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Items: 1 to 50 of 80

1.

PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression.

Park MK, Yao Y, Xia W, Setijono SR, Kim JH, Vila IK, Chiu HH, Wu Y, Billalabeitia EG, Lee MG, Kalb RG, Hung MC, Pandolfi PP, Song SJ, Song MS.

Nat Commun. 2019 Feb 7;10(1):636. doi: 10.1038/s41467-019-08481-x.

2.

Enhancing GABAergic Transmission Improves Locomotion in a Caenorhabditis elegans Model of Spinal Muscular Atrophy.

Wu CY, Gagnon DA, Sardin JS, Barot U, Telenson A, Arratia PE, Kalb RG.

eNeuro. 2019 Jan 2;5(6). pii: ENEURO.0289-18.2018. doi: 10.1523/ENEURO.0289-18.2018. eCollection 2018 Nov-Dec.

3.

Neuropeptide signaling regulates the susceptibility of developing C. elegans to anoxia.

Doshi S, Price E, Landis J, Barot U, Sabatella M, Lans H, Kalb RG.

Free Radic Biol Med. 2019 Feb 1;131:197-208. doi: 10.1016/j.freeradbiomed.2018.12.006. Epub 2018 Dec 6.

4.

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis.

McGurk L, Mojsilovic-Petrovic J, Van Deerlin VM, Shorter J, Kalb RG, Lee VM, Trojanowski JQ, Lee EB, Bonini NM.

Acta Neuropathol Commun. 2018 Aug 29;6(1):84. doi: 10.1186/s40478-018-0586-1.

5.

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization.

McGurk L, Gomes E, Guo L, Mojsilovic-Petrovic J, Tran V, Kalb RG, Shorter J, Bonini NM.

Mol Cell. 2018 Sep 6;71(5):703-717.e9. doi: 10.1016/j.molcel.2018.07.002. Epub 2018 Aug 9.

6.

SAP97 regulates behavior and expression of schizophrenia risk enriched gene sets in mouse hippocampus.

Gupta P, Uner OE, Nayak S, Grant GR, Kalb RG.

PLoS One. 2018 Jul 11;13(7):e0200477. doi: 10.1371/journal.pone.0200477. eCollection 2018.

7.

SAP97 Binding Partner CRIPT Promotes Dendrite Growth In Vitro and In Vivo.

Zhang L, Jablonski AM, Mojsilovic-Petrovic J, Ding H, Seeholzer S, Newton IP, Nathke I, Neve R, Zhai J, Shang Y, Zhang M, Kalb RG.

eNeuro. 2017 Dec 6;4(6). pii: ENEURO.0175-17.2017. doi: 10.1523/ENEURO.0175-17.2017. eCollection 2017 Nov-Dec.

8.
9.

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration.

Mor DE, Tsika E, Mazzulli JR, Gould NS, Kim H, Daniels MJ, Doshi S, Gupta P, Grossman JL, Tan VX, Kalb RG, Caldwell KA, Caldwell GA, Wolfe JH, Ischiropoulos H.

Nat Neurosci. 2017 Nov;20(11):1560-1568. doi: 10.1038/nn.4641. Epub 2017 Sep 18.

10.

The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK.

Boccitto M, Lee N, Sakamoto S, Spruce LA, Handa H, Clardy J, Seeholzer SH, Kalb RG.

Mar Drugs. 2017 Aug 7;15(8). pii: E246. doi: 10.3390/md15080246.

11.

Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance.

Ozek C, Zimmer DJ, De Jonghe BC, Kalb RG, Bence KK.

Mol Metab. 2015 Aug 18;4(11):867-80. doi: 10.1016/j.molmet.2015.08.002. eCollection 2015 Nov.

12.

Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance.

Jablonski AM, Lamitina T, Liachko NF, Sabatella M, Lu J, Zhang L, Ostrow LW, Gupta P, Wu CY, Doshi S, Mojsilovic-Petrovic J, Lans H, Wang J, Kraemer B, Kalb RG.

J Neurosci. 2015 Oct 21;35(42):14286-306. doi: 10.1523/JNEUROSCI.0642-15.2015.

13.

A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking.

White SL, Ortinski PI, Friedman SH, Zhang L, Neve RL, Kalb RG, Schmidt HD, Pierce RC.

Neuropsychopharmacology. 2016 Feb;41(3):736-50. doi: 10.1038/npp.2015.199. Epub 2015 Jul 7.

14.

Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.

Zhai J, Zhang L, Mojsilovic-Petrovic J, Jian X, Thomas J, Homma K, Schmitz A, Famulok M, Ichijo H, Argon Y, Randazzo PA, Kalb RG.

J Neurosci. 2015 Jun 17;35(24):9088-105. doi: 10.1523/JNEUROSCI.5032-13.2015.

15.

Structure-function analysis of SAP97, a modular scaffolding protein that drives dendrite growth.

Zhang L, Hsu FC, Mojsilovic-Petrovic J, Jablonski AM, Zhai J, Coulter DA, Kalb RG.

Mol Cell Neurosci. 2015 Mar;65:31-44. doi: 10.1016/j.mcn.2015.02.011. Epub 2015 Feb 19.

16.

Oxygen sensing neurons and neuropeptides regulate survival after anoxia in developing C. elegans.

Flibotte JJ, Jablonski AM, Kalb RG.

PLoS One. 2014 Jun 26;9(6):e101102. doi: 10.1371/journal.pone.0101102. eCollection 2014.

17.

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis.

Lim MA, Bence KK, Sandesara I, Andreux P, Auwerx J, Ishibashi J, Seale P, Kalb RG.

Hum Mol Genet. 2014 Sep 15;23(18):4995-5008. doi: 10.1093/hmg/ddu214. Epub 2014 May 15.

18.

GluA1 promotes the activity-dependent development of motor circuitry in the developing segmental spinal cord.

Jablonski AM, Kalb RG.

Ann N Y Acad Sci. 2013 Mar;1279:54-9. doi: 10.1111/nyas.12053. Review.

19.

The molecular basis of experience-dependent motor system development.

Kalb RG, Zhou W, Zhang L.

Adv Exp Med Biol. 2013;782:23-38. doi: 10.1007/978-1-4614-5465-6_2. No abstract available.

20.

Stress and aging induce distinct polyQ protein aggregation states.

Moronetti Mazzeo LE, Dersh D, Boccitto M, Kalb RG, Lamitina T.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10587-92. doi: 10.1073/pnas.1108766109. Epub 2012 May 29.

21.

Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans.

Boccitto M, Lamitina T, Kalb RG.

PLoS One. 2012;7(3):e33494. doi: 10.1371/journal.pone.0033494. Epub 2012 Mar 20.

22.

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, Elman L, McCluskey L, Greene R, Hakonarson H, Kalb RG, Lee VM, Trojanowski JQ, Nicholson GA, Blair IP, Bonini NM, Van Deerlin VM, Mourelatos Z, Shorter J, Gitler AD.

Hum Mol Genet. 2012 Jul 1;21(13):2899-911. doi: 10.1093/hmg/dds116. Epub 2012 Mar 27.

23.

Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease.

Lim MA, Selak MA, Xiang Z, Krainc D, Neve RL, Kraemer BC, Watts JL, Kalb RG.

J Neurosci. 2012 Jan 18;32(3):1123-41. doi: 10.1523/JNEUROSCI.6554-10.2012.

24.

A yeast functional screen predicts new candidate ALS disease genes.

Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Solski JA, Williams KL, Mojsilovic-Petrovic J, Ingre C, Boylan K, Graff-Radford NR, Dickson DW, Clay-Falcone D, Elman L, McCluskey L, Greene R, Kalb RG, Lee VM, Trojanowski JQ, Ludolph A, Robberecht W, Andersen PM, Nicholson GA, Blair IP, King OD, Bonini NM, Van Deerlin V, Rademakers R, Mourelatos Z, Gitler AD.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20881-90. doi: 10.1073/pnas.1109434108. Epub 2011 Nov 7.

25.

The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease.

Zhai J, Zhou W, Li J, Hayworth CR, Zhang L, Misawa H, Klein R, Scherer SS, Balice-Gordon RJ, Kalb RG.

Hum Mol Genet. 2011 Nov 1;20(21):4116-31. doi: 10.1093/hmg/ddr335. Epub 2011 Aug 4.

26.

PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats.

Yu Z, Zhu Y, Chen-Plotkin AS, Clay-Falcone D, McCluskey L, Elman L, Kalb RG, Trojanowski JQ, Lee VM, Van Deerlin VM, Gitler AD, Bonini NM.

PLoS One. 2011 Mar 29;6(3):e17951. doi: 10.1371/journal.pone.0017951.

27.

Regulation of Foxo-dependent transcription by post-translational modifications.

Boccitto M, Kalb RG.

Curr Drug Targets. 2011 Aug;12(9):1303-10. Review.

28.

A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration.

Perlson E, Jeong GB, Ross JL, Dixit R, Wallace KE, Kalb RG, Holzbaur EL.

J Neurosci. 2009 Aug 5;29(31):9903-17. doi: 10.1523/JNEUROSCI.0813-09.2009.

29.

FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases.

Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG.

J Neurosci. 2009 Jun 24;29(25):8236-47. doi: 10.1523/JNEUROSCI.1805-09.2009.

30.

AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location.

Lai M, Hughes EG, Peng X, Zhou L, Gleichman AJ, Shu H, Matà S, Kremens D, Vitaliani R, Geschwind MD, Bataller L, Kalb RG, Davis R, Graus F, Lynch DR, Balice-Gordon R, Dalmau J.

Ann Neurol. 2009 Apr;65(4):424-34. doi: 10.1002/ana.21589.

31.
32.

Protecting motor neurons from toxic insult by antagonism of adenosine A2a and Trk receptors.

Mojsilovic-Petrovic J, Jeong GB, Crocker A, Arneja A, David S, Russell DS, Kalb RG.

J Neurosci. 2006 Sep 6;26(36):9250-63. Erratum in: J Neurosci. 2006 Oct 4;26(40):10079. Russell, David [corrected to Russell, David S].

33.

Enprofylline protects motor neurons from in vitro excitotoxic challenge.

Mojsilovic-Petrovic J, Arneja A, Kalb RG.

Neurodegener Dis. 2005;2(3-4):160-5.

PMID:
16909021
34.

Expression of serum- and glucocorticoid-inducible kinase is regulated in an experience-dependent manner and can cause dendrite growth.

David S, Stegenga SL, Hu P, Xiong G, Kerr E, Becker KB, Venkatapathy S, Warrington JA, Kalb RG.

J Neurosci. 2005 Jul 27;25(30):7048-53.

35.

Mutant superoxide dismutase disrupts cytoplasmic dynein in motor neurons.

Ligon LA, LaMonte BH, Wallace KE, Weber N, Kalb RG, Holzbaur EL.

Neuroreport. 2005 Apr 25;16(6):533-6.

PMID:
15812301
36.
37.

Effects of limb exercise after spinal cord injury on motor neuron dendrite structure.

Gazula VR, Roberts M, Luzzio C, Jawad AF, Kalb RG.

J Comp Neurol. 2004 Aug 16;476(2):130-45.

PMID:
15248194
38.

Getting the spinal cord to think for itself.

Kalb RG.

Arch Neurol. 2003 Jun;60(6):805-8. Review.

PMID:
12810482
39.

Shuttle mission effects on glutamate receptor expression in the developing rodent spinal cord.

Stegenga SL, Eward W, Kalb RG.

Aviat Space Environ Med. 2003 Jun;74(6 Pt 1):615-21.

PMID:
12793531
40.
41.

The AMPA receptor subunit GluR1 regulates dendritic architecture of motor neurons.

Inglis FM, Crockett R, Korada S, Abraham WC, Hollmann M, Kalb RG.

J Neurosci. 2002 Sep 15;22(18):8042-51.

42.
43.

Reduction of functional N-methyl-D-aspartate receptors in neurons by RNase P-mediated cleavage of the NR1 mRNA.

Yen L, Gonzalez-Zulueta M, Feldman A, Yuan Y, Fryer H, Dawson T, Dawson V, Kalb RG.

J Neurochem. 2001 Mar;76(5):1386-94.

44.

Rho GTPases and axonal growth cone collapse.

Fournier AE, Kalb RG, Strittmatter SM.

Methods Enzymol. 2000;325:473-82. No abstract available.

PMID:
11036628
45.

Defective fluid and HCO(3)(-) absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice.

Wang T, Inglis FM, Kalb RG.

Am J Physiol Renal Physiol. 2000 Sep;279(3):F518-24.

46.

Molecular basis of semaphorin-mediated axon guidance.

Nakamura F, Kalb RG, Strittmatter SM.

J Neurobiol. 2000 Aug;44(2):219-29. Review.

PMID:
10934324
47.

Experience-dependent development of spinal motor neurons.

Inglis FM, Zuckerman KE, Kalb RG.

Neuron. 2000 May;26(2):299-305.

48.

Semaphorin3A enhances endocytosis at sites of receptor-F-actin colocalization during growth cone collapse.

Fournier AE, Nakamura F, Kawamoto S, Goshima Y, Kalb RG, Strittmatter SM.

J Cell Biol. 2000 Apr 17;149(2):411-22.

49.

Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway.

Papapetropoulos A, Fulton D, Mahboubi K, Kalb RG, O'Connor DS, Li F, Altieri DC, Sessa WC.

J Biol Chem. 2000 Mar 31;275(13):9102-5.

50.

Brain-derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the phosphatidylinositol 3-kinase pathway.

Fryer HJ, Wolf DH, Knox RJ, Strittmatter SM, Pennica D, O'Leary RM, Russell DS, Kalb RG.

J Neurochem. 2000 Feb;74(2):582-95.

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