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Items: 1 to 50 of 249

1.

Synthesis of a novel curcumin derivative as potential imaging probe in Alzheimer's disease imaging.

Sturzu A, Sheikh S, Kalbacher H, Nägele T, Weidenmaier C, Wegenast-Braun BM, Schilling N, Ernemann U, Heckl S.

Curr Alzheimer Res. 2019 Aug 16. doi: 10.2174/1567205016666190816130516. [Epub ahead of print]

PMID:
31418660
2.

In vitro immunodetection of prothymosin alpha in normal and pathological conditions.

Karachaliou CE, Kalbacher H, Voelter W, Tsitsilonis OE, Livaniou E.

Curr Med Chem. 2019 Aug 7. doi: 10.2174/0929867326666190807145212. [Epub ahead of print]

PMID:
31389310
3.

Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.

Schwenck J, Maurer A, Fehrenbacher B, Mehling R, Knopf P, Mucha N, Haupt D, Fuchs K, Griessinger CM, Bukala D, Holstein J, Schaller M, Menendez IG, Ghoreschi K, Quintanilla-Martinez L, Gütschow M, Laufer S, Reinheckel T, Röcken M, Kalbacher H, Pichler BJ, Kneilling M.

Theranostics. 2019 May 31;9(13):3903-3917. doi: 10.7150/thno.31037. eCollection 2019.

4.

Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors.

Bitschar K, Sauer B, Focken J, Dehmer H, Moos S, Konnerth M, Schilling NA, Grond S, Kalbacher H, Kurschus FC, Götz F, Krismer B, Peschel A, Schittek B.

Nat Commun. 2019 Jun 21;10(1):2730. doi: 10.1038/s41467-019-10646-7.

5.

Pepstatin pull-down at high pH is a powerful tool for detection and analysis of napsin A.

Maurer A, Kalbacher H.

Biochem Biophys Res Commun. 2019 Jul 12;515(1):145-148. doi: 10.1016/j.bbrc.2019.05.094. Epub 2019 May 23.

PMID:
31130231
6.

Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability.

Schilling NA, Berscheid A, Schumacher J, Saur JS, Konnerth MC, Wirtz SN, Beltrán-Beleña JM, Zipperer A, Krismer B, Peschel A, Kalbacher H, Brötz-Oesterhelt H, Steinem C, Grond S.

Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9234-9238. doi: 10.1002/anie.201901589. Epub 2019 May 27.

7.

Design of Linear and Cyclic Mutant Analogues of Dirucotide Peptide (MBP82⁻98) against Multiple Sclerosis: Conformational and Binding Studies to MHC Class II.

Deraos G, Kritsi E, Matsoukas MT, Christopoulou K, Kalbacher H, Zoumpoulakis P, Apostolopoulos V, Matsoukas J.

Brain Sci. 2018 Dec 4;8(12). pii: E213. doi: 10.3390/brainsci8120213.

8.

Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space.

Weinhäupl K, Lindau C, Hessel A, Wang Y, Schütze C, Jores T, Melchionda L, Schönfisch B, Kalbacher H, Bersch B, Rapaport D, Brennich M, Lindorff-Larsen K, Wiedemann N, Schanda P.

Cell. 2018 Nov 15;175(5):1365-1379.e25. doi: 10.1016/j.cell.2018.10.039.

9.

Cytosolic Hsp70 and Hsp40 chaperones enable the biogenesis of mitochondrial β-barrel proteins.

Jores T, Lawatscheck J, Beke V, Franz-Wachtel M, Yunoki K, Fitzgerald JC, Macek B, Endo T, Kalbacher H, Buchner J, Rapaport D.

J Cell Biol. 2018 Sep 3;217(9):3091-3108. doi: 10.1083/jcb.201712029. Epub 2018 Jun 21.

10.

A Novel Fluorescence-Labeled Curcumin Conjugate: Synthesis, Evaluation and Imaging on Human Cell Lines.

Sheikh S, Sturzu A, Kalbacher H, Nagele T, Weidenmaier C, Horger M, Schwentner C, Ernemann U, Heckl S.

Curr Pharm Des. 2018;24(16):1821-1826. doi: 10.2174/1381612824666180406103317.

PMID:
29623828
11.

Agonistic Autoantibodies to the β2-Adrenergic Receptor Involved in the Pathogenesis of Open-Angle Glaucoma.

Jünemann A, Hohberger B, Rech J, Sheriff A, Fu Q, Schlötzer-Schrehardt U, Voll RE, Bartel S, Kalbacher H, Hoebeke J, Rejdak R, Horn F, Wallukat G, Kunze R, Herrmann M.

Front Immunol. 2018 Feb 12;9:145. doi: 10.3389/fimmu.2018.00145. eCollection 2018.

12.

The systemin receptor SYR1 enhances resistance of tomato against herbivorous insects.

Wang L, Einig E, Almeida-Trapp M, Albert M, Fliegmann J, Mithöfer A, Kalbacher H, Felix G.

Nat Plants. 2018 Mar;4(3):152-156. doi: 10.1038/s41477-018-0106-0. Epub 2018 Feb 19.

PMID:
29459726
13.

A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε.

Dolde C, Bischof J, Grüter S, Montada A, Halekotte J, Peifer C, Kalbacher H, Baumann U, Knippschild U, Suter B.

J Cell Sci. 2018 Jan 4;131(1). pii: jcs207316. doi: 10.1242/jcs.207316.

14.

Aprotinin prevents proteolytic epithelial sodium channel (ENaC) activation and volume retention in nephrotic syndrome.

Bohnert BN, Menacher M, Janessa A, Wörn M, Schork A, Daiminger S, Kalbacher H, Häring HU, Daniel C, Amann K, Sure F, Bertog M, Haerteis S, Korbmacher C, Artunc F.

Kidney Int. 2018 Jan;93(1):159-172. doi: 10.1016/j.kint.2017.07.023. Epub 2017 Oct 14.

PMID:
29042083
15.

Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP-dependent biogenesis pathway.

Sinzel M, Tan T, Wendling P, Kalbacher H, Özbalci C, Chelius X, Westermann B, Brügger B, Rapaport D, Dimmer KS.

EMBO Rep. 2017 Oct;18(10):1869. doi: 10.15252/embr.201745020. No abstract available.

16.

Cyclic MOG35-55 ameliorates clinical and neuropathological features of experimental autoimmune encephalomyelitis.

Lourbopoulos A, Deraos G, Matsoukas MT, Touloumi O, Giannakopoulou A, Kalbacher H, Grigoriadis N, Apostolopoulos V, Matsoukas J.

Bioorg Med Chem. 2017 Aug 1;25(15):4163-4174. doi: 10.1016/j.bmc.2017.06.005. Epub 2017 Jun 7.

PMID:
28642030
17.

A fragment of the alarmin prothymosin α as a novel biomarker in murine models of bacteria-induced sepsis.

Samara P, Miriagou V, Zachariadis M, Mavrofrydi O, Promponas VJ, Dedos SG, Papazafiri P, Kalbacher H, Voelter W, Tsitsilonis O.

Oncotarget. 2017 Jul 25;8(30):48635-48649. doi: 10.18632/oncotarget.18149.

18.

Prothymosin Alpha: An Alarmin and More...

Samara P, Karachaliou CE, Ioannou K, Papaioannou NE, Voutsas IF, Zikos C, Pirmettis I, Papadopoulos M, Kalbacher H, Livaniou E, Tsitsilonis OE, Voelter W.

Curr Med Chem. 2017;24(17):1747-1760. doi: 10.2174/0929867324666170518110033. Review.

PMID:
28521686
19.

Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain.

Reimers C, Lee CH, Kalbacher H, Tian Y, Hung CH, Schmidt A, Prokop L, Kauferstein S, Mebs D, Chen CC, Gründer S.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3507-E3515. doi: 10.1073/pnas.1616232114. Epub 2017 Apr 10.

20.

In vivo biodistribution and imaging studies with a 99mTc-radiolabeled derivative of the C-terminus of prothymosin alpha in mice bearing experimentally-induced inflammation.

Karachaliou CE, Triantis C, Liolios C, Palamaris L, Zikos C, Tsitsilonis OE, Kalbacher H, Voelter W, Loudos G, Papadopoulos M, Pirmettis I, Livaniou E.

Eur J Pharm Biopharm. 2017 Apr;113:188-197. doi: 10.1016/j.ejpb.2016.12.028. Epub 2017 Jan 11.

PMID:
28087377
21.

Corrigendum: Human commensals producing a novel antibiotic impair pathogen colonization.

Zipperer A, Konnerth MC, Laux C, Berscheid A, Janek D, Weidenmaier C, Burian M, Schilling NA, Slavetinsky C, Marschal M, Willmann M, Kalbacher H, Schittek B, Brötz-Oesterhelt H, Grond S, Peschel A, Krismer B.

Nature. 2016 Nov 10;539(7628):314. doi: 10.1038/nature19781. Epub 2016 Sep 14. No abstract available.

PMID:
27626388
22.

A new monoclonal antibody (Cox mAB 31A2) detects VP1 protein of coxsackievirus B3 with high sensitivity and specificity.

Ettischer-Schmid N, Normann A, Sauter M, Kraft L, Kalbacher H, Kandolf R, Flehmig B, Klingel K.

Virchows Arch. 2016 Nov;469(5):553-562. Epub 2016 Aug 27.

PMID:
27566306
23.

Symbiotic gut commensal bacteria act as host cathepsin S activity regulators.

Steimle A, Gronbach K, Beifuss B, Schäfer A, Harmening R, Bender A, Maerz JK, Lange A, Michaelis L, Maurer A, Menz S, McCoy K, Autenrieth IB, Kalbacher H, Frick JS.

J Autoimmun. 2016 Dec;75:82-95. doi: 10.1016/j.jaut.2016.07.009. Epub 2016 Jul 30.

PMID:
27484364
24.

Human commensals producing a novel antibiotic impair pathogen colonization.

Zipperer A, Konnerth MC, Laux C, Berscheid A, Janek D, Weidenmaier C, Burian M, Schilling NA, Slavetinsky C, Marschal M, Willmann M, Kalbacher H, Schittek B, Brötz-Oesterhelt H, Grond S, Peschel A, Krismer B.

Nature. 2016 Jul 28;535(7613):511-6. doi: 10.1038/nature18634. Erratum in: Nature. 2016 Nov 10;539(7628):314.

PMID:
27466123
25.

Characterization of the targeting signal in mitochondrial β-barrel proteins.

Jores T, Klinger A, Groß LE, Kawano S, Flinner N, Duchardt-Ferner E, Wöhnert J, Kalbacher H, Endo T, Schleiff E, Rapaport D.

Nat Commun. 2016 Jun 27;7:12036. doi: 10.1038/ncomms12036.

26.

Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP-dependent biogenesis pathway.

Sinzel M, Tan T, Wendling P, Kalbacher H, Özbalci C, Chelius X, Westermann B, Brügger B, Rapaport D, Dimmer KS.

EMBO Rep. 2016 Jul;17(7):965-81. doi: 10.15252/embr.201541273. Epub 2016 May 24. Erratum in: EMBO Rep. 2017 Oct;18(10 ):1869.

27.

Fluorescein-labeled Bacitracin and Daptomycin Conjugates: Synthesis, Fluorescence Imaging and Evaluation.

Sheikh S, Sturzu A, Kalbacher H, Nagele T, Weidenmaier C, Horger M, Schwentner C, Ernemann U, Heckl S.

Med Chem. 2016;13(1):57-64. doi: 10.2174/1573406412666160330113420.

PMID:
27026529
28.

New potential peptide therapeutics perturbing CK1δ/α-tubulin interaction.

Krüger M, Kalbacher H, Kastritis PL, Bischof J, Barth H, Henne-Bruns D, Vorgias C, Sarno S, Pinna LA, Knippschild U.

Cancer Lett. 2016 Jun 1;375(2):375-383. doi: 10.1016/j.canlet.2016.03.021. Epub 2016 Mar 17.

PMID:
26996302
29.

Association of Plasminuria with Overhydration in Patients with CKD.

Schork A, Woern M, Kalbacher H, Voelter W, Nacken R, Bertog M, Haerteis S, Korbmacher C, Heyne N, Peter A, Häring HU, Artunc F.

Clin J Am Soc Nephrol. 2016 May 6;11(5):761-9. doi: 10.2215/CJN.12261115. Epub 2016 Mar 1.

30.

A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells.

Steimle A, Kalbacher H, Maurer A, Beifuss B, Bender A, Schäfer A, Müller R, Autenrieth IB, Frick JS.

J Immunol Methods. 2016 May;432:87-94. doi: 10.1016/j.jim.2016.02.015. Epub 2016 Feb 18.

PMID:
26899824
31.

Bone marrow-derived mesenchymal stromal cells differ in their attachment to fibronectin-derived peptides from term placenta-derived mesenchymal stromal cells.

Maerz JK, Roncoroni LP, Goldeck D, Abruzzese T, Kalbacher H, Rolauffs B, DeZwart P, Nieselt K, Hart ML, Klein G, Aicher WK.

Stem Cell Res Ther. 2016 Feb 11;7:29. doi: 10.1186/s13287-015-0243-6.

32.

Structure-Activity Relationship of Chlorotoxin-Like Peptides.

Ali SA, Alam M, Abbasi A, Undheim EA, Fry BG, Kalbacher H, Voelter W.

Toxins (Basel). 2016 Feb 2;8(2):36. doi: 10.3390/toxins8020036.

33.

PSM Peptides of Staphylococcus aureus Activate the p38-CREB Pathway in Dendritic Cells, Thereby Modulating Cytokine Production and T Cell Priming.

Armbruster NS, Richardson JR, Schreiner J, Klenk J, Günter M, Kretschmer D, Pöschel S, Schenke-Layland K, Kalbacher H, Clark K, Autenrieth SE.

J Immunol. 2016 Feb 1;196(3):1284-92. doi: 10.4049/jimmunol.1502232. Epub 2016 Jan 4.

34.

The rice immune receptor XA21 recognizes a tyrosine-sulfated protein from a Gram-negative bacterium.

Pruitt RN, Schwessinger B, Joe A, Thomas N, Liu F, Albert M, Robinson MR, Chan LJ, Luu DD, Chen H, Bahar O, Daudi A, De Vleesschauwer D, Caddell D, Zhang W, Zhao X, Li X, Heazlewood JL, Ruan D, Majumder D, Chern M, Kalbacher H, Midha S, Patil PB, Sonti RV, Petzold CJ, Liu CC, Brodbelt JS, Felix G, Ronald PC.

Sci Adv. 2015 Jul 24;1(6):e1500245. doi: 10.1126/sciadv.1500245. eCollection 2015 Jul.

35.

Atypical plasma lipid profiles in leukemia.

Iqbal A, Zaid M, Munir R, Usman H, Kalbacher H, Scandiuzzi L, Zaidi N.

Clin Chim Acta. 2016 Jan 15;452:129-33. doi: 10.1016/j.cca.2015.11.003. Epub 2015 Nov 6. Review.

PMID:
26549657
36.

Aberrant de novo cholesterogenesis: Clinical significance and implications.

Rashid R, Ameer F, Kalbacher H, Scandiuzzi L, Zaidi N.

Clin Chim Acta. 2015 Oct 23;450:356-61. doi: 10.1016/j.cca.2015.09.014. Epub 2015 Sep 18. Review.

PMID:
26386164
37.

Properties of myelin altered peptide ligand cyclo(87-99)(Ala91,Ala96)MBP87-99 render it a promising drug lead for immunotherapy of multiple sclerosis.

Deraos G, Rodi M, Kalbacher H, Chatzantoni K, Karagiannis F, Synodinos L, Plotas P, Papalois A, Dimisianos N, Papathanasopoulos P, Gatos D, Tselios T, Apostolopoulos V, Mouzaki A, Matsoukas J.

Eur J Med Chem. 2015 Aug 28;101:13-23. doi: 10.1016/j.ejmech.2015.06.015. Epub 2015 Jun 17.

PMID:
26112377
38.

A pilot study in prostate cancer patients treated with the AE37 Ii-key-HER-2/neu polypeptide vaccine suggests that HLA-A*24 and HLA-DRB1*11 alleles may be prognostic and predictive biomarkers for clinical benefit.

Anastasopoulou EA, Voutsas IF, Keramitsoglou T, Gouttefangeas C, Kalbacher H, Thanos A, Papamichail M, Perez SA, Baxevanis CN.

Cancer Immunol Immunother. 2015 Sep;64(9):1123-36. doi: 10.1007/s00262-015-1717-1. Epub 2015 May 31.

PMID:
26026288
39.

Solid phase synthesis, NMR structure determination of α-KTx3.8, its in silico docking to Kv1.x potassium channels, and electrophysiological analysis provide insights into toxin-channel selectivity.

Kohl B, Rothenberg I, Ali SA, Alam M, Seebohm G, Kalbacher H, Voelter W, Stoll R.

Toxicon. 2015 Jul;101:70-8. doi: 10.1016/j.toxicon.2015.04.018. Epub 2015 May 5.

PMID:
25953725
40.

Specific in vitro binding of a new (99m)Tc-radiolabeled derivative of the C-terminal decapeptide of prothymosin alpha on human neutrophils.

Karachaliou CE, Liolios C, Triantis C, Zikos C, Samara P, Tsitsilonis OE, Kalbacher H, Voelter W, Papadopoulos M, Pirmettis I, Livaniou E.

Int J Pharm. 2015;486(1-2):1-12. doi: 10.1016/j.ijpharm.2015.03.031. Epub 2015 Mar 18.

PMID:
25796124
41.

Revisiting the dyslipidemia associated with acute leukemia.

Usman H, Rashid R, Ameer F, Iqbal A, Zaid M, Hasnain S, Kalbacher H, Zaidi N.

Clin Chim Acta. 2015 Apr 15;444:43-9. doi: 10.1016/j.cca.2015.01.038. Epub 2015 Feb 11.

PMID:
25680744
42.

Tff3 is expressed in neurons and microglial cells.

Fu T, Stellmacher A, Znalesniak EB, Dieterich DC, Kalbacher H, Hoffmann W.

Cell Physiol Biochem. 2014;34(6):1912-9. doi: 10.1159/000366389. Epub 2014 Nov 21.

43.

Catalytic activity of cGMP-dependent protein kinase type I in intact cells is independent of N-terminal autophosphorylation.

Vallur R, Kalbacher H, Feil R.

PLoS One. 2014 Jun 4;9(6):e98946. doi: 10.1371/journal.pone.0098946. eCollection 2014.

44.

De novo lipogenesis in health and disease.

Ameer F, Scandiuzzi L, Hasnain S, Kalbacher H, Zaidi N.

Metabolism. 2014 Jul;63(7):895-902. doi: 10.1016/j.metabol.2014.04.003. Epub 2014 Apr 12. Review.

PMID:
24814684
45.

Tools and Strategies to Match Peptide-Ligand Receptor Pairs.

Butenko MA, Wildhagen M, Albert M, Jehle A, Kalbacher H, Aalen RB, Felix G.

Plant Cell. 2014 May;26(5):1838-1847. Epub 2014 May 7.

46.

Fluorescence imaging of human cells with a novel conjugate of the antifungal nystatin.

Sheikh S, Sturzu A, Kalbacher H, Nagele T, Weidenmaier C, Horger M, Ernemann U, Heckl S.

Med Chem. 2014 Jun;10(4):348-54.

PMID:
24725140
47.

Atypical plasma lipid profile in cancer patients: cause or consequence?

Munir R, Usman H, Hasnain S, Smans K, Kalbacher H, Zaidi N.

Biochimie. 2014 Jul;102:9-18. doi: 10.1016/j.biochi.2014.03.010. Epub 2014 Apr 2. Review.

PMID:
24704108
48.

Glutathione-conjugated sulfanylalkanols are substrates for ABCC11 and γ-glutamyl transferase 1: a potential new pathway for the formation of odorant precursors in the apocrine sweat gland.

Baumann T, Bergmann S, Schmidt-Rose T, Max H, Martin A, Enthaler B, Terstegen L, Schweiger D, Kalbacher H, Wenck H, Jedlitschky G, Jovanovic Z.

Exp Dermatol. 2014 Apr;23(4):247-52. doi: 10.1111/exd.12354.

49.

Processing of laminin α chains generates peptides involved in wound healing and host defense.

Senyürek I, Kempf WE, Klein G, Maurer A, Kalbacher H, Schäfer L, Wanke I, Christ C, Stevanovic S, Schaller M, Rousselle P, Garbe C, Biedermann T, Schittek B.

J Innate Immun. 2014;6(4):467-84. doi: 10.1159/000357032. Epub 2014 Jan 18.

50.

Mutations in the substrate binding site of human heat-shock protein 70 indicate specific interaction with HLA-DR outside the peptide binding groove.

Rohrer KM, Haug M, Schwörer D, Kalbacher H, Holzer U.

Immunology. 2014 Jun;142(2):237-47. doi: 10.1111/imm.12249.

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