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Items: 1 to 50 of 229


Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates.

Fox AS, Souaiaia T, Oler JA, Kovner R, Kim JMH, Nguyen J, French DA, Riedel MK, Fekete EM, Rabska MR, Olsen ME, Brodsky EK, Alexander AL, Block WF, Roseboom PH, Knowles JA, Kalin NH.

Biol Psychiatry. 2019 Jul 2. pii: S0006-3223(19)31487-8. doi: 10.1016/j.biopsych.2019.06.022. [Epub ahead of print]


Psychiatric Genetics: Scientific Advances and Clinical Challenges.

Kalin NH.

Am J Psychiatry. 2019 Aug 1;176(8):595-597. doi: 10.1176/appi.ajp.2019.19060644. No abstract available.


Using Neuroimaging to Characterize Brain Alterations Associated With Psychopathology.

Kalin NH.

Am J Psychiatry. 2019 Jul 1;176(7):495-497. doi: 10.1176/appi.ajp.2019.19050519. No abstract available.


Developing Novel Psychopharmacological Strategies and Therapeutics.

Kalin NH.

Am J Psychiatry. 2019 Jun 1;176(6):419-421. doi: 10.1176/appi.ajp.2019.19040392. No abstract available.


Ultrastructural localization of DREADDs in monkeys.

Galvan A, Raper J, Hu X, Paré JF, Bonaventura J, Richie CT, Michaelides M, Mueller SAL, Roseboom PH, Oler JA, Kalin NH, Hall RA, Smith Y.

Eur J Neurosci. 2019 May 7. doi: 10.1111/ejn.14429. [Epub ahead of print]


Improving the Lives of Patients With Major Depression by Focusing on New Treatment Approaches.

Kalin NH.

Am J Psychiatry. 2019 May 1;176(5):329-330. doi: 10.1176/appi.ajp.2019.19030283. No abstract available.


New Insights Into the Mechanisms of Ketamine's Antidepressant Effects: Understanding the Role of VEGF in Mediating Plasticity Processes.

Kenwood MM, Roseboom PH, Oler JA, Kalin NH.

Am J Psychiatry. 2019 May 1;176(5):333-335. doi: 10.1176/appi.ajp.2019.19030282. No abstract available.


Optimizing the Efficacy of Psychotherapy, Cognitive Training, and Internet Interventions.

Kalin NH.

Am J Psychiatry. 2019 Apr 1;176(4):257-258. doi: 10.1176/appi.ajp.2019.19020161. No abstract available.


EEG Biomarkers for Treatment Response Prediction in Major Depressive Illness.

Widge AS, Rodriguez CI, Carpenter LL, Kalin NH, McDonald W, Nemeroff CB.

Am J Psychiatry. 2019 Jan 1;176(1):82. doi: 10.1176/appi.ajp.2018.1760101. No abstract available.


An Introduction and Vision.

Kalin NH.

Am J Psychiatry. 2019 Jan 1;176(1):1-2. doi: 10.1176/appi.ajp.2018.18111286. No abstract available.


New Insights Highlighting Neurodevelopmental Issues That Predispose to Childhood and Adolescent Psychopathology.

Kalin NH.

Am J Psychiatry. 2019 Mar 1;176(3):171-172. doi: 10.1176/appi.ajp.2019.19010092. No abstract available.


New Findings Relevant to Substance Use Disorders.

Kalin NH.

Am J Psychiatry. 2019 Feb 1;176(2):A10. doi: 10.1176/appi.ajp.2018.18121421. No abstract available.


Altered Uncinate Fasciculus Microstructure in Childhood Anxiety Disorders in Boys But Not Girls.

Tromp DPM, Williams LE, Fox AS, Oler JA, Roseboom PH, Rogers GM, Benson BE, Alexander AL, Pine DS, Kalin NH.

Am J Psychiatry. 2019 Mar 1;176(3):208-216. doi: 10.1176/appi.ajp.2018.18040425. Epub 2019 Jan 18.


Somatostatin Gene and Protein Expression in the Non-human Primate Central Extended Amygdala.

Kovner R, Fox AS, French DA, Roseboom PH, Oler JA, Fudge JL, Kalin NH.

Neuroscience. 2019 Feb 21;400:157-168. doi: 10.1016/j.neuroscience.2018.12.035. Epub 2019 Jan 2.


Electroencephalographic Biomarkers for Treatment Response Prediction in Major Depressive Illness: A Meta-Analysis.

Widge AS, Bilge MT, Montana R, Chang W, Rodriguez CI, Deckersbach T, Carpenter LL, Kalin NH, Nemeroff CB.

Am J Psychiatry. 2019 Jan 1;176(1):44-56. doi: 10.1176/appi.ajp.2018.17121358. Epub 2018 Oct 3.


Association of Prenatal Maternal Depression and Anxiety Symptoms With Infant White Matter Microstructure.

Dean DC 3rd, Planalp EM, Wooten W, Kecskemeti SR, Adluru N, Schmidt CK, Frye C, Birn RM, Burghy CA, Schmidt NL, Styner MA, Short SJ, Kalin NH, Goldsmith HH, Alexander AL, Davidson RJ.

JAMA Pediatr. 2018 Oct 1;172(10):973-981. doi: 10.1001/jamapediatrics.2018.2132.


Functional Connectivity within the Primate Extended Amygdala Is Heritable and Associated with Early-Life Anxious Temperament.

Fox AS, Oler JA, Birn RM, Shackman AJ, Alexander AL, Kalin NH.

J Neurosci. 2018 Aug 29;38(35):7611-7621. doi: 10.1523/JNEUROSCI.0102-18.2018. Epub 2018 Jul 30.


Clinical Implementation of Pharmacogenetic Decision Support Tools for Antidepressant Drug Prescribing.

Zeier Z, Carpenter LL, Kalin NH, Rodriguez CI, McDonald WM, Widge AS, Nemeroff CB.

Am J Psychiatry. 2018 Sep 1;175(9):873-886. doi: 10.1176/appi.ajp.2018.17111282. Epub 2018 Apr 25.


Bayesian convolutional neural network based MRI brain extraction on nonhuman primates.

Zhao G, Liu F, Oler JA, Meyerand ME, Kalin NH, Birn RM.

Neuroimage. 2018 Jul 15;175:32-44. doi: 10.1016/j.neuroimage.2018.03.065. Epub 2018 Mar 28.


Corticotropin-Releasing Hormone Binding Protein: Stress, Psychopathology, and Antidepressant Treatment Response.

Kalin NH.

Am J Psychiatry. 2018 Mar 1;175(3):204-206. doi: 10.1176/appi.ajp.2018.18010059. No abstract available.


A multi-dimensional characterization of anxiety in monozygotic twin pairs reveals susceptibility loci in humans.

Alisch RS, Van Hulle C, Chopra P, Bhattacharyya A, Zhang SC, Davidson RJ, Kalin NH, Goldsmith HH.

Transl Psychiatry. 2017 Dec 11;7(12):1282. doi: 10.1038/s41398-017-0047-9.


Mechanisms underlying the early risk to develop anxiety and depression: A translational approach.

Kalin NH.

Eur Neuropsychopharmacol. 2017 Jun;27(6):543-553. doi: 10.1016/j.euroneuro.2017.03.004. Epub 2017 May 11. Review.


Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential.

Bogdan R, Salmeron BJ, Carey CE, Agrawal A, Calhoun VD, Garavan H, Hariri AR, Heinz A, Hill MN, Holmes A, Kalin NH, Goldman D.

Biol Psychiatry. 2017 Aug 1;82(3):165-175. doi: 10.1016/j.biopsych.2016.12.030. Epub 2017 Jan 13. Review.


Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology.

Shackman AJ, Fox AS, Oler JA, Shelton SE, Oakes TR, Davidson RJ, Kalin NH.

Mol Psychiatry. 2017 May;22(5):724-732. doi: 10.1038/mp.2016.132. Epub 2016 Aug 30.


Overexpressing Corticotropin-Releasing Factor in the Primate Amygdala Increases Anxious Temperament and Alters Its Neural Circuit.

Kalin NH, Fox AS, Kovner R, Riedel MK, Fekete EM, Roseboom PH, Tromp do PM, Grabow BP, Olsen ME, Brodsky EK, McFarlin DR, Alexander AL, Emborg ME, Block WF, Fudge JL, Oler JA.

Biol Psychiatry. 2016 Sep 1;80(5):345-55. doi: 10.1016/j.biopsych.2016.01.010. Epub 2016 Jan 30.


Connectivity between the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the non-human primate: neuronal tract tracing and developmental neuroimaging studies.

Oler JA, Tromp DP, Fox AS, Kovner R, Davidson RJ, Alexander AL, McFarlin DR, Birn RM, E Berg B, deCampo DM, Kalin NH, Fudge JL.

Brain Struct Funct. 2017 Jan;222(1):21-39. doi: 10.1007/s00429-016-1198-9. Epub 2016 Feb 23.


The cortisol awakening response at its best.

Dantzer R, Kalin NH.

Psychoneuroendocrinology. 2016 Jan;63:412-3. doi: 10.1016/j.psyneuen.2015.11.002. Epub 2015 Nov 18. No abstract available.


Intergenerational neural mediators of early-life anxious temperament.

Fox AS, Oler JA, Shackman AJ, Shelton SE, Raveendran M, McKay DR, Converse AK, Alexander A, Davidson RJ, Blangero J, Rogers J, Kalin NH.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9118-22. doi: 10.1073/pnas.1508593112. Epub 2015 Jul 6.


Extending the amygdala in theories of threat processing.

Fox AS, Oler JA, Tromp do PM, Fudge JL, Kalin NH.

Trends Neurosci. 2015 May;38(5):319-29. doi: 10.1016/j.tins.2015.03.002. Epub 2015 Apr 4. Review.


Treatment Outcome-Related White Matter Differences in Veterans with Posttraumatic Stress Disorder.

Kennis M, van Rooij SJ, Tromp do PM, Fox AS, Rademaker AR, Kahn RS, Kalin NH, Geuze E.

Neuropsychopharmacology. 2015 Sep;40(10):2434-42. doi: 10.1038/npp.2015.94. Epub 2015 Apr 3.


Preschool externalizing behavior predicts gender-specific variation in adolescent neural structure.

Caldwell JZ, Armstrong JM, Hanson JL, Sutterer MJ, Stodola DE, Koenigs M, Kalin NH, Essex MJ, Davidson RJ.

PLoS One. 2015 Feb 6;10(2):e0117453. doi: 10.1371/journal.pone.0117453. eCollection 2015.


Ventromedial prefrontal cortex damage alters resting blood flow to the bed nucleus of stria terminalis.

Motzkin JC, Philippi CL, Oler JA, Kalin NH, Baskaya MK, Koenigs M.

Cortex. 2015 Mar;64:281-8. doi: 10.1016/j.cortex.2014.11.013. Epub 2014 Dec 13.


Fear of the unknown: uncertain anticipation reveals amygdala alterations in childhood anxiety disorders.

Williams LE, Oler JA, Fox AS, McFarlin DR, Rogers GM, Jesson MA, Davidson RJ, Pine DS, Kalin NH.

Neuropsychopharmacology. 2015 May;40(6):1428-35. doi: 10.1038/npp.2014.328. Epub 2014 Dec 15.


Differentially methylated plasticity genes in the amygdala of young primates are linked to anxious temperament, an at risk phenotype for anxiety and depressive disorders.

Alisch RS, Chopra P, Fox AS, Chen K, White AT, Roseboom PH, Keles S, Kalin NH.

J Neurosci. 2014 Nov 19;34(47):15548-56. doi: 10.1523/JNEUROSCI.3338-14.2014.


A translational neuroscience approach to understanding the development of social anxiety disorder and its pathophysiology.

Fox AS, Kalin NH.

Am J Psychiatry. 2014 Nov 1;171(11):1162-73. doi: 10.1176/appi.ajp.2014.14040449. Review.


Extreme early-life anxiety is associated with an evolutionarily conserved reduction in the strength of intrinsic functional connectivity between the dorsolateral prefrontal cortex and the central nucleus of the amygdala.

Birn RM, Shackman AJ, Oler JA, Williams LE, McFarlin DR, Rogers GM, Shelton SE, Alexander AL, Pine DS, Slattery MJ, Davidson RJ, Fox AS, Kalin NH.

Mol Psychiatry. 2014 Aug;19(8):853. doi: 10.1038/mp.2014.85. No abstract available.


Adolescent adrenocortical activity and adiposity: differences by sex and exposure to early maternal depression.

Ruttle PL, Klein MH, Slattery MJ, Kalin NH, Armstrong JM, Essex MJ.

Psychoneuroendocrinology. 2014 Sep;47:68-77. doi: 10.1016/j.psyneuen.2014.04.025. Epub 2014 May 9.


Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety.

Birn RM, Shackman AJ, Oler JA, Williams LE, McFarlin DR, Rogers GM, Shelton SE, Alexander AL, Pine DS, Slattery MJ, Davidson RJ, Fox AS, Kalin NH.

Mol Psychiatry. 2014 Aug;19(8):915-22. doi: 10.1038/mp.2014.46. Epub 2014 May 27.


Neuropeptide Y receptor gene expression in the primate amygdala predicts anxious temperament and brain metabolism.

Roseboom PH, Nanda SA, Fox AS, Oler JA, Shackman AJ, Shelton SE, Davidson RJ, Kalin NH.

Biol Psychiatry. 2014 Dec 1;76(11):850-7. doi: 10.1016/j.biopsych.2013.11.012. Epub 2013 Nov 15.


Increased prefrontal cortex activity during negative emotion regulation as a predictor of depression symptom severity trajectory over 6 months.

Heller AS, Johnstone T, Peterson MJ, Kolden GG, Kalin NH, Davidson RJ.

JAMA Psychiatry. 2013 Nov;70(11):1181-9. doi: 10.1001/jamapsychiatry.2013.2430.


Neural mechanisms underlying heterogeneity in the presentation of anxious temperament.

Shackman AJ, Fox AS, Oler JA, Shelton SE, Davidson RJ, Kalin NH.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6145-50. doi: 10.1073/pnas.1214364110. Epub 2013 Mar 28.


Serotonin transporter genotype affects serotonin 5-HT1A binding in primates.

Christian BT, Wooten DW, Hillmer AT, Tudorascu DL, Converse AK, Moore CF, Ahlers EO, Barnhart TE, Kalin NH, Barr CS, Schneider ML.

J Neurosci. 2013 Feb 6;33(6):2512-6. doi: 10.1523/JNEUROSCI.4182-12.2013.


Relationships between changes in sustained fronto-striatal connectivity and positive affect in major depression resulting from antidepressant treatment.

Heller AS, Johnstone T, Light SN, Peterson MJ, Kolden GG, Kalin NH, Davidson RJ.

Am J Psychiatry. 2013 Feb;170(2):197-206. doi: 10.1176/appi.ajp.2012.12010014.


CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression.

Rogers J, Raveendran M, Fawcett GL, Fox AS, Shelton SE, Oler JA, Cheverud J, Muzny DM, Gibbs RA, Davidson RJ, Kalin NH.

Mol Psychiatry. 2013 Jun;18(6):700-7. doi: 10.1038/mp.2012.152. Epub 2012 Nov 13.


Developmental pathways to amygdala-prefrontal function and internalizing symptoms in adolescence.

Burghy CA, Stodola DE, Ruttle PL, Molloy EK, Armstrong JM, Oler JA, Fox ME, Hayes AS, Kalin NH, Essex MJ, Davidson RJ, Birn RM.

Nat Neurosci. 2012 Dec;15(12):1736-41. doi: 10.1038/nn.3257. Epub 2012 Nov 11.


A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation.

Rosenkranz MA, Davidson RJ, Maccoon DG, Sheridan JF, Kalin NH, Lutz A.

Brain Behav Immun. 2013 Jan;27(1):174-84. doi: 10.1016/j.bbi.2012.10.013. Epub 2012 Oct 22.


Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates.

Fox AS, Oler JA, Shelton SE, Nanda SA, Davidson RJ, Roseboom PH, Kalin NH.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18108-13. doi: 10.1073/pnas.1206723109. Epub 2012 Oct 15.


Evidence for coordinated functional activity within the extended amygdala of non-human and human primates.

Oler JA, Birn RM, Patriat R, Fox AS, Shelton SE, Burghy CA, Stodola DE, Essex MJ, Davidson RJ, Kalin NH.

Neuroimage. 2012 Jul 16;61(4):1059-66. doi: 10.1016/j.neuroimage.2012.03.045. Epub 2012 Mar 23.


Influence of early life stress on later hypothalamic-pituitary-adrenal axis functioning and its covariation with mental health symptoms: a study of the allostatic process from childhood into adolescence.

Essex MJ, Shirtcliff EA, Burk LR, Ruttle PL, Klein MH, Slattery MJ, Kalin NH, Armstrong JM.

Dev Psychopathol. 2011 Nov;23(4):1039-58. doi: 10.1017/S0954579411000484.


Longitudinal stability and developmental properties of salivary cortisol levels and circadian rhythms from childhood to adolescence.

Shirtcliff EA, Allison AL, Armstrong JM, Slattery MJ, Kalin NH, Essex MJ.

Dev Psychobiol. 2012 Jul;54(5):493-502. doi: 10.1002/dev.20607. Epub 2011 Sep 27.

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