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Items: 1 to 50 of 95

1.

Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation.

Rakhshandehroo M, van Eijkeren RJ, Gabriel TL, de Haar C, Gijzel SMW, Hamers N, Ferraz MJ, Aerts JMFG, Schipper HS, van Eijk M, Boes M, Kalkhoven E.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1157-1167. doi: 10.1016/j.bbalip.2019.04.016. Epub 2019 Apr 30.

2.

Gene-gene and gene-environment interactions in lipodystrophy: Lessons learned from natural PPARγ mutants.

Broekema MF, Savage DB, Monajemi H, Kalkhoven E.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):715-732. doi: 10.1016/j.bbalip.2019.02.002. Epub 2019 Feb 8. Review.

3.

Natural helix 9 mutants of PPARγ differently affect its transcriptional activity.

Broekema MF, Massink MPG, Donato C, de Ligt J, Schaarschmidt J, Borgman A, Schooneman MG, Melchers D, Gerding MN, Houtman R, Bonvin AMJJ, Majithia AR, Monajemi H, van Haaften GW, Soeters MR, Kalkhoven E.

Mol Metab. 2019 Feb;20:115-127. doi: 10.1016/j.molmet.2018.12.005. Epub 2018 Dec 16.

4.

A Single Complex Agpat2 Allele in a Patient With Partial Lipodystrophy.

Broekema MF, Massink MPG, De Ligt J, Stigter ECA, Monajemi H, De Ridder J, Burgering BMT, van Haaften GW, Kalkhoven E.

Front Physiol. 2018 Sep 26;9:1363. doi: 10.3389/fphys.2018.01363. eCollection 2018.

5.

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism.

Koenis DS, Medzikovic L, van Loenen PB, van Weeghel M, Huveneers S, Vos M, Evers-van Gogh IJ, Van den Bossche J, Speijer D, Kim Y, Wessels L, Zelcer N, Zwart W, Kalkhoven E, de Vries CJ.

Cell Rep. 2018 Aug 21;24(8):2127-2140.e7. doi: 10.1016/j.celrep.2018.07.065.

6.

Immunometabolic Activation of Invariant Natural Killer T Cells.

Ververs FA, Kalkhoven E, Van't Land B, Boes M, Schipper HS.

Front Immunol. 2018 May 28;9:1192. doi: 10.3389/fimmu.2018.01192. eCollection 2018. Review.

7.

Profiling of 3696 Nuclear Receptor-Coregulator Interactions: A Resource for Biological and Clinical Discovery.

Broekema MF, Hollman DAA, Koppen A, van den Ham HJ, Melchers D, Pijnenburg D, Ruijtenbeek R, van Mil SWC, Houtman R, Kalkhoven E.

Endocrinology. 2018 Jun 1;159(6):2397-2407. doi: 10.1210/en.2018-00149.

PMID:
29718163
8.

Monocyte gene expression in childhood obesity is associated with obesity and complexity of atherosclerosis in adults.

Keustermans GC, Kofink D, Eikendal A, de Jager W, Meerding J, Nuboer R, Waltenberger J, Kraaijeveld AO, Jukema JW, Sels JW, Garssen J, Prakken BJ, Asselbergs FW, Kalkhoven E, Hoefer IE, Pasterkamp G, Schipper HS.

Sci Rep. 2017 Dec 4;7(1):16826. doi: 10.1038/s41598-017-17195-3.

9.

Differential adipokine receptor expression on circulating leukocyte subsets in lean and obese children.

Keustermans G, van der Heijden LB, Boer B, Scholman R, Nuboer R, Pasterkamp G, Prakken B, de Jager W, Kalkhoven E, Janse AJ, Schipper HS.

PLoS One. 2017 Oct 26;12(10):e0187068. doi: 10.1371/journal.pone.0187068. eCollection 2017.

10.

Endogenous lipid antigens for invariant natural killer T cells hold the reins in adipose tissue homeostasis.

van Eijkeren RJ, Krabbe O, Boes M, Schipper HS, Kalkhoven E.

Immunology. 2018 Feb;153(2):179-189. doi: 10.1111/imm.12839. Epub 2017 Oct 26. Review.

11.

Hypoxia-Inducible Lipid Droplet-Associated Is Not a Direct Physiological Regulator of Lipolysis in Adipose Tissue.

Dijk W, Mattijssen F, de la Rosa Rodriguez M, Loza Valdes A, Loft A, Mandrup S, Kalkhoven E, Qi L, Borst JW, Kersten S.

Endocrinology. 2017 May 1;158(5):1231-1251. doi: 10.1210/en.2016-1809.

12.

Prospective functional classification of all possible missense variants in PPARG.

Majithia AR, Tsuda B, Agostini M, Gnanapradeepan K, Rice R, Peloso G, Patel KA, Zhang X, Broekema MF, Patterson N, Duby M, Sharpe T, Kalkhoven E, Rosen ED, Barroso I, Ellard S; UK Monogenic Diabetes Consortium, Kathiresan S; Myocardial Infarction Genetics Consortium, O'Rahilly S; UK Congenital Lipodystrophy Consortium, Chatterjee K, Florez JC, Mikkelsen T, Savage DB, Altshuler D.

Nat Genet. 2016 Dec;48(12):1570-1575. doi: 10.1038/ng.3700. Epub 2016 Oct 17.

13.

Muscle-specific inflammation induced by MCP-1 overexpression does not affect whole-body insulin sensitivity in mice.

Evers-van Gogh IJ, Oteng AB, Alex S, Hamers N, Catoire M, Stienstra R, Kalkhoven E, Kersten S.

Diabetologia. 2016 Mar;59(3):624-33. doi: 10.1007/s00125-015-3822-2. Epub 2015 Dec 12.

14.

Electric Pulse Stimulation of Myotubes as an In Vitro Exercise Model: Cell-Mediated and Non-Cell-Mediated Effects.

Evers-van Gogh IJ, Alex S, Stienstra R, Brenkman AB, Kersten S, Kalkhoven E.

Sci Rep. 2015 Jun 19;5:10944. doi: 10.1038/srep10944.

15.

Targeting FOXO1 as an option to treat obesity?

Dansen TB, Kalkhoven E.

Cell Cycle. 2015;14(16):2558. doi: 10.1080/15384101.2015.1060779. Epub 2015 Jun 11. No abstract available.

16.

Inflammatory characteristics of distinct abdominal adipose tissue depots relate differently to metabolic risk factors for cardiovascular disease: distinct fat depots and vascular risk factors.

Kranendonk ME, van Herwaarden JA, Stupkova T, de Jager W, Vink A, Moll FL, Kalkhoven E, Visseren FL.

Atherosclerosis. 2015 Apr;239(2):419-27. doi: 10.1016/j.atherosclerosis.2015.01.035. Epub 2015 Feb 2.

PMID:
25682042
17.

Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells.

Kranendonk ME, Visseren FL, van Herwaarden JA, Nolte-'t Hoen EN, de Jager W, Wauben MH, Kalkhoven E.

Obesity (Silver Spring). 2014 Oct;22(10):2216-23. doi: 10.1002/oby.20847. Epub 2014 Jul 17.

18.

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.

Farin HF, Karthaus WR, Kujala P, Rakhshandehroo M, Schwank G, Vries RG, Kalkhoven E, Nieuwenhuis EE, Clevers H.

J Exp Med. 2014 Jun 30;211(7):1393-405. doi: 10.1084/jem.20130753.

19.

CD1d-mediated presentation of endogenous lipid antigens by adipocytes requires microsomal triglyceride transfer protein.

Rakhshandehroo M, Gijzel SM, Siersbæk R, Broekema MF, de Haar C, Schipper HS, Boes M, Mandrup S, Kalkhoven E.

J Biol Chem. 2014 Aug 8;289(32):22128-39. doi: 10.1074/jbc.M114.551242. Epub 2014 Jun 25.

20.

Allele compensation in tip60+/- mice rescues white adipose tissue function in vivo.

Gao Y, Hamers N, Rakhshandehroo M, Berger R, Lough J, Kalkhoven E.

PLoS One. 2014 May 28;9(5):e98343. doi: 10.1371/journal.pone.0098343. eCollection 2014.

21.

TIPping the balance in adipogenesis: USP7-mediated stabilization of Tip60.

Gao Y, Kalkhoven E.

Adipocyte. 2014 Apr 1;3(2):160-5. doi: 10.4161/adip.28307. Epub 2014 Feb 25.

22.

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise.

Catoire M, Alex S, Paraskevopulos N, Mattijssen F, Evers-van Gogh I, Schaart G, Jeppesen J, Kneppers A, Mensink M, Voshol PJ, Olivecrona G, Tan NS, Hesselink MK, Berbée JF, Rensen PC, Kalkhoven E, Schrauwen P, Kersten S.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E1043-52. doi: 10.1073/pnas.1400889111. Epub 2014 Mar 3.

23.

Identification of human exercise-induced myokines using secretome analysis.

Catoire M, Mensink M, Kalkhoven E, Schrauwen P, Kersten S.

Physiol Genomics. 2014 Apr 1;46(7):256-67. doi: 10.1152/physiolgenomics.00174.2013. Epub 2014 Feb 11.

PMID:
24520153
24.

Extracellular vesicle markers in relation to obesity and metabolic complications in patients with manifest cardiovascular disease.

Kranendonk ME, de Kleijn DP, Kalkhoven E, Kanhai DA, Uiterwaal CS, van der Graaf Y, Pasterkamp G, Visseren FL; SMART Study Group.

Cardiovasc Diabetol. 2014 Feb 5;13:37. doi: 10.1186/1475-2840-13-37.

25.

An oral mixed fat load is followed by a modest anti-inflammatory adipocytokine response in overweight patients with metabolic syndrome.

Westerink J, Hajer GR, Kranendonk ME, Schipper HS, Monajemi H, Kalkhoven E, Visseren FL.

Lipids. 2014 Mar;49(3):247-54. doi: 10.1007/s11745-014-3877-8. Epub 2014 Jan 21.

PMID:
24445379
26.

Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages.

Kranendonk ME, Visseren FL, van Balkom BW, Nolte-'t Hoen EN, van Herwaarden JA, de Jager W, Schipper HS, Brenkman AB, Verhaar MC, Wauben MH, Kalkhoven E.

Obesity (Silver Spring). 2014 May;22(5):1296-308. doi: 10.1002/oby.20679. Epub 2014 Jan 9.

27.

The relation between body iron stores and adipose tissue function in patients with manifest vascular disease.

Westerink J, Olijhoek JK, Koppen A, Faber DR, Kalkhoven E, Monajemi H, van Asbeck BS, van der Graaf Y, Visseren FL.

Eur J Clin Invest. 2013 Dec;43(12):1240-9. doi: 10.1111/eci.12165. Epub 2013 Sep 23.

PMID:
24245570
28.

Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60.

Gao Y, Koppen A, Rakhshandehroo M, Tasdelen I, van de Graaf SF, van Loosdregt J, van Beekum O, Hamers N, van Leenen D, Berkers CR, Berger R, Holstege FC, Coffer PJ, Brenkman AB, Ovaa H, Kalkhoven E.

Nat Commun. 2013;4:2656. doi: 10.1038/ncomms3656.

PMID:
24141283
29.

Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.

van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE, Meerding J, Berkers CR, Barbi J, Gröne A, Sijts AJ, Maurice MM, Kalkhoven E, Prakken BJ, Ovaa H, Pan F, Zaiss DM, Coffer PJ.

Immunity. 2013 Aug 22;39(2):259-71. doi: 10.1016/j.immuni.2013.05.018.

30.

Invariant natural killer T cells in adipose tissue: novel regulators of immune-mediated metabolic disease.

Rakhshandehroo M, Kalkhoven E, Boes M.

Cell Mol Life Sci. 2013 Dec;70(24):4711-27. doi: 10.1007/s00018-013-1414-1. Epub 2013 Jul 9. Review.

PMID:
23835837
31.

Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity.

Reyman M, Verrijn Stuart AA, van Summeren M, Rakhshandehroo M, Nuboer R, de Boer FK, van den Ham HJ, Kalkhoven E, Prakken B, Schipper HS.

Int J Obes (Lond). 2014 Jan;38(1):46-52. doi: 10.1038/ijo.2013.75. Epub 2013 May 20.

PMID:
23736361
32.

PPARγ regulates expression of carbohydrate sulfotransferase 11 (CHST11/C4ST1), a regulator of LPL cell surface binding.

Tasdelen I, Berger R, Kalkhoven E.

PLoS One. 2013 May 16;8(5):e64284. doi: 10.1371/journal.pone.0064284. Print 2013.

33.

Pmch-deficiency in rats is associated with normal adipocyte differentiation and lower sympathetic adipose drive.

Mul JD, O'Duibhir E, Shrestha YB, Koppen A, Vargoviç P, Toonen PW, Zarebidaki E, Kvetnansky R, Kalkhoven E, Cuppen E, Bartness TJ.

PLoS One. 2013;8(3):e60214. doi: 10.1371/journal.pone.0060214. Epub 2013 Mar 26.

34.

A Patient with Congenital Generalized Lipodystrophy Due To a Novel Mutation in BSCL2: Indications for Secondary Mitochondrial Dysfunction.

Jeninga EH, de Vroede M, Hamers N, Breur JM, Verhoeven-Duif NM, Berger R, Kalkhoven E.

JIMD Rep. 2012;4:47-54. doi: 10.1007/8904_2011_86. Epub 2011 Nov 4.

35.

Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ.

Alex S, Lange K, Amolo T, Grinstead JS, Haakonsson AK, Szalowska E, Koppen A, Mudde K, Haenen D, Al-Lahham S, Roelofsen H, Houtman R, van der Burg B, Mandrup S, Bonvin AM, Kalkhoven E, Müller M, Hooiveld GJ, Kersten S.

Mol Cell Biol. 2013 Apr;33(7):1303-16. doi: 10.1128/MCB.00858-12. Epub 2013 Jan 22.

36.

The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity.

Tasdelen I, van Beekum O, Gorbenko O, Fleskens V, van den Broek NJ, Koppen A, Hamers N, Berger R, Coffer PJ, Brenkman AB, Kalkhoven E.

Biochem J. 2013 Apr 1;451(1):45-53. doi: 10.1042/BJ20121113.

PMID:
23320500
37.

Conditioned media from (pre)adipocytes stimulate fibrinogen and PAI-1 production by HepG2 hepatoma cells.

Faber DR, Kalkhoven E, Westerink J, Bouwman JJ, Monajemi HM, Visseren FL.

Nutr Diabetes. 2012 Dec 3;2:e52. doi: 10.1038/nutd.2012.25.

38.

Natural killer T cells in adipose tissue prevent insulin resistance.

Schipper HS, Rakhshandehroo M, van de Graaf SF, Venken K, Koppen A, Stienstra R, Prop S, Meerding J, Hamers N, Besra G, Boon L, Nieuwenhuis EE, Elewaut D, Prakken B, Kersten S, Boes M, Kalkhoven E.

J Clin Invest. 2012 Sep;122(9):3343-54. doi: 10.1172/JCI62739. Epub 2012 Aug 6.

39.

Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery.

Strassburg K, Huijbrechts AM, Kortekaas KA, Lindeman JH, Pedersen TL, Dane A, Berger R, Brenkman A, Hankemeier T, van Duynhoven J, Kalkhoven E, Newman JW, Vreeken RJ.

Anal Bioanal Chem. 2012 Sep;404(5):1413-26. doi: 10.1007/s00216-012-6226-x. Epub 2012 Jul 20.

40.

Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14++ monocytes.

Schipper HS, Nuboer R, Prop S, van den Ham HJ, de Boer FK, Kesmir Ç, Mombers IMH, van Bekkum KA, Woudstra J, Kieft JH, Hoefer IE, de Jager W, Prakken B, van Summeren M, Kalkhoven E.

Diabetologia. 2012 Oct;55(10):2800-2810. doi: 10.1007/s00125-012-2641-y. Epub 2012 Jul 18.

PMID:
22806355
41.

Adipose tissue-resident immune cells: key players in immunometabolism.

Schipper HS, Prakken B, Kalkhoven E, Boes M.

Trends Endocrinol Metab. 2012 Aug;23(8):407-15. doi: 10.1016/j.tem.2012.05.011. Epub 2012 Jul 12. Review.

PMID:
22795937
42.

A novel RNAi lethality rescue screen to identify regulators of adipogenesis.

van Beekum O, Gao Y, Berger R, Koppen A, Kalkhoven E.

PLoS One. 2012;7(6):e37680. doi: 10.1371/journal.pone.0037680. Epub 2012 Jun 5.

43.

Pref-1 preferentially inhibits heat production in brown adipose tissue.

Rakhshandehroo M, Koppen A, Kalkhoven E.

Biochem J. 2012 May 1;443(3):e3-5. doi: 10.1042/BJ20120382.

PMID:
22507130
44.

PPARγ as a therapeutic target in cystic fibrosis.

Dekkers JF, van der Ent CK, Kalkhoven E, Beekman JM.

Trends Mol Med. 2012 May;18(5):283-91. doi: 10.1016/j.molmed.2012.03.004. Epub 2012 Apr 9. Review.

PMID:
22494945
45.

Altered plasma adipokine levels and in vitro adipocyte differentiation in pediatric type 1 diabetes.

Verrijn Stuart AA, Schipper HS, Tasdelen I, Egan DA, Prakken BJ, Kalkhoven E, de Jager W.

J Clin Endocrinol Metab. 2012 Feb;97(2):463-72. doi: 10.1210/jc.2011-1858. Epub 2011 Nov 23.

PMID:
22112811
46.

Adipose tissue quantity and composition contribute to adipokine concentrations in the subclavian vein and the inferior mesenteric vein.

Faber DR, Moll FL, Vink A, van der Waal C, Kalkhoven E, Schipper HS, Hajer GR, Monajemi H, Visseren FL.

Int J Obes (Lond). 2012 Aug;36(8):1078-85. doi: 10.1038/ijo.2011.214. Epub 2011 Nov 8.

PMID:
22064157
47.

Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids.

Roodhart JM, Daenen LG, Stigter EC, Prins HJ, Gerrits J, Houthuijzen JM, Gerritsen MG, Schipper HS, Backer MJ, van Amersfoort M, Vermaat JS, Moerer P, Ishihara K, Kalkhoven E, Beijnen JH, Derksen PW, Medema RH, Martens AC, Brenkman AB, Voest EE.

Cancer Cell. 2011 Sep 13;20(3):370-83. doi: 10.1016/j.ccr.2011.08.010.

48.

Adipose tissue dysfunction and hypertriglyceridemia: mechanisms and management.

van de Woestijne AP, Monajemi H, Kalkhoven E, Visseren FL.

Obes Rev. 2011 Oct;12(10):829-40. doi: 10.1111/j.1467-789X.2011.00900.x. Epub 2011 Jul 12. Review.

PMID:
21749607
49.

Characterisation of non-obese diabetic patients with marked insulin resistance identifies a novel familial partial lipodystrophy-associated PPARγ mutation (Y151C).

Visser ME, Kropman E, Kranendonk ME, Koppen A, Hamers N, Stroes ES, Kalkhoven E, Monajemi H.

Diabetologia. 2011 Jul;54(7):1639-44. doi: 10.1007/s00125-011-2142-4. Epub 2011 Apr 9.

50.

Central players in inherited lipodystrophies.

Jeninga EH, Kalkhoven E.

Trends Endocrinol Metab. 2010 Oct;21(10):581-8. doi: 10.1016/j.tem.2010.06.006. Epub 2010 Jul 10.

PMID:
20621503

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