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Items: 15


Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy.

Hernandez G, Luo T, Javed TA, Wen L, Kalwat MA, Vale K, Ammouri F, Husain SZ, Kliewer SA, Mangelsdorf DJ.

Sci Transl Med. 2020 Jan 8;12(525). pii: eaay5186. doi: 10.1126/scitranslmed.aay5186.


Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic β cells.

Kalwat MA, Hwang IH, Macho J, Grzemska MG, Yang JZ, McGlynn K, MacMillan JB, Cobb MH.

J Gen Physiol. 2018 Dec 3;150(12):1747-1757. doi: 10.1085/jgp.201812177. Epub 2018 Oct 23.


Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways.

Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH.

ACS Sens. 2017 Feb 24;2(2):316. doi: 10.1021/acssensors.7b00012. Epub 2017 Jan 24. No abstract available.


Mechanisms of the amplifying pathway of insulin secretion in the β cell.

Kalwat MA, Cobb MH.

Pharmacol Ther. 2017 Nov;179:17-30. doi: 10.1016/j.pharmthera.2017.05.003. Epub 2017 May 18. Review.


Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis.

Guerra ML, Kalwat MA, McGlynn K, Cobb MH.

FEBS Open Bio. 2017 Jan 18;7(2):174-186. doi: 10.1002/2211-5463.12172. eCollection 2017 Feb.


Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways.

Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH.

ACS Sens. 2016 Oct 28;1(10):1208-1212. Epub 2016 Oct 12.


Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells.

Kalwat MA, Huang Z, Wichaidit C, McGlynn K, Earnest S, Savoia C, Dioum EM, Schneider JW, Hutchison MR, Cobb MH.

ACS Chem Biol. 2016 Apr 15;11(4):1128-36. doi: 10.1021/acschembio.5b00993. Epub 2016 Feb 10.


Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells.

Kalwat MA, Thurmond DC.

Exp Mol Med. 2013 Aug 23;45:e37. doi: 10.1038/emm.2013.73. Review.


A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells.

Kalwat MA, Yoder SM, Wang Z, Thurmond DC.

Biochem Pharmacol. 2013 Mar 15;85(6):808-16. doi: 10.1016/j.bcp.2012.12.003. Epub 2012 Dec 16.


Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity.

Ramalingam L, Oh E, Yoder SM, Brozinick JT, Kalwat MA, Groffen AJ, Verhage M, Thurmond DC.

Diabetes. 2012 Oct;61(10):2424-32. Epub 2012 Jun 14.


Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms.

Oh E, Kalwat MA, Kim MJ, Verhage M, Thurmond DC.

J Biol Chem. 2012 Jul 27;287(31):25821-33. doi: 10.1074/jbc.M112.361501. Epub 2012 Jun 8.


Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis.

Kalwat MA, Wiseman DA, Luo W, Wang Z, Thurmond DC.

Mol Endocrinol. 2012 Jan;26(1):128-41. doi: 10.1210/me.2011-1112. Epub 2011 Nov 22.


Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion.

Kepner EM, Yoder SM, Oh E, Kalwat MA, Wang Z, Quilliam LA, Thurmond DC.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1072-80. doi: 10.1152/ajpendo.00312.2011. Epub 2011 Aug 9.


Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis.

Jewell JL, Oh E, Ramalingam L, Kalwat MA, Tagliabracci VS, Tackett L, Elmendorf JS, Thurmond DC.

J Cell Biol. 2011 Apr 4;193(1):185-99. doi: 10.1083/jcb.201007176. Epub 2011 Mar 28.


Stimulus-induced S-nitrosylation of Syntaxin 4 impacts insulin granule exocytosis.

Wiseman DA, Kalwat MA, Thurmond DC.

J Biol Chem. 2011 May 6;286(18):16344-54. doi: 10.1074/jbc.M110.214031. Epub 2011 Mar 10.

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