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Understanding Addiction Using Animal Models.

Kuhn BN, Kalivas PW, Bobadilla AC.

Front Behav Neurosci. 2019 Nov 29;13:262. doi: 10.3389/fnbeh.2019.00262. eCollection 2019.


The loss of NMDAR-dependent LTD following cannabinoid self-administration is restored by positive allosteric modulation of CB1 receptors.

Neuhofer D, Spencer SM, Chioma VC, Beloate LN, Schwartz D, Kalivas PW.

Addict Biol. 2019 Nov 16:e12843. doi: 10.1111/adb.12843. [Epub ahead of print]


Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking.

Kruyer A, Ball LE, Townsend DM, Kalivas PW, Uys JD.

PLoS One. 2019 Sep 24;14(9):e0223037. doi: 10.1371/journal.pone.0223037. eCollection 2019.


Heroin Cue-Evoked Astrocytic Structural Plasticity at Nucleus Accumbens Synapses Inhibits Heroin Seeking.

Kruyer A, Scofield MD, Wood D, Reissner KJ, Kalivas PW.

Biol Psychiatry. 2019 Dec 1;86(11):811-819. doi: 10.1016/j.biopsych.2019.06.026. Epub 2019 Jul 8.


The Opioid-Addicted Tetrapartite Synapse.

Kruyer A, Chioma VC, Kalivas PW.

Biol Psychiatry. 2020 Jan 1;87(1):34-43. doi: 10.1016/j.biopsych.2019.05.025. Epub 2019 Jun 13. Review.


N-Acetylcysteine treatment during acute stress prevents stress-induced augmentation of addictive drug use and relapse.

Garcia-Keller C, Smiley C, Monforton C, Melton S, Kalivas PW, Gass J.

Addict Biol. 2019 Jul 7:e12798. doi: 10.1111/adb.12798. [Epub ahead of print]


Extracellular Matrix Signaling Through β3 Integrin Mediates Cocaine Cue-Induced Transient Synaptic Plasticity and Relapse.

Garcia-Keller C, Neuhofer D, Bobadilla AC, Spencer S, Chioma VC, Monforton C, Kalivas PW.

Biol Psychiatry. 2019 Sep 1;86(5):377-387. doi: 10.1016/j.biopsych.2019.03.982. Epub 2019 Apr 3.


Transient synaptic potentiation in nucleus accumbens shell during refraining from cocaine seeking.

Roberts-Wolfe DJ, Heinsbroek JA, Spencer SM, Bobadilla AC, Smith ACW, Gipson CD, Kalivas PW.

Addict Biol. 2019 May 6:e12759. doi: 10.1111/adb.12759. [Epub ahead of print]


Effects of Methamphetamine Self-Administration and Extinction on Astrocyte Structure and Function in the Nucleus Accumbens Core.

Siemsen BM, Reichel CM, Leong KC, Garcia-Keller C, Gipson CD, Spencer S, McFaddin JA, Hooker KN, Kalivas PW, Scofield MD.

Neuroscience. 2019 May 15;406:528-541. doi: 10.1016/j.neuroscience.2019.03.040. Epub 2019 Mar 26.


Ventral Pallidum Is the Primary Target for Accumbens D1 Projections Driving Cocaine Seeking.

Pardo-Garcia TR, Garcia-Keller C, Penaloza T, Richie CT, Pickel J, Hope BT, Harvey BK, Kalivas PW, Heinsbroek JA.

J Neurosci. 2019 Mar 13;39(11):2041-2051. doi: 10.1523/JNEUROSCI.2822-18.2018. Epub 2019 Jan 8.


Reply to: N-Acetylcysteine in Treatment of Substance Use Disorders.

Kalivas PW, Spencer S.

Biol Psychiatry. 2019 Jun 1;85(11):e61. doi: 10.1016/j.biopsych.2018.11.019. Epub 2018 Dec 15. No abstract available.


Deconstructing and Reconstructing the Dichotomy That Is Dopamine Receptor-1- and Dopamine Receptor-2-Expressing Neurons.

Kalivas PW.

Biol Psychiatry. 2018 Dec 15;84(12):862-864. doi: 10.1016/j.biopsych.2018.10.007. No abstract available.


Targeting redox regulation to treat substance use disorder using N-acetylcysteine.

Womersley JS, Townsend DM, Kalivas PW, Uys JD.

Eur J Neurosci. 2019 Aug;50(3):2538-2551. doi: 10.1111/ejn.14130. Epub 2018 Sep 24. Review.


Drug Refraining and Seeking Potentiate Synapses on Distinct Populations of Accumbens Medium Spiny Neurons.

Roberts-Wolfe D, Bobadilla AC, Heinsbroek JA, Neuhofer D, Kalivas PW.

J Neurosci. 2018 Aug 8;38(32):7100-7107. doi: 10.1523/JNEUROSCI.0791-18.2018. Epub 2018 Jul 5.


Accumbens brain-derived neurotrophic factor (BDNF) transmission inhibits cocaine seeking.

Bobadilla AC, Garcia-Keller C, Chareunsouk V, Hyde J, Medina Camacho D, Heinsbroek JA, Kalivas PW.

Addict Biol. 2019 Sep;24(5):860-873. doi: 10.1111/adb.12638. Epub 2018 Jun 11.


A Model of Δ9-Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens.

Spencer S, Neuhofer D, Chioma VC, Garcia-Keller C, Schwartz DJ, Allen N, Scofield MD, Ortiz-Ithier T, Kalivas PW.

Biol Psychiatry. 2018 Oct 15;84(8):601-610. doi: 10.1016/j.biopsych.2018.04.016. Epub 2018 May 3. Erratum in: Biol Psychiatry. 2019 May 15;85(10):881.


Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior.

Bobadilla AC, Heinsbroek JA, Gipson CD, Griffin WC, Fowler CD, Kenny PJ, Kalivas PW.

Prog Brain Res. 2017;235:93-112. doi: 10.1016/bs.pbr.2017.07.013. Epub 2017 Oct 12. Review.


HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.

Taniguchi M, Carreira MB, Cooper YA, Bobadilla AC, Heinsbroek JA, Koike N, Larson EB, Balmuth EA, Hughes BW, Penrod RD, Kumar J, Smith LN, Guzman D, Takahashi JS, Kim TK, Kalivas PW, Self DW, Lin Y, Cowan CW.

Neuron. 2017 Sep 27;96(1):130-144.e6. doi: 10.1016/j.neuron.2017.09.015.


Accumbens Mechanisms for Cued Sucrose Seeking.

Bobadilla AC, Garcia-Keller C, Heinsbroek JA, Scofield MD, Chareunsouk V, Monforton C, Kalivas PW.

Neuropsychopharmacology. 2017 Nov;42(12):2377-2386. doi: 10.1038/npp.2017.153. Epub 2017 Jul 20.


Glutamate Transport: A New Bench to Bedside Mechanism for Treating Drug Abuse.

Spencer S, Kalivas PW.

Int J Neuropsychopharmacol. 2017 Oct 1;20(10):797-812. doi: 10.1093/ijnp/pyx050. Review.


New vistas on cannabis use disorder.

Melis M, Frau R, Kalivas PW, Spencer S, Chioma V, Zamberletti E, Rubino T, Parolaro D.

Neuropharmacology. 2017 Sep 15;124:62-72. doi: 10.1016/j.neuropharm.2017.03.033. Epub 2017 Mar 31. Review.


Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking.

Heinsbroek JA, Neuhofer DN, Griffin WC 3rd, Siegel GS, Bobadilla AC, Kupchik YM, Kalivas PW.

J Neurosci. 2017 Jan 25;37(4):757-767. doi: 10.1523/JNEUROSCI.2659-16.2016.


Accumbens nNOS Interneurons Regulate Cocaine Relapse.

Smith ACW, Scofield MD, Heinsbroek JA, Gipson CD, Neuhofer D, Roberts-Wolfe DJ, Spencer S, Garcia-Keller C, Stankeviciute NM, Smith RJ, Allen NP, Lorang MR, Griffin WC 3rd, Boger HA, Kalivas PW.

J Neurosci. 2017 Jan 25;37(4):742-756. doi: 10.1523/JNEUROSCI.2673-16.2016.


The Direct and Indirect Pathways of the Nucleus Accumbens are not What You Think.

Kupchik YM, Kalivas PW.

Neuropsychopharmacology. 2017 Jan;42(1):369-370. doi: 10.1038/npp.2016.160. No abstract available.


Cocaine Use Reverses Striatal Plasticity Produced During Cocaine Seeking.

Spencer S, Garcia-Keller C, Roberts-Wolfe D, Heinsbroek JA, Mulvaney M, Sorrell A, Kalivas PW.

Biol Psychiatry. 2017 Apr 1;81(7):616-624. doi: 10.1016/j.biopsych.2016.08.033. Epub 2016 Sep 13.


A Double-Blind, Randomized, Controlled Pilot Trial of N-Acetylcysteine in Veterans With Posttraumatic Stress Disorder and Substance Use Disorders.

Back SE, McCauley JL, Korte KJ, Gros DF, Leavitt V, Gray KM, Hamner MB, DeSantis SM, Malcolm R, Brady KT, Kalivas PW.

J Clin Psychiatry. 2016 Nov;77(11):e1439-e1446. doi: 10.4088/JCP.15m10239.


Chemogenetic Activation of an Extinction Neural Circuit Reduces Cue-Induced Reinstatement of Cocaine Seeking.

Augur IF, Wyckoff AR, Aston-Jones G, Kalivas PW, Peters J.

J Neurosci. 2016 Sep 28;36(39):10174-80. doi: 10.1523/JNEUROSCI.0773-16.2016. Epub 2016 Sep 28.


The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis.

Scofield MD, Heinsbroek JA, Gipson CD, Kupchik YM, Spencer S, Smith AC, Roberts-Wolfe D, Kalivas PW.

Pharmacol Rev. 2016 Jul;68(3):816-71. doi: 10.1124/pr.116.012484. Review.


The good and bad news about glutamate in drug addiction.

Spencer S, Scofield M, Kalivas PW.

J Psychopharmacol. 2016 Nov;30(11):1095-1098. Epub 2016 Jun 28. Review.


Abstinence From Drug Dependence After Bilateral Globus Pallidus Hypoxic-Ischemic Injury.

Moussawi K, Kalivas PW, Lee JW.

Biol Psychiatry. 2016 Nov 1;80(9):e79-e80. doi: 10.1016/j.biopsych.2016.04.005. Epub 2016 Apr 16. No abstract available.


Signals from the Fourth Dimension Regulate Drug Relapse.

Mulholland PJ, Chandler LJ, Kalivas PW.

Trends Neurosci. 2016 Jul;39(7):472-485. doi: 10.1016/j.tins.2016.04.007. Epub 2016 May 10. Review.


Corticostriatal circuitry in regulating diseases characterized by intrusive thinking.

Kalivas BC, Kalivas PW.

Dialogues Clin Neurosci. 2016 Mar;18(1):65-76. Review.


Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core.

Scofield MD, Li H, Siemsen BM, Healey KL, Tran PK, Woronoff N, Boger HA, Kalivas PW, Reissner KJ.

Biol Psychiatry. 2016 Aug 1;80(3):207-15. doi: 10.1016/j.biopsych.2015.12.022. Epub 2015 Dec 31.


Addiction-like Synaptic Impairments in Diet-Induced Obesity.

Brown RM, Kupchik YM, Spencer S, Garcia-Keller C, Spanswick DC, Lawrence AJ, Simonds SE, Schwartz DJ, Jordan KA, Jhou TC, Kalivas PW.

Biol Psychiatry. 2017 May 1;81(9):797-806. doi: 10.1016/j.biopsych.2015.11.019. Epub 2015 Dec 2.


Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration.

Garcia-Keller C, Kupchik YM, Gipson CD, Brown RM, Spencer S, Bollati F, Esparza MA, Roberts-Wolfe DJ, Heinsbroek JA, Bobadilla AC, Cancela LM, Kalivas PW.

Mol Psychiatry. 2016 Aug;21(8):1063-9. doi: 10.1038/mp.2015.151. Epub 2015 Oct 6.


The effects of N-Acetylcysteine on frontostriatal resting-state functional connectivity, withdrawal symptoms and smoking abstinence: A double-blind, placebo-controlled fMRI pilot study.

Froeliger B, McConnell PA, Stankeviciute N, McClure EA, Kalivas PW, Gray KM.

Drug Alcohol Depend. 2015 Nov 1;156:234-242. doi: 10.1016/j.drugalcdep.2015.09.021. Epub 2015 Sep 26.


Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections.

Kupchik YM, Brown RM, Heinsbroek JA, Lobo MK, Schwartz DJ, Kalivas PW.

Nat Neurosci. 2015 Sep;18(9):1230-2. doi: 10.1038/nn.4068. Epub 2015 Jul 27.


Glutamate Transporter GLT-1 as a Therapeutic Target for Substance Use Disorders.

Roberts-Wolfe DJ, Kalivas PW.

CNS Neurol Disord Drug Targets. 2015;14(6):745-56. Review.


Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking.

Scofield MD, Boger HA, Smith RJ, Li H, Haydon PG, Kalivas PW.

Biol Psychiatry. 2015 Oct 1;78(7):441-51. doi: 10.1016/j.biopsych.2015.02.016. Epub 2015 Feb 24.


The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction.

Smith AC, Scofield MD, Kalivas PW.

Brain Res. 2015 Dec 2;1628(Pt A):29-39. doi: 10.1016/j.brainres.2015.03.027. Epub 2015 Mar 30. Review.


Phenotype-dependent inhibition of glutamatergic transmission on nucleus accumbens medium spiny neurons by the abused inhalant toluene.

Beckley JT, Randall PK, Smith RJ, Hughes BA, Kalivas PW, Woodward JJ.

Addict Biol. 2016 May;21(3):530-46. doi: 10.1111/adb.12235. Epub 2015 Mar 6.


Optogenetic inhibition of cortical afferents in the nucleus accumbens simultaneously prevents cue-induced transient synaptic potentiation and cocaine-seeking behavior.

Stefanik MT, Kupchik YM, Kalivas PW.

Brain Struct Funct. 2016 Apr;221(3):1681-9. doi: 10.1007/s00429-015-0997-8. Epub 2015 Feb 7.


More cocaine-more glutamate-more addiction.

Gipson CD, Kalivas PW.

Biol Psychiatry. 2014 Nov 15;76(10):765-6. doi: 10.1016/j.biopsych.2014.08.010. Epub 2014 Oct 31. No abstract available.


Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases.

Smith AC, Kupchik YM, Scofield MD, Gipson CD, Wiggins A, Thomas CA, Kalivas PW.

Nat Neurosci. 2014 Dec;17(12):1655-7. doi: 10.1038/nn.3846. Epub 2014 Oct 19.


An open-label pilot trial of N-acetylcysteine and varenicline in adult cigarette smokers.

McClure EA, Baker NL, Gipson CD, Carpenter MJ, Roper AP, Froeliger BE, Kalivas PW, Gray KM.

Am J Drug Alcohol Abuse. 2015 Jan;41(1):52-6. doi: 10.3109/00952990.2014.933839. Epub 2014 Jul 25.


α2δ-1 signaling in nucleus accumbens is necessary for cocaine-induced relapse.

Spencer S, Brown RM, Quintero GC, Kupchik YM, Thomas CA, Reissner KJ, Kalivas PW.

J Neurosci. 2014 Jun 18;34(25):8605-11. doi: 10.1523/JNEUROSCI.1204-13.2014.


"Mourning" a lost opportunity.

Kalivas PW, Gipson CD.

Psychopharmacology (Berl). 2014 Oct;231(19):3921-2. doi: 10.1007/s00213-014-3626-y. Epub 2014 May 27. No abstract available.


Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse.

Shen HW, Scofield MD, Boger H, Hensley M, Kalivas PW.

J Neurosci. 2014 Apr 16;34(16):5649-57. doi: 10.1523/JNEUROSCI.4564-13.2014.


Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement.

Reissner KJ, Gipson CD, Tran PK, Knackstedt LA, Scofield MD, Kalivas PW.

Addict Biol. 2015 Mar;20(2):316-23. doi: 10.1111/adb.12127. Epub 2014 Feb 25.


Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis.

Scofield MD, Kalivas PW.

Neuroscientist. 2014 Dec;20(6):610-22. doi: 10.1177/1073858413520347. Epub 2014 Feb 3. Review.

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