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Items: 11


Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis.

Xu H, Lee MS, Tsai PY, Adler AS, Curry NL, Challa S, Freinkman E, Hitchcock DS, Copps KD, White MF, Bronson RT, Marcotrigiano M, Wu Y, Clish CB, Kalaany NY.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4228-4233. doi: 10.1073/pnas.1718414115. Epub 2018 Apr 2.


Critical role for arginase 2 in obesity-associated pancreatic cancer.

Zaytouni T, Tsai PY, Hitchcock DS, DuBois CD, Freinkman E, Lin L, Morales-Oyarvide V, Lenehan PJ, Wolpin BM, Mino-Kenudson M, Torres EM, Stylopoulos N, Clish CB, Kalaany NY.

Nat Commun. 2017 Aug 14;8(1):242. doi: 10.1038/s41467-017-00331-y.


Starved epithelial cells uptake extracellular matrix for survival.

Muranen T, Iwanicki MP, Curry NL, Hwang J, DuBois CD, Coloff JL, Hitchcock DS, Clish CB, Brugge JS, Kalaany NY.

Nat Commun. 2017 Jan 10;8:13989. doi: 10.1038/ncomms13989.


Autophagy is required for glucose homeostasis and lung tumor maintenance.

Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E.

Cancer Discov. 2014 Aug;4(8):914-27. doi: 10.1158/2159-8290.CD-14-0363. Epub 2014 May 29.


Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.

Curry NL, Mino-Kenudson M, Oliver TG, Yilmaz OH, Yilmaz VO, Moon JY, Jacks T, Sabatini DM, Kalaany NY.

Cancer Discov. 2013 Aug;3(8):908-21. doi: 10.1158/2159-8290.CD-12-0507. Epub 2013 May 29.


Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM.

Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350.


Tumours with PI3K activation are resistant to dietary restriction.

Kalaany NY, Sabatini DM.

Nature. 2009 Apr 9;458(7239):725-31. doi: 10.1038/nature07782. Epub 2009 Mar 11.


Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM.

Dev Cell. 2006 Dec;11(6):859-71.


LXRS and FXR: the yin and yang of cholesterol and fat metabolism.

Kalaany NY, Mangelsdorf DJ.

Annu Rev Physiol. 2006;68:159-91. Review.


LXRs regulate the balance between fat storage and oxidation.

Kalaany NY, Gauthier KC, Zavacki AM, Mammen PP, Kitazume T, Peterson JA, Horton JD, Garry DJ, Bianco AC, Mangelsdorf DJ.

Cell Metab. 2005 Apr;1(4):231-44.


ECM-induced gap junctional communication enhances mammary epithelial cell differentiation.

El-Sabban ME, Sfeir AJ, Daher MH, Kalaany NY, Bassam RA, Talhouk RS.

J Cell Sci. 2003 Sep 1;116(Pt 17):3531-41.

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