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Items: 38

1.

Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats.

de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O.

Nat Commun. 2019 Mar 18;10(1):1238. doi: 10.1038/s41467-019-09183-0.

2.

An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse.

Kallupi M, Xue S, Zhou B, Janda KD, George O.

Sci Adv. 2018 Oct 17;4(10):eaat4751. doi: 10.1126/sciadv.aat4751. eCollection 2018 Oct.

3.

Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood.

Kononoff J, Melas PA, Kallupi M, de Guglielmo G, Kimbrough A, Scherma M, Fadda P, Kandel DB, Kandel ER, George O.

Sci Rep. 2018 Sep 17;8(1):13893. doi: 10.1038/s41598-018-31921-5.

4.

Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats.

Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O.

eNeuro. 2018 Jul 2;5(3). pii: ENEURO.0153-18.2018. doi: 10.1523/ENEURO.0153-18.2018. eCollection 2018 May-Jun.

5.

Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats.

Rupprecht LE, Kreisler AD, Spierling SR, de Guglielmo G, Kallupi M, George O, Donny EC, Zorrilla EP, Sved AF.

Psychopharmacology (Berl). 2018 Apr;235(4):1131-1140. doi: 10.1007/s00213-018-4830-y. Epub 2018 Jan 21.

PMID:
29354872
6.

An enzymatic advance in nicotine cessation therapy.

Xue S, Kallupi M, Zhou B, Smith LC, Miranda PO, George O, Janda KD.

Chem Commun (Camb). 2018 Feb 13;54(14):1686-1689. doi: 10.1039/c7cc09134f.

7.

Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence.

Matzeu A, Kallupi M, George O, Schweitzer P, Martin-Fardon R.

Neuropsychopharmacology. 2018 Apr;43(5):1010-1020. doi: 10.1038/npp.2017.250. Epub 2017 Oct 20.

PMID:
29052613
8.

CRF1 Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure.

Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O.

Alcohol Clin Exp Res. 2017 Nov;41(11):1886-1895. doi: 10.1111/acer.13484. Epub 2017 Sep 22.

9.

Nicotine Vapor Method to Induce Nicotine Dependence in Rodents.

Kallupi M, George O.

Curr Protoc Neurosci. 2017 Jul 5;80:8.41.1-8.41.10. doi: 10.1002/cpns.34.

10.

Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption.

Kallupi M, Shen Q, de Guglielmo G, Yasuda D, Journigan VB, Zaveri NT, Ciccocioppo R.

Addict Biol. 2018 Mar;23(2):585-595. doi: 10.1111/adb.12513. Epub 2017 Jun 21.

11.

Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration.

de Guglielmo G, Kallupi M, Cole MD, George O.

Psychopharmacology (Berl). 2017 Jul;234(13):2009-2018. doi: 10.1007/s00213-017-4608-7. Epub 2017 Mar 24.

12.

High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats.

Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O.

Neuropsychopharmacology. 2017 Aug;42(9):1850-1859. doi: 10.1038/npp.2016.270. Epub 2016 Dec 5.

13.

Pioglitazone attenuates the opioid withdrawal and vulnerability to relapse to heroin seeking in rodents.

de Guglielmo G, Kallupi M, Scuppa G, Demopulos G, Gaitanaris G, Ciccocioppo R.

Psychopharmacology (Berl). 2017 Jan;234(2):223-234. doi: 10.1007/s00213-016-4452-1. Epub 2016 Oct 6.

PMID:
27714428
14.

Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction.

Kallupi M, Scuppa G, de Guglielmo G, Calò G, Weiss F, Statnick MA, Rorick-Kehn LM, Ciccocioppo R.

Neuropsychopharmacology. 2017 Feb;42(3):695-706. doi: 10.1038/npp.2016.171. Epub 2016 Aug 26.

15.

Neuropeptide S differently modulates alcohol-related behaviors in alcohol-preferring and non-preferring rats.

Cannella N, Kallupi M, Li HW, Stopponi S, Cifani C, Ciccocioppo R, Ubaldi M.

Psychopharmacology (Berl). 2016 Aug;233(15-16):2915-24. doi: 10.1007/s00213-016-4333-7. Epub 2016 May 28.

16.

Activation of Hypocretin-1/Orexin-A Neurons Projecting to the Bed Nucleus of the Stria Terminalis and Paraventricular Nucleus Is Critical for Reinstatement of Alcohol Seeking by Neuropeptide S.

Ubaldi M, Giordano A, Severi I, Li H, Kallupi M, de Guglielmo G, Ruggeri B, Stopponi S, Ciccocioppo R, Cannella N.

Biol Psychiatry. 2016 Mar 15;79(6):452-62. doi: 10.1016/j.biopsych.2015.04.021. Epub 2015 May 2.

PMID:
26055195
17.

PPARc activation attenuates opioid consumption and modulates mesolimbic dopamine transmission.

de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, Ciccocioppo R.

Neuropsychopharmacology. 2015 Mar;40(4):1052. doi: 10.1038/npp.2014.305. No abstract available.

18.

PPARγ activation attenuates opioid consumption and modulates mesolimbic dopamine transmission.

de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, Ciccocioppo R.

Neuropsychopharmacology. 2015 Mar;40(4):927-37. doi: 10.1038/npp.2014.268. Epub 2014 Sep 14. Erratum in: Neuropsychopharmacology. 2015 Mar;40(4):1052.

19.

Analgesic tolerance to morphine is regulated by PPARγ.

de Guglielmo G, Kallupi M, Scuppa G, Stopponi S, Demopulos G, Gaitanaris G, Ciccocioppo R.

Br J Pharmacol. 2014 Dec;171(23):5407-16. doi: 10.1111/bph.12851.

20.

MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala.

Kallupi M, Oleata CS, Luu G, Teshima K, Ciccocioppo R, Roberto M.

Front Integr Neurosci. 2014 Feb 18;8:18. doi: 10.3389/fnint.2014.00018. eCollection 2014.

21.

Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors.

Ciccocioppo R, de Guglielmo G, Hansson AC, Ubaldi M, Kallupi M, Cruz MT, Oleata CS, Heilig M, Roberto M.

J Neurosci. 2014 Jan 8;34(2):363-72. doi: 10.1523/JNEUROSCI.2400-13.2014.

22.

Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats.

Kallupi M, Varodayan FP, Oleata CS, Correia D, Luu G, Roberto M.

Neuropsychopharmacology. 2014 Apr;39(5):1081-92. doi: 10.1038/npp.2013.308. Epub 2013 Oct 30.

23.

Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction.

Kallupi M, Wee S, Edwards S, Whitfield TW Jr, Oleata CS, Luu G, Schmeichel BE, Koob GF, Roberto M.

Biol Psychiatry. 2013 Oct 1;74(7):520-8. doi: 10.1016/j.biopsych.2013.04.028. Epub 2013 Jun 14.

24.

Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats.

Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW.

Addict Biol. 2014 Sep;19(5):755-7. doi: 10.1111/adb.12059. Epub 2013 May 3.

25.

Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats.

Stopponi S, de Guglielmo G, Somaini L, Cippitelli A, Cannella N, Kallupi M, Ubaldi M, Heilig M, Demopulos G, Gaitanaris G, Ciccocioppo R.

Alcohol Clin Exp Res. 2013 Aug;37(8):1351-60. doi: 10.1111/acer.12091. Epub 2013 Mar 29.

PMID:
23550625
26.

Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects.

Herman MA, Kallupi M, Luu G, Oleata CS, Heilig M, Koob GF, Ciccocioppo R, Roberto M.

Neuropharmacology. 2013 Apr;67:337-48. doi: 10.1016/j.neuropharm.2012.11.026. Epub 2012 Dec 4.

27.

Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat.

Kallupi M, de Guglielmo G, Cannella N, Li HW, Caló G, Guerrini R, Ubaldi M, Renger JJ, Uebele VN, Ciccocioppo R.

Psychopharmacology (Berl). 2013 Mar;226(2):347-55. doi: 10.1007/s00213-012-2910-y. Epub 2012 Nov 13.

PMID:
23149909
28.

The role of the neuropeptide S system in addiction: focus on its interaction with the CRF and hypocretin/orexin neurotransmission.

Cannella N, Kallupi M, Ruggeri B, Ciccocioppo R, Ubaldi M.

Prog Neurobiol. 2013 Jan;100:48-59. doi: 10.1016/j.pneurobio.2012.09.005. Epub 2012 Oct 3. Review.

PMID:
23041581
29.

Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat.

de Guglielmo G, Cippitelli A, Somaini L, Gerra G, Li H, Stopponi S, Ubaldi M, Kallupi M, Ciccocioppo R.

Addict Biol. 2013 Jul;18(4):644-53. doi: 10.1111/j.1369-1600.2012.00468.x. Epub 2012 Jun 27.

PMID:
22734646
30.

Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure.

Cruz MT, Herman MA, Kallupi M, Roberto M.

Biol Psychiatry. 2012 Apr 15;71(8):666-76. doi: 10.1016/j.biopsych.2011.10.032. Epub 2011 Dec 6.

31.

Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition.

Cippitelli A, Astarita G, Duranti A, Caprioli G, Ubaldi M, Stopponi S, Kallupi M, Sagratini G, Rodrìguez de Fonseca F, Piomelli D, Ciccocioppo R.

PLoS One. 2011;6(11):e28142. doi: 10.1371/journal.pone.0028142. Epub 2011 Nov 30.

32.

Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat.

Stopponi S, Somaini L, Cippitelli A, de Guglielmo G, Kallupi M, Cannella N, Gerra G, Massi M, Ciccocioppo R.

Psychopharmacology (Berl). 2012 Mar;220(1):87-96. doi: 10.1007/s00213-011-2457-3. Epub 2011 Sep 2.

PMID:
21887495
33.

Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking.

Stopponi S, Somaini L, Cippitelli A, Cannella N, Braconi S, Kallupi M, Ruggeri B, Heilig M, Demopulos G, Gaitanaris G, Massi M, Ciccocioppo R.

Biol Psychiatry. 2011 Apr 1;69(7):642-9. doi: 10.1016/j.biopsych.2010.12.010. Epub 2011 Jan 31.

PMID:
21276964
34.

Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system.

Kallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo R.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19567-72. doi: 10.1073/pnas.1004100107. Epub 2010 Oct 25.

35.

Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond.

Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Economidou D, Stopponi S, Cannella N, Braconi S, Kallupi M, de Guglielmo G, Massi M, George DT, Gilman J, Hersh J, Tauscher JT, Hunt SP, Hommer D, Heilig M.

Alcohol. 2009 Nov;43(7):491-8. doi: 10.1016/j.alcohol.2009.08.003. Review.

36.

Neuropeptide S receptor gene expression in alcohol withdrawal and protracted abstinence in postdependent rats.

Ruggeri B, Braconi S, Cannella N, Kallupi M, Soverchia L, Ciccocioppo R, Ubaldi M.

Alcohol Clin Exp Res. 2010 Jan;34(1):90-7. doi: 10.1111/j.1530-0277.2009.01070.x. Epub 2009 Oct 23.

PMID:
19860802
37.

The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S.

Fedeli A, Braconi S, Economidou D, Cannella N, Kallupi M, Guerrini R, Calò G, Cifani C, Massi M, Ciccocioppo R.

Eur J Neurosci. 2009 Oct;30(8):1594-602. doi: 10.1111/j.1460-9568.2009.06948.x. Epub 2009 Oct 12.

PMID:
19821837
38.

Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system.

Cannella N, Economidou D, Kallupi M, Stopponi S, Heilig M, Massi M, Ciccocioppo R.

Neuropsychopharmacology. 2009 Aug;34(9):2125-34. doi: 10.1038/npp.2009.37. Epub 2009 Mar 25.

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