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Items: 40

1.

Regional differences in the inflammatory and heat shock response in glia: implications for ALS.

Clarke BE, Gil RS, Yip J, Kalmar B, Greensmith L.

Cell Stress Chaperones. 2019 Sep;24(5):857-870. doi: 10.1007/s12192-019-01005-y. Epub 2019 Jun 5.

2.

Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS.

Gibbs KL, Kalmar B, Rhymes ER, Fellows AD, Ahmed M, Whiting P, Davies CH, Greensmith L, Schiavo G.

Cell Death Dis. 2018 May 22;9(6):596. doi: 10.1038/s41419-018-0624-8.

3.

Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro.

Wilson ER, Kugathasan U, Abramov AY, Clark AJ, Bennett DLH, Reilly MM, Greensmith L, Kalmar B.

Neurobiol Dis. 2018 Sep;117:1-14. doi: 10.1016/j.nbd.2018.05.008. Epub 2018 May 18.

4.

Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.

Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas JM, Kalmar B, Ule A, Yu Y, Birsa N, Bodo C, Collins T, Conicella AE, Mejia Maza A, Marrero-Gagliardi A, Stewart M, Mianne J, Corrochano S, Emmett W, Codner G, Groves M, Fukumura R, Gondo Y, Lythgoe M, Pauws E, Peskett E, Stanier P, Teboul L, Hallegger M, Calvo A, Chiò A, Isaacs AM, Fawzi NL, Wang E, Housman DE, Baralle F, Greensmith L, Buratti E, Plagnol V, Fisher EM, Acevedo-Arozena A.

EMBO J. 2018 Jun 1;37(11). pii: e98684. doi: 10.15252/embj.201798684. Epub 2018 May 15.

5.

Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.

Watson-Scales S, Kalmar B, Lana-Elola E, Gibbins D, La Russa F, Wiseman F, Williamson M, Saccon R, Slender A, Olerinyova A, Mahmood R, Nye E, Cater H, Wells S, Yu YE, Bennett DLH, Greensmith L, Fisher EMC, Tybulewicz VLJ.

PLoS Genet. 2018 May 10;14(5):e1007383. doi: 10.1371/journal.pgen.1007383. eCollection 2018 May.

6.

Assessment of metal concentrations in the SOD1G93A mouse model of amyotrophic lateral sclerosis and its potential role in muscular denervation, with particular focus on muscle tissue.

Enge TG, Ecroyd H, Jolley DF, Yerbury JJ, Kalmar B, Dosseto A.

Mol Cell Neurosci. 2018 Apr;88:319-329. doi: 10.1016/j.mcn.2018.03.001. Epub 2018 Mar 7.

PMID:
29524628
7.

Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in 'FUSDelta14' knockin mice.

Devoy A, Kalmar B, Stewart M, Park H, Burke B, Noy SJ, Redhead Y, Humphrey J, Lo K, Jaeger J, Mejia Maza A, Sivakumar P, Bertolin C, Soraru G, Plagnol V, Greensmith L, Acevedo Arozena A, Isaacs AM, Davies B, Fratta P, Fisher EMC.

Brain. 2017 Nov 1;140(11):2797-2805. doi: 10.1093/brain/awx248.

8.

Cellular Chaperones As Therapeutic Targets in ALS to Restore Protein Homeostasis and Improve Cellular Function.

Kalmar B, Greensmith L.

Front Mol Neurosci. 2017 Sep 8;10:251. doi: 10.3389/fnmol.2017.00251. eCollection 2017. Review.

9.

Mitochondrial deficits and abnormal mitochondrial retrograde axonal transport play a role in the pathogenesis of mutant Hsp27-induced Charcot Marie Tooth Disease.

Kalmar B, Innes A, Wanisch K, Kolaszynska AK, Pandraud A, Kelly G, Abramov AY, Reilly MM, Schiavo G, Greensmith L.

Hum Mol Genet. 2017 Sep 1;26(17):3313-3326. doi: 10.1093/hmg/ddx216.

10.

Expression of Kv3.1b potassium channel is widespread in macaque motor cortex pyramidal cells: A histological comparison between rat and macaque.

Soares D, Goldrick I, Lemon RN, Kraskov A, Greensmith L, Kalmar B.

J Comp Neurol. 2017 Jun 15;525(9):2164-2174. doi: 10.1002/cne.24192. Epub 2017 Mar 14.

11.

Targeting protein homeostasis in sporadic inclusion body myositis.

Ahmed M, Machado PM, Miller A, Spicer C, Herbelin L, He J, Noel J, Wang Y, McVey AL, Pasnoor M, Gallagher P, Statland J, Lu CH, Kalmar B, Brady S, Sethi H, Samandouras G, Parton M, Holton JL, Weston A, Collinson L, Taylor JP, Schiavo G, Hanna MG, Barohn RJ, Dimachkie MM, Greensmith L.

Sci Transl Med. 2016 Mar 23;8(331):331ra41. doi: 10.1126/scitranslmed.aad4583.

12.

In vivo imaging of axonal transport in murine motor and sensory neurons.

Gibbs KL, Kalmar B, Sleigh JN, Greensmith L, Schiavo G.

J Neurosci Methods. 2016 Jan 15;257:26-33. doi: 10.1016/j.jneumeth.2015.09.018. Epub 2015 Sep 28.

13.

Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing.

Carroll J, Page TK, Chiang SC, Kalmar B, Bode D, Greensmith L, Mckinnon PJ, Thorpe JR, Hafezparast M, El-Khamisy SF.

Hum Mol Genet. 2015 Feb 1;24(3):828-40. doi: 10.1093/hmg/ddu500. Epub 2014 Sep 30.

14.

The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa.

Parfitt DA, Aguila M, McCulley CH, Bevilacqua D, Mendes HF, Athanasiou D, Novoselov SS, Kanuga N, Munro PM, Coffey PJ, Kalmar B, Greensmith L, Cheetham ME.

Cell Death Dis. 2014 May 22;5:e1236. doi: 10.1038/cddis.2014.214.

15.

A dominant mutation in FBXO38 causes distal spinal muscular atrophy with calf predominance.

Sumner CJ, d'Ydewalle C, Wooley J, Fawcett KA, Hernandez D, Gardiner AR, Kalmar B, Baloh RH, Gonzalez M, Züchner S, Stanescu HC, Kleta R, Mankodi A, Cornblath DR, Boylan KB, Reilly MM, Greensmith L, Singleton AB, Harms MB, Rossor AM, Houlden H.

Am J Hum Genet. 2013 Nov 7;93(5):976-83. doi: 10.1016/j.ajhg.2013.10.006. Epub 2013 Oct 24.

16.

Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Novoselov SS, Mustill WJ, Gray AL, Dick JR, Kanuga N, Kalmar B, Greensmith L, Cheetham ME.

PLoS One. 2013 Aug 30;8(8):e73944. doi: 10.1371/journal.pone.0073944. eCollection 2013.

17.

The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol.

Kalmar B, Lu CH, Greensmith L.

Pharmacol Ther. 2014 Jan;141(1):40-54. doi: 10.1016/j.pharmthera.2013.08.003. Epub 2013 Aug 23. Review.

PMID:
23978556
18.

Hydroximic acid derivatives: pleiotropic HSP co-inducers restoring homeostasis and robustness.

Crul T, Toth N, Piotto S, Literati-Nagy P, Tory K, Haldimann P, Kalmar B, Greensmith L, Torok Z, Balogh G, Gombos I, Campana F, Concilio S, Gallyas F, Nagy G, Berente Z, Gungor B, Peter M, Glatz A, Hunya A, Literati-Nagy Z, Vigh L Jr, Hoogstra-Berends F, Heeres A, Kuipers I, Loen L, Seerden JP, Zhang D, Meijering RA, Henning RH, Brundel BJ, Kampinga HH, Koranyi L, Szilvassy Z, Mandl J, Sumegi B, Febbraio MA, Horvath I, Hooper PL, Vigh L.

Curr Pharm Des. 2013;19(3):309-46. Review.

PMID:
22920902
19.

Plasma neurofilament heavy chain levels correlate to markers of late stage disease progression and treatment response in SOD1(G93A) mice that model ALS.

Lu CH, Petzold A, Kalmar B, Dick J, Malaspina A, Greensmith L.

PLoS One. 2012;7(7):e40998. doi: 10.1371/journal.pone.0040998. Epub 2012 Jul 16.

20.

A novel p.Gln175X [corrected] premature stop mutation in the C-terminal end of HSP27 is a cause of CMT2.

Rossor AM, Davidson GL, Blake J, Polke JM, Murphy SM, Houlden H, Innes A, Kalmar B, Greensmith L, Reilly MM.

J Peripher Nerv Syst. 2012 Jun;17(2):201-5. doi: 10.1111/j.1529-8027.2012.00400.x. Erratum in: J Peripher Nerv Syst. 2014 Sep;19(3):250-89.

PMID:
22734906
21.

Treatment with a coinducer of the heat shock response delays muscle denervation in the SOD1-G93A mouse model of amyotrophic lateral sclerosis.

Kalmar B, Edet-Amana E, Greensmith L.

Amyotroph Lateral Scler. 2012 Jun;13(4):378-92. doi: 10.3109/17482968.2012.660953. Epub 2012 May 16.

PMID:
22591194
22.

Activated leukocyte cell adhesion molecule modulates neurotrophin signaling.

Wade A, Thomas C, Kalmar B, Terenzio M, Garin J, Greensmith L, Schiavo G.

J Neurochem. 2012 May;121(4):575-86. doi: 10.1111/j.1471-4159.2012.07658.x. Epub 2012 Feb 10.

23.

Determination of Muscle Fiber Type in Rodents.

Kalmar B, Blanco G, Greensmith L.

Curr Protoc Mouse Biol. 2012 Sep 1;2(3):231-43. doi: 10.1002/9780470942390.mo110229.

PMID:
26069013
24.

In Vivo Assessment of Mouse Hindlimb Muscle Force, Contractile, and Fatigue Characteristics, and Motor Unit Number.

Kalmar B, Greensmith L.

Curr Protoc Mouse Biol. 2012 Mar 1;2(1):89-101. doi: 10.1002/9780470942390.mo110155.

PMID:
26069007
25.

The distal hereditary motor neuropathies.

Rossor AM, Kalmar B, Greensmith L, Reilly MM.

J Neurol Neurosurg Psychiatry. 2012 Jan;83(1):6-14. doi: 10.1136/jnnp-2011-300952. Epub 2011 Oct 25. Review.

PMID:
22028385
26.

A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis.

Acevedo-Arozena A, Kalmar B, Essa S, Ricketts T, Joyce P, Kent R, Rowe C, Parker A, Gray A, Hafezparast M, Thorpe JR, Greensmith L, Fisher EM.

Dis Model Mech. 2011 Sep;4(5):686-700. doi: 10.1242/dmm.007237. Epub 2011 May 2.

27.

Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.

Banks GT, Haas MA, Line S, Shepherd HL, Alqatari M, Stewart S, Rishal I, Philpott A, Kalmar B, Kuta A, Groves M, Parkinson N, Acevedo-Arozena A, Brandner S, Bannerman D, Greensmith L, Hafezparast M, Koltzenburg M, Deacon R, Fainzilber M, Fisher EM.

J Neurosci. 2011 Apr 6;31(14):5483-94. doi: 10.1523/JNEUROSCI.5244-10.2011.

28.

A method to solubilise protein aggregates for immunoassay quantification which overcomes the neurofilament "hook" effect.

Lu CH, Kalmar B, Malaspina A, Greensmith L, Petzold A.

J Neurosci Methods. 2011 Feb 15;195(2):143-50. doi: 10.1016/j.jneumeth.2010.11.026. Epub 2010 Dec 4.

PMID:
21134399
29.

Excitability properties of mouse motor axons in the mutant SOD1(G93A) model of amyotrophic lateral sclerosis.

Boërio D, Kalmar B, Greensmith L, Bostock H.

Muscle Nerve. 2010 Jun;41(6):774-84. doi: 10.1002/mus.21579.

PMID:
20095022
30.

Induction of heat shock proteins for protection against oxidative stress.

Kalmar B, Greensmith L.

Adv Drug Deliv Rev. 2009 Apr 28;61(4):310-8. doi: 10.1016/j.addr.2009.02.003. Epub 2009 Feb 25. Review.

PMID:
19248813
31.

Activation of the heat shock response in a primary cellular model of motoneuron neurodegeneration-evidence for neuroprotective and neurotoxic effects.

Kalmar B, Greensmith L.

Cell Mol Biol Lett. 2009;14(2):319-35. doi: 10.2478/s11658-009-0002-8. Epub 2009 Jan 28.

32.

Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1 mouse model of ALS.

Kalmar B, Novoselov S, Gray A, Cheetham ME, Margulis B, Greensmith L.

J Neurochem. 2008 Oct;107(2):339-50. doi: 10.1111/j.1471-4159.2008.05595.x. Epub 2008 Sep 2.

33.

Molecular chaperones as therapeutic targets in amyotrophic lateral sclerosis.

Kalmar B, Kieran D, Greensmith L.

Biochem Soc Trans. 2005 Aug;33(Pt 4):551-2.

PMID:
16042542
34.

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice.

Kieran D, Kalmar B, Dick JR, Riddoch-Contreras J, Burnstock G, Greensmith L.

Nat Med. 2004 Apr;10(4):402-5. Epub 2004 Mar 21.

PMID:
15034571
35.

The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury.

Kalmar B, Greensmith L, Malcangio M, McMahon SB, Csermely P, Burnstock G.

Exp Neurol. 2003 Dec;184(2):636-47.

PMID:
14769355
36.

Upregulation of heat shock proteins rescues motoneurones from axotomy-induced cell death in neonatal rats.

Kalmar B, Burnstock G, Vrbová G, Urbanics R, Csermely P, Greensmith L.

Exp Neurol. 2002 Jul;176(1):87-97.

PMID:
12093085
37.

The effect of neonatal nerve injury on the expression of heat shock proteins in developing rat motoneurones.

Kalmár B, Burnstock G, Vrbová G, Greensmith L.

J Neurotrauma. 2002 May;19(5):667-79.

PMID:
12042100
38.

Cultured astrocytes react to LPS with increased cyclooxygenase activity and phagocytosis.

Kalmár B, Kittel A, Lemmens R, Környei Z, Madarász E.

Neurochem Int. 2001 Apr;38(5):453-61.

PMID:
11222926
40.

[Left cervical position anomaly of the aortic arch with formation of an aneurysm].

Montgomery FU, Kalmár B.

Rofo. 1981 Nov;135(5):608-9. German. No abstract available.

PMID:
6213479

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