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Items: 17

1.

An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration.

Garrison AT, Abouelhassan Y, Kallifidas D, Tan H, Kim YS, Jin S, Luesch H, Huigens RW 3rd.

J Med Chem. 2018 May 10;61(9):3962-3983. doi: 10.1021/acs.jmedchem.7b01903. Epub 2018 Apr 19.

PMID:
29638121
2.

High-Yield Production of Herbicidal Thaxtomins and Thaxtomin Analogs in a Nonpathogenic Streptomyces Strain.

Jiang G, Zhang Y, Powell MM, Zhang P, Zuo R, Zhang Y, Kallifidas D, Tieu AM, Luesch H, Loria R, Ding Y.

Appl Environ Microbiol. 2018 May 17;84(11). pii: e00164-18. doi: 10.1128/AEM.00164-18. Print 2018 Jun 1.

3.

Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters.

Kallifidas D, Jiang G, Ding Y, Luesch H.

Microb Cell Fact. 2018 Feb 17;17(1):25. doi: 10.1186/s12934-018-0874-2.

4.

A Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis.

Yang H, Abouelhassan Y, Burch GM, Kallifidas D, Huang G, Yousaf H, Jin S, Luesch H, Huigens RW.

Sci Rep. 2017 May 17;7(1):2003. doi: 10.1038/s41598-017-01045-3.

5.

Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis.

Garrison AT, Abouelhassan Y, Norwood VM 4th, Kallifidas D, Bai F, Nguyen MT, Rolfe M, Burch GM, Jin S, Luesch H, Huigens RW 3rd.

J Med Chem. 2016 Apr 28;59(8):3808-25. doi: 10.1021/acs.jmedchem.5b02004. Epub 2016 Apr 6.

PMID:
27018907
6.

Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis.

Garrison AT, Abouelhassan Y, Kallifidas D, Bai F, Ukhanova M, Mai V, Jin S, Luesch H, Huigens RW 3rd.

Angew Chem Int Ed Engl. 2015 Dec 1;54(49):14819-23. doi: 10.1002/anie.201508155. Epub 2015 Oct 20.

PMID:
26480852
7.

Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters.

Kallifidas D, Kang HS, Brady SF.

J Am Chem Soc. 2012 Dec 5;134(48):19552-5. doi: 10.1021/ja3093828. Epub 2012 Nov 27.

8.

Reassembly of functionally intact environmental DNA-derived biosynthetic gene clusters.

Kallifidas D, Brady SF.

Methods Enzymol. 2012;517:225-39. doi: 10.1016/B978-0-12-404634-4.00011-5.

9.

Natural product biosynthetic gene diversity in geographically distinct soil microbiomes.

Reddy BV, Kallifidas D, Kim JH, Charlop-Powers Z, Feng Z, Brady SF.

Appl Environ Microbiol. 2012 May;78(10):3744-52. doi: 10.1128/AEM.00102-12. Epub 2012 Mar 16.

10.

Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites.

Feng Z, Kallifidas D, Brady SF.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12629-34. doi: 10.1073/pnas.1103921108. Epub 2011 Jul 18.

11.

Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.

Kim JH, Feng Z, Bauer JD, Kallifidas D, Calle PY, Brady SF.

Biopolymers. 2010 Sep;93(9):833-44. doi: 10.1002/bip.21450.

12.

The sigmaR regulon of Streptomyces coelicolor A32 reveals a key role in protein quality control during disulphide stress.

Kallifidas D, Thomas D, Doughty P, Paget MS.

Microbiology. 2010 Jun;156(Pt 6):1661-72. doi: 10.1099/mic.0.037804-0. Epub 2010 Feb 25.

PMID:
20185507
13.

The zinc-responsive regulator Zur controls expression of the coelibactin gene cluster in Streptomyces coelicolor.

Kallifidas D, Pascoe B, Owen GA, Strain-Damerell CM, Hong HJ, Paget MS.

J Bacteriol. 2010 Jan;192(2):608-11. doi: 10.1128/JB.01022-09. Epub 2009 Nov 13.

14.

Zinc-responsive regulation of alternative ribosomal protein genes in Streptomyces coelicolor involves zur and sigmaR.

Owen GA, Pascoe B, Kallifidas D, Paget MS.

J Bacteriol. 2007 Jun;189(11):4078-86. Epub 2007 Mar 30.

15.

Distribution of streptomycin resistance and biosynthesis genes in streptomycetes recovered from different soil sites.

Tolba S, Egan S, Kallifidas D, Wellington EM.

FEMS Microbiol Ecol. 2002 Nov 1;42(2):269-76. doi: 10.1111/j.1574-6941.2002.tb01017.x.

16.

Phylogeny of Streptomyces species and evidence for horizontal transfer of entire and partial antibiotic gene clusters.

Egan S, Wiener P, Kallifidas D, Wellington EM.

Antonie Van Leeuwenhoek. 2001 Jun;79(2):127-33.

PMID:
11519998
17.

Transfer of streptomycin biosynthesis gene clusters within streptomycetes isolated from soil.

Egan S, Wiener P, Kallifidas D, Wellington EM.

Appl Environ Microbiol. 1998 Dec;64(12):5061-3.

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