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Items: 1 to 50 of 51

1.

Kinin B1 Receptor Is Important in the Pathogenesis of Myeloperoxidase-Specific ANCA GN.

Hu P, Su H, Xiao H, Gou SJ, Herrera CA, Alba MA, Kakoki M, Falk RJ, Jennette JC.

J Am Soc Nephrol. 2019 Nov 26. pii: ASN.2019010032. doi: 10.1681/ASN.2019010032. [Epub ahead of print]

PMID:
31772138
2.

Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production.

Kakoki M, Bahnson EM, Hagaman JR, Siletzky RM, Grant R, Kayashima Y, Li F, Lee EY, Sun MT, Taylor JM, Rice JC, Almeida MF, Bahr BA, Jennette JC, Smithies O, Maeda-Smithies N.

JCI Insight. 2019 Jun 20;4(12). pii: 127660. doi: 10.1172/jci.insight.127660. eCollection 2019 Jun 20.

3.

Aging phenotype(s) in kidneys of diabetic mice are p66ShcA dependent.

Vashistha H, Marrero L, Reiss K, Cohen AJ, Malhotra A, Javed T, Bradley A, Abbruscato F, Giusti S, Jimenez A, Mehra S, Kaushal D, Giorgio M, Pelicci PG, Kakoki M, Singhal PC, Bunnell B, Meggs LG.

Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1833-F1842. doi: 10.1152/ajprenal.00608.2017. Epub 2018 Sep 12.

4.

Bufalin induces DNA damage response under hypoxic condition in myeloma cells.

Fujii E, Inada Y, Kakoki M, Nishimura N, Endo S, Fujiwara S, Wada N, Kawano Y, Okuno Y, Sugimoto T, Hata H.

Oncol Lett. 2018 May;15(5):6443-6449. doi: 10.3892/ol.2018.8091. Epub 2018 Feb 21.

5.

Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice.

Li F, Kakoki M, Smid M, Boggess K, Wilder J, Hiller S, Bounajim C, Parnell SE, Sulik KK, Smithies O, Maeda-Smithies N.

Hypertension. 2018 May;71(5):894-903. doi: 10.1161/HYPERTENSIONAHA.117.10849. Epub 2018 Apr 2.

6.

GRAF3 serves as a blood volume-sensitive rheostat to control smooth muscle contractility and blood pressure.

Bai X, Mangum K, Kakoki M, Smithies O, Mack CP, Taylor JM.

Small GTPases. 2017 Nov 3:1-10. doi: 10.1080/21541248.2017.1375602. [Epub ahead of print]

PMID:
29099324
7.

Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase.

Chang AS, Grant R, Tomita H, Kim HS, Smithies O, Kakoki M.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12538-12543. Epub 2016 Oct 17.

8.

High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy.

Hathaway CK, Chang AS, Grant R, Kim HS, Madden VJ, Bagnell CR Jr, Jennette JC, Smithies O, Kakoki M.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2218-22. doi: 10.1073/pnas.1600511113. Epub 2016 Feb 8.

9.

Transforming growth factor-β1 and diabetic nephropathy.

Chang AS, Hathaway CK, Smithies O, Kakoki M.

Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F689-F696. doi: 10.1152/ajprenal.00502.2015. Epub 2015 Dec 30. Review.

10.

Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice.

Hathaway CK, Gasim AM, Grant R, Chang AS, Kim HS, Madden VJ, Bagnell CR Jr, Jennette JC, Smithies O, Kakoki M.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5815-20. doi: 10.1073/pnas.1504777112. Epub 2015 Apr 20.

11.

Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade.

Hathaway CK, Grant R, Hagaman JR, Hiller S, Li F, Xu L, Chang AS, Madden VJ, Bagnell CR, Rojas M, Kim HS, Wu B, Zhou B, Smithies O, Kakoki M.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5141-6. doi: 10.1073/pnas.1504557112. Epub 2015 Apr 6.

12.

Transforming growth factor beta1 and aldosterone.

Matsuki K, Hathaway CK, Chang AS, Smithies O, Kakoki M.

Curr Opin Nephrol Hypertens. 2015 Mar;24(2):139-44. doi: 10.1097/MNH.0000000000000100. Review.

13.

The role of transforming growth factor β1 in the regulation of blood pressure.

Matsuki K, Hathaway CK, Lawrence MG, Smithies O, Kakoki M.

Curr Hypertens Rev. 2014;10(4):223-38. Review.

14.

The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension.

Bai X, Lenhart KC, Bird KE, Suen AA, Rojas M, Kakoki M, Li F, Smithies O, Mack CP, Taylor JM.

Nat Commun. 2013;4:2910. doi: 10.1038/ncomms3910.

15.

Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1.

Kakoki M, Pochynyuk OM, Hathaway CM, Tomita H, Hagaman JR, Kim HS, Zaika OL, Mamenko M, Kayashima Y, Matsuki K, Hiller S, Li F, Xu L, Grant R, Bertorello AM, Smithies O.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5600-5. doi: 10.1073/pnas.1302641110. Epub 2013 Mar 15.

16.

Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney.

Vashistha H, Singhal PC, Malhotra A, Husain M, Mathieson P, Saleem MA, Kuriakose C, Seshan S, Wilk A, Delvalle L, Peruzzi F, Giorgio M, Pelicci PG, Smithies O, Kim HS, Kakoki M, Reiss K, Meggs LG.

Am J Physiol Renal Physiol. 2012 Dec 15;303(12):F1629-40. doi: 10.1152/ajprenal.00246.2012. Epub 2012 Sep 26.

17.

The kallikrein-kinin system in diabetic nephropathy.

Tomita H, Sanford RB, Smithies O, Kakoki M.

Kidney Int. 2012 Apr;81(8):733-44. doi: 10.1038/ki.2011.499. Epub 2012 Feb 8. Review.

18.

The kallikrein-kinin system and oxidative stress.

Kayashima Y, Smithies O, Kakoki M.

Curr Opin Nephrol Hypertens. 2012 Jan;21(1):92-6. doi: 10.1097/MNH.0b013e32834d54b1. Review.

19.

Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.

Wende AR, Soto J, Olsen CD, Pires KM, Schell JC, Larrieu-Lahargue F, Litwin SE, Kakoki M, Takahashi N, Smithies O, Abel ED.

Endocrinology. 2010 Aug;151(8):3536-42. doi: 10.1210/en.2010-0256. Epub 2010 May 25.

20.

Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.

Kakoki M, Sullivan KA, Backus C, Hayes JM, Oh SS, Hua K, Gasim AM, Tomita H, Grant R, Nossov SB, Kim HS, Jennette JC, Feldman EL, Smithies O.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10190-5. doi: 10.1073/pnas.1005144107. Epub 2010 May 17.

21.

Mouse models of diabetic nephropathy.

Brosius FC 3rd, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T; Animal Models of Diabetic Complications Consortium.

J Am Soc Nephrol. 2009 Dec;20(12):2503-12. doi: 10.1681/ASN.2009070721. Epub 2009 Sep 3. Review.

22.

The kallikrein-kinin system in health and in diseases of the kidney.

Kakoki M, Smithies O.

Kidney Int. 2009 May;75(10):1019-30. doi: 10.1038/ki.2008.647. Epub 2009 Feb 4. Review.

23.

Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury.

Kakoki M, McGarrah RW, Kim HS, Smithies O.

Proc Natl Acad Sci U S A. 2007 May 1;104(18):7576-81. Epub 2007 Apr 23.

24.

Quantitative effects of common genetic variations in the 3'UTR of the human LDL-receptor gene and their associations with plasma lipid levels in the Atherosclerosis Risk in Communities study.

Muallem H, North KE, Kakoki M, Wojczynski MK, Li X, Grove M, Boerwinkle E, Wilhelmsen KC, Heiss G, Maeda N.

Hum Genet. 2007 May;121(3-4):421-31. Epub 2007 Feb 2. Erratum in: Hum Genet. 2007 Nov;122(3-4):421-2.

PMID:
17273844
25.

Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors.

Kakoki M, Kizer CM, Yi X, Takahashi N, Kim HS, Bagnell CR, Edgell CJ, Maeda N, Jennette JC, Smithies O.

J Clin Invest. 2006 May;116(5):1302-9. Epub 2006 Apr 6.

26.

Amino acids as modulators of endothelium-derived nitric oxide.

Kakoki M, Kim HS, Edgell CJ, Maeda N, Smithies O, Mattson DL.

Am J Physiol Renal Physiol. 2006 Aug;291(2):F297-304. Epub 2006 Mar 28.

27.

Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor.

Kakoki M, Takahashi N, Jennette JC, Smithies O.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13302-5. Epub 2004 Aug 23.

28.

L-Arginine uptake affects nitric oxide production and blood flow in the renal medulla.

Kakoki M, Kim HS, Arendshorst WJ, Mattson DL.

Am J Physiol Regul Integr Comp Physiol. 2004 Dec;287(6):R1478-85. Epub 2004 Aug 19.

29.

Altering the expression in mice of genes by modifying their 3' regions.

Kakoki M, Tsai YS, Kim HS, Hatada S, Ciavatta DJ, Takahashi N, Arnold LW, Maeda N, Smithies O.

Dev Cell. 2004 Apr;6(4):597-606.

30.

Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice.

Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Suzuki E, Sata M, Satonaka H, Takeda R, Nagata D, Kakoki M, Hayakawa H, Kangawa K, Matsuo H, Kitamura T, Nagai R.

Hypertens Res. 2003 Feb;26 Suppl:S79-84.

31.

Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury: studies on transgenic/knockout mice of adrenomedullin gene.

Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Kakoki M, Nagata D, Hayakawa H, Satonaka H, Sata M, Tojo A, Suzuki E, Kangawa K, Matsuo H, Kitamura T, Nagai R.

Circ Res. 2002 Apr 5;90(6):657-63.

PMID:
11934832
32.

Cationic amino acid transport in the renal medulla and blood pressure regulation.

Kakoki M, Wang W, Mattson DL.

Hypertension. 2002 Feb;39(2):287-92.

PMID:
11847199
33.

Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.

Shindo T, Kurihara Y, Nishimatsu H, Moriyama N, Kakoki M, Wang Y, Imai Y, Ebihara A, Kuwaki T, Ju KH, Minamino N, Kangawa K, Ishikawa T, Fukuda M, Akimoto Y, Kawakami H, Imai T, Morita H, Yazaki Y, Nagai R, Hirata Y, Kurihara H.

Circulation. 2001 Oct 16;104(16):1964-71.

PMID:
11602502
34.

The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney.

Kakoki M, Zou AP, Mattson DL.

Am J Physiol Regul Integr Comp Physiol. 2001 Jul;281(1):R91-7.

35.

Cyclin A downregulation and p21(cip1) upregulation correlate with GATA-6-induced growth arrest in glomerular mesangial cells.

Nagata D, Suzuki E, Nishimatsu H, Yoshizumi M, Mano T, Walsh K, Sata M, Kakoki M, Goto A, Omata M, Hirata Y.

Circ Res. 2000 Oct 13;87(8):699-704.

PMID:
11029406
36.

Effects of vasodilatory antihypertensive agents on endothelial dysfunction in rats with ischemic acute renal failure.

Kakoki M, Hirata Y, Hayakawa H, Suzuki E, Nagata D, Nishimatsu H, Kimura K, Goto A, Omata M.

Hypertens Res. 2000 Sep;23(5):527-33.

37.

Adrenomedullin and nitric oxide inhibit human endothelial cell apoptosis via a cyclic GMP-independent mechanism.

Sata M, Kakoki M, Nagata D, Nishimatsu H, Suzuki E, Aoyagi T, Sugiura S, Kojima H, Nagano T, Kangawa K, Matsuo H, Omata M, Nagai R, Hirata Y.

Hypertension. 2000 Jul;36(1):83-8.

PMID:
10904017
38.

Effects of tetrahydrobiopterin on endothelial dysfunction in rats with ischemic acute renal failure.

Kakoki M, Hirata Y, Hayakawa H, Suzuki E, Nagata D, Tojo A, Nishimatsu H, Nakanishi N, Hattori Y, Kikuchi K, Nagano T, Omata M.

J Am Soc Nephrol. 2000 Feb;11(2):301-9.

40.

Analysis of nitric oxide in the exhaled air of patients with chronic glomerulonephritis.

Kakoki M, Matsumoto A, Nagata D, Kobayakawa N, Kimura K, Momomura S, Hirata Y.

Clin Nephrol. 1999 Aug;52(2):83-90.

PMID:
10480218
41.

Hypoxia-induced adrenomedullin production in the kidney.

Nagata D, Hirata Y, Suzuki E, Kakoki M, Hayakawa H, Goto A, Ishimitsu T, Minamino N, Ono Y, Kangawa K, Matsuo H, Omata M.

Kidney Int. 1999 Apr;55(4):1259-67.

42.
43.

Effects of hypertension, diabetes mellitus, and hypercholesterolemia on endothelin type B receptor-mediated nitric oxide release from rat kidney.

Kakoki M, Hirata Y, Hayakawa H, Tojo A, Nagata D, Suzuki E, Kimura K, Goto A, Kikuchi K, Nagano T, Omata M.

Circulation. 1999 Mar 9;99(9):1242-8.

PMID:
10069794
44.

Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat.

Hayakawa H, Hirata Y, Kakoki M, Suzuki Y, Nishimatsu H, Nagata D, Suzuki E, Kikuchi K, Nagano T, Kangawa K, Matsuo H, Sugimoto T, Omata M.

Hypertension. 1999 Feb;33(2):689-93.

PMID:
10024329
45.

Effects of vasodilatory beta-adrenoceptor antagonists on endothelium-derived nitric oxide release in rat kidney.

Kakoki M, Hirata Y, Hayakawa H, Nishimatsu H, Suzuki Y, Nagata D, Suzuki E, Kikuchi K, Nagano T, Omata M.

Hypertension. 1999 Jan;33(1 Pt 2):467-71.

PMID:
9931149
46.

Increased excretion of nitric oxide in exhaled air of patients with chronic renal failure.

Matsumoto A, Hirata Y, Kakoki M, Nagata D, Momomura Si, Sugimoto T, Tagawa H, Omata M.

Clin Sci (Lond). 1999 Jan;96(1):67-74.

PMID:
9857108
47.

Receptor subtype for vasopressin-induced release of nitric oxide from rat kidney.

Hirata Y, Hayakawa H, Kakoki M, Tojo A, Suzuki E, Nagata D, Kimura K, Goto A, Kikuchi K, Nagano T, Hirobe M, Omata M.

Hypertension. 1997 Jan;29(1 Pt 1):58-64.

PMID:
9039081
48.
49.

Nitric oxide release from kidneys of hypertensive rats treated with imidapril.

Hirata Y, Hayakawa H, Kakoki M, Tojo A, Suzuki E, Kimura K, Goto A, Kikuchi K, Nagano T, Hirobe M, Omata M.

Hypertension. 1996 Mar;27(3 Pt 2):672-8.

PMID:
8613223
50.

Increased nitric oxide in the exhaled air of patients with decompensated liver cirrhosis.

Matsumoto A, Ogura K, Hirata Y, Kakoki M, Watanabe F, Takenaka K, Shiratori Y, Momomura S, Omata M.

Ann Intern Med. 1995 Jul 15;123(2):110-3.

PMID:
7778822

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