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Items: 1 to 50 of 76


Modelling the MYC-driven normal-to-tumour switch in breast cancer.

Lourenco C, Kalkat M, Houlahan KE, De Melo J, Longo J, Done SJ, Boutros PC, Penn LZ.

Dis Model Mech. 2019 Jul 26;12(7). pii: dmm038083. doi: 10.1242/dmm.038083.


Video-assisted thoracoscopic lobectomy: which patients require postoperative physiotherapy?

Agostini P, Lugg ST, Adams K, Smith T, Kalkat M, Rajesh PB, Steyn RS, Naidu B, Rushton A, Bishay E.

Physiotherapy. 2019 Jan 11. pii: S0031-9406(19)30006-9. doi: 10.1016/ [Epub ahead of print]


Perioperative immune function and pain control may underlie early hospital readmission and 90 day mortality following lung cancer resection: A prospective cohort study of 932 patients.

Oswald N, Halle-Smith J, Kerr A, Webb J, Agostini P, Bishay E, Kalkat M, Steyn R, Naidu B.

Eur J Surg Oncol. 2019 May;45(5):863-869. doi: 10.1016/j.ejso.2019.02.001. Epub 2019 Feb 5.


MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

Kalkat M, Resetca D, Lourenco C, Chan PK, Wei Y, Shiah YJ, Vitkin N, Tong Y, Sunnerhagen M, Done SJ, Boutros PC, Raught B, Penn LZ.

Mol Cell. 2018 Dec 6;72(5):836-848.e7. doi: 10.1016/j.molcel.2018.09.031. Epub 2018 Nov 8.


MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability.

Dingar D, Tu WB, Resetca D, Lourenco C, Tamachi A, De Melo J, Houlahan KE, Kalkat M, Chan PK, Boutros PC, Raught B, Penn LZ.

Nat Commun. 2018 Aug 29;9(1):3502. doi: 10.1038/s41467-018-05660-0.


Chest Wall Reconstruction with Porcine Acellular Dermal Matrix (Strattice) and Autologous Tissue Transfer for High Risk Patients with Chest Wall Tumors.

Khalil HH, Kalkat M, Malahias MN, Rhobaye S, Ashour T, Djearaman MG, Naidu B.

Plast Reconstr Surg Glob Open. 2018 May 18;6(5):e1703. doi: 10.1097/GOX.0000000000001703. eCollection 2018 May.


Risk factors and short-term outcomes of postoperative pulmonary complications after VATS lobectomy.

Agostini PJ, Lugg ST, Adams K, Smith T, Kalkat MS, Rajesh PB, Steyn RS, Naidu B, Rushton A, Bishay E.

J Cardiothorac Surg. 2018 Apr 12;13(1):28. doi: 10.1186/s13019-018-0717-6.


Patients want more information after surgery: a prospective audit of satisfaction with perioperative information in lung cancer surgery.

Oswald N, Hardman J, Kerr A, Bishay E, Steyn R, Rajesh P, Kalkat M, Naidu B.

J Cardiothorac Surg. 2018 Feb 1;13(1):18. doi: 10.1186/s13019-018-0707-8.


Inhibiting MYC binding to the E-box DNA motif by ME47 decreases tumour xenograft growth.

Lustig LC, Dingar D, Tu WB, Lourenco C, Kalkat M, Inamoto I, Ponzielli R, Chan WCW, Shin JA, Penn LZ.

Oncogene. 2017 Dec 7;36(49):6830-6837. doi: 10.1038/onc.2017.275. Epub 2017 Aug 14.


A rare case of spontaneous tracheal perforation.

Lugg ST, Grudzinska F, Kalkat MS, Sutton B.

BMJ Case Rep. 2017 Jul 18;2017. pii: bcr-2017-220731. doi: 10.1136/bcr-2017-220731. No abstract available.


Smoking and timing of cessation on postoperative pulmonary complications after curative-intent lung cancer surgery.

Lugg ST, Tikka T, Agostini PJ, Kerr A, Adams K, Kalkat MS, Steyn RS, Rajesh PB, Bishay E, Thickett DR, Naidu B.

J Cardiothorac Surg. 2017 Jun 19;12(1):52. doi: 10.1186/s13019-017-0614-4.


MYC Deregulation in Primary Human Cancers.

Kalkat M, De Melo J, Hickman KA, Lourenco C, Redel C, Resetca D, Tamachi A, Tu WB, Penn LZ.

Genes (Basel). 2017 May 25;8(6). pii: E151. doi: 10.3390/genes8060151. Review.


Postoperative pulmonary complications and rehabilitation requirements following lobectomy: a propensity score matched study of patients undergoing video-assisted thoracoscopic surgery versus thoracotomy†.

Agostini P, Lugg ST, Adams K, Vartsaba N, Kalkat MS, Rajesh PB, Steyn RS, Naidu B, Rushton A, Bishay E.

Interact Cardiovasc Thorac Surg. 2017 Jun 1;24(6):931-937. doi: 10.1093/icvts/ivx002.


Representation of the body in the lateral striatum of the freely moving rat: Fast Spiking Interneurons respond to stimulation of individual body parts.

Kulik JM, Pawlak AP, Kalkat M, Coffey KR, West MO.

Brain Res. 2017 Feb 15;1657:101-108. doi: 10.1016/j.brainres.2016.11.033. Epub 2016 Nov 30.


Cholesterol granuloma of the anterior mediastinum.

Drury NE, Smith DN, Phillips LM, Trotter SE, Kalkat MS.

Thorax. 2017 Jul;72(7):671-672. doi: 10.1136/thoraxjnl-2016-209481. Epub 2016 Oct 31. No abstract available.


Emergency management of life-threatening haemoptysis due to invasive pulmonary aspergillosis in a sarcoidosis patient.

Popescu F, Lutz M, Kalkat MS, Aktuerk D.

ANZ J Surg. 2018 Oct;88(10):1085-1086. doi: 10.1111/ans.13754. Epub 2016 Oct 30. No abstract available.


Thoracic splenosis masquerading as advanced lung cancer.

Remtulla M, Drury NE, Kaushal NA, Trotter SE, Kalkat MS.

Thorax. 2017 Feb;72(2):189-190. doi: 10.1136/thoraxjnl-2016-209068. Epub 2016 Sep 5. No abstract available.


Multidisciplinary Oncoplastic Approach Reduces Infection in Chest Wall Resection and Reconstruction for Malignant Chest Wall Tumors.

Khalil HH, Malahias MN, Balasubramanian B, Djearaman MG, Naidu B, Grainger MF, Kalkat M.

Plast Reconstr Surg Glob Open. 2016 Jul 20;4(7):e809. doi: 10.1097/GOX.0000000000000751. eCollection 2016 Jul.


A 20-year review of pectus surgery: an analysis of factors predictive of recurrence and outcomes.

Tikka T, Kalkat MS, Bishay E, Steyn RS, Rajesh PB, Naidu B.

Interact Cardiovasc Thorac Surg. 2016 Dec;23(6):908-913. Epub 2016 Aug 11.


Pectus patient information website has improved access to care and patient reported outcomes.

Tikka T, Webb J, Agostini P, Kerr A, Mannion G, Steyn RS, Bishay E, Kalkat MS, Rajesh PB, Naidu B.

J Cardiothorac Surg. 2016 Apr 26;11(1):69. doi: 10.1186/s13019-016-0470-7.


Long-term impact of developing a postoperative pulmonary complication after lung surgery.

Lugg ST, Agostini PJ, Tikka T, Kerr A, Adams K, Bishay E, Kalkat MS, Steyn RS, Rajesh PB, Thickett DR, Naidu B.

Thorax. 2016 Feb;71(2):171-6. doi: 10.1136/thoraxjnl-2015-207697.


Surgery corrects asynchrony of ribcage secondary to extra-thoracic tumor but leads to expiratory dysfunction during exercise.

Elshafie G, Aliverti A, Pippa L, Kumar P, Kalkat M, Naidu B.

J Cardiothorac Surg. 2015 Dec 18;10:187. doi: 10.1186/s13019-015-0355-1.


Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

Pandyra AA, Mullen PJ, Goard CA, Ericson E, Sharma P, Kalkat M, Yu R, Pong JT, Brown KR, Hart T, Gebbia M, Lang KS, Giaever G, Nislow C, Moffat J, Penn LZ.

Oncotarget. 2015 Sep 29;6(29):26909-21. doi: 10.18632/oncotarget.4817.


Tracheo-oesophageal fistula in a patient with chronic sarcoidosis.

Darr A, Mohamed S, Eaton D, Kalkat MS.

Ann R Coll Surg Engl. 2015 Oct;97(7):e100-2. doi: 10.1308/003588415X14181254790446. Epub 2015 Aug 14.


BioID data of c-MYC interacting protein partners in cultured cells and xenograft tumors.

Chan PK, Srikumar T, Dingar D, Kalkat M, Penn LZ, Raught B.

Data Brief. 2014 Oct 14;1:76-8. doi: 10.1016/j.dib.2014.10.001. eCollection 2014 Dec.


Bronchoscopic management of patients with symptomatic airway stenosis and prognostic factors for survival.

Okiror L, Jiang L, Oswald N, Bille A, Rajesh P, Bishay E, Steyn R, Naidu B, Kalkat M.

Ann Thorac Surg. 2015 May;99(5):1725-30. doi: 10.1016/j.athoracsur.2015.01.061. Epub 2015 Mar 25.


Survival following Pulmonary Metastasectomy for Sarcoma.

Okiror L, Peleki A, Moffat D, Bille A, Bishay E, Rajesh P, Steyn R, Naidu B, Grimer R, Kalkat M.

Thorac Cardiovasc Surg. 2016 Mar;64(2):146-9. doi: 10.1055/s-0035-1546430. Epub 2015 Mar 5.


Identification of c-MYC SUMOylation by mass spectrometry.

Kalkat M, Chan PK, Wasylishen AR, Srikumar T, Kim SS, Ponzielli R, Bazett-Jones DP, Raught B, Penn LZ.

PLoS One. 2014 Dec 18;9(12):e115337. doi: 10.1371/journal.pone.0115337. eCollection 2014.


Complete resection of a large phosphaturic mesenchymal tumour by chest wall resection and reconstruction.

Okiror L, Khalil H, Vaiyapuri S, Kalkat M.

Gen Thorac Cardiovasc Surg. 2016 Jun;64(6):355-8. doi: 10.1007/s11748-014-0505-8. Epub 2014 Dec 13.


BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

Dingar D, Kalkat M, Chan PK, Srikumar T, Bailey SD, Tu WB, Coyaud E, Ponzielli R, Kolyar M, Jurisica I, Huang A, Lupien M, Penn LZ, Raught B.

J Proteomics. 2015 Apr 6;118:95-111. doi: 10.1016/j.jprot.2014.09.029. Epub 2014 Oct 18.


Potentially modifiable factors contribute to limitation in physical activity following thoracotomy and lung resection: a prospective observational study.

Agostini PJ, Naidu B, Rajesh P, Steyn R, Bishay E, Kalkat M, Singh S.

J Cardiothorac Surg. 2014 Sep 27;9:128. doi: 10.1186/1749-8090-9-128.


Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.

Pandyra A, Mullen PJ, Kalkat M, Yu R, Pong JT, Li Z, Trudel S, Lang KS, Minden MD, Schimmer AD, Penn LZ.

Cancer Res. 2014 Sep 1;74(17):4772-82. doi: 10.1158/0008-5472.CAN-14-0130. Epub 2014 Jul 3.


Dramatic improvement after bilateral diaphragmatic plication in Charcot-Marie-Tooth disease.

Srivastava V, Pasha T, Knowles A, Boothman B, Paracha M, Kalkat M, Zacharias J.

Ann Thorac Surg. 2014 Jun;97(6):2177-9. doi: 10.1016/j.athoracsur.2013.04.143.


Does the revised cardiac risk index predict cardiac complications following elective lung resection?

Wotton R, Marshall A, Kerr A, Bishay E, Kalkat M, Rajesh P, Steyn R, Naidu B, Abdelaziz M, Hussain K.

J Cardiothorac Surg. 2013 Dec 1;8:220. doi: 10.1186/1749-8090-8-220. Erratum in: J Cardiothorac Surg. 2013;8:220. Abdelaziz, Mahmoud and Hussain, Khalid [Added].


Placental autophagy regulation by the BOK-MCL1 rheostat.

Kalkat M, Garcia J, Ebrahimi J, Melland-Smith M, Todros T, Post M, Caniggia I.

Autophagy. 2013 Dec;9(12):2140-53. doi: 10.4161/auto.26452. Epub 2013 Oct 8.


Delayed haemoptysis from explosive device fragments.

Johnston AM, West AT, Kendrew JM, Steyn RS, Kalkat MS, Graham TR.

Lancet. 2013 Sep 28;382(9898):1152. doi: 10.1016/S0140-6736(13)61651-7. No abstract available.


MYC phosphorylation at novel regulatory regions suppresses transforming activity.

Wasylishen AR, Chan-Seng-Yue M, Bros C, Dingar D, Tu WB, Kalkat M, Chan PK, Mullen PJ, Huang L, Meyer N, Raught B, Boutros PC, Penn LZ.

Cancer Res. 2013 Nov 1;73(21):6504-15. doi: 10.1158/0008-5472.CAN-12-4063. Epub 2013 Sep 12.


Pulmonary rehabilitation programme for patients undergoing curative lung cancer surgery.

Bradley A, Marshall A, Stonehewer L, Reaper L, Parker K, Bevan-Smith E, Jordan C, Gillies J, Agostini P, Bishay E, Kalkat M, Steyn R, Rajesh P, Dunn J, Naidu B.

Eur J Cardiothorac Surg. 2013 Oct;44(4):e266-71. doi: 10.1093/ejcts/ezt381. Epub 2013 Aug 19.


MYC activity is negatively regulated by a C-terminal lysine cluster.

Wasylishen AR, Kalkat M, Kim SS, Pandyra A, Chan PK, Oliveri S, Sedivy E, Konforte D, Bros C, Raught B, Penn LZ.

Oncogene. 2014 Feb 20;33(8):1066-72. doi: 10.1038/onc.2013.36. Epub 2013 Feb 25.


Effectiveness of incentive spirometry in patients following thoracotomy and lung resection including those at high risk for developing pulmonary complications.

Agostini P, Naidu B, Cieslik H, Steyn R, Rajesh PB, Bishay E, Kalkat MS, Singh S.

Thorax. 2013 Jun;68(6):580-5. doi: 10.1136/thoraxjnl-2012-202785. Epub 2013 Feb 21.


Thoracoscore fails to predict complications following elective lung resection.

Bradley A, Marshall A, Abdelaziz M, Hussain K, Agostini P, Bishay E, Kalkat M, Steyn R, Rajesh P, Dunn J, Naidu B.

Eur Respir J. 2012 Dec;40(6):1496-501. doi: 10.1183/09031936.00218111. Epub 2012 Apr 10.


Intrathymic primary intrathoracic goiter in a patient with breast malignancy.

Barker TA, Daultrey CR, Trotter SE, Kalkat M.

Ann Thorac Surg. 2012 Feb;93(2):e35-6. doi: 10.1016/j.athoracsur.2011.09.052.


Comparison of recognition tools for postoperative pulmonary complications following thoracotomy.

Agostini P, Naidu B, Cieslik H, Rathinam S, Bishay E, Kalkat MS, Rajesh PB, Steyn RS, Singh S.

Physiotherapy. 2011 Dec;97(4):278-83. doi: 10.1016/ Epub 2011 Feb 8.


More than MAX: Discovering the Myc interactome.

Kalkat M, Wasylishen AR, Kim SS, Penn L.

Cell Cycle. 2011 Feb 1;10(3):374-5. Epub 2011 Feb 1. No abstract available.


Postoperative pulmonary complications following thoracic surgery: are there any modifiable risk factors?

Agostini P, Cieslik H, Rathinam S, Bishay E, Kalkat MS, Rajesh PB, Steyn RS, Singh S, Naidu B.

Thorax. 2010 Sep;65(9):815-8. doi: 10.1136/thx.2009.123083.


Inflammatory myofibroblastic tumour at the pacemaker site.

Rathinam S, Kuntz H, Panting J, Kalkat MS.

Interact Cardiovasc Thorac Surg. 2010 Mar;10(3):443-5. doi: 10.1510/icvts.2009.221945. Epub 2009 Dec 29.


Postoperative oncological referral patterns for adjuvant treatment of patients undergoing curative resections for non-small-cell lung cancer at a regional thoracic centre.

Pai RK, Rathinam S, Sharma V, Bishay E, Steyn RS, Rajesh PB, Kalkat M.

Eur J Cardiothorac Surg. 2010 Apr;37(4):782-6. doi: 10.1016/j.ejcts.2009.09.044. Epub 2009 Dec 5.


Can chest trauma patients provide breath sample with Lion SD-400 Alcometer?

Rathinam S, Luke D, Nanjaiah P, Kalkat MS, Steyn RS.

Asian Cardiovasc Thorac Ann. 2009 Jun;17(3):282-4. doi: 10.1177/0218492309104774.


BioGlue and Peri-strips in lung volume reduction surgery: pilot randomised controlled trial.

Rathinam S, Naidu BV, Nanjaiah P, Loubani M, Kalkat MS, Rajesh PB.

J Cardiothorac Surg. 2009 Jul 17;4:37. doi: 10.1186/1749-8090-4-37.


Intraoperative coronary vein graft thrombosis: should we blame the use of aprotinin?

Sivasubramaniam S, Murali B, Smallpiece CJ, Smith B, Kalkat M.

Ann Card Anaesth. 2009 Jan-Jun;12(1):84-6. No abstract available.

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