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Items: 1 to 50 of 216

1.

Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease.

Runeberg-Roos P, Piccinini E, Penttinen AM, Mätlik K, Heikkinen H, Kuure S, Bespalov MM, Peränen J, Garea-Rodríguez E, Fuchs E, Airavaara M, Kalkkinen N, Penn R, Saarma M.

Neurobiol Dis. 2016 Dec;96:335-345. doi: 10.1016/j.nbd.2016.07.008. Epub 2016 Jul 15.

PMID:
27425888
2.

IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA for Its Quantification.

Rytkönen-Nissinen M, Saarelainen S, Randell J, Häyrinen J, Kalkkinen N, Virtanen T.

Allergy Asthma Immunol Res. 2015 Jul;7(4):384-92. doi: 10.4168/aair.2015.7.4.384. Epub 2015 Mar 5.

3.

Association between the intrinsically disordered protein PEX19 and PEX3.

Hattula K, Hirschberg D, Kalkkinen N, Butcher SJ, Ora A.

PLoS One. 2014 Jul 25;9(7):e103101. doi: 10.1371/journal.pone.0103101. eCollection 2014.

4.

Genomics and Proteomics Provide New Insight into the Commensal and Pathogenic Lifestyles of Bovine- and Human-Associated Staphylococcus epidermidis Strains.

Savijoki K, Iivanainen A, Siljamäki P, Laine PK, Paulin L, Karonen T, Pyörälä S, Kankainen M, Nyman TA, Salomäki T, Koskinen P, Holm L, Simojoki H, Taponen S, Sukura A, Kalkkinen N, Auvinen P, Varmanen P.

J Proteome Res. 2014 Aug 1;13(8):3748-3762. doi: 10.1021/pr500322d. Epub 2014 Jul 18.

PMID:
25014494
5.

Protein secretome of moss plants (Physcomitrella patens) with emphasis on changes induced by a fungal elicitor.

Lehtonen MT, Takikawa Y, Rönnholm G, Akita M, Kalkkinen N, Ahola-Iivarinen E, Somervuo P, Varjosalo M, Valkonen JP.

J Proteome Res. 2014 Feb 7;13(2):447-59. doi: 10.1021/pr400827a. Epub 2013 Dec 6.

PMID:
24295333
6.

Proteomic changes during B cell maturation: 2D-DIGE approach.

Salonen J, Rönnholm G, Kalkkinen N, Vihinen M.

PLoS One. 2013 Oct 29;8(10):e77894. doi: 10.1371/journal.pone.0077894. eCollection 2013.

7.

Human single-chain urokinase is activated by the omptins PgtE of Salmonella enterica and Pla of Yersinia pestis despite mutations of active site residues.

Järvinen HM, Laakkonen L, Haiko J, Johansson T, Juuti K, Suomalainen M, Buchrieser C, Kalkkinen N, Korhonen TK.

Mol Microbiol. 2013 Aug;89(3):507-17. doi: 10.1111/mmi.12293. Epub 2013 Jul 11.

8.

Glial cell line-derived neurotrophic factor: characterization of mammalian posttranslational modifications.

Piccinini E, Kalkkinen N, Saarma M, Runeberg-Roos P.

Ann Med. 2013 Feb;45(1):66-73. doi: 10.3109/07853890.2012.663927. Epub 2012 Mar 9.

PMID:
23305235
9.

Characterization of the genome, proteome, and structure of yersiniophage ϕR1-37.

Skurnik M, Hyytiäinen HJ, Happonen LJ, Kiljunen S, Datta N, Mattinen L, Williamson K, Kristo P, Szeliga M, Kalin-Mänttäri L, Ahola-Iivarinen E, Kalkkinen N, Butcher SJ.

J Virol. 2012 Dec;86(23):12625-42. doi: 10.1128/JVI.01783-12. Epub 2012 Sep 12.

10.

Regulation of AT1R expression through HuR by insulin.

Paukku K, Backlund M, De Boer RA, Kalkkinen N, Kontula KK, Lehtonen JY.

Nucleic Acids Res. 2012 Jul;40(12):5250-61. doi: 10.1093/nar/gks170. Epub 2012 Feb 23.

11.

Effect of acid stress on protein expression and phosphorylation in Lactobacillus rhamnosus GG.

Koponen J, Laakso K, Koskenniemi K, Kankainen M, Savijoki K, Nyman TA, de Vos WM, Tynkkynen S, Kalkkinen N, Varmanen P.

J Proteomics. 2012 Feb 2;75(4):1357-74. doi: 10.1016/j.jprot.2011.11.009. Epub 2011 Nov 16.

PMID:
22119544
12.

Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo.

Jørgensen JR, Fransson A, Fjord-Larsen L, Thompson LH, Houchins JP, Andrade N, Torp M, Kalkkinen N, Andersson E, Lindvall O, Ulfendahl M, Brunak S, Johansen TE, Wahlberg LU.

Exp Neurol. 2012 Jan;233(1):172-81. doi: 10.1016/j.expneurol.2011.09.027. Epub 2011 Oct 2.

13.

Growth phase-associated changes in the proteome and transcriptome of Lactobacillus rhamnosus GG in industrial-type whey medium.

Laakso K, Koskenniemi K, Koponen J, Kankainen M, Surakka A, Salusjärvi T, Auvinen P, Savijoki K, Nyman TA, Kalkkinen N, Tynkkynen S, Varmanen P.

Microb Biotechnol. 2011 Nov;4(6):746-66. doi: 10.1111/j.1751-7915.2011.00275.x. Epub 2011 Sep 1.

14.

Nucleolar proteins with altered expression in leukemic cell lines.

Teittinen KJ, Kärkkäinen P, Salonen J, Rönnholm G, Korkeamäki H, Vihinen M, Kalkkinen N, Lohi O.

Leuk Res. 2012 Feb;36(2):232-6. doi: 10.1016/j.leukres.2011.06.038. Epub 2011 Jul 23.

PMID:
21783252
15.

Identification and characterization of gushing-active hydrophobins from Fusarium graminearum and related species.

Sarlin T, Kivioja T, Kalkkinen N, Linder MB, Nakari-Setälä T.

J Basic Microbiol. 2012 Apr;52(2):184-94. doi: 10.1002/jobm.201100053. Epub 2011 Jul 21.

PMID:
21780148
16.

Production and characterization of virus-like particles and the P domain protein of GII.4 norovirus.

Koho T, Huhti L, Blazevic V, Nurminen K, Butcher SJ, Laurinmäki P, Kalkkinen N, Rönnholm G, Vesikari T, Hytönen VP, Kulomaa MS.

J Virol Methods. 2012 Jan;179(1):1-7. doi: 10.1016/j.jviromet.2011.05.009. Epub 2011 May 12.

PMID:
21600929
17.

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity.

Leppänen VM, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, Toivanen P, Ylä-Herttuala S, Ballmer-Hofer K, Alitalo K.

Blood. 2011 Feb 3;117(5):1507-15. doi: 10.1182/blood-2010-08-301549. Epub 2010 Dec 8.

18.

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization.

Tvorogov D, Anisimov A, Zheng W, Leppänen VM, Tammela T, Laurinavicius S, Holnthoner W, Heloterä H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen H, Ojala PM, Alitalo K.

Cancer Cell. 2010 Dec 14;18(6):630-40. doi: 10.1016/j.ccr.2010.11.001. Epub 2010 Dec 2.

19.

Proteomics and transcriptomics characterization of bile stress response in probiotic Lactobacillus rhamnosus GG.

Koskenniemi K, Laakso K, Koponen J, Kankainen M, Greco D, Auvinen P, Savijoki K, Nyman TA, Surakka A, Salusjärvi T, de Vos WM, Tynkkynen S, Kalkkinen N, Varmanen P.

Mol Cell Proteomics. 2011 Feb;10(2):M110.002741. doi: 10.1074/mcp.M110.002741. Epub 2010 Nov 15.

20.

A new tyrosine-specific chymotrypsin-like and angiotensin-degrading serine proteinase from Vipera lebetina snake venom.

Siigur E, Tõnismägi K, Trummal K, Samel M, Vija H, Aaspõllu A, Rönnholm G, Subbi J, Kalkkinen N, Siigur J.

Biochimie. 2011 Feb;93(2):321-30. doi: 10.1016/j.biochi.2010.10.004. Epub 2010 Oct 13.

PMID:
20950666
21.

The bioactivity of human bone morphogenetic protein-15 is sensitive to C-terminal modification: characterization of the purified untagged processed mature region.

Pulkki MM, Myllymaa S, Pasternack A, Lun S, Ludlow H, Al-Qahtani A, Korchynskyi O, Groome N, Juengel JL, Kalkkinen N, Laitinen M, Ritvos O, Mottershead DG.

Mol Cell Endocrinol. 2011 Jan 30;332(1-2):106-15. doi: 10.1016/j.mce.2010.10.002. Epub 2010 Oct 16.

PMID:
20937357
22.

The omptins of Yersinia pestis and Salmonella enterica cleave the reactive center loop of plasminogen activator inhibitor 1.

Haiko J, Laakkonen L, Juuti K, Kalkkinen N, Korhonen TK.

J Bacteriol. 2010 Sep;192(18):4553-61. doi: 10.1128/JB.00458-10. Epub 2010 Jul 16.

23.

Human L-selectin preferentially binds synthetic glycosulfopeptides modeled after endoglycan and containing tyrosine sulfate residues and sialyl Lewis x in core 2 O-glycans.

Leppänen A, Parviainen V, Ahola-Iivarinen E, Kalkkinen N, Cummings RD.

Glycobiology. 2010 Sep;20(9):1170-85. doi: 10.1093/glycob/cwq083. Epub 2010 May 27.

24.

Structural determinants of growth factor binding and specificity by VEGF receptor 2.

Leppänen VM, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, Lankinen H, Goldman A, Ballmer-Hofer K, Alitalo K.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2425-30. doi: 10.1073/pnas.0914318107.

25.

Analysis of the potential role of GluA4 carboxyl-terminus in PDZ interactions.

Coleman SK, Cai C, Kalkkinen N, Korpi ER, Keinänen K.

PLoS One. 2010 Jan 14;5(1):e8715. doi: 10.1371/journal.pone.0008715.

26.

Recombination and selection pressure in the ipomovirus sweet potato mild mottle virus (Potyviridae) in wild species and cultivated sweetpotato in the centre of evolution in East Africa.

Tugume AK, Mukasa SB, Kalkkinen N, Valkonen JP.

J Gen Virol. 2010 Apr;91(Pt 4):1092-108. doi: 10.1099/vir.0.016089-0. Epub 2009 Nov 18.

PMID:
19923261
27.

Interaction of a potyviral VPg with anionic phospholipid vesicles.

Rantalainen KI, Christensen PA, Hafrén A, Otzen DE, Kalkkinen N, Mäkinen K.

Virology. 2009 Dec 5;395(1):114-20. doi: 10.1016/j.virol.2009.09.009. Epub 2009 Oct 2.

28.

Proteome analysis of Lactobacillus rhamnosus GG using 2-D DIGE and mass spectrometry shows differential protein production in laboratory and industrial-type growth media.

Koskenniemi K, Koponen J, Kankainen M, Savijoki K, Tynkkynen S, de Vos WM, Kalkkinen N, Varmanen P.

J Proteome Res. 2009 Nov;8(11):4993-5007. doi: 10.1021/pr9003823.

PMID:
19780546
29.

The closest relatives of icosahedral viruses of thermophilic bacteria are among viruses and plasmids of the halophilic archaea.

Jalasvuori M, Jaatinen ST, Laurinavicius S, Ahola-Iivarinen E, Kalkkinen N, Bamford DH, Bamford JK.

J Virol. 2009 Sep;83(18):9388-97. doi: 10.1128/JVI.00869-09. Epub 2009 Jul 8.

30.

Quickly-released peroxidase of moss in defense against fungal invaders.

Lehtonen MT, Akita M, Kalkkinen N, Ahola-Iivarinen E, Rönnholm G, Somervuo P, Thelander M, Valkonen JP.

New Phytol. 2009;183(2):432-43. doi: 10.1111/j.1469-8137.2009.02864.x. Epub 2009 May 15.

31.

Actin and RIG-I/MAVS signaling components translocate to mitochondria upon influenza A virus infection of human primary macrophages.

Ohman T, Rintahaka J, Kalkkinen N, Matikainen S, Nyman TA.

J Immunol. 2009 May 1;182(9):5682-92. doi: 10.4049/jimmunol.0803093.

32.

An ssDNA virus infecting archaea: a new lineage of viruses with a membrane envelope.

Pietilä MK, Roine E, Paulin L, Kalkkinen N, Bamford DH.

Mol Microbiol. 2009 Apr;72(2):307-19. doi: 10.1111/j.1365-2958.2009.06642.x. Epub 2009 Mar 4.

33.

Characterization of Meteorin--an evolutionary conserved neurotrophic factor.

Jørgensen JR, Thompson L, Fjord-Larsen L, Krabbe C, Torp M, Kalkkinen N, Hansen C, Wahlberg L.

J Mol Neurosci. 2009 Sep;39(1-2):104-16. doi: 10.1007/s12031-009-9189-4. Epub 2009 Mar 4.

PMID:
19259827
34.

The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional.

Parkash V, Lindholm P, Peränen J, Kalkkinen N, Oksanen E, Saarma M, Leppänen VM, Goldman A.

Protein Eng Des Sel. 2009 Apr;22(4):233-41. doi: 10.1093/protein/gzn080. Epub 2009 Mar 3.

PMID:
19258449
35.

Posttranscriptional regulation of angiotensin II type 1 receptor expression by glyceraldehyde 3-phosphate dehydrogenase.

Backlund M, Paukku K, Daviet L, De Boer RA, Valo E, Hautaniemi S, Kalkkinen N, Ehsan A, Kontula KK, Lehtonen JY.

Nucleic Acids Res. 2009 Apr;37(7):2346-58. doi: 10.1093/nar/gkp098. Epub 2009 Feb 26.

36.

Production of recombinant HIV-1 nef protein using different expression host systems: a techno-economical comparison.

Vermasvuori R, Koskinen J, Salonen K, Sirén N, Weegar J, Dahlbacka J, Kalkkinen N, von Weymarn N.

Biotechnol Prog. 2009 Jan-Feb;25(1):95-102. doi: 10.1002/btpr.69.

PMID:
19224559
37.

Novel Coprinopsis cinerea polyesterase that hydrolyzes cutin and suberin.

Kontkanen H, Westerholm-Parvinen A, Saloheimo M, Bailey M, Rättö M, Mattila I, Mohsina M, Kalkkinen N, Nakari-Setälä T, Buchert J.

Appl Environ Microbiol. 2009 Apr;75(7):2148-57. doi: 10.1128/AEM.02103-08. Epub 2009 Feb 6.

38.

Proteomic analysis of Chlamydia pneumoniae-infected HL cells reveals extensive degradation of cytoskeletal proteins.

Savijoki K, Alvesalo J, Vuorela P, Leinonen M, Kalkkinen N.

FEMS Immunol Med Microbiol. 2008 Dec;54(3):375-84. doi: 10.1111/j.1574-695X.2008.00488.x.

39.

Two-dimensional difference gel electrophoresis analysis of Streptococcus uberis in response to mutagenesis-inducing ciprofloxacin challenge.

Poutanen M, Varhimo E, Kalkkinen N, Sukura A, Varmanen P, Savijoki K.

J Proteome Res. 2009 Jan;8(1):246-55. doi: 10.1021/pr800384j.

PMID:
19032024
40.

Decreased oxygen saturation as a result of haemoglobin Titusville.

Avellan-Hietanen H, Aittomaki J, Ekroos H, Aittomäki K, Turpeinen U, Kalkkinen N, Sovijärvi A.

Clin Respir J. 2008 Oct;2(4):242-4. doi: 10.1111/j.1752-699X.2008.00072.x.

PMID:
20298341
41.

MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain.

Lindholm P, Peränen J, Andressoo JO, Kalkkinen N, Kokaia Z, Lindvall O, Timmusk T, Saarma M.

Mol Cell Neurosci. 2008 Nov;39(3):356-71. doi: 10.1016/j.mcn.2008.07.016. Epub 2008 Jul 30.

PMID:
18718866
42.

Synthesis and stability of monolayer-protected Au38 clusters.

Toikkanen O, Ruiz V, Rönnholm G, Kalkkinen N, Liljeroth P, Quinn BM.

J Am Chem Soc. 2008 Aug 20;130(33):11049-55. doi: 10.1021/ja802317t. Epub 2008 Jul 25.

PMID:
18652456
43.

p100 increases AT1R expression through interaction with AT1R 3'-UTR.

Paukku K, Kalkkinen N, Silvennoinen O, Kontula KK, Lehtonen JY.

Nucleic Acids Res. 2008 Aug;36(13):4474-87. doi: 10.1093/nar/gkn411. Epub 2008 Jul 4.

44.

Potato virus A genome-linked protein VPg is an intrinsically disordered molten globule-like protein with a hydrophobic core.

Rantalainen KI, Uversky VN, Permi P, Kalkkinen N, Dunker AK, Mäkinen K.

Virology. 2008 Aug 1;377(2):280-8. doi: 10.1016/j.virol.2008.04.025. Epub 2008 Jun 3.

45.

L-Amino acid oxidase from Naja naja oxiana venom.

Samel M, Tõnismägi K, Rönnholm G, Vija H, Siigur J, Kalkkinen N, Siigur E.

Comp Biochem Physiol B Biochem Mol Biol. 2008 Apr;149(4):572-80. doi: 10.1016/j.cbpb.2007.11.008. Epub 2007 Nov 28.

PMID:
18294891
46.

Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolism.

Lyly A, Marjavaara SK, Kyttälä A, Uusi-Rauva K, Luiro K, Kopra O, Martinez LO, Tanhuanpää K, Kalkkinen N, Suomalainen A, Jauhiainen M, Jalanko A.

Hum Mol Genet. 2008 May 15;17(10):1406-17. doi: 10.1093/hmg/ddn028. Epub 2008 Feb 1.

PMID:
18245779
47.

ClpL is essential for induction of thermotolerance and is potentially part of the HrcA regulon in Lactobacillus gasseri.

Suokko A, Poutanen M, Savijoki K, Kalkkinen N, Varmanen P.

Proteomics. 2008 Mar;8(5):1029-41. doi: 10.1002/pmic.200700925.

PMID:
18240137
48.

Mass spectrometric detection of tyrosine sulfation in human pancreatic trypsinogens, but not in tumor-associated trypsinogen.

Itkonen O, Helin J, Saarinen J, Kalkkinen N, Ivanov KI, Stenman UH, Valmu L.

FEBS J. 2008 Jan;275(2):289-301. Epub 2007 Dec 10.

49.

DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity.

Liiv I, Rebane A, Org T, Saare M, Maslovskaja J, Kisand K, Juronen E, Valmu L, Bottomley MJ, Kalkkinen N, Peterson P.

Biochim Biophys Acta. 2008 Jan;1783(1):74-83. Epub 2007 Oct 4.

50.

Latex allergy: low prevalence of immunoglobulin E to highly purified proteins Hev b 2 and Hev b 13.

Palosuo T, Lehto M, Kotovuori A, Kalkkinen N, Blanco C, Poza P, Carrillo T, Hamilton RG, Alenius H, Reunala T, Turjanmaa K.

Clin Exp Allergy. 2007 Oct;37(10):1502-11. Epub 2007 Sep 10.

PMID:
17850383

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