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Items: 1 to 50 of 59

1.

Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity.

Lienau C, Gräwert T, Alves Avelar LA, Illarionov B, Held J, Knaab TC, Lungerich B, van Geelen L, Meier D, Geissler S, Cynis H, Riederer U, Buchholz M, Kalscheuer R, Bacher A, Mordmüller B, Fischer M, Kurz T.

Eur J Med Chem. 2019 Nov 1;181:111555. doi: 10.1016/j.ejmech.2019.07.058. Epub 2019 Jul 22.

PMID:
31382119
2.

The Mycobacterium tuberculosis capsule: a cell structure with key implications in pathogenesis.

Kalscheuer R, Palacios A, Anso I, Cifuente J, Anguita J, Jacobs WR Jr, Guerin ME, Prados-Rosales R.

Biochem J. 2019 Jul 18;476(14):1995-2016. doi: 10.1042/BCJ20190324. Review.

3.

Bypassing lantibiotic resistance by an effective nisin derivative.

Zaschke-Kriesche J, Behrmann LV, Reiners J, Lagedroste M, Gröner Y, Kalscheuer R, Smits SHJ.

Bioorg Med Chem. 2019 Aug 1;27(15):3454-3462. doi: 10.1016/j.bmc.2019.06.031. Epub 2019 Jun 20.

PMID:
31253534
4.

Dithiodiketopiperazine derivatives from endophytic fungi Trichoderma harzianum and Epicoccum nigrum.

Harwoko H, Daletos G, Stuhldreier F, Lee J, Wesselborg S, Feldbrügge M, Müller WEG, Kalscheuer R, Ancheeva E, Proksch P.

Nat Prod Res. 2019 Jun 18:1-9. doi: 10.1080/14786419.2019.1627348. [Epub ahead of print]

PMID:
31210064
5.

3-O-Methyl-Alkylgallates Inhibit Fatty Acid Desaturation in Mycobacterium tuberculosis.

Rehberg N, Omeje E, Ebada SS, van Geelen L, Liu Z, Sureechatchayan P, Kassack MU, Ioerger TR, Proksch P, Kalscheuer R.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00136-19. doi: 10.1128/AAC.00136-19. Print 2019 Sep.

PMID:
31209015
6.

Induction of Secondary Metabolites from the Marine-Derived Fungus Aspergillus versicolor through Co-cultivation with Bacillus subtilis.

Abdel-Wahab NM, Scharf S, Özkaya FC, Kurtán T, Mándi A, Fouad MA, Kamel MS, Müller WEG, Kalscheuer R, Lin W, Daletos G, Ebrahim W, Liu Z, Proksch P.

Planta Med. 2019 Apr;85(6):503-512. doi: 10.1055/a-0835-2332. Epub 2019 Jan 30.

PMID:
30699456
7.

A proteomics approach for the identification of species-specific immunogenic proteins in the Mycobacterium abscessus complex.

Steindor M, Nkwouano V, Stefanski A, Stuehler K, Ioerger TR, Bogumil D, Jacobsen M, Mackenzie CR, Kalscheuer R.

Microbes Infect. 2019 Apr - May;21(3-4):154-162. doi: 10.1016/j.micinf.2018.10.006. Epub 2018 Nov 13.

PMID:
30445130
8.

Induction of new metabolites from sponge-associated fungus Aspergillus carneus by OSMAC approach.

Özkaya FC, Ebrahim W, El-Neketi M, Tansel Tanrıkul T, Kalscheuer R, Müller WEG, Guo Z, Zou K, Liu Z, Proksch P.

Fitoterapia. 2018 Nov;131:9-14. doi: 10.1016/j.fitote.2018.10.008. Epub 2018 Oct 10.

PMID:
30312652
9.

A new depsidone derivative from mangrove sediment derived fungus Lasiodiplodia theobromae.

Umeokoli BO, Ebrahim W, El-Neketi M, Müller WEG, Kalscheuer R, Lin W, Liu Z, Proksch P.

Nat Prod Res. 2019 Aug;33(15):2215-2222. doi: 10.1080/14786419.2018.1496430. Epub 2018 Aug 20.

PMID:
30124067
10.

Tanzawaic acid derivatives from freshwater sediment-derived fungus Penicillium sp.

Abdelwahab MF, Fouad MA, Kamel MS, Özkaya FC, Kalscheuer R, Müller WEG, Lin W, Liu Z, Ebrahim W, Daletos G, Proksch P.

Fitoterapia. 2018 Jul;128:258-264. doi: 10.1016/j.fitote.2018.05.019. Epub 2018 May 17.

PMID:
29778575
11.

Metabolites from the endophytic fungus Cylindrocarpon sp. isolated from tropical plant Sapium ellipticum.

Kamdem RST, Pascal W, Rehberg N, van Geelen L, Höfert SP, Knedel TO, Janiak C, Sureechatchaiyan P, Kassack MU, Lin W, Kalscheuer R, Liu Z, Proksch P.

Fitoterapia. 2018 Jul;128:175-179. doi: 10.1016/j.fitote.2018.05.020. Epub 2018 May 17.

PMID:
29778573
12.

Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe.

Kamariza M, Shieh P, Ealand CS, Peters JS, Chu B, Rodriguez-Rivera FP, Babu Sait MR, Treuren WV, Martinson N, Kalscheuer R, Kana BD, Bertozzi CR.

Sci Transl Med. 2018 Feb 28;10(430). pii: eaam6310. doi: 10.1126/scitranslmed.aam6310.

13.

(Some) current concepts in antibacterial drug discovery.

van Geelen L, Meier D, Rehberg N, Kalscheuer R.

Appl Microbiol Biotechnol. 2018 Apr;102(7):2949-2963. doi: 10.1007/s00253-018-8843-6. Epub 2018 Feb 17. Review.

PMID:
29455386
14.

Chlorflavonin Targets Acetohydroxyacid Synthase Catalytic Subunit IlvB1 for Synergistic Killing of Mycobacterium tuberculosis.

Rehberg N, Akone HS, Ioerger TR, Erlenkamp G, Daletos G, Gohlke H, Proksch P, Kalscheuer R.

ACS Infect Dis. 2018 Feb 9;4(2):123-134. doi: 10.1021/acsinfecdis.7b00055. Epub 2017 Nov 16.

PMID:
29108416
15.

Cyclic Cystine-Bridged Peptides from the Marine Sponge Clathria basilana Induce Apoptosis in Tumor Cells and Depolarize the Bacterial Cytoplasmic Membrane.

Mokhlesi A, Stuhldreier F, Wex KW, Berscheid A, Hartmann R, Rehberg N, Sureechatchaiyan P, Chaidir C, Kassack MU, Kalscheuer R, Brötz-Oesterhelt H, Wesselborg S, Stork B, Daletos G, Proksch P.

J Nat Prod. 2017 Nov 22;80(11):2941-2952. doi: 10.1021/acs.jnatprod.7b00477. Epub 2017 Nov 2.

PMID:
29094598
16.

New amide and dioxopiperazine derivatives from leaves of Breynia nivosa.

Umeokoli BO, Onyegbule FA, Okoye FBC, Wang H, Kalscheuer R, Müller WEG, Hartmann R, Liu Z, Proksch P.

Fitoterapia. 2017 Oct;122:16-19. doi: 10.1016/j.fitote.2017.08.009. Epub 2017 Aug 19.

PMID:
28830789
17.

Mining marine shell wastes for polyelectrolyte chitosan anti-biofoulants: Fabrication of high-performance economic and ecofriendly anti-biofouling coatings.

Elshaarawy RFM, Mustafa FHA, van Geelen L, Abou-Taleb AEA, Tadros HRZ, Kalscheuer R, Janiak C.

Carbohydr Polym. 2017 Sep 15;172:352-364. doi: 10.1016/j.carbpol.2017.05.059. Epub 2017 May 24.

PMID:
28606544
18.

Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.

Prados-Rosales R, Carreño L, Cheng T, Blanc C, Weinrick B, Malek A, Lowary TL, Baena A, Joe M, Bai Y, Kalscheuer R, Batista-Gonzalez A, Saavedra NA, Sampedro L, Tomás J, Anguita J, Hung SC, Tripathi A, Xu J, Glatman-Freedman A, Jacobs WR Jr, Chan J, Porcelli SA, Achkar JM, Casadevall A.

PLoS Pathog. 2017 Mar 9;13(3):e1006250. doi: 10.1371/journal.ppat.1006250. eCollection 2017 Mar.

19.

A novel mycobacterial In Vitro infection assay identifies differences of induced macrophage apoptosis between CD4+ and CD8+ T cells.

Nkwouano V, Witkowski S, Rehberg N, Kalscheuer R, Nausch N, Mayatepek E, Jacobsen M.

PLoS One. 2017 Feb 15;12(2):e0171817. doi: 10.1371/journal.pone.0171817. eCollection 2017.

20.

Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa.

Muharini R, Díaz A, Ebrahim W, Mándi A, Kurtán T, Rehberg N, Kalscheuer R, Hartmann R, Orfali RS, Lin W, Liu Z, Proksch P.

J Nat Prod. 2017 Jan 27;80(1):169-180. doi: 10.1021/acs.jnatprod.6b00809. Epub 2017 Jan 11.

PMID:
28075580
21.

Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.

Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR Jr, Bornemann S, Ioerger TR, Ehrt S, Kalscheuer R.

PLoS Pathog. 2016 Dec 9;12(12):e1006043. doi: 10.1371/journal.ppat.1006043. eCollection 2016 Dec.

22.

Antimycobacterial Metabolites from Marine Invertebrates.

Daletos G, Ancheeva E, Chaidir C, Kalscheuer R, Proksch P.

Arch Pharm (Weinheim). 2016 Oct;349(10):763-773. doi: 10.1002/ardp.201600128. Epub 2016 Aug 26. Review.

PMID:
27561360
23.

Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis.

Koliwer-Brandl H, Syson K, van de Weerd R, Chandra G, Appelmelk B, Alber M, Ioerger TR, Jacobs WR Jr, Geurtsen J, Bornemann S, Kalscheuer R.

PLoS Pathog. 2016 Aug 11;12(8):e1005768. doi: 10.1371/journal.ppat.1005768. eCollection 2016 Aug.

24.

Imatinib Triggers Phagolysosome Acidification and Antimicrobial Activity against Mycobacterium bovis Bacille Calmette-Guérin in Glucocorticoid-Treated Human Macrophages.

Steiger J, Stephan A, Inkeles MS, Realegeno S, Bruns H, Kröll P, de Castro Kroner J, Sommer A, Batinica M, Pitzler L, Kalscheuer R, Hartmann P, Plum G, Stenger S, Pellegrini M, Brachvogel B, Modlin RL, Fabri M.

J Immunol. 2016 Jul 1;197(1):222-32. doi: 10.4049/jimmunol.1502407. Epub 2016 May 27.

25.

Assembly of α-Glucan by GlgE and GlgB in Mycobacteria and Streptomycetes.

Rashid AM, Batey SF, Syson K, Koliwer-Brandl H, Miah F, Barclay JE, Findlay KC, Nartowski KP, Khimyak YZ, Kalscheuer R, Bornemann S.

Biochemistry. 2016 Jun 14;55(23):3270-84. doi: 10.1021/acs.biochem.6b00209. Epub 2016 Jun 2.

26.

Metabolites from the Fungal Endophyte Aspergillus austroafricanus in Axenic Culture and in Fungal-Bacterial Mixed Cultures.

Ebrahim W, El-Neketi M, Lewald LI, Orfali RS, Lin W, Rehberg N, Kalscheuer R, Daletos G, Proksch P.

J Nat Prod. 2016 Apr 22;79(4):914-22. doi: 10.1021/acs.jnatprod.5b00975. Epub 2016 Apr 12.

PMID:
27070198
27.

Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.

Famulla K, Sass P, Malik I, Akopian T, Kandror O, Alber M, Hinzen B, Ruebsamen-Schaeff H, Kalscheuer R, Goldberg AL, Brötz-Oesterhelt H.

Mol Microbiol. 2016 Jul;101(2):194-209. doi: 10.1111/mmi.13362. Epub 2016 Apr 1.

28.

Callyaerins from the Marine Sponge Callyspongia aerizusa: Cyclic Peptides with Antitubercular Activity.

Daletos G, Kalscheuer R, Koliwer-Brandl H, Hartmann R, de Voogd NJ, Wray V, Lin W, Proksch P.

J Nat Prod. 2015 Aug 28;78(8):1910-25. doi: 10.1021/acs.jnatprod.5b00266. Epub 2015 Jul 27.

PMID:
26213786
29.

Genetics of Mycobacterial Trehalose Metabolism.

Kalscheuer R, Koliwer-Brandl H.

Microbiol Spectr. 2014 Jun;2(3). doi: 10.1128/microbiolspec.MGM2-0002-2013. Review.

PMID:
26103976
30.

Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria.

Ates LS, Ummels R, Commandeur S, van de Weerd R, Sparrius M, Weerdenburg E, Alber M, Kalscheuer R, Piersma SR, Abdallah AM, Abd El Ghany M, Abdel-Haleem AM, Pain A, Jiménez CR, Bitter W, Houben EN.

PLoS Genet. 2015 May 4;11(5):e1005190. doi: 10.1371/journal.pgen.1005190. eCollection 2015 May. Erratum in: PLoS Genet. 2015 May;11(5):e1005270. van der Weerd, Robert [corrected to van de Weerd, Robert].

31.

Chemoenzymatic synthesis of trehalose analogues: rapid access to chemical probes for investigating mycobacteria.

Urbanek BL, Wing DC, Haislop KS, Hamel CJ, Kalscheuer R, Woodruff PJ, Swarts BM.

Chembiochem. 2014 Sep 22;15(14):2066-70. doi: 10.1002/cbic.201402288. Epub 2014 Aug 19.

PMID:
25139066
32.

Mycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated antituberculosis target, is negatively regulated by Ser/Thr phosphorylation.

Leiba J, Syson K, Baronian G, Zanella-Cléon I, Kalscheuer R, Kremer L, Bornemann S, Molle V.

J Biol Chem. 2013 Jun 7;288(23):16546-56. doi: 10.1074/jbc.M112.398503. Epub 2013 Apr 22.

33.

Flux through trehalose synthase flows from trehalose to the alpha anomer of maltose in mycobacteria.

Miah F, Koliwer-Brandl H, Rejzek M, Field RA, Kalscheuer R, Bornemann S.

Chem Biol. 2013 Apr 18;20(4):487-93. doi: 10.1016/j.chembiol.2013.02.014.

34.

Probing the mycobacterial trehalome with bioorthogonal chemistry.

Swarts BM, Holsclaw CM, Jewett JC, Alber M, Fox DM, Siegrist MS, Leary JA, Kalscheuer R, Bertozzi CR.

J Am Chem Soc. 2012 Oct 3;134(39):16123-6. doi: 10.1021/ja3062419. Epub 2012 Sep 24.

35.

Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice.

Prados-Rosales R, Baena A, Martinez LR, Luque-Garcia J, Kalscheuer R, Veeraraghavan U, Camara C, Nosanchuk JD, Besra GS, Chen B, Jimenez J, Glatman-Freedman A, Jacobs WR Jr, Porcelli SA, Casadevall A.

J Clin Invest. 2011 Apr;121(4):1471-83. doi: 10.1172/JCI44261.

36.

The significance of GlgE as a new target for tuberculosis.

Kalscheuer R, Jacobs WR Jr.

Drug News Perspect. 2010 Dec;23(10):619-24. doi: 10.1358/dnp.2010.23.10.1534855.

PMID:
21180647
37.

Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis.

Kalscheuer R, Weinrick B, Veeraraghavan U, Besra GS, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21761-6. doi: 10.1073/pnas.1014642108. Epub 2010 Nov 30.

38.

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway.

Kalscheuer R, Syson K, Veeraraghavan U, Weinrick B, Biermann KE, Liu Z, Sacchettini JC, Besra G, Bornemann S, Jacobs WR Jr.

Nat Chem Biol. 2010 May;6(5):376-84. doi: 10.1038/nchembio.340. Epub 2010 Mar 21.

39.

Isolation and characterization of a mutant of the marine bacterium Alcanivorax borkumensis SK2 defective in lipid biosynthesis.

Manilla-Pérez E, Lange AB, Hetzler S, Wältermann M, Kalscheuer R, Steinbüchel A.

Appl Environ Microbiol. 2010 May;76(9):2884-94. doi: 10.1128/AEM.02832-09. Epub 2010 Mar 19.

40.

Analysis of lipid export in hydrocarbonoclastic bacteria of the genus Alcanivorax: identification of lipid export-negative mutants of Alcanivorax borkumensis SK2 and Alcanivorax jadensis T9.

Manilla-Pérez E, Reers C, Baumgart M, Hetzler S, Reichelt R, Malkus U, Kalscheuer R, Wältermann M, Steinbüchel A.

J Bacteriol. 2010 Feb;192(3):643-56. doi: 10.1128/JB.00700-09. Epub 2009 Nov 20.

41.

Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids.

Capyk JK, Kalscheuer R, Stewart GR, Liu J, Kwon H, Zhao R, Okamoto S, Jacobs WR Jr, Eltis LD, Mohn WW.

J Biol Chem. 2009 Dec 18;284(51):35534-42. doi: 10.1074/jbc.M109.072132.

42.

Analysis of neutral lipid biosynthesis in Streptomyces avermitilis MA-4680 and characterization of an acyltransferase involved herein.

Kaddor C, Biermann K, Kalscheuer R, Steinbüchel A.

Appl Microbiol Biotechnol. 2009 Aug;84(1):143-55. doi: 10.1007/s00253-009-2018-4. Epub 2009 May 8.

PMID:
19424691
43.

Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.

Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR Jr, Strynadka N, Eltis LD.

PLoS Pathog. 2009 Mar;5(3):e1000344. doi: 10.1371/journal.ppat.1000344. Epub 2009 Mar 20.

44.

Cloning and characterization of a gene involved in triacylglycerol biosynthesis and identification of additional homologous genes in the oleaginous bacterium Rhodococcus opacus PD630.

Alvarez AF, Alvarez HM, Kalscheuer R, Wältermann M, Steinbüchel A.

Microbiology. 2008 Aug;154(Pt 8):2327-35. doi: 10.1099/mic.0.2008/016568-0.

PMID:
18667565
45.

Analysis of storage lipid accumulation in Alcanivorax borkumensis: Evidence for alternative triacylglycerol biosynthesis routes in bacteria.

Kalscheuer R, Stöveken T, Malkus U, Reichelt R, Golyshin PN, Sabirova JS, Ferrer M, Timmis KN, Steinbüchel A.

J Bacteriol. 2007 Feb;189(3):918-28. Epub 2006 Nov 22.

46.

Mutation in a "tesB-like" hydroxyacyl-coenzyme A-specific thioesterase gene causes hyperproduction of extracellular polyhydroxyalkanoates by Alcanivorax borkumensis SK2.

Sabirova JS, Ferrer M, Lünsdorf H, Wray V, Kalscheuer R, Steinbüchel A, Timmis KN, Golyshin PN.

J Bacteriol. 2006 Dec;188(24):8452-9. Epub 2006 Sep 22.

47.

Microdiesel: Escherichia coli engineered for fuel production.

Kalscheuer R, Stölting T, Steinbüchel A.

Microbiology. 2006 Sep;152(Pt 9):2529-36.

PMID:
16946248
48.

Neutral lipid biosynthesis in engineered Escherichia coli: jojoba oil-like wax esters and fatty acid butyl esters.

Kalscheuer R, Stöveken T, Luftmann H, Malkus U, Reichelt R, Steinbüchel A.

Appl Environ Microbiol. 2006 Feb;72(2):1373-9.

49.

Thio wax ester biosynthesis utilizing the unspecific bifunctional wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase of Acinetobacter sp. strain ADP1.

Uthoff S, Stöveken T, Weber N, Vosmann K, Klein E, Kalscheuer R, Steinbüchel A.

Appl Environ Microbiol. 2005 Feb;71(2):790-6.

50.

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