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Items: 12

1.

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma.

Iniguez AB, Stolte B, Wang EJ, Conway AS, Alexe G, Dharia NV, Kwiatkowski N, Zhang T, Abraham BJ, Mora J, Kalev P, Leggett A, Chowdhury D, Benes CH, Young RA, Gray NS, Stegmaier K.

Cancer Cell. 2018 Feb 12;33(2):202-216.e6. doi: 10.1016/j.ccell.2017.12.009. Epub 2018 Jan 18.

2.

PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development.

Sents W, Meeusen B, Kalev P, Radaelli E, Sagaert X, Miermans E, Haesen D, Lambrecht C, Dewerchin M, Carmeliet P, Westermarck J, Sablina A, Janssens V.

Cancer Res. 2017 Dec 15;77(24):6825-6837. doi: 10.1158/0008-5472.CAN-16-2911. Epub 2017 Oct 18.

3.

p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity.

Adriaens C, Standaert L, Barra J, Latil M, Verfaillie A, Kalev P, Boeckx B, Wijnhoven PW, Radaelli E, Vermi W, Leucci E, Lapouge G, Beck B, van den Oord J, Nakagawa S, Hirose T, Sablina AA, Lambrechts D, Aerts S, Blanpain C, Marine JC.

Nat Med. 2016 Aug;22(8):861-8. doi: 10.1038/nm.4135. Epub 2016 Jul 4.

PMID:
27376578
4.

Emerging role of protein phosphatases changes the landscape of phospho-signaling in DNA damage response.

Zheng XF, Kalev P, Chowdhury D.

DNA Repair (Amst). 2015 Aug;32:58-65. doi: 10.1016/j.dnarep.2015.04.014. Epub 2015 May 1. Review.

PMID:
25956864
5.

Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks.

Lee DH, Acharya SS, Kwon M, Drane P, Guan Y, Adelmant G, Kalev P, Shah J, Pellman D, Marto JA, Chowdhury D.

Mol Cell. 2014 May 8;54(3):512-25. doi: 10.1016/j.molcel.2014.03.020. Epub 2014 Apr 3.

6.

p16INK4a impairs homologous recombination-mediated DNA repair in human papillomavirus-positive head and neck tumors.

Dok R, Kalev P, Van Limbergen EJ, Asbagh LA, Vázquez I, Hauben E, Sablina A, Nuyts S.

Cancer Res. 2014 Mar 15;74(6):1739-51. doi: 10.1158/0008-5472.CAN-13-2479. Epub 2014 Jan 28.

7.

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.

Simicek M, Lievens S, Laga M, Guzenko D, Aushev VN, Kalev P, Baietti MF, Strelkov SV, Gevaert K, Tavernier J, Sablina AA.

Nat Cell Biol. 2013 Oct;15(10):1220-30. doi: 10.1038/ncb2847. Epub 2013 Sep 22.

PMID:
24056301
8.

RNF4 is required for DNA double-strand break repair in vivo.

Vyas R, Kumar R, Clermont F, Helfricht A, Kalev P, Sotiropoulou P, Hendriks IA, Radaelli E, Hochepied T, Blanpain C, Sablina A, van Attikum H, Olsen JV, Jochemsen AG, Vertegaal AC, Marine JC.

Cell Death Differ. 2013 Mar;20(3):490-502. doi: 10.1038/cdd.2012.145. Epub 2012 Nov 30.

9.

Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition.

Kalev P, Simicek M, Vazquez I, Munck S, Chen L, Soin T, Danda N, Chen W, Sablina A.

Cancer Res. 2012 Dec 15;72(24):6414-24. doi: 10.1158/0008-5472.CAN-12-1667. Epub 2012 Oct 18.

10.

Protein phosphatase 2A as a potential target for anticancer therapy.

Kalev P, Sablina AA.

Anticancer Agents Med Chem. 2011 Jan;11(1):38-46. Review.

PMID:
21288198
11.

The complexity of double-strand break ends is a factor in the repair pathway choice.

Mladenov E, Kalev P, Anachkova B.

Radiat Res. 2009 Apr;171(4):397-404. doi: 10.1667/RR1487.1.

PMID:
19397440
12.

Nuclear matrix binding site in the Rad51 recombinase.

Mladenov EV, Kalev PS, Anachkova BB.

J Cell Physiol. 2009 Apr;219(1):202-8. doi: 10.1002/jcp.21665.

PMID:
19097142

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