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Items: 1 to 50 of 195

1.

Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells.

Durán V, Yasar H, Becker J, Thiyagarajan D, Loretz B, Kalinke U, Lehr CM.

Nanomedicine. 2019 Jul 31;21:102073. doi: 10.1016/j.nano.2019.102073. [Epub ahead of print]

2.

STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus.

Tegtmeyer PK, Spanier J, Borst K, Becker J, Riedl A, Hirche C, Ghita L, Skerra J, Baumann K, Lienenklaus S, Doering M, Ruzsics Z, Kalinke U.

Nat Commun. 2019 Jun 27;10(1):2830. doi: 10.1038/s41467-019-10863-0.

3.

Reply to: "Unveiling the depletion of Kupffer cells in experimental hepatocarcinogenesis through liver macrophage subtype-specific markers".

Borst K, Graalmann T, Kalinke U.

J Hepatol. 2019 Sep;71(3):633-635. doi: 10.1016/j.jhep.2019.05.012. Epub 2019 Jun 18. No abstract available.

PMID:
31227257
4.

Type I interferon induced by TLR2-TLR4-MyD88-TRIF-IRF3 controls Mycobacterium abscessus subsp. abscessus persistence in murine macrophages via nitric oxide.

Ruangkiattikul N, Rys D, Abdissa K, Rohde M, Semmler T, Tegtmeyer PK, Kalinke U, Schwarz C, Lewin A, Goethe R.

Int J Med Microbiol. 2019 Jul;309(5):307-318. doi: 10.1016/j.ijmm.2019.05.007. Epub 2019 Jun 1.

PMID:
31178418
5.

TLR7 Controls VSV Replication in CD169+ SCS Macrophages and Associated Viral Neuroinvasion.

Solmaz G, Puttur F, Francozo M, Lindenberg M, Guderian M, Swallow M, Duhan V, Khairnar V, Kalinke U, Ludewig B, Clausen BE, Wagner H, Lang KS, Sparwasser TD.

Front Immunol. 2019 Mar 15;10:466. doi: 10.3389/fimmu.2019.00466. eCollection 2019.

6.

Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation.

Döring M, Blees H, Koller N, Tischer-Zimmermann S, Müsken M, Henrich F, Becker J, Grabski E, Wang J, Janssen H, Zuschratter W, Neefjes J, Klawonn F, Eiz-Vesper B, Tampé R, Kalinke U.

Blood Adv. 2019 Mar 26;3(6):839-850. doi: 10.1182/bloodadvances.2018027268.

7.

RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockade.

Heidegger S, Kreppel D, Bscheider M, Stritzke F, Nedelko T, Wintges A, Bek S, Fischer JC, Graalmann T, Kalinke U, Bassermann F, Haas T, Poeck H.

EBioMedicine. 2019 Mar;41:146-155. doi: 10.1016/j.ebiom.2019.02.056. Epub 2019 Mar 6.

8.

Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1.

Gawish R, Bulat T, Biaggio M, Lassnig C, Bago-Horvath Z, Macho-Maschler S, Poelzl A, Simonović N, Prchal-Murphy M, Rom R, Amenitsch L, Ferrarese L, Kornhoff J, Lederer T, Svinka J, Eferl R, Bosmann M, Kalinke U, Stoiber D, Sexl V, Krmpotić A, Jonjić S, Müller M, Strobl B.

Cell Rep. 2019 Feb 26;26(9):2394-2406.e5. doi: 10.1016/j.celrep.2019.02.017.

9.

Interferon-γ Receptor Signaling in Dendritic Cells Restrains Spontaneous Proliferation of CD4+ T Cells in Chronic Lymphopenic Mice.

Knop L, Frommer C, Stoycheva D, Deiser K, Kalinke U, Blankenstein T, Kammertoens T, Dunay IR, Schüler T.

Front Immunol. 2019 Feb 7;10:140. doi: 10.3389/fimmu.2019.00140. eCollection 2019.

10.

Reply to: "Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation".

Borst K, Graalmann T, Kalinke U.

J Hepatol. 2019 Apr;70(4):815-816. doi: 10.1016/j.jhep.2018.12.034. Epub 2019 Feb 1. No abstract available.

PMID:
30712975
11.

Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis.

Tsay HC, Yuan Q, Balakrishnan A, Kaiser M, Möbus S, Kozdrowska E, Farid M, Tegtmeyer PK, Borst K, Vondran FWR, Kalinke U, Kispert A, Manns MP, Ott M, Sharma AD.

J Hepatol. 2019 Apr;70(4):722-734. doi: 10.1016/j.jhep.2018.12.016. Epub 2018 Dec 22.

PMID:
30582979
12.

Human monocyte-derived macrophages inhibit HCMV spread independent of classical antiviral cytokines.

Becker J, Kinast V, Döring M, Lipps C, Duran V, Spanier J, Tegtmeyer PK, Wirth D, Cicin-Sain L, Alcamí A, Kalinke U.

Virulence. 2018;9(1):1669-1684. doi: 10.1080/21505594.2018.1535785.

PMID:
30403913
13.

The olfactory epithelium as a port of entry in neonatal neurolisteriosis.

Pägelow D, Chhatbar C, Beineke A, Liu X, Nerlich A, van Vorst K, Rohde M, Kalinke U, Förster R, Halle S, Valentin-Weigand P, Hornef MW, Fulde M.

Nat Commun. 2018 Oct 15;9(1):4269. doi: 10.1038/s41467-018-06668-2.

14.

Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis.

Chhatbar C, Detje CN, Grabski E, Borst K, Spanier J, Ghita L, Elliott DA, Jordão MJC, Mueller N, Sutton J, Prajeeth CK, Gudi V, Klein MA, Prinz M, Bradke F, Stangel M, Kalinke U.

Cell Rep. 2018 Oct 2;25(1):118-129.e4. doi: 10.1016/j.celrep.2018.09.003.

15.

Immunogenic cell death of dendritic cells following modified vaccinia virus Ankara infection enhances CD8+ T cell proliferation.

Tappe KA, Budida R, Stankov MV, Frenz T, R Shah H, Volz A, Sutter G, Kalinke U, Behrens GMN.

Eur J Immunol. 2018 Dec;48(12):2042-2054. doi: 10.1002/eji.201847632. Epub 2018 Oct 10.

PMID:
30259962
16.

Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage.

Waltl I, Käufer C, Gerhauser I, Chhatbar C, Ghita L, Kalinke U, Löscher W.

Brain Behav Immun. 2018 Nov;74:186-204. doi: 10.1016/j.bbi.2018.09.006. Epub 2018 Sep 11.

PMID:
30217535
17.

Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures.

Käufer C, Chhatbar C, Bröer S, Waltl I, Ghita L, Gerhauser I, Kalinke U, Löscher W.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8929-E8938. doi: 10.1073/pnas.1806754115. Epub 2018 Sep 4.

18.

Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice.

Koestner W, Spanier J, Klause T, Tegtmeyer PK, Becker J, Herder V, Borst K, Todt D, Lienenklaus S, Gerhauser I, Detje CN, Geffers R, Langereis MA, Vondran FWR, Yuan Q, van Kuppeveld FJM, Ott M, Staeheli P, Steinmann E, Baumgärtner W, Wacker F, Kalinke U.

PLoS Pathog. 2018 Aug 3;14(8):e1007235. doi: 10.1371/journal.ppat.1007235. eCollection 2018 Aug.

19.

Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells.

Vendelova E, Ashour D, Blank P, Erhard F, Saliba AE, Kalinke U, Lutz MB.

Front Immunol. 2018 Feb 28;9:333. doi: 10.3389/fimmu.2018.00333. eCollection 2018. Review.

20.

Regulatory T-Cells Mediate IFN-α-Induced Resistance against Antigen-Induced Arthritis.

Chenna Narendra S, Chalise JP, Biggs S, Kalinke U, Magnusson M.

Front Immunol. 2018 Feb 19;9:285. doi: 10.3389/fimmu.2018.00285. eCollection 2018.

21.

Type I Interferon Signaling Is Required for CpG-Oligodesoxynucleotide-Induced Control of Leishmania major, but Not for Spontaneous Cure of Subcutaneous Primary or Secondary L. major Infection.

Schleicher U, Liese J, Justies N, Mischke T, Haeberlein S, Sebald H, Kalinke U, Weiss S, Bogdan C.

Front Immunol. 2018 Feb 5;9:79. doi: 10.3389/fimmu.2018.00079. eCollection 2018.

22.

Personalized adoptive immunotherapy for patients with EBV-associated tumors and complications: Evaluation of novel naturally processed and presented EBV-derived T-cell epitopes.

Bieling M, Tischer S, Kalinke U, Blasczyk R, Buus S, Maecker-Kolhoff B, Eiz-Vesper B.

Oncotarget. 2017 Dec 21;9(4):4737-4757. doi: 10.18632/oncotarget.23531. eCollection 2018 Jan 12.

23.

Application of light sheet microscopy for qualitative and quantitative analysis of bronchus-associated lymphoid tissue in mice.

Mzinza DT, Fleige H, Laarmann K, Willenzon S, Ristenpart J, Spanier J, Sutter G, Kalinke U, Valentin-Weigand P, Förster R.

Cell Mol Immunol. 2018 Oct;15(10):875-887. doi: 10.1038/cmi.2017.150. Epub 2018 Feb 12.

PMID:
29429996
24.

Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis.

Borst K, Frenz T, Spanier J, Tegtmeyer PK, Chhatbar C, Skerra J, Ghita L, Namineni S, Lienenklaus S, Köster M, Heikenwaelder M, Sutter G, Kalinke U.

J Hepatol. 2018 Apr;68(4):682-690. doi: 10.1016/j.jhep.2017.11.029. Epub 2017 Dec 21.

PMID:
29274730
25.

[Pulmonary Immune Mechanisms in Tuberculosis].

Herzmann C, Dallenga T, Kalinke U.

Pneumologie. 2018 Jul;72(7):493-502. doi: 10.1055/s-0043-122961. Epub 2017 Dec 21. Review. German.

PMID:
29270952
26.

Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages.

Neehus AL, Lam J, Haake K, Merkert S, Schmidt N, Mucci A, Ackermann M, Schubert M, Happle C, Kühnel MP, Blank P, Philipp F, Goethe R, Jonigk D, Martin U, Kalinke U, Baumann U, Schambach A, Roesler J, Lachmann N.

Stem Cell Reports. 2018 Jan 9;10(1):7-16. doi: 10.1016/j.stemcr.2017.11.011. Epub 2017 Dec 14.

27.

Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections.

Hetzel M, Mucci A, Blank P, Nguyen AHH, Schiller J, Halle O, Kühnel MP, Billig S, Meineke R, Brand D, Herder V, Baumgärtner W, Bange FC, Goethe R, Jonigk D, Förster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N.

Blood. 2018 Feb 1;131(5):533-545. doi: 10.1182/blood-2017-10-812859. Epub 2017 Dec 12.

28.

Macrophage depletion by liposome-encapsulated clodronate suppresses seizures but not hippocampal damage after acute viral encephalitis.

Waltl I, Käufer C, Bröer S, Chhatbar C, Ghita L, Gerhauser I, Anjum M, Kalinke U, Löscher W.

Neurobiol Dis. 2018 Feb;110:192-205. doi: 10.1016/j.nbd.2017.12.001. Epub 2017 Dec 5.

PMID:
29208406
29.

Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection.

Ivin M, Dumigan A, de Vasconcelos FN, Ebner F, Borroni M, Kavirayani A, Przybyszewska KN, Ingram RJ, Lienenklaus S, Kalinke U, Stoiber D, Bengoechea JA, Kovarik P.

PLoS Pathog. 2017 Nov 7;13(11):e1006696. doi: 10.1371/journal.ppat.1006696. eCollection 2017 Nov.

30.

Identification of a Predominantly Interferon-λ-Induced Transcriptional Profile in Murine Intestinal Epithelial Cells.

Selvakumar TA, Bhushal S, Kalinke U, Wirth D, Hauser H, Köster M, Hornef MW.

Front Immunol. 2017 Oct 16;8:1302. doi: 10.3389/fimmu.2017.01302. eCollection 2017.

31.

Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Guérin (BCG) via Synergistic Activation of Innate Immune Receptors.

Speth MT, Repnik U, Müller E, Spanier J, Kalinke U, Corthay A, Griffiths G.

Mol Pharm. 2017 Nov 6;14(11):4098-4112. doi: 10.1021/acs.molpharmaceut.7b00795. Epub 2017 Oct 19.

PMID:
28974092
32.

cGAMP Quantification in Virus-Infected Human Monocyte-Derived Cells by HPLC-Coupled Tandem Mass Spectrometry.

Paijo J, Kaever V, Kalinke U.

Methods Mol Biol. 2017;1656:153-166. doi: 10.1007/978-1-4939-7237-1_9.

PMID:
28808968
33.

Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway.

Lirussi D, Ebensen T, Schulze K, Trittel S, Duran V, Liebich I, Kalinke U, Guzmán CA.

EBioMedicine. 2017 Aug;22:100-111. doi: 10.1016/j.ebiom.2017.07.016. Epub 2017 Jul 19.

34.

Enhancement of IFNγ Production by Distinct Commensals Ameliorates Salmonella-Induced Disease.

Thiemann S, Smit N, Roy U, Lesker TR, Gálvez EJC, Helmecke J, Basic M, Bleich A, Goodman AL, Kalinke U, Flavell RA, Erhardt M, Strowig T.

Cell Host Microbe. 2017 Jun 14;21(6):682-694.e5. doi: 10.1016/j.chom.2017.05.005.

35.

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.

Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer PK, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U.

Cell Rep. 2017 Jun 13;19(11):2345-2356. doi: 10.1016/j.celrep.2017.05.063.

36.

A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle.

Matschulla T, Berry R, Gerke C, Döring M, Busch J, Paijo J, Kalinke U, Momburg F, Hengel H, Halenius A.

Sci Rep. 2017 Jun 7;7(1):2933. doi: 10.1038/s41598-017-02994-5.

37.

Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration.

González-Motos V, Jürgens C, Ritter B, Kropp KA, Durán V, Larsen O, Binz A, Ouwendijk WJD, Lenac Rovis T, Jonjic S, Verjans GMGM, Sodeik B, Krey T, Bauerfeind R, Schulz TF, Kaufer BB, Kalinke U, Proudfoot AEI, Rosenkilde MM, Viejo-Borbolla A.

PLoS Pathog. 2017 May 25;13(5):e1006346. doi: 10.1371/journal.ppat.1006346. eCollection 2017 May.

38.

RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury.

Fischer JC, Bscheider M, Eisenkolb G, Lin CC, Wintges A, Otten V, Lindemans CA, Heidegger S, Rudelius M, Monette S, Porosnicu Rodriguez KA, Calafiore M, Liebermann S, Liu C, Lienenklaus S, Weiss S, Kalinke U, Ruland J, Peschel C, Shono Y, Docampo M, Velardi E, Jenq RR, Hanash AM, Dudakov JA, Haas T, van den Brink MRM, Poeck H.

Sci Transl Med. 2017 Apr 19;9(386). pii: eaag2513. doi: 10.1126/scitranslmed.aag2513.

39.

cGAS-STING-TBK1-IRF3/7 induced interferon-β contributes to the clearing of non tuberculous mycobacterial infection in mice.

Ruangkiattikul N, Nerlich A, Abdissa K, Lienenklaus S, Suwandi A, Janze N, Laarmann K, Spanier J, Kalinke U, Weiss S, Goethe R.

Virulence. 2017 Oct 3;8(7):1303-1315. doi: 10.1080/21505594.2017.1321191. Epub 2017 Apr 19.

40.

Immune protection against reinfection with nonprimate hepacivirus.

Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJ, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Kalinke U, Wagner B, Bartenschlager R, Baumgärtner W, Feige K, Pietschmann T, Cavalleri JM, Steinmann E.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2430-E2439. doi: 10.1073/pnas.1619380114. Epub 2017 Mar 8.

41.

A Polymorphism within the Internal Fusion Loop of the Ebola Virus Glycoprotein Modulates Host Cell Entry.

Hoffmann M, Crone L, Dietzel E, Paijo J, González-Hernández M, Nehlmeier I, Kalinke U, Becker S, Pöhlmann S.

J Virol. 2017 Apr 13;91(9). pii: e00177-17. doi: 10.1128/JVI.00177-17. Print 2017 May 1.

42.

Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication.

Kindler E, Gil-Cruz C, Spanier J, Li Y, Wilhelm J, Rabouw HH, Züst R, Hwang M, V'kovski P, Stalder H, Marti S, Habjan M, Cervantes-Barragan L, Elliot R, Karl N, Gaughan C, van Kuppeveld FJ, Silverman RH, Keller M, Ludewig B, Bergmann CC, Ziebuhr J, Weiss SR, Kalinke U, Thiel V.

PLoS Pathog. 2017 Feb 3;13(2):e1006195. doi: 10.1371/journal.ppat.1006195. eCollection 2017 Feb.

43.

A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects.

Ziegler A, Soldner C, Lienenklaus S, Spanier J, Trittel S, Riese P, Kramps T, Weiss S, Heidenreich R, Jasny E, Guzmán CA, Kallen KJ, Fotin-Mleczek M, Kalinke U.

J Immunol. 2017 Feb 15;198(4):1595-1605. doi: 10.4049/jimmunol.1601129. Epub 2017 Jan 11.

44.

The European Regulatory Environment of RNA-Based Vaccines.

Hinz T, Kallen K, Britten CM, Flamion B, Granzer U, Hoos A, Huber C, Khleif S, Kreiter S, Rammensee HG, Sahin U, Singh-Jasuja H, Türeci Ö, Kalinke U.

Methods Mol Biol. 2017;1499:203-222. Review.

PMID:
27987152
45.

Hepatitis C Virus Stimulates Murine CD8α-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner.

Pfaender S, Grabski E, Detje CN, Riebesehl N, Lienenklaus S, Steinmann E, Kalinke U, Pietschmann T.

PLoS Pathog. 2016 Jul 6;12(7):e1005736. doi: 10.1371/journal.ppat.1005736. eCollection 2016 Jul.

46.

Type I interferon promotes alveolar epithelial type II cell survival during pulmonary Streptococcus pneumoniae infection and sterile lung injury in mice.

Maier BB, Hladik A, Lakovits K, Korosec A, Martins R, Kral JB, Mesteri I, Strobl B, Müller M, Kalinke U, Merad M, Knapp S.

Eur J Immunol. 2016 Sep;46(9):2175-86. doi: 10.1002/eji.201546201. Epub 2016 Jul 12.

47.

Correction: Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia.

Högner K, Wolff T, Pleschka S, Plog S, Gruber AD, Kalinke U, Walmrath HD, Bodner J, Gattenlöhner S, Lewe-Schlosser P, Matrosovich M, Seeger W, Lohmeyer J, Herold S.

PLoS Pathog. 2016 Jun 15;12(6):e1005716. doi: 10.1371/journal.ppat.1005716. eCollection 2016 Jun.

48.

CD4(+) T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion.

Frenz T, Grabski E, Buschjäger D, Vaas LA, Burgdorf N, Schmidt RE, Witte T, Kalinke U.

J Allergy Clin Immunol. 2016 Aug;138(2):586-589.e10. doi: 10.1016/j.jaci.2016.04.013. Epub 2016 Jun 2. No abstract available.

PMID:
27264455
49.

Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization.

Lückoff A, Caramoy A, Scholz R, Prinz M, Kalinke U, Langmann T.

EMBO Mol Med. 2016 Jun 1;8(6):670-8. doi: 10.15252/emmm.201505994. Print 2016 Jun.

50.

Growing tumors induce a local STING dependent Type I IFN response in dendritic cells.

Andzinski L, Spanier J, Kasnitz N, Kröger A, Jin L, Brinkmann MM, Kalinke U, Weiss S, Jablonska J, Lienenklaus S.

Int J Cancer. 2016 Sep 15;139(6):1350-7. doi: 10.1002/ijc.30159. Epub 2016 May 17.

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