1002/adbi.201700167. Epub 2018 Jan 18.


Durable Interactions of T Cells with T Cell Receptor Stimuli in the Absence of a Stable Immunological Synapse.

Mayya V, Judokusumo E, Abu Shah E, Peel CG, Neiswanger W, Depoil D, Blair DA, Wiggins CH, Kam LC, Dustin ML.

Cell Rep. 2018 Jan 9;22(2):340-349. doi: 10.1016/j.celrep.2017.12.052.


Probing Synaptic Biomechanics Using Micropillar Arrays.

Jin W, Black CT, Kam LC, Huse M.

Methods Mol Biol. 2017;1584:333-346. doi: 10.1007/978-1-4939-6881-7_19.


Revealing the Role of Microscale Architecture in Immune Synapse Function Through Surface Micropatterning.

Lee JH, Kam LC.

Methods Mol Biol. 2017;1584:291-306. doi: 10.1007/978-1-4939-6881-7_17.


Improving T Cell Expansion with a Soft Touch.

Lambert LH, Goebrecht GK, De Leo SE, O'Connor RS, Nunez-Cruz S, Li TD, Yuan J, Milone MC, Kam LC.

Nano Lett. 2017 Feb 8;17(2):821-826. doi: 10.1021/acs.nanolett.6b04071. Epub 2017 Jan 30.


Tapping out a mechanical code for T cell triggering.

Dustin ML, Kam LC.

J Cell Biol. 2016 Jun 6;213(5):501-3. doi: 10.1083/jcb.201605072.


High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography.

Hu J, Gondarenko AA, Dang AP, Bashour KT, O'Connor RS, Lee S, Liapis A, Ghassemi S, Milone MC, Sheetz MP, Dustin ML, Kam LC, Hone JC.

Nano Lett. 2016 Apr 13;16(4):2198-204. doi: 10.1021/acs.nanolett.5b04364. Epub 2016 Mar 23.


Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing.

Basu R, Whitlock BM, Husson J, Le Floc'h A, Jin W, Oyler-Yaniv A, Dotiwala F, Giannone G, Hivroz C, Biais N, Lieberman J, Kam LC, Huse M.

Cell. 2016 Mar 24;165(1):100-110. doi: 10.1016/j.cell.2016.01.021. Epub 2016 Feb 25.


A microfluidic platform reveals differential response of regulatory T cells to micropatterned costimulation arrays.

Lee JH, Dustin ML, Kam LC.

Integr Biol (Camb). 2015 Nov;7(11):1442-53. doi: 10.1039/c5ib00215j.


Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells.

Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC, Iskratsch T.

Integr Biol (Camb). 2015 Oct;7(10):1272-84. doi: 10.1039/c5ib00032g. Epub 2015 Jul 9.


Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway.

Kumari S, Depoil D, Martinelli R, Judokusumo E, Carmona G, Gertler FB, Kam LC, Carman CV, Burkhardt JK, Irvine DJ, Dustin ML.

Elife. 2015 Mar 11;4. doi: 10.7554/eLife.04953.


Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.

Choudhuri K, Llodrá J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML.

Nature. 2014 Mar 6;507(7490):118-23. doi: 10.1038/nature12951. Epub 2014 Feb 2.


Micropatterned, multicomponent supported lipid bilayers for cellular systems.

Dutta D, Kam LC.

Methods Cell Biol. 2014;120:53-67. doi: 10.1016/B978-0-12-417136-7.00004-5.


CD28 and CD3 have complementary roles in T-cell traction forces.

Bashour KT, Gondarenko A, Chen H, Shen K, Liu X, Huse M, Hone JC, Kam LC.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2241-6. doi: 10.1073/pnas.1315606111. Epub 2014 Jan 27.


Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility.

Bashour KT, Tsai J, Shen K, Lee JH, Sun E, Milone MC, Dustin ML, Kam LC.

Mol Cell Biol. 2014 Mar;34(6):955-64. doi: 10.1128/MCB.00842-13. Epub 2013 Dec 30.


Active women before/after an intervention designed to restore menstrual function: resting metabolic rate and comparison of four methods to quantify energy expenditure and energy availability.

Guebels CP, Kam LC, Maddalozzo GF, Manore MM.

Int J Sport Nutr Exerc Metab. 2014 Feb;24(1):37-46. doi: 10.1123/ijsnem.2012-0165. Epub 2013 Aug 5.


Micro- and nanoscale engineering of cell signaling.

Kam LC, Shen K, Dustin ML.

Annu Rev Biomed Eng. 2013;15:305-26. doi: 10.1146/annurev-bioeng-071811-150050. Review.


Site-specific differentiation of neural stem cell regulated by micropatterned multicomponent interfaces.

Wang Y, Xu Z, Kam LC, Shi P.

Adv Healthc Mater. 2014 Feb;3(2):214-20. doi: 10.1002/adhm.201300082. Epub 2013 Jun 25.


Investigative and clinical applications of synthetic immune synapses.

Milone MC, Kam LC.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Jan-Feb;5(1):75-85. doi: 10.1002/wnan.1195. Epub 2012 Aug 23. Review.


Substrate rigidity regulates human T cell activation and proliferation.

O'Connor RS, Hao X, Shen K, Bashour K, Akimova T, Hancock WW, Kam LC, Milone MC.

J Immunol. 2012 Aug 1;189(3):1330-9. doi: 10.4049/jimmunol.1102757. Epub 2012 Jun 25.


Mechanosensing in T lymphocyte activation.

Judokusumo E, Tabdanov E, Kumari S, Dustin ML, Kam LC.

Biophys J. 2012 Jan 18;102(2):L5-7. doi: 10.1016/j.bpj.2011.12.011.


Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues.

Nédelec S, Peljto M, Shi P, Amoroso MW, Kam LC, Wichterle H.

J Neurosci. 2012 Jan 25;32(4):1496-506. doi: 10.1523/JNEUROSCI.4176-11.2012.


High-resolution extracellular stimulation of dispersed hippocampal culture with high-density CMOS multielectrode array based on non-Faradaic electrodes.

Lei N, Ramakrishnan S, Shi P, Orcutt JS, Yuste R, Kam LC, Shepard KL.

J Neural Eng. 2011 Aug;8(4):044003. doi: 10.1088/1741-2560/8/4/044003. Epub 2011 Jul 4.


Dynamic Force Generation by Neural Stem Cells.

Shi P, Shen K, Ghassemi S, Hone J, Kam LC.

Cell Mol Bioeng. 2009 Dec 2;2(4):464-474.


Combined microfluidics/protein patterning platform for pharmacological interrogation of axon pathfinding.

Shi P, Nedelec S, Wichterle H, Kam LC.

Lab Chip. 2010 Apr 21;10(8):1005-10. doi: 10.1039/b922143c. Epub 2010 Jan 25.


Self-aligned supported lipid bilayers for patterning the cell-substrate interface.

Shen K, Tsai J, Shi P, Kam LC.

J Am Chem Soc. 2009 Sep 23;131(37):13204-5. doi: 10.1021/ja904721h.


Capturing the nanoscale complexity of cellular membranes in supported lipid bilayers.

Kam LC.

J Struct Biol. 2009 Oct;168(1):3-10. doi: 10.1016/j.jsb.2009.05.006. Epub 2009 Jun 12. Review.


Microcontact printing of proteins for cell biology.

Shen K, Qi J, Kam LC.

J Vis Exp. 2008 Dec 5;(22). pii: 1065. doi: 10.3791/1065.


Nanoengineering of Immune Cell Function.

Shen K, Milone MC, Dustin ML, Kam LC.

Mater Res Soc Symp Proc. 2009 Jan 1;1209. pii: 1209-YY03-01.


Micropatterning of costimulatory ligands enhances CD4+ T cell function.

Shen K, Thomas VK, Dustin ML, Kam LC.

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7791-6. doi: 10.1073/pnas.0710295105. Epub 2008 May 27.


Non-Brownian diffusion of membrane molecules in nanopatterned supported lipid bilayers.

Tsai J, Sun E, Gao Y, Hone JC, Kam LC.

Nano Lett. 2008 Feb;8(2):425-30. doi: 10.1021/nl072304q. Epub 2008 Jan 19.


The female athlete triad: components, nutrition issues, and health consequences.

Manore MM, Kam LC, Loucks AB; International Association of Athletics Federations.

J Sports Sci. 2007;25 Suppl 1:S61-71. Review. Erratum in: J Sports Sci. 2009 Apr;27(6):667.


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